The tau A0 allele in Parkinson's disease
Identifieur interne : 004667 ( Main/Curation ); précédent : 004666; suivant : 004668The tau A0 allele in Parkinson's disease
Auteurs : Lawrence I. Golbe [États-Unis] ; Alice M. Lazzarini [États-Unis] ; John R. Spychala [États-Unis] ; William G. Johnson [États-Unis] ; Edward S. Stenroos [États-Unis] ; Margery H. Mark [États-Unis] ; Jacob I. Sage [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2001-05.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Aged, Alleles, Case-Control Studies, Female, Gene Frequency, Genetic Markers, Genotype, Human, Humans, Male, Metaanalysis, Middle Aged, Nerve Tissue Proteins (genetics), Parkinson Disease (classification), Parkinson Disease (genetics), Parkinson disease, Parkinson's disease, Pathophysiology, Polymerase chain reaction, Protein Isoforms, Supranuclear Palsy, Progressive (genetics), Synucleins, Tau protein, genetics, progressive supranuclear palsy, tau, tau Proteins (genetics).
- MESH :
- chemical , genetics : Nerve Tissue Proteins, tau Proteins.
- chemical : Genetic Markers, Protein Isoforms, Synucleins.
- classification : Parkinson Disease.
- genetics : Parkinson Disease, Supranuclear Palsy, Progressive.
- Aged, Alleles, Case-Control Studies, Female, Gene Frequency, Genotype, Humans, Male, Middle Aged.
Abstract
Parkinson's disease (PD) is primarily an α‐synucle‐ inopathy, rather than a tauopathy, but there is evidence for an indirect association of tau with the pathogenetic process in PD. We therefore assessed the frequency in PD of the tau A0 allele, a dinucleotide repeat marker that has been associated with a sporadic tauopathy, progressive supranuclear palsy (PSP). We found the A0 allele to comprise 79.2% of 758 alleles from PD patients and 71.2% of 264 control alleles (P = 0.008). We also performed a meta‐analysis of three previous reports, two of which failed to produce statistically significant results. Taken together, they also support a PD/A0 allelic association, even after correction for misdiagnosis of PSP as PD (P< 0.001). The A0/A0 genotype frequency in our patients (62.3%) did not differ significantly from that in controls (53.0%, P = 0.062), but the meta‐analysis, even after correction for misdiagnosis, showed a significant result, with P = 0.002. The frequency of A0 allele and the A0/A0 genotype were compatible with Hardy‐Weinberg equilibrium. The frequency of the A0 allele and the A0/A0 genotype in our patients with familial PD was not significantly greater than in those with sporadic PD. We conclude that the tau protein may play a small role in the pathogenesis of PD and that biochemical characterization of this role may suggest opportunities for PD prophylaxis. © 2001 Movement Disorder Society.
