Baroreflex sensitivity and power spectral analysis during autonomic testing in different extrapyramidal syndromes
Identifieur interne : 001E34 ( Main/Exploration ); précédent : 001E33; suivant : 001E35Baroreflex sensitivity and power spectral analysis during autonomic testing in different extrapyramidal syndromes
Auteurs : Constanze Friedrich [Allemagne] ; Heinz Rüdiger [Allemagne] ; Claudia Schmidt [Allemagne] ; Birgit Herting [Allemagne] ; Silke Prieur [Allemagne] ; Susann Junghanns [Allemagne] ; Katherine Schweitzer [Allemagne] ; Christoph Globas [Allemagne] ; Ludger Schöls [Allemagne] ; Daniela Berg [Allemagne] ; Heinz Reichmann [Allemagne] ; Tjalf Ziemssen [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-02-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Aged, Autonomic Nervous System Diseases (diagnosis), Autonomic Nervous System Diseases (etiology), Baroreflex, Baroreflex (physiology), Basal Ganglia Diseases (classification), Basal Ganglia Diseases (complications), Blood Preservation (methods), Dysfunction, Electrocardiography (methods), Extrapyramidal syndrome, Female, Humans, Male, Middle Aged, Nervous system diseases, Power spectrum, Respiration Disorders (diagnosis), Respiration Disorders (etiology), Sensitivity analysis, Sensitivity and Specificity, Spectral analysis, Spectral sensitivity, Spectrum Analysis (methods), Statistics, Nonparametric, Valsalva Maneuver (physiology), autonomic dysfunction, autonomic testing, baroreflex sensitivity, extrapyramidal disease, spectral analysis.
- MESH :
- classification : Basal Ganglia Diseases.
- complications : Basal Ganglia Diseases.
- diagnosis : Autonomic Nervous System Diseases, Respiration Disorders.
- etiology : Autonomic Nervous System Diseases, Respiration Disorders.
- methods : Blood Preservation, Electrocardiography, Spectrum Analysis.
- physiology : Baroreflex, Valsalva Maneuver.
- Aged, Female, Humans, Male, Middle Aged, Sensitivity and Specificity, Statistics, Nonparametric.
Abstract
Autonomic dysfunction has been frequently demonstrated in patients with extrapyramidal diseases by cardiovascular autonomic testing. In addition to classical testing, we applied the more detailed baroreflex and spectral analysis on three traditional cardiovascular tests in this study to get additional information on autonomic outflow. We recorded continuously blood pressure, electrocardiogram, and respiration in 35 patients with multiple system atrophy, 32 patients with progressive supranuclear palsy, 46 patients with idiopathic Parkinson's disease and in 27 corresponding healthy subjects during cardiovascular autonomic testing (metronomic breathing, Valsalva manoeuvre, head‐up tilt). Baroreflex and spectral analyses were performed by using trigonometric regressive spectral analysis between and during the manoeuvres. Consistent with previous interpretations, our data showed an increase of sympathetic activity in head‐up tilt and Valsalva test in healthy controls. This sympathetic activity was significantly decreased in patients with typical and atypical Parkinson syndromes. Significant modulation of baroreflex activity could be observed especially during metronomic breathing; again it was significantly lower in all patient groups. Baroreflex and spectral parameters could not only differentiate between patients and healthy controls, but also differentiate between clinically symptomatic (with autonomic dysfunction as eg. orthostatic hypotension) and asymptomatic patients. In conclusion, our approach allows the evaluation of autonomic variability during short and nonstationary periods of time and may constitute a useful advance in the assessment of autonomic function in both physiological and pathological conditions. © 2009 Movement Disorder Society
Url:
DOI: 10.1002/mds.22844
Affiliations:
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<term>Autonomic Nervous System Diseases (diagnosis)</term>
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<term>Baroreflex</term>
<term>Baroreflex (physiology)</term>
<term>Basal Ganglia Diseases (classification)</term>
<term>Basal Ganglia Diseases (complications)</term>
<term>Blood Preservation (methods)</term>
<term>Dysfunction</term>
<term>Electrocardiography (methods)</term>
<term>Extrapyramidal syndrome</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Nervous system diseases</term>
<term>Power spectrum</term>
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<term>Spectrum Analysis (methods)</term>
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<term>autonomic dysfunction</term>
<term>autonomic testing</term>
<term>baroreflex sensitivity</term>
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<front><div type="abstract" xml:lang="en">Autonomic dysfunction has been frequently demonstrated in patients with extrapyramidal diseases by cardiovascular autonomic testing. In addition to classical testing, we applied the more detailed baroreflex and spectral analysis on three traditional cardiovascular tests in this study to get additional information on autonomic outflow. We recorded continuously blood pressure, electrocardiogram, and respiration in 35 patients with multiple system atrophy, 32 patients with progressive supranuclear palsy, 46 patients with idiopathic Parkinson's disease and in 27 corresponding healthy subjects during cardiovascular autonomic testing (metronomic breathing, Valsalva manoeuvre, head‐up tilt). Baroreflex and spectral analyses were performed by using trigonometric regressive spectral analysis between and during the manoeuvres. Consistent with previous interpretations, our data showed an increase of sympathetic activity in head‐up tilt and Valsalva test in healthy controls. This sympathetic activity was significantly decreased in patients with typical and atypical Parkinson syndromes. Significant modulation of baroreflex activity could be observed especially during metronomic breathing; again it was significantly lower in all patient groups. Baroreflex and spectral parameters could not only differentiate between patients and healthy controls, but also differentiate between clinically symptomatic (with autonomic dysfunction as eg. orthostatic hypotension) and asymptomatic patients. In conclusion, our approach allows the evaluation of autonomic variability during short and nonstationary periods of time and may constitute a useful advance in the assessment of autonomic function in both physiological and pathological conditions. © 2009 Movement Disorder Society</div>
</front>
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<name sortKey="Schweitzer, Katherine" sort="Schweitzer, Katherine" uniqKey="Schweitzer K" first="Katherine" last="Schweitzer">Katherine Schweitzer</name>
<name sortKey="Ziemssen, Tjalf" sort="Ziemssen, Tjalf" uniqKey="Ziemssen T" first="Tjalf" last="Ziemssen">Tjalf Ziemssen</name>
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