The role of EDTA in provoking allergic reactions to subcutaneous infusion of apomorphine in patients with Parkinson's disease: a histologic study.
Identifieur interne : 004E68 ( Ncbi/Checkpoint ); précédent : 004E67; suivant : 004E69The role of EDTA in provoking allergic reactions to subcutaneous infusion of apomorphine in patients with Parkinson's disease: a histologic study.
Auteurs : T. Van Laar ; B. Van Hilten ; C. Neef ; A W Rutgers ; S. Pavel ; J A BruijnSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1998.
English descriptors
- KwdEn :
- Abdominal Muscles (pathology), Antiparkinson Agents (adverse effects), Apomorphine (adverse effects), Chelating Agents (adverse effects), Drug Combinations, Drug Eruptions (pathology), Edetic Acid (adverse effects), Female, Humans, Injections, Subcutaneous, Intervention Studies, Longitudinal Studies, Male, Middle Aged, Vasculitis, Leukocytoclastic, Cutaneous (chemically induced), Vasculitis, Leukocytoclastic, Cutaneous (pathology).
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Apomorphine, Chelating Agents, Edetic Acid.
- chemically induced : Vasculitis, Leukocytoclastic, Cutaneous.
- pathology : Abdominal Muscles, Drug Eruptions, Vasculitis, Leukocytoclastic, Cutaneous.
- chemical : Drug Combinations, Female, Humans, Injections, Subcutaneous, Intervention Studies, Longitudinal Studies, Male, Middle Aged.
Abstract
One of the formulations of apomorphine, used in clinical practice, contains sodium edetate (EDTA). EDTA is a chelator which indirectly prevents oxidation of apomorphine. A clinical and histologic study in four patients revealed that apomorphine with EDTA caused severe subcutaneous nodules, histologically characterized by an inflammatory infiltrate with a large amount of eosinophils, indicating a cell-mediated allergic reaction. After withdrawal of EDTA, this allergic component completely disappeared, which was accompanied clinically by less extensive nodule formation with a softer consistency. It is therefore recommended that EDTA be excluded from apomorphine formulations.
DOI: 10.1002/mds.870130113
PubMed: 9452326
Affiliations:
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Neef</name></author><author><name sortKey="Rutgers, A W" sort="Rutgers, A W" uniqKey="Rutgers A" first="A W" last="Rutgers">A W Rutgers</name></author><author><name sortKey="Pavel, S" sort="Pavel, S" uniqKey="Pavel S" first="S" last="Pavel">S. 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Van Laar</name><affiliation><nlm:affiliation>Department of Neurology, University Hospital Leiden.</nlm:affiliation><wicri:noCountry code="subField">University Hospital Leiden</wicri:noCountry></affiliation></author><author><name sortKey="Van Hilten, B" sort="Van Hilten, B" uniqKey="Van Hilten B" first="B" last="Van Hilten">B. Van Hilten</name></author><author><name sortKey="Neef, C" sort="Neef, C" uniqKey="Neef C" first="C" last="Neef">C. Neef</name></author><author><name sortKey="Rutgers, A W" sort="Rutgers, A W" uniqKey="Rutgers A" first="A W" last="Rutgers">A W Rutgers</name></author><author><name sortKey="Pavel, S" sort="Pavel, S" uniqKey="Pavel S" first="S" last="Pavel">S. Pavel</name></author><author><name sortKey="Bruijn, J A" sort="Bruijn, J A" uniqKey="Bruijn J" first="J A" last="Bruijn">J A Bruijn</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="1998" type="published">1998</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Abdominal Muscles (pathology)</term><term>Antiparkinson Agents (adverse effects)</term><term>Apomorphine (adverse effects)</term><term>Chelating Agents (adverse effects)</term><term>Drug Combinations</term><term>Drug Eruptions (pathology)</term><term>Edetic Acid (adverse effects)</term><term>Female</term><term>Humans</term><term>Injections, Subcutaneous</term><term>Intervention Studies</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term><term>Vasculitis, Leukocytoclastic, Cutaneous (chemically induced)</term><term>Vasculitis, Leukocytoclastic, Cutaneous (pathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term><term>Apomorphine</term><term>Chelating Agents</term><term>Edetic Acid</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Vasculitis, Leukocytoclastic, Cutaneous</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Abdominal Muscles</term><term>Drug Eruptions</term><term>Vasculitis, Leukocytoclastic, Cutaneous</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Drug Combinations</term><term>Female</term><term>Humans</term><term>Injections, Subcutaneous</term><term>Intervention Studies</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">One of the formulations of apomorphine, used in clinical practice, contains sodium edetate (EDTA). EDTA is a chelator which indirectly prevents oxidation of apomorphine. A clinical and histologic study in four patients revealed that apomorphine with EDTA caused severe subcutaneous nodules, histologically characterized by an inflammatory infiltrate with a large amount of eosinophils, indicating a cell-mediated allergic reaction. After withdrawal of EDTA, this allergic component completely disappeared, which was accompanied clinically by less extensive nodule formation with a softer consistency. It is therefore recommended that EDTA be excluded from apomorphine formulations.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Bruijn, J A" sort="Bruijn, J A" uniqKey="Bruijn J" first="J A" last="Bruijn">J A Bruijn</name><name sortKey="Neef, C" sort="Neef, C" uniqKey="Neef C" first="C" last="Neef">C. Neef</name><name sortKey="Pavel, S" sort="Pavel, S" uniqKey="Pavel S" first="S" last="Pavel">S. Pavel</name><name sortKey="Rutgers, A W" sort="Rutgers, A W" uniqKey="Rutgers A" first="A W" last="Rutgers">A W Rutgers</name><name sortKey="Van Hilten, B" sort="Van Hilten, B" uniqKey="Van Hilten B" first="B" last="Van Hilten">B. Van Hilten</name><name sortKey="Van Laar, T" sort="Van Laar, T" uniqKey="Van Laar T" first="T" last="Van Laar">T. Van Laar</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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