Baroreflex sensitivity and power spectral analysis during autonomic testing in different extrapyramidal syndromes
Identifieur interne : 000966 ( Istex/Corpus ); précédent : 000965; suivant : 000967Baroreflex sensitivity and power spectral analysis during autonomic testing in different extrapyramidal syndromes
Auteurs : Constanze Friedrich ; Heinz Rüdiger ; Claudia Schmidt ; Birgit Herting ; Silke Prieur ; Susann Junghanns ; Katherine Schweitzer ; Christoph Globas ; Ludger Schöls ; Daniela Berg ; Heinz Reichmann ; Tjalf ZiemssenSource :
- Movement Disorders [ 0885-3185 ] ; 2010-02-15.
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Abstract
Autonomic dysfunction has been frequently demonstrated in patients with extrapyramidal diseases by cardiovascular autonomic testing. In addition to classical testing, we applied the more detailed baroreflex and spectral analysis on three traditional cardiovascular tests in this study to get additional information on autonomic outflow. We recorded continuously blood pressure, electrocardiogram, and respiration in 35 patients with multiple system atrophy, 32 patients with progressive supranuclear palsy, 46 patients with idiopathic Parkinson's disease and in 27 corresponding healthy subjects during cardiovascular autonomic testing (metronomic breathing, Valsalva manoeuvre, head‐up tilt). Baroreflex and spectral analyses were performed by using trigonometric regressive spectral analysis between and during the manoeuvres. Consistent with previous interpretations, our data showed an increase of sympathetic activity in head‐up tilt and Valsalva test in healthy controls. This sympathetic activity was significantly decreased in patients with typical and atypical Parkinson syndromes. Significant modulation of baroreflex activity could be observed especially during metronomic breathing; again it was significantly lower in all patient groups. Baroreflex and spectral parameters could not only differentiate between patients and healthy controls, but also differentiate between clinically symptomatic (with autonomic dysfunction as eg. orthostatic hypotension) and asymptomatic patients. In conclusion, our approach allows the evaluation of autonomic variability during short and nonstationary periods of time and may constitute a useful advance in the assessment of autonomic function in both physiological and pathological conditions. © 2009 Movement Disorder Society
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DOI: 10.1002/mds.22844
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syndromes</title><author><name sortKey="Friedrich, Constanze" sort="Friedrich, Constanze" uniqKey="Friedrich C" first="Constanze" last="Friedrich">Constanze Friedrich</name><affiliation><mods:affiliation>Autonomic and Neuroendocrinological Laboratory, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</mods:affiliation></affiliation></author><author><name sortKey="Rudiger, Heinz" sort="Rudiger, Heinz" uniqKey="Rudiger H" first="Heinz" last="Rüdiger">Heinz Rüdiger</name><affiliation><mods:affiliation>Autonomic and Neuroendocrinological Laboratory, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</mods:affiliation></affiliation></author><author><name sortKey="Schmidt, Claudia" sort="Schmidt, Claudia" uniqKey="Schmidt C" first="Claudia" last="Schmidt">Claudia Schmidt</name><affiliation><mods:affiliation>Autonomic and Neuroendocrinological Laboratory, University Clinic Carl Gustav Carus, Dresden University of Technology, 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University of Technology, Germany</mods:affiliation></affiliation></author><author><name sortKey="Schweitzer, Katherine" sort="Schweitzer, Katherine" uniqKey="Schweitzer K" first="Katherine" last="Schweitzer">Katherine Schweitzer</name><affiliation><mods:affiliation>Center of Neurology, Department of Neurodegeneration and Hertie‐Institute for Clinical Brain Research, University of Tübingen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Globas, Christoph" sort="Globas, Christoph" uniqKey="Globas C" first="Christoph" last="Globas">Christoph Globas</name><affiliation><mods:affiliation>Center of Neurology, Department of Neurodegeneration and Hertie‐Institute for Clinical Brain Research, University of Tübingen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Schols, Ludger" sort="Schols, Ludger" uniqKey="Schols L" first="Ludger" last="Schöls">Ludger Schöls</name><affiliation><mods:affiliation>Center of Neurology, Department of Neurodegeneration and Hertie‐Institute for Clinical Brain Research, University of Tübingen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name><affiliation><mods:affiliation>Center of Neurology, Department of Neurodegeneration and Hertie‐Institute for Clinical Brain Research, University of Tübingen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Reichmann, Heinz" sort="Reichmann, Heinz" uniqKey="Reichmann H" first="Heinz" last="Reichmann">Heinz Reichmann</name><affiliation><mods:affiliation>Movement Disorders Research Group, Department of Neurology, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</mods:affiliation></affiliation></author><author><name sortKey="Ziemssen, Tjalf" sort="Ziemssen, Tjalf" uniqKey="Ziemssen T" first="Tjalf" last="Ziemssen">Tjalf Ziemssen</name><affiliation><mods:affiliation>Autonomic and Neuroendocrinological Laboratory, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. 