A tale on animal models of Parkinson's disease
Identifieur interne : 001830 ( Main/Exploration ); précédent : 001829; suivant : 001831A tale on animal models of Parkinson's disease
Auteurs : Erwan Bezard [France] ; Serge Przedborski [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-05.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP), 6‐hydroxydopamine (6‐OHDA), Animal, Animal model, Animals, Disease Models, Animal, History, 20th Century, Humans, LRRK2, Mouse, Nervous system diseases, Neurodegenerative Diseases (pathology), Neurodegenerative Diseases (physiopathology), Parkinson Disease (etiology), Parkinson Disease (genetics), Parkinson Disease (history), Parkinson disease, Primates, Rat, mouse, primate, rat, synuclein.
- MESH :
- etiology : Parkinson Disease.
- genetics : Parkinson Disease.
- history : Parkinson Disease.
- pathology : Neurodegenerative Diseases.
- physiopathology : Neurodegenerative Diseases.
- Animals, Disease Models, Animal, History, 20th Century, Humans.
Abstract
Parkinson's disease is a neurodegenerative disorder whose cardinal manifestations are due primarily to a profound deficit in brain dopamine. Since the 1980s, several therapeutic strategies have been discovered to treat the symptoms of this neurological disorder, but as of yet, none halts or retards the neurodegenerative process. In an attempt to shed light on the neurobiology of Parkinson's disease, a number of experimental models have been developed, especially during the last 25 years. They come essentially in 3 flavors: pharmacological (eg, reserpine), toxic (eg, 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine), and genetic (eg, transgenic synuclein mice). These models can also be recast as etiologic, pathogenic, and symptomatic/pathophysiologic, as each may contribute to our understanding of the cause, the mechanisms, and the treatment of Parkinson's disease. In this review, we will discuss the question of Parkinson's disease models, starting from the period when this journal was born to today. During this journey of 25 years, we will discuss both the significant contributions of the Parkinson's disease models and hurdles that remain to be overcome to one day cure this neurological disease. © 2011 Movement Disorder Society
Url:
- https://api.istex.fr/document/8AE9E48366F7D98702E5A22CB84145106BC1C18D/fulltext/pdf
- https://hal.archives-ouvertes.fr/hal-01218108
DOI: 10.1002/mds.23696
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000949
- to stream Istex, to step Curation: 000949
- to stream Istex, to step Checkpoint: 000563
- to stream PubMed, to step Corpus: 001178
- to stream PubMed, to step Curation: 001178
- to stream PubMed, to step Checkpoint: 001495
- to stream Ncbi, to step Merge: 003250
- to stream Ncbi, to step Curation: 003250
- to stream Ncbi, to step Checkpoint: 003250
- to stream Main, to step Merge: 001884
- to stream Hal, to step Corpus: 000000
- to stream Hal, to step Curation: 000000
- to stream Hal, to step Checkpoint: 000018
- to stream Main, to step Merge: 001294
- to stream PascalFrancis, to step Corpus: 000578
- to stream PascalFrancis, to step Curation: 002740
- to stream PascalFrancis, to step Checkpoint: 000731
- to stream Main, to step Merge: 001D21
- to stream Main, to step Curation: 001830
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">A tale on animal models of Parkinson's disease</title>
<author><name sortKey="Bezard, Erwan" sort="Bezard, Erwan" uniqKey="Bezard E" first="Erwan" last="Bezard">Erwan Bezard</name>
</author>
<author><name sortKey="Przedborski, Serge" sort="Przedborski, Serge" uniqKey="Przedborski S" first="Serge" last="Przedborski">Serge Przedborski</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:8AE9E48366F7D98702E5A22CB84145106BC1C18D</idno>
<date when="2011" year="2011">2011</date>
<idno type="doi">10.1002/mds.23696</idno>
<idno type="url">https://api.istex.fr/document/8AE9E48366F7D98702E5A22CB84145106BC1C18D/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000949</idno>
<idno type="wicri:Area/Istex/Curation">000949</idno>
<idno type="wicri:Area/Istex/Checkpoint">000563</idno>
<idno type="wicri:doubleKey">0885-3185:2011:Bezard E:a:tale:on</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:21626544</idno>
<idno type="wicri:Area/PubMed/Corpus">001178</idno>
<idno type="wicri:Area/PubMed/Curation">001178</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001495</idno>
<idno type="wicri:Area/Ncbi/Merge">003250</idno>
<idno type="wicri:Area/Ncbi/Curation">003250</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">003250</idno>
<idno type="wicri:Area/Main/Merge">001884</idno>
<idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:hal-01218108</idno>
<idno type="url">https://hal.archives-ouvertes.fr/hal-01218108</idno>
<idno type="wicri:Area/Hal/Corpus">000000</idno>
<idno type="wicri:Area/Hal/Curation">000000</idno>
<idno type="wicri:Area/Hal/Checkpoint">000018</idno>
<idno type="wicri:doubleKey">0885-3185:2011:Bezard E:a:tale:on</idno>
<idno type="wicri:Area/Main/Merge">001294</idno>
<idno type="wicri:source">INIST</idno>
