Parkinsonism and motor neuron diseases: Twenty‐seven patients with diverse overlap syndromes
Identifieur interne : 000A19 ( Istex/Corpus ); précédent : 000A18; suivant : 000A20Parkinsonism and motor neuron diseases: Twenty‐seven patients with diverse overlap syndromes
Auteurs : Rebecca M. Wolf Gilbert ; Stanley Fahn ; Hiroshi Mitsumoto ; Lewis P. RowlandSource :
- Movement Disorders [ 0885-3185 ] ; 2010-09-15.
English descriptors
- KwdEn :
Abstract
It has long been recognized that signs of motor neuron disease (MND) may accompany clinical evidence of parkinsonism in different neurodegenerative conditions. By using the Columbia University Division of Movement Disorders database, we reviewed data from 5,500 cases of parkinsonism and recorded the presence of upper motor neuron (UMN) dysfunction, lower motor neuron (LMN) dysfunction, or both. Among the 27 patients so identified, we counted those with autonomic dysfunction, cerebellar dysfunction, or dementia. Among the 27 cases, seven had UMN signs and LMN signs as well as parkinsonism and were diagnosed with amyotrophic lateral sclerosis (ALS)‐parkinsonism (Brait‐Fahn disease). Three of the seven had dementia that was not deemed to be frontotemporal dementia (FTD). Six other patients had no LMN signs but had UMN signs and parkinsonism and were classified as having primary lateral sclerosis (PLS)‐parkinsonism. Four patients had both UMN and LMN signs with parkinsonism as well as the characteristic dementia of FTD; they were diagnosed with FTD‐parkinsonism‐ALS. Seven patients had MND, parkinsonism, and autonomic or cerebellar dysfunction, a combination compatible with multiple system atrophy (MSA). Three patients had syndromes compatible with hereditary spastic paraplegia (HSP). In sum, we found that MND occurs in association with diverse parkinsonian syndromes; some are heritable, others sporadic and causes are uncertain. Having MND may be a risk factor forparkinsonism. A prospective study may elucidate this possibility. © 2010 Movement Disorder Society.
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DOI: 10.1002/mds.23200
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<front><div type="abstract" xml:lang="en">It has long been recognized that signs of motor neuron disease (MND) may accompany clinical evidence of parkinsonism in different neurodegenerative conditions. By using the Columbia University Division of Movement Disorders database, we reviewed data from 5,500 cases of parkinsonism and recorded the presence of upper motor neuron (UMN) dysfunction, lower motor neuron (LMN) dysfunction, or both. Among the 27 patients so identified, we counted those with autonomic dysfunction, cerebellar dysfunction, or dementia. Among the 27 cases, seven had UMN signs and LMN signs as well as parkinsonism and were diagnosed with amyotrophic lateral sclerosis (ALS)‐parkinsonism (Brait‐Fahn disease). Three of the seven had dementia that was not deemed to be frontotemporal dementia (FTD). Six other patients had no LMN signs but had UMN signs and parkinsonism and were classified as having primary lateral sclerosis (PLS)‐parkinsonism. Four patients had both UMN and LMN signs with parkinsonism as well as the characteristic dementia of FTD; they were diagnosed with FTD‐parkinsonism‐ALS. Seven patients had MND, parkinsonism, and autonomic or cerebellar dysfunction, a combination compatible with multiple system atrophy (MSA). Three patients had syndromes compatible with hereditary spastic paraplegia (HSP). In sum, we found that MND occurs in association with diverse parkinsonian syndromes; some are heritable, others sporadic and causes are uncertain. Having MND may be a risk factor forparkinsonism. A prospective study may elucidate this possibility. © 2010 Movement Disorder Society.</div>
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<notesStmt><note type="content">*Potential conflict of interest: Dr. Wolf Gilbert's fellowship while performing this work was supported by the Parkinson's Disease Foundation. She has no conflict of interest related to this research. Drs. Fahn, Mitsumoto, and Rowland did not receive funding for this project and have no conflicts of interest related to this research.</note>
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<!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Parkinsonism and motor neuron diseases: Twenty‐seven patients with diverse overlap syndromes</title>
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<titleInfo type="abbreviated" lang="en"><title>Parkinsonism and Motor Neuron Diseases</title>
</titleInfo>
<titleInfo type="alternative" contentType="CDATA" lang="en"><title>Parkinsonism and motor neuron diseases: Twenty‐seven patients with diverse overlap syndromes</title>
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<name type="personal"><namePart type="given">Rebecca M. Wolf</namePart>
<namePart type="family">Gilbert</namePart>
<namePart type="termsOfAddress">MD, PhD</namePart>
<affiliation>Department of Neurology, NYU Langone Medical Center, New York, New York, USA</affiliation>
<description>Correspondence: 145 East 32nd Street, 2nd floor, New York, NY 10016</description>