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In addition to classical testing, we applied the more detailed baroreflex and spectral analysis on three traditional cardiovascular tests in this study to get additional information on autonomic outflow. We recorded continuously blood pressure, electrocardiogram, and respiration in 35 patients with multiple system atrophy, 32 patients with progressive supranuclear palsy, 46 patients with idiopathic Parkinson's disease and in 27 corresponding healthy subjects during cardiovascular autonomic testing (metronomic breathing, Valsalva manoeuvre, head‐up tilt). Baroreflex and spectral analyses were performed by using trigonometric regressive spectral analysis between and during the manoeuvres. Consistent with previous interpretations, our data showed an increase of sympathetic activity in head‐up tilt and Valsalva test in healthy controls. This sympathetic activity was significantly decreased in patients with typical and atypical Parkinson syndromes. Significant modulation of baroreflex activity could be observed especially during metronomic breathing; again it was significantly lower in all patient groups. Baroreflex and spectral parameters could not only differentiate between patients and healthy controls, but also differentiate between clinically symptomatic (with autonomic dysfunction as eg. orthostatic hypotension) and asymptomatic patients. In conclusion, our approach allows the evaluation of autonomic variability during short and nonstationary periods of time and may constitute a useful advance in the assessment of autonomic function in both physiological and pathological conditions. © 2009 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Constanze Friedrich MD</name><affiliations><json:string>Autonomic and Neuroendocrinological Laboratory, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</json:string></affiliations></json:item><json:item><name>Heinz Rüdiger PhD</name><affiliations><json:string>Autonomic and Neuroendocrinological Laboratory, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</json:string></affiliations></json:item><json:item><name>Claudia Schmidt MD</name><affiliations><json:string>Autonomic and Neuroendocrinological Laboratory, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</json:string></affiliations></json:item><json:item><name>Birgit Herting MD</name><affiliations><json:string>Movement Disorders Research Group, Department of Neurology, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</json:string></affiliations></json:item><json:item><name>Silke Prieur RN</name><affiliations><json:string>Autonomic and Neuroendocrinological Laboratory, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</json:string></affiliations></json:item><json:item><name>Susann Junghanns MD</name><affiliations><json:string>Movement Disorders Research Group, Department of Neurology, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</json:string></affiliations></json:item><json:item><name>Katherine Schweitzer MD</name><affiliations><json:string>Center of Neurology, Department of Neurodegeneration and Hertie‐Institute for Clinical Brain Research, University of Tübingen, Germany</json:string></affiliations></json:item><json:item><name>Christoph Globas MD</name><affiliations><json:string>Center of Neurology, Department of Neurodegeneration and Hertie‐Institute for Clinical Brain Research, University of Tübingen, Germany</json:string></affiliations></json:item><json:item><name>Ludger Schöls MD</name><affiliations><json:string>Center of Neurology, Department of Neurodegeneration and Hertie‐Institute for Clinical Brain Research, University of Tübingen, Germany</json:string></affiliations></json:item><json:item><name>Daniela Berg MD</name><affiliations><json:string>Center of Neurology, Department of Neurodegeneration and Hertie‐Institute for Clinical Brain Research, University of Tübingen, Germany</json:string></affiliations></json:item><json:item><name>Heinz Reichmann MD</name><affiliations><json:string>Movement Disorders Research Group, Department of Neurology, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</json:string></affiliations></json:item><json:item><name>Tjalf Ziemssen MD</name><affiliations><json:string>Autonomic and Neuroendocrinological Laboratory, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>autonomic dysfunction</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>baroreflex sensitivity</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>extrapyramidal disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>spectral