Assessment of involuntary choreatic movements in Huntington's disease—Toward objective and quantitative measures
Identifieur interne : 001801 ( Main/Exploration ); précédent : 001800; suivant : 001802Assessment of involuntary choreatic movements in Huntington's disease—Toward objective and quantitative measures
Auteurs : Ralf Reilmann [Allemagne] ; Stefan Bohlen [Allemagne] ; Florian Kirsten [Allemagne] ; E. Bernd Ringelstein [Allemagne] ; Herwig W. Lange [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-10.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Analysis of Variance, Basal ganglion, Case-Control Studies, Chorea, Clinical trial, Disability Evaluation, Dyskinesias (diagnosis), Dyskinesias (etiology), Female, Hand Strength (physiology), Humans, Huntington Disease (complications), Huntington disease, Huntington's disease, Involuntary movement, Male, Middle Aged, Motor control, Nervous system diseases, Orientation, Posture, Psychometrics (methods), Statistics as Topic, Weight Lifting (physiology), basal ganglia, chorea, clinical trials, motor control.
- MESH :
- complications : Huntington Disease.
- diagnosis : Dyskinesias.
- etiology : Dyskinesias.
- methods : Psychometrics.
- physiology : Hand Strength, Weight Lifting.
- Adult, Analysis of Variance, Case-Control Studies, Disability Evaluation, Female, Humans, Male, Middle Aged, Orientation, Posture, Statistics as Topic.
Abstract
Objective measures of motor impairment may improve the sensitivity and reliability of motor end points in clinical trials. In Huntington's disease, involuntary choreatic movements are one of the hallmarks of motor dysfunction. Chorea is commonly assessed by subitems of the Unified‐Huntington's Disease Rating Scale. However, clinical rating scales are limited by inter‐ and intrarater variability, subjective error, and categorical design. We hypothesized that assessment of position and orientation changes interfering with a static upper extremity holding task may provide objective and quantitative measures of involuntary movements in patients with Huntington's disease. Subjects with symptomatic Huntington's disease (n = 19), premanifest gene carriers (n = 15; Unified‐Huntington's Disease Rating Scale total motor score ≤ 3), and matched controls (n = 19) were asked to grasp and lift a device (250 and 500 g) equipped with an electromagnetic sensor. While subjects were instructed to hold the device as stable as possible, changes in position (x, y, z) and orientation (roll, pitch, yaw) were recorded. These were used to calculate a position index and an orientation index, both depicting the amount of choreatic movement interfering with task performance. Both indices were increased in patients with symptomatic Huntington's disease compared with controls and premanifest gene carriers for both weights, whereas only the position index with 500 g was increased in premanifest gene carriers compared with controls. Correlations were observed with the Disease Burden Score based on CAG‐repeat length and age and with the Unified‐Huntington's Disease Rating Scale. We conclude that quantitative assessment of chorea is feasible in Huntington's disease. The method is safe, noninvasive, and easily applicable and can be used repeatedly in outpatient settings. A use in clinical trials should be further explored in larger cohorts and follow‐up studies. © 2011 Movement Disorder Society
Url:
DOI: 10.1002/mds.23816
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000B04
- to stream Istex, to step Curation: 000B04
- to stream Istex, to step Checkpoint: 000534
- to stream PubMed, to step Corpus: 001134
- to stream PubMed, to step Curation: 001134
- to stream PubMed, to step Checkpoint: 001467
- to stream Ncbi, to step Merge: 003294
- to stream Ncbi, to step Curation: 003294
- to stream Ncbi, to step Checkpoint: 003294
- to stream Main, to step Merge: 001855
- to stream PascalFrancis, to step Corpus: 000369
- to stream PascalFrancis, to step Curation: 002949
- to stream PascalFrancis, to step Checkpoint: 000706
- to stream Main, to step Merge: 001C96
- to stream Main, to step Curation: 001801
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Assessment of involuntary choreatic movements in Huntington's disease—Toward objective and quantitative measures</title>
<author><name sortKey="Reilmann, Ralf" sort="Reilmann, Ralf" uniqKey="Reilmann R" first="Ralf" last="Reilmann">Ralf Reilmann</name>
</author>
<author><name sortKey="Bohlen, Stefan" sort="Bohlen, Stefan" uniqKey="Bohlen S" first="Stefan" last="Bohlen">Stefan Bohlen</name>
</author>
<author><name sortKey="Kirsten, Florian" sort="Kirsten, Florian" uniqKey="Kirsten F" first="Florian" last="Kirsten">Florian Kirsten</name>
