Symptomatic animal models for dystonia
Identifieur interne : 000759 ( Main/Exploration ); précédent : 000758; suivant : 000760Symptomatic animal models for dystonia
Auteurs : Bethany K. Wilson ; Ellen J. HessSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2013.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Neurotransmitter Agents.
- complications : Dystonia.
- genetics : Dystonia.
- chemical , metabolism : Neurotransmitter Agents.
- pathology : Basal Ganglia, Dystonia.
- Animals, Animals, Genetically Modified, Disease Models, Animal, Humans.
Abstract
Symptomatic animal models have clinical features consistent with human disorders and are often used to identify the anatomical and physiological processes involved in the expression of symptoms and to experimentally demonstrate causality where it would be infeasible in the patient population. Rodent and primate models of dystonia have identified basal ganglia abnormalities, including alterations in striatal GABAergic and dopaminergic transmission. Symptomatic animal models have also established the critical role of the cerebellum in dystonia, particularly abnormal glutamate signaling and aberrant Purkinje cell activity. Further, experiments suggest that the basal ganglia and cerebellum are nodes in an integrated network that is dysfunctional in dystonia. The knowledge gained from experiments in symptomatic animal models may serve as the foundation for the development of novel therapeutic interventions to treat dystonia.
Url:
DOI: 10.1002/mds.25526
PubMed: 23893454
PubMed Central: 3728703
Affiliations:
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Le document en format XML
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