Assessment of involuntary choreatic movements in Huntington's disease—Toward objective and quantitative measures
Identifieur interne : 001855 ( Main/Merge ); précédent : 001854; suivant : 001856Assessment of involuntary choreatic movements in Huntington's disease—Toward objective and quantitative measures
Auteurs : Ralf Reilmann [Allemagne] ; Stefan Bohlen [Allemagne] ; Florian Kirsten [Allemagne] ; E. Bernd Ringelstein [Allemagne] ; Herwig W. Lange [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-10.
English descriptors
- KwdEn :
- Adult, Analysis of Variance, Case-Control Studies, Disability Evaluation, Dyskinesias (diagnosis), Dyskinesias (etiology), Female, Hand Strength (physiology), Humans, Huntington Disease (complications), Huntington's disease, Male, Middle Aged, Orientation, Posture, Psychometrics (methods), Statistics as Topic, Weight Lifting (physiology), basal ganglia, chorea, clinical trials, motor control.
- MESH :
- complications : Huntington Disease.
- diagnosis : Dyskinesias.
- etiology : Dyskinesias.
- methods : Psychometrics.
- physiology : Hand Strength, Weight Lifting.
- Adult, Analysis of Variance, Case-Control Studies, Disability Evaluation, Female, Humans, Male, Middle Aged, Orientation, Posture, Statistics as Topic.
Abstract
Objective measures of motor impairment may improve the sensitivity and reliability of motor end points in clinical trials. In Huntington's disease, involuntary choreatic movements are one of the hallmarks of motor dysfunction. Chorea is commonly assessed by subitems of the Unified‐Huntington's Disease Rating Scale. However, clinical rating scales are limited by inter‐ and intrarater variability, subjective error, and categorical design. We hypothesized that assessment of position and orientation changes interfering with a static upper extremity holding task may provide objective and quantitative measures of involuntary movements in patients with Huntington's disease. Subjects with symptomatic Huntington's disease (n = 19), premanifest gene carriers (n = 15; Unified‐Huntington's Disease Rating Scale total motor score ≤ 3), and matched controls (n = 19) were asked to grasp and lift a device (250 and 500 g) equipped with an electromagnetic sensor. While subjects were instructed to hold the device as stable as possible, changes in position (x, y, z) and orientation (roll, pitch, yaw) were recorded. These were used to calculate a position index and an orientation index, both depicting the amount of choreatic movement interfering with task performance. Both indices were increased in patients with symptomatic Huntington's disease compared with controls and premanifest gene carriers for both weights, whereas only the position index with 500 g was increased in premanifest gene carriers compared with controls. Correlations were observed with the Disease Burden Score based on CAG‐repeat length and age and with the Unified‐Huntington's Disease Rating Scale. We conclude that quantitative assessment of chorea is feasible in Huntington's disease. The method is safe, noninvasive, and easily applicable and can be used repeatedly in outpatient settings. A use in clinical trials should be further explored in larger cohorts and follow‐up studies. © 2011 Movement Disorder Society
Url:
DOI: 10.1002/mds.23816
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Bernd" last="Ringelstein">E. Bernd Ringelstein</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Clinic Muenster, Westfaelische Wilhelms University of Muenster, Muenster</wicri:regionArea><wicri:noRegion>Muenster</wicri:noRegion><wicri:noRegion>Muenster</wicri:noRegion></affiliation></author><author><name sortKey="Lange, Herwig W" sort="Lange, Herwig W" uniqKey="Lange H" first="Herwig W." last="Lange">Herwig W. Lange</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Clinic Muenster, Westfaelische Wilhelms University of Muenster, Muenster</wicri:regionArea><wicri:noRegion>Muenster</wicri:noRegion><wicri:noRegion>Muenster</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-10">2011-10</date><biblScope unit="vol">26</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="2267">2267</biblScope><biblScope unit="page" to="2273">2273</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">9194B55558E3CEBBB9194983DF3BFC479EFCB6B2</idno><idno type="DOI">10.1002/mds.23816</idno><idno type="ArticleID">MDS23816</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Analysis of Variance</term><term>Case-Control Studies</term><term>Disability Evaluation</term><term>Dyskinesias (diagnosis)</term><term>Dyskinesias (etiology)</term><term>Female</term><term>Hand Strength (physiology)</term><term>Humans</term><term>Huntington Disease (complications)</term><term>Huntington's disease</term><term>Male</term><term>Middle Aged</term><term>Orientation</term><term>Posture</term><term>Psychometrics (methods)</term><term>Statistics as Topic</term><term>Weight Lifting (physiology)</term><term>basal ganglia</term><term>chorea</term><term>clinical trials</term><term>motor