<role><roleTerm type="text">author</roleTerm>
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</name>
<name type="personal"><namePart type="given">Stanley</namePart>
<namePart type="family">Fahn</namePart>
<namePart type="termsOfAddress">MD</namePart>
<affiliation>Department of Neurology, Columbia University Medical Center, New York, New York, USA</affiliation>
<role><roleTerm type="text">author</roleTerm>
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</name>
<name type="personal"><namePart type="given">Hiroshi</namePart>
<namePart type="family">Mitsumoto</namePart>
<namePart type="termsOfAddress">MD</namePart>
<affiliation>Department of Neurology, Columbia University Medical Center, New York, New York, USA</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Lewis P.</namePart>
<namePart type="family">Rowland</namePart>
<namePart type="termsOfAddress">MD</namePart>
<affiliation>Department of Neurology, Columbia University Medical Center, New York, New York, USA</affiliation>
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<originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<place><placeTerm type="text">Hoboken</placeTerm>
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<dateIssued encoding="w3cdtf">2010-09-15</dateIssued>
<dateCaptured encoding="w3cdtf">2009-06-29</dateCaptured>
<dateValid encoding="w3cdtf">2010-03-29</dateValid>
<copyrightDate encoding="w3cdtf">2010</copyrightDate>
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<language><languageTerm type="code" authority="rfc3066">en</languageTerm>
<languageTerm type="code" authority="iso639-2b">eng</languageTerm>
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<abstract lang="en">It has long been recognized that signs of motor neuron disease (MND) may accompany clinical evidence of parkinsonism in different neurodegenerative conditions. By using the Columbia University Division of Movement Disorders database, we reviewed data from 5,500 cases of parkinsonism and recorded the presence of upper motor neuron (UMN) dysfunction, lower motor neuron (LMN) dysfunction, or both. Among the 27 patients so identified, we counted those with autonomic dysfunction, cerebellar dysfunction, or dementia. Among the 27 cases, seven had UMN signs and LMN signs as well as parkinsonism and were diagnosed with amyotrophic lateral sclerosis (ALS)‐parkinsonism (Brait‐Fahn disease). Three of the seven had dementia that was not deemed to be frontotemporal dementia (FTD). Six other patients had no LMN signs but had UMN signs and parkinsonism and were classified as having primary lateral sclerosis (PLS)‐parkinsonism. Four patients had both UMN and LMN signs with parkinsonism as well as the characteristic dementia of FTD; they were diagnosed with FTD‐parkinsonism‐ALS. Seven patients had MND, parkinsonism, and autonomic or cerebellar dysfunction, a combination compatible with multiple system atrophy (MSA). Three patients had syndromes compatible with hereditary spastic paraplegia (HSP). In sum, we found that MND occurs in association with diverse parkinsonian syndromes; some are heritable, others sporadic and causes are uncertain. Having MND may be a risk factor forparkinsonism. A prospective study may elucidate this possibility. © 2010 Movement Disorder Society.</abstract>
<note type="content">*Potential conflict of interest: Dr. Wolf Gilbert's fellowship while performing this work was supported by the Parkinson's Disease Foundation. She has no conflict of interest related to this research. Drs. Fahn, Mitsumoto, and Rowland did not receive funding for this project and have no conflicts of interest related to this research.</note>
<subject lang="en"><genre>Keywords</genre>
<topic>motor neuron disease</topic>
<topic>amyotrophic lateral sclerosis</topic>
<topic>primary lateral sclerosis</topic>
<topic>frontotemporal dementia</topic>
<topic>multiple system atrophy</topic>
<topic>parkinsonism</topic>
</subject>
<relatedItem type="host"><titleInfo><title>Movement Disorders</title>
</titleInfo>
<titleInfo type="abbreviated"><title>Mov. Disord.</title>
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<subject><genre>article category</genre>
<topic>Research Article</topic>
</subject>
<identifier type="ISSN">0885-3185</identifier>
<identifier type="eISSN">1531-8257</identifier>
<identifier type="DOI">10.1002/(ISSN)1531-8257</identifier>
<identifier type="PublisherID">MDS</identifier>
<part><date>2010</date>
<detail type="volume"><caption>vol.</caption>
<number>25</number>
</detail>
<detail type="issue"><caption>no.</caption>
<number>12</number>
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<extent unit="pages"><start>1868</start>
<end>1875</end>
<total>8</total>
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<identifier type="istex">7C83527D711E75B3604D4B60C7490EC5DD3EA55C</identifier>
<identifier type="DOI">10.1002/mds.23200</identifier>
<identifier type="ArticleID">MDS23200</identifier>
<accessCondition type="use and reproduction" contentType="copyright">Copyright © 2010 Movement Disorder Society</accessCondition>
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