Quantitative susceptibility mapping of the midbrain in Parkinson's disease.
Identifieur interne : 000038 ( PubMed/Corpus ); précédent : 000037; suivant : 000039Quantitative susceptibility mapping of the midbrain in Parkinson's disease.
Auteurs : Guangwei Du ; Tian Liu ; Mechelle M. Lewis ; Lan Kong ; Yi Wang ; James Connor ; Richard B. Mailman ; Xuemei HuangSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.
Abstract
Parkinson's disease (PD) is marked pathologically by dopamine neuron loss and iron overload in the substantia nigra pars compacta. Midbrain iron content is reported to be increased in PD based on magnetic resonance imaging (MRI) R2* changes. Because quantitative susceptibility mapping is a novel MRI approach to measure iron content, we compared it with R2* for assessing midbrain changes in PD.
DOI: 10.1002/mds.26417
PubMed: 26362242
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Quantitative susceptibility mapping of the midbrain in Parkinson's disease.</title><author><name sortKey="Du, Guangwei" sort="Du, Guangwei" uniqKey="Du G" first="Guangwei" last="Du">Guangwei Du</name><affiliation><nlm:affiliation>Department of Neurology, Penn State University-Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Tian" sort="Liu, Tian" uniqKey="Liu T" first="Tian" last="Liu">Tian Liu</name><affiliation><nlm:affiliation>MedImageMetric LLC, New York, New York, United States.</nlm:affiliation></affiliation></author><author><name sortKey="Lewis, Mechelle M" sort="Lewis, Mechelle M" uniqKey="Lewis M" first="Mechelle M" last="Lewis">Mechelle M. Lewis</name><affiliation><nlm:affiliation>Department of Neurology, Penn State University-Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States.</nlm:affiliation></affiliation></author><author><name sortKey="Kong, Lan" sort="Kong, Lan" uniqKey="Kong L" first="Lan" last="Kong">Lan Kong</name><affiliation><nlm:affiliation>Department of Public Health Sciences, Penn State University-Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Yi" sort="Wang, Yi" uniqKey="Wang Y" first="Yi" last="Wang">Yi Wang</name><affiliation><nlm:affiliation>Department of Radiology, Weill Cornell Medical College, New York, New York, United States.</nlm:affiliation></affiliation></author><author><name sortKey="Connor, James" sort="Connor, James" uniqKey="Connor J" first="James" last="Connor">James Connor</name><affiliation><nlm:affiliation>Department of Neurosurgery, Penn State University-Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States.</nlm:affiliation></affiliation></author><author><name sortKey="Mailman, Richard B" sort="Mailman, Richard B" uniqKey="Mailman R" first="Richard B" last="Mailman">Richard B. Mailman</name><affiliation><nlm:affiliation>Department of Neurology, Penn State University-Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States.</nlm:affiliation></affiliation></author><author><name sortKey="Huang, Xuemei" sort="Huang, Xuemei" uniqKey="Huang X" first="Xuemei" last="Huang">Xuemei Huang</name><affiliation><nlm:affiliation>Department of Neurology, Penn State University-Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="doi">10.1002/mds.26417</idno><idno type="RBID">pubmed:26362242</idno><idno type="pmid">26362242</idno><idno type="wicri:Area/PubMed/Corpus">000038</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Quantitative susceptibility mapping of the midbrain in Parkinson's disease.</title><author><name sortKey="Du, Guangwei" sort="Du, Guangwei" uniqKey="Du G" first="Guangwei" last="Du">Guangwei Du</name><affiliation><nlm:affiliation>Department of Neurology, Penn State University-Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Tian" sort="Liu, Tian" uniqKey="Liu T" first="Tian" last="Liu">Tian Liu</name><affiliation><nlm:affiliation>MedImageMetric LLC, New York, New York, United States.</nlm:affiliation></affiliation></author><author><name sortKey="Lewis, Mechelle M" sort="Lewis, Mechelle M" uniqKey="Lewis M" first="Mechelle M" last="Lewis">Mechelle M. Lewis</name><affiliation><nlm:affiliation>Department of Neurology, Penn State University-Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States.</nlm:affiliation></affiliation></author><author><name sortKey="Kong, Lan" sort="Kong, Lan" uniqKey="Kong L" first="Lan" last="Kong">Lan Kong</name><affiliation><nlm:affiliation>Department of Public Health Sciences, Penn State University-Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Yi" sort="Wang, Yi" uniqKey="Wang Y" first="Yi" last="Wang">Yi Wang</name><affiliation><nlm:affiliation>Department of Radiology, Weill Cornell Medical College, New York, New York, United States.</nlm:affiliation></affiliation></author><author><name sortKey="Connor, James" sort="Connor, James" uniqKey="Connor J" first="James" last="Connor">James Connor</name><affiliation><nlm:affiliation>Department of Neurosurgery, Penn State University-Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States.</nlm:affiliation></affiliation></author><author><name sortKey="Mailman, Richard B" sort="Mailman, Richard B" uniqKey="Mailman R" first="Richard B" last="Mailman">Richard B. Mailman</name><affiliation><nlm:affiliation>Department of Neurology, Penn State University-Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States.</nlm:affiliation></affiliation></author><author><name sortKey="Huang, Xuemei" sort="Huang, Xuemei" uniqKey="Huang X" first="Xuemei" last="Huang">Xuemei Huang</name><affiliation><nlm:affiliation>Department of Neurology, Penn State University-Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parkinson's disease (PD) is marked pathologically by dopamine neuron loss and iron overload in the substantia nigra pars compacta. Midbrain iron content is reported to be increased in PD based on magnetic resonance imaging (MRI) R2* changes. Because quantitative susceptibility mapping is a novel MRI approach to measure iron content, we compared it with R2* for assessing midbrain changes in PD.