control</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Dyskinesias</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Dyskinesias</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Psychometrics</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Hand Strength</term><term>Weight Lifting</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Analysis of Variance</term><term>Case-Control Studies</term><term>Disability Evaluation</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Orientation</term><term>Posture</term><term>Statistics as Topic</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective measures of motor impairment may improve the sensitivity and reliability of motor end points in clinical trials. In Huntington's disease, involuntary choreatic movements are one of the hallmarks of motor dysfunction. Chorea is commonly assessed by subitems of the Unified‐Huntington's Disease Rating Scale. However, clinical rating scales are limited by inter‐ and intrarater variability, subjective error, and categorical design. We hypothesized that assessment of position and orientation changes interfering with a static upper extremity holding task may provide objective and quantitative measures of involuntary movements in patients with Huntington's disease. Subjects with symptomatic Huntington's disease (n = 19), premanifest gene carriers (n = 15; Unified‐Huntington's Disease Rating Scale total motor score ≤ 3), and matched controls (n = 19) were asked to grasp and lift a device (250 and 500 g) equipped with an electromagnetic sensor. While subjects were instructed to hold the device as stable as possible, changes in position (x, y, z) and orientation (roll, pitch, yaw) were recorded. These were used to calculate a position index and an orientation index, both depicting the amount of choreatic movement interfering with task performance. Both indices were increased in patients with symptomatic Huntington's disease compared with controls and premanifest gene carriers for both weights, whereas only the position index with 500 g was increased in premanifest gene carriers compared with controls. Correlations were observed with the Disease Burden Score based on CAG‐repeat length and age and with the Unified‐Huntington's Disease Rating Scale. We conclude that quantitative assessment of chorea is feasible in Huntington's disease. The method is safe, noninvasive, and easily applicable and can be used repeatedly in outpatient settings. A use in clinical trials should be further explored in larger cohorts and follow‐up studies. © 2011 Movement Disorder Society</div></front></TEI><double doi="10.1002/mds.23816"><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Assessment of involuntary choreatic movements in Huntington's disease—Toward objective and quantitative measures</title><author><name sortKey="Reilmann, Ralf" sort="Reilmann, Ralf" uniqKey="Reilmann R" first="Ralf" last="Reilmann">Ralf Reilmann</name></author><author><name sortKey="Bohlen, Stefan" sort="Bohlen, Stefan" uniqKey="Bohlen S" first="Stefan" last="Bohlen">Stefan Bohlen</name></author><author><name sortKey="Kirsten, Florian" sort="Kirsten, Florian" uniqKey="Kirsten F" first="Florian" last="Kirsten">Florian Kirsten</name></author><author><name sortKey="Ringelstein, E Bernd" sort="Ringelstein, E Bernd" uniqKey="Ringelstein E" first="E. Bernd" last="Ringelstein">E. Bernd Ringelstein</name></author><author><name sortKey="Lange, Herwig W" sort="Lange, Herwig W" uniqKey="Lange H" first="Herwig W." last="Lange">Herwig W. Lange</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:9194B55558E3CEBBB9194983DF3BFC479EFCB6B2</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/mds.23816</idno><idno type="url">https://api.istex.fr/document/9194B55558E3CEBBB9194983DF3BFC479EFCB6B2/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000B04</idno><idno type="wicri:Area/Istex/Curation">000B04</idno><idno type="wicri:Area/Istex/Checkpoint">000534</idno><idno type="wicri:doubleKey">0885-3185:2011:Reilmann R:assessment:of:involuntary</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Assessment of involuntary choreatic movements in Huntington's disease—Toward objective and quantitative measures</title><author><name sortKey="Reilmann, Ralf" sort="Reilmann, Ralf" uniqKey="Reilmann R" first="Ralf" last="Reilmann">Ralf Reilmann</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Clinic Muenster, Westfaelische Wilhelms University of Muenster, Muenster</wicri:regionArea><wicri:noRegion>Muenster</wicri:noRegion><wicri:noRegion>Muenster</wicri:noRegion></affiliation></author><author><name sortKey="Bohlen, Stefan" sort="Bohlen, Stefan" uniqKey="Bohlen S" first="Stefan" last="Bohlen">Stefan Bohlen</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Clinic Muenster, Westfaelische Wilhelms University of Muenster, Muenster</wicri:regionArea><wicri:noRegion>Muenster</wicri:noRegion><wicri:noRegion>Muenster</wicri:noRegion></affiliation></author><author><name sortKey="Kirsten, Florian" sort="Kirsten, Florian" uniqKey="Kirsten F" first="Florian" last="Kirsten">Florian