MovDisordV3, Main, Curation, bibRecord, 004E85

The role of EDTA in provoking allergic reactions to subcutaneous infusion of apomorphine in patients with Parkinson's disease: A histologic study

Identifieur interne : 004E85 ( Main/Curation ); précédent : 004E84; suivant : 004E86

The role of EDTA in provoking allergic reactions to subcutaneous infusion of apomorphine in patients with Parkinson's disease: A histologic study

Auteurs : van Laar ; Bob Van Hilten ; Cees Neef ; A. Wijnand F. Rutgers ; Stan Pavel ; J. Anthony Bruijn

Source :

Movement Disorders [ 0885-3185 ] ; 1998-01.

RBID : ISTEX:02347E989E81A2D17EF3F66851FD28752E163E26

English descriptors

KwdEn :
- Abdominal Muscles (pathology), Allergic reactions, Antiparkinson Agents (adverse effects), Apomorphine, Apomorphine (adverse effects), Chelating Agents (adverse effects), Drug Combinations, Drug Eruptions (pathology), EDTA, Edetic Acid (adverse effects), Female, Humans, Injections, Subcutaneous, Intervention Studies, Longitudinal Studies, Male, Middle Aged, Subcutaneous nodules, Vasculitis, Leukocytoclastic, Cutaneous (chemically induced), Vasculitis, Leukocytoclastic, Cutaneous (pathology).
MESH :
- chemical , adverse effects : Antiparkinson Agents, Apomorphine, Chelating Agents, Edetic Acid.
- chemically induced : Vasculitis, Leukocytoclastic, Cutaneous.
- pathology : Abdominal Muscles, Drug Eruptions, Vasculitis, Leukocytoclastic, Cutaneous.
- chemical : Drug Combinations, Female, Humans, Injections, Subcutaneous, Intervention Studies, Longitudinal Studies, Male, Middle Aged.

Abstract

One of the formulations of apomorphine, used in clinical practice, contains sodium edetate (EDTA). EDTA is a chelator which indirectly prevents oxidation of apomorphine. A clinical and histologic study in four patients revealed that apomorphine with EDTA caused severe subcutaneous nodules, histologically characterized by an inflammatory infiltrate with a large amount of eosinophils, indicating a cell‐mediated allergic reaction. After withdrawal of EDTA, this allergic component completely disappeared, which was accompanied clinically by less extensive nodule formation with a softer consistency. It is therefore recommended that EDTA be excluded from apomorphine formulations.

Url:

https://api.istex.fr/document/02347E989E81A2D17EF3F66851FD28752E163E26/fulltext/pdf

DOI: 10.1002/mds.870130113

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van Laar

<affiliation><wicri:noCountry code="subField">University Hospital Leiden</wicri:noCountry>
</affiliation>

Bob Van Hilten

<affiliation><wicri:noCountry code="subField">University Hospital Leiden</wicri:noCountry>
</affiliation>

Cees Neef

<affiliation><wicri:noCountry code="subField">Hospital Medisch Spectrum Twente</wicri:noCountry>
</affiliation>

A. Wijnand F. Rutgers

<affiliation><wicri:noCountry code="subField">Martini Hospital Groningen</wicri:noCountry>
</affiliation>

Stan Pavel

<affiliation><wicri:noCountry code="subField">University Hospital Leiden</wicri:noCountry>
</affiliation>

J. Anthony Bruijn

<affiliation><wicri:noCountry code="subField">University Hospital Leiden</wicri:noCountry>
</affiliation>

Le document en format XML

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<author><name sortKey="Rutgers, A Wijnand F" sort="Rutgers, A Wijnand F" uniqKey="Rutgers A" first="A. Wijnand F." last="Rutgers">A. Wijnand F. Rutgers</name>
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<pubPlace>Hoboken</pubPlace>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Abdominal Muscles (pathology)</term>
<term>Allergic reactions</term>
<term>Antiparkinson Agents (adverse effects)</term>
<term>Apomorphine</term>
<term>Apomorphine (adverse effects)</term>
<term>Chelating Agents (adverse effects)</term>
<term>Drug Combinations</term>
<term>Drug Eruptions (pathology)</term>
<term>EDTA</term>
<term>Edetic Acid (adverse effects)</term>
<term>Female</term>
<term>Humans</term>
<term>Injections, Subcutaneous</term>
<term>Intervention Studies</term>
<term>Longitudinal Studies</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Subcutaneous nodules</term>
<term>Vasculitis, Leukocytoclastic, Cutaneous (chemically induced)</term>
<term>Vasculitis, Leukocytoclastic, Cutaneous (pathology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term>
<term>Apomorphine</term>
<term>Chelating Agents</term>
<term>Edetic Acid</term>
</keywords>
<keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Vasculitis, Leukocytoclastic, Cutaneous</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Abdominal Muscles</term>
<term>Drug Eruptions</term>
<term>Vasculitis, Leukocytoclastic, Cutaneous</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Drug Combinations</term>
<term>Female</term>
<term>Humans</term>
<term>Injections, Subcutaneous</term>
<term>Intervention Studies</term>
<term>Longitudinal Studies</term>
<term>Male</term>
<term>Middle Aged</term>
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<front><div type="abstract" xml:lang="en">One of the formulations of apomorphine, used in clinical practice, contains sodium edetate (EDTA). EDTA is a chelator which indirectly prevents oxidation of apomorphine. A clinical and histologic study in four patients revealed that apomorphine with EDTA caused severe subcutaneous nodules, histologically characterized by an inflammatory infiltrate with a large amount of eosinophils, indicating a cell‐mediated allergic reaction. After withdrawal of EDTA, this allergic component completely disappeared, which was accompanied clinically by less extensive nodule formation with a softer consistency. It is therefore recommended that EDTA be excluded from apomorphine formulations.</div>
</front>
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	Movement Disorders (revue)
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Movement Disorders (revue)

The role of EDTA in provoking allergic reactions to subcutaneous infusion of apomorphine in patients with Parkinson's disease: A histologic study

The role of EDTA in provoking allergic reactions to subcutaneous infusion of apomorphine in patients with Parkinson's disease: A histologic study

Source :

English descriptors

Abstract

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