Url:
DOI: 10.1002/mds.1087
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001292
- to stream Istex, to step Curation: Pour aller vers cette notice dans l'étape Curation :001292
- to stream Istex, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :002E93
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :006B48
- to stream PascalFrancis, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002A07
- to stream PascalFrancis, to step Curation: Pour aller vers cette notice dans l'étape Curation :000314
- to stream PascalFrancis, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :002886
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :006D85
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :003D50
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :003D50
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :003C23
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000501
- to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :000501
- to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000501
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :006925
Links to Exploration step
ISTEX:785EF73A2A3DAB87D2F6CC4C9448E17C2F2C4804Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">The tau A0 allele in Parkinson's disease</title>
<author><name sortKey="Golbe, Lawrence I" sort="Golbe, Lawrence I" uniqKey="Golbe L" first="Lawrence I." last="Golbe">Lawrence I. Golbe</name>
</author>
<author><name sortKey="Lazzarini, Alice M" sort="Lazzarini, Alice M" uniqKey="Lazzarini A" first="Alice M." last="Lazzarini">Alice M. Lazzarini</name>
</author>
<author><name sortKey="Spychala, John R" sort="Spychala, John R" uniqKey="Spychala J" first="John R." last="Spychala">John R. Spychala</name>
</author>
<author><name sortKey="Johnson, William G" sort="Johnson, William G" uniqKey="Johnson W" first="William G." last="Johnson">William G. Johnson</name>
</author>
<author><name sortKey="Stenroos, Edward S" sort="Stenroos, Edward S" uniqKey="Stenroos E" first="Edward S." last="Stenroos">Edward S. Stenroos</name>
</author>
<author><name sortKey="Mark, Margery H" sort="Mark, Margery H" uniqKey="Mark M" first="Margery H." last="Mark">Margery H. Mark</name>
</author>
<author><name sortKey="Sage, Jacob I" sort="Sage, Jacob I" uniqKey="Sage J" first="Jacob I." last="Sage">Jacob I. Sage</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:785EF73A2A3DAB87D2F6CC4C9448E17C2F2C4804</idno>
<date when="2001" year="2001">2001</date>
<idno type="doi">10.1002/mds.1087</idno>
<idno type="url">https://api.istex.fr/document/785EF73A2A3DAB87D2F6CC4C9448E17C2F2C4804/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001292</idno>
<idno type="wicri:Area/Istex/Curation">001292</idno>
<idno type="wicri:Area/Istex/Checkpoint">002E93</idno>
<idno type="wicri:doubleKey">0885-3185:2001:Golbe L:the:tau:a</idno>
<idno type="wicri:Area/Main/Merge">006B48</idno>
<idno type="wicri:source">INIST</idno>
<idno type="RBID">Pascal:01-0377453</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">002A07</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000314</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">002886</idno>
<idno type="wicri:doubleKey">0885-3185:2001:Golbe L:the:tau:a</idno>
<idno type="wicri:Area/Main/Merge">006D85</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:11391737</idno>
<idno type="wicri:Area/PubMed/Corpus">003D50</idno>
<idno type="wicri:Area/PubMed/Curation">003D50</idno>
<idno type="wicri:Area/PubMed/Checkpoint">003C23</idno>
<idno type="wicri:Area/Ncbi/Merge">000501</idno>
<idno type="wicri:Area/Ncbi/Curation">000501</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000501</idno>
<idno type="wicri:doubleKey">0885-3185:2001:Golbe L:the:tau:a</idno>
<idno type="wicri:Area/Main/Merge">006925</idno>
<idno type="wicri:Area/Main/Curation">004667</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">The tau A0 allele in Parkinson's disease</title>
<author><name sortKey="Golbe, Lawrence I" sort="Golbe, Lawrence I" uniqKey="Golbe L" first="Lawrence I." last="Golbe">Lawrence I. Golbe</name>
<affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, UMDNJ‐Robert Wood Johnson Medical School, New Brunswick, New Jersey</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lazzarini, Alice M" sort="Lazzarini, Alice M" uniqKey="Lazzarini A" first="Alice M." last="Lazzarini">Alice M. Lazzarini</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, UMDNJ‐Robert Wood Johnson Medical School, New Brunswick, New Jersey</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Spychala, John R" sort="Spychala, John R" uniqKey="Spychala J" first="John R." last="Spychala">John R. Spychala</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, UMDNJ‐Robert Wood Johnson Medical School, New Brunswick, New Jersey</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Johnson, William G" sort="Johnson, William G" uniqKey="Johnson W" first="William G." last="Johnson">William G. Johnson</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, UMDNJ‐Robert Wood Johnson Medical School, New Brunswick, New Jersey</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stenroos, Edward S" sort="Stenroos, Edward S" uniqKey="Stenroos E" first="Edward S." last="Stenroos">Edward S. Stenroos</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, UMDNJ‐Robert Wood Johnson Medical School, New Brunswick, New Jersey</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mark, Margery H" sort="Mark, Margery H" uniqKey="Mark M" first="Margery H." last="Mark">Margery H. Mark</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, UMDNJ‐Robert Wood Johnson Medical School, New Brunswick, New Jersey</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sage, Jacob I" sort="Sage, Jacob I" uniqKey="Sage J" first="Jacob I." last="Sage">Jacob I. Sage</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, UMDNJ‐Robert Wood Johnson Medical School, New Brunswick, New Jersey</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>John Wiley & Sons, Inc.</publisher>
<pubPlace>New York</pubPlace>
<date type="published" when="2001-05">2001-05</date>
<biblScope unit="vol">16</biblScope>
<biblScope unit="issue">3</biblScope>
<biblScope unit="page" from="442">442</biblScope>
<biblScope unit="page" to="447">447</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">785EF73A2A3DAB87D2F6CC4C9448E17C2F2C4804</idno>
<idno type="DOI">10.1002/mds.1087</idno>
<idno type="ArticleID">MDS1087</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Alleles</term>
<term>Case-Control Studies</term>
<term>Female</term>
<term>Gene Frequency</term>
<term>Genetic Markers</term>
<term>Genotype</term>
<term>Human</term>
<term>Humans</term>
<term>Male</term>
<term>Metaanalysis</term>
<term>Middle Aged</term>
<term>Nerve Tissue Proteins (genetics)</term>
<term>Parkinson Disease (classification)</term>
<term>Parkinson Disease (genetics)</term>
<term>Parkinson disease</term>
<term>Parkinson's disease</term>
<term>Pathophysiology</term>
<term>Polymerase chain reaction</term>
<term>Protein Isoforms</term>
<term>Supranuclear Palsy, Progressive (genetics)</term>
<term>Synucleins</term>
<term>Tau protein</term>
<term>genetics</term>
<term>progressive supranuclear palsy</term>
<term>tau</term>
<term>tau Proteins (genetics)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Nerve Tissue Proteins</term>
<term>tau Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Genetic Markers</term>
<term>Protein Isoforms</term>
<term>Synucleins</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term>
<term>Supranuclear Palsy, Progressive</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Alleles</term>
<term>Case-Control Studies</term>
<term>Female</term>
<term>Gene Frequency</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Homme</term>
<term>Métaanalyse</term>
<term>Parkinson maladie</term>
<term>Physiopathologie</term>
<term>Protéine tau</term>
<term>Réaction chaîne polymérase</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Parkinson's disease (PD) is primarily an α‐synucle‐ inopathy, rather than a tauopathy, but there is evidence for an indirect association of tau with the pathogenetic process in PD. We therefore assessed the frequency in PD of the tau A0 allele, a dinucleotide repeat marker that has been associated with a sporadic tauopathy, progressive supranuclear palsy (PSP). We found the A0 allele to comprise 79.2% of 758 alleles from PD patients and 71.2% of 264 control alleles (P = 0.008). We also performed a meta‐analysis of three previous reports, two of which failed to produce statistically significant results. Taken together, they also support a PD/A0 allelic association, even after correction for misdiagnosis of PSP as PD (P< 0.001). The A0/A0 genotype frequency in our patients (62.3%) did not differ significantly from that in controls (53.0%, P = 0.062), but the meta‐analysis, even after correction for misdiagnosis, showed a significant result, with P = 0.002. The frequency of A0 allele and the A0/A0 genotype were compatible with Hardy‐Weinberg equilibrium. The frequency of the A0 allele and the A0/A0 genotype in our patients with familial PD was not significantly greater than in those with sporadic PD. We conclude that the tau protein may play a small role in the pathogenesis of PD and that biochemical characterization of this role may suggest opportunities for PD prophylaxis. © 2001 Movement Disorder Society.</div>
