Biochemical premotor biomarkers for Parkinson's disease.
Identifieur interne : 000E05 ( PubMed/Corpus ); précédent : 000E04; suivant : 000E06Biochemical premotor biomarkers for Parkinson's disease.
Auteurs : Brit Mollenhauer ; Jing ZhangSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2012.
English descriptors
- KwdEn :
- Biological Markers (cerebrospinal fluid), Early Diagnosis, Humans, Intracellular Signaling Peptides and Proteins (cerebrospinal fluid), Oncogene Proteins (cerebrospinal fluid), Parkinson Disease (cerebrospinal fluid), Parkinson Disease (diagnosis), Parkinson Disease (etiology), alpha-Synuclein (cerebrospinal fluid).
- MESH :
- chemical , cerebrospinal fluid : Biological Markers, Intracellular Signaling Peptides and Proteins, Oncogene Proteins, alpha-Synuclein.
- cerebrospinal fluid : Parkinson Disease.
- diagnosis : Parkinson Disease.
- etiology : Parkinson Disease.
- Early Diagnosis, Humans.
Abstract
A biomarker is a biological characteristic that is objectively measured and evaluated as an indicator of normal biological or pathologic processes or of pharmacologic responses to a therapeutic intervention. We reviewed the current status of target protein biomarkers (eg, total/oligomeric α-synuclein and DJ-1) in cerebrospinal fluid, as well as on unbiased processes that can be used to discover novel biomarkers. We have also provide details about strategies toward potential populations/models and technologies, including the need for standardized sampling techniques, to pursue the identification of new biochemical markers in the premotor stage of Parkinson's disease in the future.
DOI: 10.1002/mds.24956
PubMed: 22508282
Links to Exploration step
pubmed:22508282Le document en format XML
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We reviewed the current status of target protein biomarkers (eg, total/oligomeric α-synuclein and DJ-1) in cerebrospinal fluid, as well as on unbiased processes that can be used to discover novel biomarkers. We have also provide details about strategies toward potential populations/models and technologies, including the need for standardized sampling techniques, to pursue the identification of new biochemical markers in the premotor stage of Parkinson's disease in the future.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">22508282</PMID><DateCreated><Year>2012</Year><Month>04</Month><Day>17</Day></DateCreated><DateCompleted><Year>2012</Year><Month>08</Month><Day>23</Day></DateCompleted><DateRevised><Year>2014</Year><Month>10</Month><Day>16</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>27</Volume><Issue>5</Issue><PubDate><Year>2012</Year><Month>Apr</Month><Day>15</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Biochemical premotor biomarkers for Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>644-50</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.24956</ELocationID><Abstract><AbstractText>A biomarker is a biological characteristic that is objectively measured and evaluated as an indicator of normal biological or pathologic processes or of pharmacologic responses to a therapeutic intervention. We reviewed the current status of target protein biomarkers (eg, total/oligomeric α-synuclein and DJ-1) in cerebrospinal fluid, as well as on unbiased processes that can be used to discover novel biomarkers. 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