Biochemical Pre-motor Biomarkers for Parkinson Disease
Identifieur interne : 000E70 ( Main/Exploration ); précédent : 000E69; suivant : 000E71Biochemical Pre-motor Biomarkers for Parkinson Disease
Auteurs : Brit Mollenhauer ; Jing ZhangSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2012.
English descriptors
- KwdEn :
- Biological Markers (cerebrospinal fluid), Early Diagnosis, Humans, Intracellular Signaling Peptides and Proteins (cerebrospinal fluid), Oncogene Proteins (cerebrospinal fluid), Parkinson Disease (cerebrospinal fluid), Parkinson Disease (diagnosis), Parkinson Disease (etiology), alpha-Synuclein (cerebrospinal fluid).
- MESH :
- chemical , cerebrospinal fluid : Biological Markers, Intracellular Signaling Peptides and Proteins, Oncogene Proteins, alpha-Synuclein.
- cerebrospinal fluid : Parkinson Disease.
- diagnosis : Parkinson Disease.
- etiology : Parkinson Disease.
- Early Diagnosis, Humans.
Abstract
A biomarker is a biological characteristic that is objectively measured and evaluated as an indicator of normal biological or pathologic processes or of pharmacologic responses to a therapeutic intervention. We review the current status on target protein biomarkers (e.g. total/oligomeric α-synuclein and DJ-1) in cerebrospinal fluid, as well as on unbiased processes that can be used to discover novel biomarkers. We also give details about strategies towards potential populations/models and technologies, including the need for standardized sampling techniques, to pursue the identification of new biochemical markers in the pre-motor stage of Parkinson disease in the future.
Url:
DOI: 10.1002/mds.24956
PubMed: 22508282
PubMed Central: 3428741
Affiliations:
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Le document en format XML
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