</front>
</TEI>
<double idat="0885-3185:2001:Golbe L:the:tau:a"><INIST><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">The tau A0 allele in Parkinson's disease</title>
<author><name sortKey="Golbe, Lawrence I" sort="Golbe, Lawrence I" uniqKey="Golbe L" first="Lawrence I." last="Golbe">Lawrence I. Golbe</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, UMDNJ-Robert Wood Johnson Medical School</s1>
<s2>New Brunswick, New Jersey</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lazzarini, Alice M" sort="Lazzarini, Alice M" uniqKey="Lazzarini A" first="Alice M." last="Lazzarini">Alice M. Lazzarini</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, UMDNJ-Robert Wood Johnson Medical School</s1>
<s2>New Brunswick, New Jersey</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Spychala, John R" sort="Spychala, John R" uniqKey="Spychala J" first="John R." last="Spychala">John R. Spychala</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, UMDNJ-Robert Wood Johnson Medical School</s1>
<s2>New Brunswick, New Jersey</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Johnson, William G" sort="Johnson, William G" uniqKey="Johnson W" first="William G." last="Johnson">William G. Johnson</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, UMDNJ-Robert Wood Johnson Medical School</s1>
<s2>New Brunswick, New Jersey</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stenroos, Edward S" sort="Stenroos, Edward S" uniqKey="Stenroos E" first="Edward S." last="Stenroos">Edward S. Stenroos</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, UMDNJ-Robert Wood Johnson Medical School</s1>
<s2>New Brunswick, New Jersey</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mark, Margery H" sort="Mark, Margery H" uniqKey="Mark M" first="Margery H." last="Mark">Margery H. Mark</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, UMDNJ-Robert Wood Johnson Medical School</s1>
<s2>New Brunswick, New Jersey</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sage, Jacob I" sort="Sage, Jacob I" uniqKey="Sage J" first="Jacob I." last="Sage">Jacob I. Sage</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, UMDNJ-Robert Wood Johnson Medical School</s1>
<s2>New Brunswick, New Jersey</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">01-0377453</idno>
<date when="2001">2001</date>
<idno type="stanalyst">PASCAL 01-0377453 INIST</idno>
<idno type="RBID">Pascal:01-0377453</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">002A07</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000314</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">002886</idno>
<idno type="wicri:doubleKey">0885-3185:2001:Golbe L:the:tau:a</idno>
<idno type="wicri:Area/Main/Merge">006D85</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">The tau A0 allele in Parkinson's disease</title>
<author><name sortKey="Golbe, Lawrence I" sort="Golbe, Lawrence I" uniqKey="Golbe L" first="Lawrence I." last="Golbe">Lawrence I. Golbe</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, UMDNJ-Robert Wood Johnson Medical School</s1>
<s2>New Brunswick, New Jersey</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lazzarini, Alice M" sort="Lazzarini, Alice M" uniqKey="Lazzarini A" first="Alice M." last="Lazzarini">Alice M. Lazzarini</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, UMDNJ-Robert Wood Johnson Medical School</s1>
<s2>New Brunswick, New Jersey</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Spychala, John R" sort="Spychala, John R" uniqKey="Spychala J" first="John R." last="Spychala">John R. Spychala</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, UMDNJ-Robert Wood Johnson Medical School</s1>
<s2>New Brunswick, New Jersey</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Johnson, William G" sort="Johnson, William G" uniqKey="Johnson W" first="William G." last="Johnson">William G. Johnson</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, UMDNJ-Robert Wood Johnson Medical School</s1>
<s2>New Brunswick, New Jersey</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stenroos, Edward S" sort="Stenroos, Edward S" uniqKey="Stenroos E" first="Edward S." last="Stenroos">Edward S. Stenroos</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, UMDNJ-Robert Wood Johnson Medical School</s1>