Kirsten</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Clinic Muenster, Westfaelische Wilhelms University of Muenster, Muenster</wicri:regionArea><wicri:noRegion>Muenster</wicri:noRegion><wicri:noRegion>Muenster</wicri:noRegion></affiliation></author><author><name sortKey="Ringelstein, E Bernd" sort="Ringelstein, E Bernd" uniqKey="Ringelstein E" first="E. Bernd" last="Ringelstein">E. Bernd Ringelstein</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Clinic Muenster, Westfaelische Wilhelms University of Muenster, Muenster</wicri:regionArea><wicri:noRegion>Muenster</wicri:noRegion><wicri:noRegion>Muenster</wicri:noRegion></affiliation></author><author><name sortKey="Lange, Herwig W" sort="Lange, Herwig W" uniqKey="Lange H" first="Herwig W." last="Lange">Herwig W. Lange</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Clinic Muenster, Westfaelische Wilhelms University of Muenster, Muenster</wicri:regionArea><wicri:noRegion>Muenster</wicri:noRegion><wicri:noRegion>Muenster</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-10">2011-10</date><biblScope unit="vol">26</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="2267">2267</biblScope><biblScope unit="page" to="2273">2273</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">9194B55558E3CEBBB9194983DF3BFC479EFCB6B2</idno><idno type="DOI">10.1002/mds.23816</idno><idno type="ArticleID">MDS23816</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Huntington's disease</term><term>basal ganglia</term><term>chorea</term><term>clinical trials</term><term>motor control</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective measures of motor impairment may improve the sensitivity and reliability of motor end points in clinical trials. In Huntington's disease, involuntary choreatic movements are one of the hallmarks of motor dysfunction. Chorea is commonly assessed by subitems of the Unified‐Huntington's Disease Rating Scale. However, clinical rating scales are limited by inter‐ and intrarater variability, subjective error, and categorical design. We hypothesized that assessment of position and orientation changes interfering with a static upper extremity holding task may provide objective and quantitative measures of involuntary movements in patients with Huntington's disease. Subjects with symptomatic Huntington's disease (n = 19), premanifest gene carriers (n = 15; Unified‐Huntington's Disease Rating Scale total motor score ≤ 3), and matched controls (n = 19) were asked to grasp and lift a device (250 and 500 g) equipped with an electromagnetic sensor. While subjects were instructed to hold the device as stable as possible, changes in position (x, y, z) and orientation (roll, pitch, yaw) were recorded. These were used to calculate a position index and an orientation index, both depicting the amount of choreatic movement interfering with task performance. Both indices were increased in patients with symptomatic Huntington's disease compared with controls and premanifest gene carriers for both weights, whereas only the position index with 500 g was increased in premanifest gene carriers compared with controls. Correlations were observed with the Disease Burden Score based on CAG‐repeat length and age and with the Unified‐Huntington's Disease Rating Scale. We conclude that quantitative assessment of chorea is feasible in Huntington's disease. The method is safe, noninvasive, and easily applicable and can be used repeatedly in outpatient settings. A use in clinical trials should be further explored in larger cohorts and follow‐up studies. © 2011 Movement Disorder Society</div></front></TEI></ISTEX><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Assessment of involuntary choreatic movements in Huntington's disease--toward objective and quantitative measures.</title><author><name sortKey="Reilmann, Ralf" sort="Reilmann, Ralf" uniqKey="Reilmann R" first="Ralf" last="Reilmann">Ralf Reilmann</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University Clinic Muenster, Westfaelische Wilhelms University of Muenster, Muenster, Germany. r.reilmann@uni-muenster.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Clinic Muenster, Westfaelische Wilhelms University of Muenster, Muenster</wicri:regionArea><wicri:noRegion>Muenster</wicri:noRegion><wicri:noRegion>Muenster</wicri:noRegion><wicri:noRegion>Muenster</wicri:noRegion></affiliation></author><author><name sortKey="Bohlen, Stefan" sort="Bohlen, Stefan" uniqKey="Bohlen S" first="Stefan" last="Bohlen">Stefan Bohlen</name></author><author><name sortKey="Kirsten, Florian" sort="Kirsten, Florian" uniqKey="Kirsten F" first="Florian" last="Kirsten">Florian Kirsten</name></author><author><name sortKey="Ringelstein, E Bernd" sort="Ringelstein, E Bernd" uniqKey="Ringelstein E" first="E Bernd" last="Ringelstein">E Bernd Ringelstein</name></author><author><name sortKey="Lange, Herwig W" sort="Lange, Herwig W" uniqKey="Lange H" first="Herwig W" last="Lange">Herwig W. Lange</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="doi">10.1002/mds.23816</idno><idno type="RBID">pubmed:21661053</idno><idno type="pmid">21661053</idno><idno type="wicri:Area/PubMed/Corpus">001134</idno><idno type="wicri:Area/PubMed/Curation">001134</idno><idno type="wicri:Area/PubMed/Checkpoint">001467</idno><idno type="wicri:Area/Ncbi/Merge">003294</idno><idno type="wicri:Area/Ncbi/Curation">003294</idno><idno type="wicri:Area/Ncbi/Checkpoint">003294</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Assessment of involuntary choreatic movements in Huntington's disease--toward objective and quantitative measures.