Long‐term stability of effects of subthalamic stimulation in Parkinson's disease: Indian Experience
Identifieur interne : 001B95 ( Main/Exploration ); précédent : 001B94; suivant : 001B96Long‐term stability of effects of subthalamic stimulation in Parkinson's disease: Indian Experience
Auteurs : Asha Kishore [Inde] ; Ravimohan Rao [Inde] ; Syam Krishnan [Inde] ; Dilip Panikar [Inde] ; Gangadhara Sarma [Inde] ; Mathuranath Pavagada Sivasanakaran [Inde] ; Sankara Sarma [Inde]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-10-30.
Descripteurs français
- Pascal (Inist)
- Wicri :
English descriptors
- KwdEn :
- Adult, Antiparkinson Agents (therapeutic use), Asia, Attention (physiology), Cognition Disorders (etiology), Cognition Disorders (therapy), Deep Brain Stimulation (methods), Deep brain stimulation, Dyskinesias (etiology), Dyskinesias (therapy), Executive Function (physiology), Experience, Female, Fluctuations, Humans, India (epidemiology), Indian, Levodopa (therapeutic use), Long term, Longitudinal Studies, Male, Middle Aged, Nervous system diseases, Neuropsychological Tests, Parkinson Disease (complications), Parkinson Disease (therapy), Parkinson disease, Parkinson's disease, Quality of Life, Retrospective Studies, Single-Blind Method, Stability, Subthalamic Nucleus (physiology), Subthalamic nucleus, Time Factors, Treatment Outcome, deep brain stimulation, motor fluctuations, subthalamic nucleus.
- MESH :
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- geographic , epidemiology : India.
- complications : Parkinson Disease.
- etiology : Cognition Disorders, Dyskinesias.
- methods : Deep Brain Stimulation.
- physiology : Attention, Executive Function, Subthalamic Nucleus.
- therapy : Cognition Disorders, Dyskinesias, Parkinson Disease.
- Adult, Female, Humans, Longitudinal Studies, Male, Middle Aged, Neuropsychological Tests, Quality of Life, Retrospective Studies, Single-Blind Method, Time Factors, Treatment Outcome.
Abstract
Reports of long‐term effects of subthalamic (STN) stimulation for Parkinson's disease (PD) are few, mostly open‐label evaluations and from Western centers. We used single‐blind and open‐label motor, cognitive and quality of life (QOL) evaluations to study the effects of bilateral STN stimulation in 45 patients over 5 years. Our patients showed a stable and substantial reduction in the cardinal signs of PD, motor fluctuations, and dyskinesias but less so for axial signs. The reduction in medications and the intensity of electrical stimulation needed also remained stable during follow up. Although the total QOL and its parkinsonism and social components showed sustained benefits till 5 years, the gains in emotional and systemic subsets were short lasting. Global scores for mood and cognition did not show significant worsening. Benefits of STN stimulation on the cardinal signs, motor complications, and QOL of advanced PD were substantial and sustained till 5 years. The initial benefits in axial motor signs and emotional and psychological aspects of QOL did not show similar stability. In general, the procedure had insignificant impact on cognition and mood. This is the first report of STN stimulation in Asian patients with PD. © Movement Disorder Society
Url:
DOI: 10.1002/mds.23269
Affiliations:
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<term>Cognition Disorders (therapy)</term>
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<term>Dyskinesias (therapy)</term>
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<term>Noyau sousthalamique</term>
<term>Pathologie du système nerveux</term>
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<term>Stimulation cérébrale profonde</term>
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<front><div type="abstract" xml:lang="en">Reports of long‐term effects of subthalamic (STN) stimulation for Parkinson's disease (PD) are few, mostly open‐label evaluations and from Western centers. We used single‐blind and open‐label motor, cognitive and quality of life (QOL) evaluations to study the effects of bilateral STN stimulation in 45 patients over 5 years. Our patients showed a stable and substantial reduction in the cardinal signs of PD, motor fluctuations, and dyskinesias but less so for axial signs. The reduction in medications and the intensity of electrical stimulation needed also remained stable during follow up. Although the total QOL and its parkinsonism and social components showed sustained benefits till 5 years, the gains in emotional and systemic subsets were short lasting. Global scores for mood and cognition did not show significant worsening. Benefits of STN stimulation on the cardinal signs, motor complications, and QOL of advanced PD were substantial and sustained till 5 years. The initial benefits in axial motor signs and emotional and psychological aspects of QOL did not show similar stability. In general, the procedure had insignificant impact on cognition and mood. This is the first report of STN stimulation in Asian patients with PD. © Movement Disorder Society</div>
</front>
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<name sortKey="Rao, Ravimohan" sort="Rao, Ravimohan" uniqKey="Rao R" first="Ravimohan" last="Rao">Ravimohan Rao</name>
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<name sortKey="Sarma, Sankara" sort="Sarma, Sankara" uniqKey="Sarma S" first="Sankara" last="Sarma">Sankara Sarma</name>
<name sortKey="Sivasanakaran, Mathuranath Pavagada" sort="Sivasanakaran, Mathuranath Pavagada" uniqKey="Sivasanakaran M" first="Mathuranath Pavagada" last="Sivasanakaran">Mathuranath Pavagada Sivasanakaran</name>
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