analysis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>autonomic testing</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Autonomic dysfunction has been frequently demonstrated in patients with extrapyramidal diseases by cardiovascular autonomic testing. In addition to classical testing, we applied the more detailed baroreflex and spectral analysis on three traditional cardiovascular tests in this study to get additional information on autonomic outflow. We recorded continuously blood pressure, electrocardiogram, and respiration in 35 patients with multiple system atrophy, 32 patients with progressive supranuclear palsy, 46 patients with idiopathic Parkinson's disease and in 27 corresponding healthy subjects during cardiovascular autonomic testing (metronomic breathing, Valsalva manoeuvre, head‐up tilt). Baroreflex and spectral analyses were performed by using trigonometric regressive spectral analysis between and during the manoeuvres. Consistent with previous interpretations, our data showed an increase of sympathetic activity in head‐up tilt and Valsalva test in healthy controls. This sympathetic activity was significantly decreased in patients with typical and atypical Parkinson syndromes. Significant modulation of baroreflex activity could be observed especially during metronomic breathing; again it was significantly lower in all patient groups. Baroreflex and spectral parameters could not only differentiate between patients and healthy controls, but also differentiate between clinically symptomatic (with autonomic dysfunction as eg. orthostatic hypotension) and asymptomatic patients. In conclusion, our approach allows the evaluation of autonomic variability during short and nonstationary periods of time and may constitute a useful advance in the assessment of autonomic function in both physiological and pathological conditions. © 2009 Movement Disorder Society</abstract><qualityIndicators><score>7.111</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>1776</abstractCharCount><pdfWordCount>4363</pdfWordCount><pdfCharCount>28529</pdfCharCount><pdfPageCount>10</pdfPageCount><abstractWordCount>229</abstractWordCount></qualityIndicators><title>Baroreflex sensitivity and power spectral analysis during autonomic testing in different extrapyramidal syndromes</title><genre><json:string>Serial 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type="first">Heinz</forename><surname>Rüdiger</surname><roleName type="degree">PhD</roleName></persName><affiliation>Autonomic and Neuroendocrinological Laboratory, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</affiliation></author><author><persName><forename type="first">Claudia</forename><surname>Schmidt</surname><roleName type="degree">MD</roleName></persName><affiliation>Autonomic and Neuroendocrinological Laboratory, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</affiliation></author><author><persName><forename type="first">Birgit</forename><surname>Herting</surname><roleName type="degree">MD</roleName></persName><affiliation>Movement Disorders Research Group, Department of Neurology, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</affiliation></author><author><persName><forename type="first">Silke</forename><surname>Prieur</surname><roleName type="degree">RN</roleName></persName><affiliation>Autonomic and Neuroendocrinological Laboratory, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</affiliation></author><author><persName><forename type="first">Susann</forename><surname>Junghanns</surname><roleName type="degree">MD</roleName></persName><affiliation>Movement Disorders Research Group, Department of Neurology, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</affiliation></author><author><persName><forename type="first">Katherine</forename><surname>Schweitzer</surname><roleName type="degree">MD</roleName></persName><affiliation>Center of Neurology, Department of Neurodegeneration and Hertie‐Institute for Clinical Brain Research, University of Tübingen, Germany</affiliation></author><author><persName><forename type="first">Christoph</forename><surname>Globas</surname><roleName type="degree">MD</roleName></persName><affiliation>Center of Neurology, Department of Neurodegeneration and Hertie‐Institute for Clinical Brain Research, University of Tübingen, Germany</affiliation></author><author><persName><forename type="first">Ludger</forename><surname>Schöls</surname><roleName type="degree">MD</roleName></persName><affiliation>Center of Neurology, Department of Neurodegeneration and Hertie‐Institute for Clinical Brain Research, University of Tübingen, Germany</affiliation></author><author><persName><forename type="first">Daniela</forename><surname>Berg</surname><roleName type="degree">MD</roleName></persName><affiliation>Center of Neurology, Department of Neurodegeneration and Hertie‐Institute for Clinical Brain Research, University of Tübingen, Germany</affiliation></author><author><persName><forename type="first">Heinz</forename><surname>Reichmann</surname><roleName