</title><author><name sortKey="Reilmann, Ralf" sort="Reilmann, Ralf" uniqKey="Reilmann R" first="Ralf" last="Reilmann">Ralf Reilmann</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University Clinic Muenster, Westfaelische Wilhelms University of Muenster, Muenster, Germany. r.reilmann@uni-muenster.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Clinic Muenster, Westfaelische Wilhelms University of Muenster, Muenster</wicri:regionArea><wicri:noRegion>Muenster</wicri:noRegion><wicri:noRegion>Muenster</wicri:noRegion><wicri:noRegion>Muenster</wicri:noRegion></affiliation></author><author><name sortKey="Bohlen, Stefan" sort="Bohlen, Stefan" uniqKey="Bohlen S" first="Stefan" last="Bohlen">Stefan Bohlen</name></author><author><name sortKey="Kirsten, Florian" sort="Kirsten, Florian" uniqKey="Kirsten F" first="Florian" last="Kirsten">Florian Kirsten</name></author><author><name sortKey="Ringelstein, E Bernd" sort="Ringelstein, E Bernd" uniqKey="Ringelstein E" first="E Bernd" last="Ringelstein">E Bernd Ringelstein</name></author><author><name sortKey="Lange, Herwig W" sort="Lange, Herwig W" uniqKey="Lange H" first="Herwig W" last="Lange">Herwig W. Lange</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Analysis of Variance</term><term>Case-Control Studies</term><term>Disability Evaluation</term><term>Dyskinesias (diagnosis)</term><term>Dyskinesias (etiology)</term><term>Female</term><term>Hand Strength (physiology)</term><term>Humans</term><term>Huntington Disease (complications)</term><term>Male</term><term>Middle Aged</term><term>Orientation</term><term>Posture</term><term>Psychometrics (methods)</term><term>Statistics as Topic</term><term>Weight Lifting (physiology)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Dyskinesias</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Dyskinesias</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Psychometrics</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Hand Strength</term><term>Weight Lifting</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Analysis of Variance</term><term>Case-Control Studies</term><term>Disability Evaluation</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Orientation</term><term>Posture</term><term>Statistics as Topic</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective measures of motor impairment may improve the sensitivity and reliability of motor end points in clinical trials. In Huntington's disease, involuntary choreatic movements are one of the hallmarks of motor dysfunction. Chorea is commonly assessed by subitems of the Unified-Huntington's Disease Rating Scale. However, clinical rating scales are limited by inter- and intrarater variability, subjective error, and categorical design. We hypothesized that assessment of position and orientation changes interfering with a static upper extremity holding task may provide objective and quantitative measures of involuntary movements in patients with Huntington's disease. Subjects with symptomatic Huntington's disease (n = 19), premanifest gene carriers (n = 15; Unified-Huntington's Disease Rating Scale total motor score ≤ 3), and matched controls (n = 19) were asked to grasp and lift a device (250 and 500 g) equipped with an electromagnetic sensor. While subjects were instructed to hold the device as stable as possible, changes in position (x, y, z) and orientation (roll, pitch, yaw) were recorded. These were used to calculate a position index and an orientation index, both depicting the amount of choreatic movement interfering with task performance. Both indices were increased in patients with symptomatic Huntington's disease compared with controls and premanifest gene carriers for both weights, whereas only the position index with 500 g was increased in premanifest gene carriers compared with controls. Correlations were observed with the Disease Burden Score based on CAG-repeat length and age and with the Unified-Huntington's Disease Rating Scale. We conclude that quantitative assessment of chorea is feasible in Huntington's disease. The method is safe, noninvasive, and easily applicable and can be used repeatedly in outpatient settings. A use in clinical trials should be further explored in larger cohorts and follow-up studies.</div></front></TEI></PubMed></double></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Assessment of involuntary choreatic movements in Huntington's disease—Toward objective and quantitative measures
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| This area was generated with Dilib version V0.6.23. |  |