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">26362242</PMID><DateCreated><Year>2015</Year><Month>9</Month><Day>12</Day></DateCreated><DateRevised><Year>2015</Year><Month>9</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2015</Year><Month>Sep</Month><Day>12</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Quantitative susceptibility mapping of the midbrain in Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn></MedlinePgn></Pagination><ELocationID EIdType="doi">10.1002/mds.26417</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Parkinson's disease (PD) is marked pathologically by dopamine neuron loss and iron overload in the substantia nigra pars compacta. Midbrain iron content is reported to be increased in PD based on magnetic resonance imaging (MRI) R2* changes. Because quantitative susceptibility mapping is a novel MRI approach to measure iron content, we compared it with R2* for assessing midbrain changes in PD.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Quantitative susceptibility mapping and R2* maps were obtained from 47 PD patients and 47 healthy controls. Midbrain susceptibility and R2* values were analyzed by using both voxel-based and region-of-interest approaches in normalized space, and analyzed along with clinical data, including disease duration, Unified Parkinson's Disease Rating Scale (UPDRS) I, II, and III subscores, and levodopa-equivalent daily dosage. All studies were done while PD patients were "on drug."</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Compared with controls, PD patients showed significantly increased susceptibility values in both right (cluster size = 106 mm(3) ) and left (164 mm(3) ) midbrain, located ventrolateral to the red nucleus that corresponded to the substantia nigra pars compacta. Susceptibility values in this region were correlated significantly with disease duration, UPDRS II, and levodopa-equivalent daily dosage. Conversely, R2* was increased significantly only in a much smaller region (62 mm(3) ) of the left lateral substantia nigra pars compacta and was not significantly correlated with clinical parameters.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The use of quantitative susceptibility mapping demonstrated marked nigral changes that correlated with clinical PD status more sensitively than R2*. These data suggest that quantitative susceptibility mapping may be a superior imaging biomarker to R2* for estimating brain iron levels in PD. © 2015 Movement Disorder Society.</AbstractText><CopyrightInformation>© 2015 International Parkinson and Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList><Author><LastName>Du</LastName><ForeName>Guangwei</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Neurology, Penn State University-Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States.</Affiliation></AffiliationInfo></Author><Author><LastName>Liu</LastName><ForeName>Tian</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>MedImageMetric LLC, New York, New York, United States.</Affiliation></AffiliationInfo></Author><Author><LastName>Lewis</LastName><ForeName>Mechelle M</ForeName><Initials>MM</Initials><AffiliationInfo><Affiliation>Department of Neurology, Penn State University-Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Pharmacology, Penn State University-Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States.</Affiliation></AffiliationInfo></Author><Author><LastName>Kong</LastName><ForeName>Lan</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Public Health Sciences, Penn State University-Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States.</Affiliation></AffiliationInfo></Author><Author><LastName>Wang</LastName><ForeName>Yi</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Radiology, Weill Cornell Medical College, New York, New York, United States.</Affiliation></AffiliationInfo></Author><Author><LastName>Connor</LastName><ForeName>James</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Neurosurgery, Penn State University-Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States.</Affiliation></AffiliationInfo></Author><Author><LastName>Mailman</LastName><ForeName>Richard B</ForeName><Initials>RB</Initials><AffiliationInfo><Affiliation>Department of Neurology, Penn State University-Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Pharmacology, Penn State University-Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States.</Affiliation></AffiliationInfo></Author><Author><LastName>Huang</LastName><ForeName>Xuemei</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Department of Neurology, Penn State University-Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Pharmacology, Penn State University-Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Neurosurgery, Penn State University-Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Radiology, Penn State University-Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Kinesiology, Penn State University-Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States.</Affiliation></AffiliationInfo></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="">JOURNAL ARTICLE</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>9</Month><Day>12</Day></ArticleDate></Article><MedlineJournalInfo><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Parkinson's disease</Keyword><Keyword MajorTopicYN="N">iron</Keyword><Keyword MajorTopicYN="N">magnetic resonance imaging</Keyword><Keyword MajorTopicYN="N">quantitative susceptibility mapping</Keyword><Keyword MajorTopicYN="N">substantia nigra</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>3</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>7</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>8</Month><Day>5</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>9</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>9</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>9</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.26417</ArticleId><ArticleId IdType="pubmed">26362242</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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