type="degree">MD</roleName></persName><affiliation>Movement Disorders Research Group, Department of Neurology, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</affiliation></author><author><persName><forename type="first">Tjalf</forename><surname>Ziemssen</surname><roleName type="degree">MD</roleName></persName><note type="correspondence"><p>Correspondence: Department of Neurology, University Clinic Carl Gustav Carus, Dresden University of Technology, Fetscherstraße 74, D‐01307 Dresden, Germany===</p></note><affiliation>Autonomic and Neuroendocrinological Laboratory, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-02-15"></date><biblScope unit="vol">25</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="315">315</biblScope><biblScope unit="page" to="324">324</biblScope></imprint></monogr><idno type="istex">310050E4843D2290D841768C1CB370D2352D9089</idno><idno type="DOI">10.1002/mds.22844</idno><idno type="ArticleID">MDS22844</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2010</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Autonomic dysfunction has been frequently demonstrated in patients with extrapyramidal diseases by cardiovascular autonomic testing. In addition to classical testing, we applied the more detailed baroreflex and spectral analysis on three traditional cardiovascular tests in this study to get additional information on autonomic outflow. We recorded continuously blood pressure, electrocardiogram, and respiration in 35 patients with multiple system atrophy, 32 patients with progressive supranuclear palsy, 46 patients with idiopathic Parkinson's disease and in 27 corresponding healthy subjects during cardiovascular autonomic testing (metronomic breathing, Valsalva manoeuvre, head‐up tilt). Baroreflex and spectral analyses were performed by using trigonometric regressive spectral analysis between and during the manoeuvres. Consistent with previous interpretations, our data showed an increase of sympathetic activity in head‐up tilt and Valsalva test in healthy controls. This sympathetic activity was significantly decreased in patients with typical and atypical Parkinson syndromes. Significant modulation of baroreflex activity could be observed especially during metronomic breathing; again it was significantly lower in all patient groups. Baroreflex and spectral parameters could not only differentiate between patients and healthy controls, but also differentiate between clinically symptomatic (with autonomic dysfunction as eg. orthostatic hypotension) and asymptomatic patients. In conclusion, our approach allows the evaluation of autonomic variability during short and nonstationary periods of time and may constitute a useful advance in the assessment of autonomic function in both physiological and pathological conditions. © 2009 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>autonomic dysfunction</term></item><item><term>baroreflex sensitivity</term></item><item><term>extrapyramidal disease</term></item><item><term>spectral analysis</term></item><item><term>autonomic testing</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2009-06-11">Received</change><change when="2009-09-19">Registration</change><change when="2010-02-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/310050E4843D2290D841768C1CB370D2352D9089/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="30"><doi origin="wiley" registered="yes">10.1002/mds.v25:3</doi><numberingGroup><numbering type="journalVolume" number="25">25</numbering><numbering type="journalIssue">3</numbering></numberingGroup><coverDate startDate="2010-02-15">15 February 2010</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="100" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.22844</doi><idGroup><id type="unit" value="MDS22844"></id></idGroup><countGroup><count type="pageTotal" number="10"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="thirdParty">Copyright © 2009 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2009-06-11"></event><event type="manuscriptRevised" date="2009-09-09"></event><event type="manuscriptAccepted" date="2009-09-19"></event><event type="firstOnline" date="2009-12-11"></event><event type="publishedOnlineFinalForm" date="2010-02-24"></event><event type="publishedOnlineAcceptedOrEarlyUnpaginated" date="2009-12-11"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:3.3.2 mode:FullText" date="2014-07-01"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.3.2 mode:FullText" date="2014-07-01"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">315</numbering><numbering type="pageLast">324</numbering></numberingGroup><correspondenceTo>Department of Neurology, University Clinic Carl Gustav Carus, Dresden University of Technology, Fetscherstraße 74, D‐01307 Dresden, Germany===</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS22844.