</author>
<author><name sortKey="Ringelstein, E Bernd" sort="Ringelstein, E Bernd" uniqKey="Ringelstein E" first="E. Bernd" last="Ringelstein">E. Bernd Ringelstein</name>
</author>
<author><name sortKey="Lange, Herwig W" sort="Lange, Herwig W" uniqKey="Lange H" first="Herwig W." last="Lange">Herwig W. Lange</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:9194B55558E3CEBBB9194983DF3BFC479EFCB6B2</idno>
<date when="2011" year="2011">2011</date>
<idno type="doi">10.1002/mds.23816</idno>
<idno type="url">https://api.istex.fr/document/9194B55558E3CEBBB9194983DF3BFC479EFCB6B2/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000B04</idno>
<idno type="wicri:Area/Istex/Curation">000B04</idno>
<idno type="wicri:Area/Istex/Checkpoint">000534</idno>
<idno type="wicri:doubleKey">0885-3185:2011:Reilmann R:assessment:of:involuntary</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:21661053</idno>
<idno type="wicri:Area/PubMed/Corpus">001134</idno>
<idno type="wicri:Area/PubMed/Curation">001134</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001467</idno>
<idno type="wicri:Area/Ncbi/Merge">003294</idno>
<idno type="wicri:Area/Ncbi/Curation">003294</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">003294</idno>
<idno type="wicri:Area/Main/Merge">001855</idno>
<idno type="wicri:source">INIST</idno>
<idno type="RBID">Pascal:11-0481765</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000369</idno>
<idno type="wicri:Area/PascalFrancis/Curation">002949</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000706</idno>
<idno type="wicri:doubleKey">0885-3185:2011:Reilmann R:assessment:of:involuntary</idno>
<idno type="wicri:Area/Main/Merge">001C96</idno>
<idno type="wicri:Area/Main/Curation">001801</idno>
<idno type="wicri:Area/Main/Exploration">001801</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Assessment of involuntary choreatic movements in Huntington's disease—Toward objective and quantitative measures</title>
<author><name sortKey="Reilmann, Ralf" sort="Reilmann, Ralf" uniqKey="Reilmann R" first="Ralf" last="Reilmann">Ralf Reilmann</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University Clinic Muenster, Westfaelische Wilhelms University of Muenster, Muenster</wicri:regionArea>
<wicri:noRegion>Muenster</wicri:noRegion>
<wicri:noRegion>Muenster</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bohlen, Stefan" sort="Bohlen, Stefan" uniqKey="Bohlen S" first="Stefan" last="Bohlen">Stefan Bohlen</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University Clinic Muenster, Westfaelische Wilhelms University of Muenster, Muenster</wicri:regionArea>
<wicri:noRegion>Muenster</wicri:noRegion>
<wicri:noRegion>Muenster</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kirsten, Florian" sort="Kirsten, Florian" uniqKey="Kirsten F" first="Florian" last="Kirsten">Florian Kirsten</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University Clinic Muenster, Westfaelische Wilhelms University of Muenster, Muenster</wicri:regionArea>
<wicri:noRegion>Muenster</wicri:noRegion>
<wicri:noRegion>Muenster</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ringelstein, E Bernd" sort="Ringelstein, E Bernd" uniqKey="Ringelstein E" first="E. Bernd" last="Ringelstein">E. Bernd Ringelstein</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University Clinic Muenster, Westfaelische Wilhelms University of Muenster, Muenster</wicri:regionArea>
<wicri:noRegion>Muenster</wicri:noRegion>
<wicri:noRegion>Muenster</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lange, Herwig W" sort="Lange, Herwig W" uniqKey="Lange H" first="Herwig W." last="Lange">Herwig W. Lange</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University Clinic Muenster, Westfaelische Wilhelms University of Muenster, Muenster</wicri:regionArea>
<wicri:noRegion>Muenster</wicri:noRegion>
<wicri:noRegion>Muenster</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2011-10">2011-10</date>
<biblScope unit="vol">26</biblScope>
<biblScope unit="issue">12</biblScope>
<biblScope unit="page" from="2267">2267</biblScope>
<biblScope unit="page" to="2273">2273</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">9194B55558E3CEBBB9194983DF3BFC479EFCB6B2</idno>
<idno type="DOI">10.1002/mds.23816</idno>
<idno type="ArticleID">MDS23816</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Analysis of Variance</term>
<term>Basal ganglion</term>
<term>Case-Control Studies</term>
<term>Chorea</term>
<term>Clinical trial</term>
<term>Disability Evaluation</term>
<term>Dyskinesias (diagnosis)</term>
<term>Dyskinesias (etiology)</term>
<term>Female</term>
