Movement Disorders (revue)

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Quantitative susceptibility mapping of the midbrain in Parkinson's disease.

Identifieur interne : 000097 ( Main/Exploration ); précédent : 000096; suivant : 000098

Quantitative susceptibility mapping of the midbrain in Parkinson's disease.

Auteurs : Guangwei Du [États-Unis] ; Tian Liu [États-Unis] ; Mechelle M. Lewis [États-Unis] ; Lan Kong [États-Unis] ; Yi Wang [États-Unis] ; James Connor [États-Unis] ; Richard B. Mailman [États-Unis] ; Xuemei Huang [États-Unis]

Source :

RBID : pubmed:26362242

Abstract

Parkinson's disease (PD) is marked pathologically by dopamine neuron loss and iron overload in the substantia nigra pars compacta. Midbrain iron content is reported to be increased in PD based on magnetic resonance imaging (MRI) R2* changes. Because quantitative susceptibility mapping is a novel MRI approach to measure iron content, we compared it with R2* for assessing midbrain changes in PD.

DOI: 10.1002/mds.26417
PubMed: 26362242


Affiliations:


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<div type="abstract" xml:lang="en">Parkinson's disease (PD) is marked pathologically by dopamine neuron loss and iron overload in the substantia nigra pars compacta. Midbrain iron content is reported to be increased in PD based on magnetic resonance imaging (MRI) R2* changes. Because quantitative susceptibility mapping is a novel MRI approach to measure iron content, we compared it with R2* for assessing midbrain changes in PD.</div>
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<name sortKey="Du, Guangwei" sort="Du, Guangwei" uniqKey="Du G" first="Guangwei" last="Du">Guangwei Du</name>
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<name sortKey="Connor, James" sort="Connor, James" uniqKey="Connor J" first="James" last="Connor">James Connor</name>
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