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="5"></count><count type="tableTotal" number="1"></count><count type="referenceTotal" number="25"></count><count type="wordTotal" number="5285"></count></countGroup><titleGroup><title type="main" xml:lang="en">Baroreflex sensitivity and power spectral analysis during autonomic testing in different extrapyramidal syndromes<link href="#fn1"></link></title><title type="short" xml:lang="en">BRS and Spectral Analysis</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Constanze</givenNames><familyName>Friedrich</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Heinz</givenNames><familyName>Rüdiger</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Claudia</givenNames><familyName>Schmidt</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Birgit</givenNames><familyName>Herting</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Silke</givenNames><familyName>Prieur</familyName><degrees>RN</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Susann</givenNames><familyName>Junghanns</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Katherine</givenNames><familyName>Schweitzer</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Christoph</givenNames><familyName>Globas</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Ludger</givenNames><familyName>Schöls</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au10" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Daniela</givenNames><familyName>Berg</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au11" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Heinz</givenNames><familyName>Reichmann</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au12" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Tjalf</givenNames><familyName>Ziemssen</familyName><degrees>MD</degrees></personName><contactDetails><email normalForm="tjalf.ziemssen@uniklinikum-dresden.de">tjalf.ziemssen@uniklinikum‐dresden.de</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="DE" type="organization"><unparsedAffiliation>Autonomic and Neuroendocrinological Laboratory, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="DE" type="organization"><unparsedAffiliation>Movement Disorders Research Group, Department of Neurology, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="DE" type="organization"><unparsedAffiliation>Center of Neurology, Department of Neurodegeneration and Hertie‐Institute for Clinical Brain Research, University of Tübingen, Germany</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">autonomic dysfunction</keyword><keyword xml:id="kwd2">baroreflex sensitivity</keyword><keyword xml:id="kwd3">extrapyramidal disease</keyword><keyword xml:id="kwd4">spectral analysis</keyword><keyword xml:id="kwd5">autonomic testing</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Autonomic dysfunction has been frequently demonstrated in patients with extrapyramidal diseases by cardiovascular autonomic testing. In addition to classical testing, we applied the more detailed baroreflex and spectral analysis on three traditional cardiovascular tests in this study to get additional information on autonomic outflow. We recorded continuously blood pressure, electrocardiogram, and respiration in 35 patients with multiple system atrophy, 32 patients with progressive supranuclear palsy, 46 patients with idiopathic Parkinson's disease and in 27 corresponding healthy subjects during cardiovascular autonomic testing (metronomic breathing, Valsalva manoeuvre, head‐up tilt). Baroreflex and spectral analyses were performed by using trigonometric regressive spectral analysis between and during the manoeuvres. Consistent with previous interpretations, our data showed an increase of sympathetic activity in head‐up tilt and Valsalva test in healthy controls. This sympathetic activity was significantly decreased in patients with typical and atypical Parkinson syndromes. Significant modulation of baroreflex activity could be observed especially during metronomic breathing; again it was significantly lower in all patient groups. Baroreflex and spectral parameters could not only differentiate between patients and healthy controls, but also differentiate between clinically symptomatic (with autonomic dysfunction as eg. orthostatic hypotension) and asymptomatic patients. In conclusion, our approach allows the evaluation of autonomic variability during short and nonstationary periods of time and may constitute a useful advance in the assessment of autonomic function in both physiological and pathological conditions. © 2009 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Potential conflict of interest: Nothing to report.