Parkinsonism and motor neuron diseases: Twenty‐seven patients with diverse overlap syndromes
Identifieur interne : 001B14 ( Main/Exploration ); précédent : 001B13; suivant : 001B15Parkinsonism and motor neuron diseases: Twenty‐seven patients with diverse overlap syndromes
Auteurs : Rebecca M. Wolf Gilbert [États-Unis] ; Stanley Fahn [États-Unis] ; Hiroshi Mitsumoto [États-Unis] ; Lewis P. Rowland [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-09-15.
English descriptors
- KwdEn :
- Adult, Aged, Female, Humans, Male, Middle Aged, Motor Neuron Disease (diagnosis), Motor Neuron Disease (physiopathology), Parkinsonian Disorders (diagnosis), Parkinsonian Disorders (physiopathology), Retrospective Studies, amyotrophic lateral sclerosis, frontotemporal dementia, motor neuron disease, multiple system atrophy, parkinsonism, primary lateral sclerosis.
- MESH :
- diagnosis : Motor Neuron Disease, Parkinsonian Disorders.
- physiopathology : Motor Neuron Disease, Parkinsonian Disorders.
- Adult, Aged, Female, Humans, Male, Middle Aged, Retrospective Studies.
Abstract
It has long been recognized that signs of motor neuron disease (MND) may accompany clinical evidence of parkinsonism in different neurodegenerative conditions. By using the Columbia University Division of Movement Disorders database, we reviewed data from 5,500 cases of parkinsonism and recorded the presence of upper motor neuron (UMN) dysfunction, lower motor neuron (LMN) dysfunction, or both. Among the 27 patients so identified, we counted those with autonomic dysfunction, cerebellar dysfunction, or dementia. Among the 27 cases, seven had UMN signs and LMN signs as well as parkinsonism and were diagnosed with amyotrophic lateral sclerosis (ALS)‐parkinsonism (Brait‐Fahn disease). Three of the seven had dementia that was not deemed to be frontotemporal dementia (FTD). Six other patients had no LMN signs but had UMN signs and parkinsonism and were classified as having primary lateral sclerosis (PLS)‐parkinsonism. Four patients had both UMN and LMN signs with parkinsonism as well as the characteristic dementia of FTD; they were diagnosed with FTD‐parkinsonism‐ALS. Seven patients had MND, parkinsonism, and autonomic or cerebellar dysfunction, a combination compatible with multiple system atrophy (MSA). Three patients had syndromes compatible with hereditary spastic paraplegia (HSP). In sum, we found that MND occurs in association with diverse parkinsonian syndromes; some are heritable, others sporadic and causes are uncertain. Having MND may be a risk factor forparkinsonism. A prospective study may elucidate this possibility. © 2010 Movement Disorder Society.
Url:
DOI: 10.1002/mds.23200
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">It has long been recognized that signs of motor neuron disease (MND) may accompany clinical evidence of parkinsonism in different neurodegenerative conditions. By using the Columbia University Division of Movement Disorders database, we reviewed data from 5,500 cases of parkinsonism and recorded the presence of upper motor neuron (UMN) dysfunction, lower motor neuron (LMN) dysfunction, or both. Among the 27 patients so identified, we counted those with autonomic dysfunction, cerebellar dysfunction, or dementia. Among the 27 cases, seven had UMN signs and LMN signs as well as parkinsonism and were diagnosed with amyotrophic lateral sclerosis (ALS)‐parkinsonism (Brait‐Fahn disease). Three of the seven had dementia that was not deemed to be frontotemporal dementia (FTD). Six other patients had no LMN signs but had UMN signs and parkinsonism and were classified as having primary lateral sclerosis (PLS)‐parkinsonism. Four patients had both UMN and LMN signs with parkinsonism as well as the characteristic dementia of FTD; they were diagnosed with FTD‐parkinsonism‐ALS. Seven patients had MND, parkinsonism, and autonomic or cerebellar dysfunction, a combination compatible with multiple system atrophy (MSA). Three patients had syndromes compatible with hereditary spastic paraplegia (HSP). In sum, we found that MND occurs in association with diverse parkinsonian syndromes; some are heritable, others sporadic and causes are uncertain. Having MND may be a risk factor forparkinsonism. A prospective study may elucidate this possibility. © 2010 Movement Disorder Society.</div>
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