<term>Hand Strength (physiology)</term>
<term>Humans</term>
<term>Huntington Disease (complications)</term>
<term>Huntington disease</term>
<term>Huntington's disease</term>
<term>Involuntary movement</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Motor control</term>
<term>Nervous system diseases</term>
<term>Orientation</term>
<term>Posture</term>
<term>Psychometrics (methods)</term>
<term>Statistics as Topic</term>
<term>Weight Lifting (physiology)</term>
<term>basal ganglia</term>
<term>chorea</term>
<term>clinical trials</term>
<term>motor control</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Huntington Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Dyskinesias</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Dyskinesias</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Psychometrics</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Hand Strength</term>
<term>Weight Lifting</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Analysis of Variance</term>
<term>Case-Control Studies</term>
<term>Disability Evaluation</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Orientation</term>
<term>Posture</term>
<term>Statistics as Topic</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Chorée de Huntington</term>
<term>Contrôle moteur</term>
<term>Essai clinique</term>
<term>Mouvement involontaire</term>
<term>Noyau gris central</term>
<term>Pathologie du système nerveux</term>
<term>Syndrome choréique</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Objective measures of motor impairment may improve the sensitivity and reliability of motor end points in clinical trials. In Huntington's disease, involuntary choreatic movements are one of the hallmarks of motor dysfunction. Chorea is commonly assessed by subitems of the Unified‐Huntington's Disease Rating Scale. However, clinical rating scales are limited by inter‐ and intrarater variability, subjective error, and categorical design. We hypothesized that assessment of position and orientation changes interfering with a static upper extremity holding task may provide objective and quantitative measures of involuntary movements in patients with Huntington's disease. Subjects with symptomatic Huntington's disease (n = 19), premanifest gene carriers (n = 15; Unified‐Huntington's Disease Rating Scale total motor score ≤ 3), and matched controls (n = 19) were asked to grasp and lift a device (250 and 500 g) equipped with an electromagnetic sensor. While subjects were instructed to hold the device as stable as possible, changes in position (x, y, z) and orientation (roll, pitch, yaw) were recorded. These were used to calculate a position index and an orientation index, both depicting the amount of choreatic movement interfering with task performance. Both indices were increased in patients with symptomatic Huntington's disease compared with controls and premanifest gene carriers for both weights, whereas only the position index with 500 g was increased in premanifest gene carriers compared with controls. Correlations were observed with the Disease Burden Score based on CAG‐repeat length and age and with the Unified‐Huntington's Disease Rating Scale. We conclude that quantitative assessment of chorea is feasible in Huntington's disease. The method is safe, noninvasive, and easily applicable and can be used repeatedly in outpatient settings. A use in clinical trials should be further explored in larger cohorts and follow‐up studies. © 2011 Movement Disorder Society</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
</country>
</list>
<tree><country name="Allemagne"><noRegion><name sortKey="Reilmann, Ralf" sort="Reilmann, Ralf" uniqKey="Reilmann R" first="Ralf" last="Reilmann">Ralf Reilmann</name>
</noRegion>
<name sortKey="Bohlen, Stefan" sort="Bohlen, Stefan" uniqKey="Bohlen S" first="Stefan" last="Bohlen">Stefan Bohlen</name>
<name sortKey="Kirsten, Florian" sort="Kirsten, Florian" uniqKey="Kirsten F" first="Florian" last="Kirsten">Florian Kirsten</name>
<name sortKey="Lange, Herwig W" sort="Lange, Herwig W" uniqKey="Lange H" first="Herwig W." last="Lange">Herwig W. Lange</name>
<name sortKey="Ringelstein, E Bernd" sort="Ringelstein, E Bernd" uniqKey="Ringelstein E" first="E. Bernd" last="Ringelstein">E. Bernd Ringelstein</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001801 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001801 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:9194B55558E3CEBBB9194983DF3BFC479EFCB6B2 |texte= Assessment of involuntary choreatic movements in Huntington's disease—Toward objective and quantitative measures }}
This area was generated with Dilib version V0.6.23. |