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Baroreflex sensitivity and power spectral analysis during autonomic testing in different extrapyramidal syndromes</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>BRS and Spectral Analysis</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Baroreflex sensitivity and power spectral analysis during autonomic testing in different extrapyramidal syndromes</title></titleInfo><name type="personal"><namePart type="given">Constanze</namePart><namePart type="family">Friedrich</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Autonomic and Neuroendocrinological Laboratory, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Heinz</namePart><namePart type="family">Rüdiger</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Autonomic and Neuroendocrinological Laboratory, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Claudia</namePart><namePart type="family">Schmidt</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Autonomic and Neuroendocrinological Laboratory, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Birgit</namePart><namePart type="family">Herting</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Movement Disorders Research Group, Department of Neurology, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Silke</namePart><namePart type="family">Prieur</namePart><namePart type="termsOfAddress">RN</namePart><affiliation>Autonomic and Neuroendocrinological Laboratory, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Susann</namePart><namePart type="family">Junghanns</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Movement Disorders Research Group, Department of Neurology, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Katherine</namePart><namePart type="family">Schweitzer</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Center of Neurology, Department of Neurodegeneration and Hertie‐Institute for Clinical Brain Research, University of Tübingen, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Christoph</namePart><namePart type="family">Globas</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Center of Neurology, Department of Neurodegeneration and Hertie‐Institute for Clinical Brain Research, University of Tübingen, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ludger</namePart><namePart type="family">Schöls</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Center of Neurology, Department of Neurodegeneration and Hertie‐Institute for Clinical Brain Research, University of Tübingen, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Daniela</namePart><namePart type="family">Berg</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Center of Neurology, Department of Neurodegeneration and Hertie‐Institute for Clinical Brain Research, University of Tübingen, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Heinz</namePart><namePart type="family">Reichmann</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Movement Disorders Research Group, Department of Neurology, 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encoding="w3cdtf">2009-06-11</dateCaptured><dateValid encoding="w3cdtf">2009-09-19</dateValid><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">5</extent><extent unit="tables">1</extent><extent unit="references">25</extent><extent unit="words">5285</extent></physicalDescription><abstract lang="en">Autonomic dysfunction has been frequently demonstrated in patients with extrapyramidal diseases by cardiovascular autonomic testing. In addition to classical testing, we applied the more detailed baroreflex and spectral analysis on three traditional cardiovascular tests in this study to get additional information on autonomic outflow. We recorded continuously blood pressure, electrocardiogram, and respiration in 35 patients with multiple system atrophy, 32 patients with progressive supranuclear palsy, 46 patients with idiopathic Parkinson's disease and in 27 corresponding healthy subjects during cardiovascular autonomic testing (metronomic breathing, Valsalva manoeuvre, head‐up tilt). Baroreflex and spectral analyses were performed by using trigonometric regressive spectral analysis between and during the manoeuvres. Consistent with previous interpretations, our data showed an increase of sympathetic activity in head‐up tilt and Valsalva test in healthy controls. This sympathetic activity was significantly decreased in patients with typical and atypical Parkinson syndromes. Significant modulation of baroreflex activity could be observed especially during metronomic breathing; again it was significantly lower in all patient groups. Baroreflex and spectral parameters could not only differentiate between patients and healthy controls, but also differentiate between clinically symptomatic (with autonomic dysfunction as eg. orthostatic hypotension) and asymptomatic patients. In conclusion, our approach allows the evaluation of autonomic variability during short and nonstationary periods of time and may constitute a useful advance in the assessment of autonomic function in both physiological and pathological conditions. © 2009 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: Nothing to report.</note><subject lang="en"><genre>Keywords</genre><topic>autonomic dysfunction</topic><topic>baroreflex sensitivity</topic><topic>extrapyramidal disease</topic><topic>spectral analysis</topic><topic>autonomic testing</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. 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