<idno type="RBID">Pascal:11-0264646</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000578</idno>
<idno type="wicri:Area/PascalFrancis/Curation">002740</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000731</idno>
<idno type="wicri:doubleKey">0885-3185:2011:Bezard E:a:tale:on</idno>
<idno type="wicri:Area/Main/Merge">001D21</idno>
<idno type="wicri:Area/Main/Curation">001830</idno>
<idno type="wicri:Area/Main/Exploration">001830</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">A tale on animal models of Parkinson's disease</title>
<author><name sortKey="Bezard, Erwan" sort="Bezard, Erwan" uniqKey="Bezard E" first="Erwan" last="Bezard">Erwan Bezard</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Insitute of Neurodegenerative Diseases, Université Victor Ségalen‐Bordeaux II, Centre National de la Recherche Scientifique, Bordeaux</wicri:regionArea>
<placeName><settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Przedborski, Serge" sort="Przedborski, Serge" uniqKey="Przedborski S" first="Serge" last="Przedborski">Serge Przedborski</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Neurology, Pathology, and Cell Biology and the Center for Motor Neuron. Biology and Disease, Columbia University, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2011-05">2011-05</date>
<biblScope unit="vol">26</biblScope>
<biblScope unit="issue">6</biblScope>
<biblScope unit="page" from="993">993</biblScope>
<biblScope unit="page" to="1002">1002</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">8AE9E48366F7D98702E5A22CB84145106BC1C18D</idno>
<idno type="DOI">10.1002/mds.23696</idno>
<idno type="ArticleID">MDS23696</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)</term>
<term>6‐hydroxydopamine (6‐OHDA)</term>
<term>Animal</term>
<term>Animal model</term>
<term>Animals</term>
<term>Disease Models, Animal</term>
<term>History, 20th Century</term>
<term>Humans</term>
<term>LRRK2</term>
<term>Mouse</term>
<term>Nervous system diseases</term>
<term>Neurodegenerative Diseases (pathology)</term>
<term>Neurodegenerative Diseases (physiopathology)</term>
<term>Parkinson Disease (etiology)</term>
<term>Parkinson Disease (genetics)</term>
<term>Parkinson Disease (history)</term>
<term>Parkinson disease</term>
<term>Primates</term>
<term>Rat</term>
<term>mouse</term>
<term>primate</term>
<term>rat</term>
<term>synuclein</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="history" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Neurodegenerative Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Neurodegenerative Diseases</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Disease Models, Animal</term>
<term>History, 20th Century</term>
<term>Humans</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Animal</term>
<term>Maladie de Parkinson</term>
<term>Modèle animal</term>
<term>Pathologie du système nerveux</term>
<term>Primates</term>
<term>Rat</term>
<term>Souris</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Parkinson's disease is a neurodegenerative disorder whose cardinal manifestations are due primarily to a profound deficit in brain dopamine. Since the 1980s, several therapeutic strategies have been discovered to treat the symptoms of this neurological disorder, but as of yet, none halts or retards the neurodegenerative process. In an attempt to shed light on the neurobiology of Parkinson's disease, a number of experimental models have been developed, especially during the last 25 years. They come essentially in 3 flavors: pharmacological (eg, reserpine), toxic (eg, 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine), and genetic (eg, transgenic synuclein mice). These models can also be recast as etiologic, pathogenic, and symptomatic/pathophysiologic, as each may contribute to our understanding of the cause, the mechanisms, and the treatment of Parkinson's disease. In this review, we will discuss the question of Parkinson's disease models, starting from the period when this journal was born to today. During this journey of 25 years, we will discuss both the significant contributions of the Parkinson's disease models and hurdles that remain to be overcome to one day cure this neurological disease. © 2011 Movement Disorder Society</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
<li>États-Unis</li>
</country>
<region><li>État de New York</li>
</region>
<settlement><li>Bordeaux</li>
<li>New York</li>
</settlement>
<orgName><li>Université Columbia</li>
</orgName>
</list>
<tree><country name="France"><noRegion><name sortKey="Bezard, Erwan" sort="Bezard, Erwan" uniqKey="Bezard E" first="Erwan" last="Bezard">Erwan Bezard</name>
</noRegion>
</country>
<country name="États-Unis"><region name="État de New York"><name sortKey="Przedborski, Serge" sort="Przedborski, Serge" uniqKey="Przedborski S" first="Serge" last="Przedborski">Serge Przedborski</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001830 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001830 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:8AE9E48366F7D98702E5A22CB84145106BC1C18D |texte= A tale on animal models of Parkinson's disease }}
This area was generated with Dilib version V0.6.23. |