<s2>New Brunswick, New Jersey</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mark, Margery H" sort="Mark, Margery H" uniqKey="Mark M" first="Margery H." last="Mark">Margery H. Mark</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, UMDNJ-Robert Wood Johnson Medical School</s1>
<s2>New Brunswick, New Jersey</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sage, Jacob I" sort="Sage, Jacob I" uniqKey="Sage J" first="Jacob I." last="Sage">Jacob I. Sage</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, UMDNJ-Robert Wood Johnson Medical School</s1>
<s2>New Brunswick, New Jersey</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2001">2001</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Human</term>
<term>Metaanalysis</term>
<term>Parkinson disease</term>
<term>Pathophysiology</term>
<term>Polymerase chain reaction</term>
<term>Tau protein</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term>
<term>Réaction chaîne polymérase</term>
<term>Protéine tau</term>
<term>Métaanalyse</term>
<term>Physiopathologie</term>
<term>Homme</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Parkinson's disease (PD) is primarily an α-synucleinopathy, rather than a tauopathy, but there is evidence for an indirect association of tau with the pathogenetic process in PD. We therefore assessed the frequency in PD of the tau A0 allele, a dinucleotide repeat marker that has been associated with a sporadic tauopathy, progressive supranuclear palsy (PSP). We found the A0 allele to comprise 79.2% of 758 alleles from PD patients and 71.2% of 264 control alleles (P = 0.008), We also performed a meta-analysis of three previous reports, two of which failed to produce statistically significant results. Taken together, they also support a PD/A0 allelic association, even after correction for misdiagnosis of PSP as PD (P< 0.001). The A0/A0 genotype frequency in our patients (62.3%) did not differ significantly from that in controls (53.0%, P = 0.062), but the meta-analysis, even after correction for misdiagnosis, showed a significant result, with P = 0.002. The frequency of A0 allele and the A0/A0 genotype were compatible with Hardy-Weinberg equilibrium. The frequency of the A0 allele and the A0/A0 genotype in our patients with familial PD was not significantly greater than in those with sporadic PD. We conclude that the tau protein may play a small role in the pathogenesis of PD and that biochemical characterization of this role may suggest opportunities for PD prophylaxis.</div>
</front>
</TEI>
</INIST>
<ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">The tau A0 allele in Parkinson's disease</title>
<author><name sortKey="Golbe, Lawrence I" sort="Golbe, Lawrence I" uniqKey="Golbe L" first="Lawrence I." last="Golbe">Lawrence I. Golbe</name>
</author>
<author><name sortKey="Lazzarini, Alice M" sort="Lazzarini, Alice M" uniqKey="Lazzarini A" first="Alice M." last="Lazzarini">Alice M. Lazzarini</name>
</author>
<author><name sortKey="Spychala, John R" sort="Spychala, John R" uniqKey="Spychala J" first="John R." last="Spychala">John R. Spychala</name>
</author>
<author><name sortKey="Johnson, William G" sort="Johnson, William G" uniqKey="Johnson W" first="William G." last="Johnson">William G. Johnson</name>
</author>
<author><name sortKey="Stenroos, Edward S" sort="Stenroos, Edward S" uniqKey="Stenroos E" first="Edward S." last="Stenroos">Edward S. Stenroos</name>
</author>
<author><name sortKey="Mark, Margery H" sort="Mark, Margery H" uniqKey="Mark M" first="Margery H." last="Mark">Margery H. Mark</name>
</author>
<author><name sortKey="Sage, Jacob I" sort="Sage, Jacob I" uniqKey="Sage J" first="Jacob I." last="Sage">Jacob I. Sage</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:785EF73A2A3DAB87D2F6CC4C9448E17C2F2C4804</idno>
<date when="2001" year="2001">2001</date>
<idno type="doi">10.1002/mds.1087</idno>
<idno type="url">https://api.istex.fr/document/785EF73A2A3DAB87D2F6CC4C9448E17C2F2C4804/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001292</idno>
<idno type="wicri:Area/Istex/Curation">001292</idno>
<idno type="wicri:Area/Istex/Checkpoint">002E93</idno>
<idno type="wicri:doubleKey">0885-3185:2001:Golbe L:the:tau:a</idno>
<idno type="wicri:Area/Main/Merge">006B48</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">The tau A0 allele in Parkinson's disease</title>
<author><name sortKey="Golbe, Lawrence I" sort="Golbe, Lawrence I" uniqKey="Golbe L" first="Lawrence I." last="Golbe">Lawrence I. Golbe</name>
<affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, UMDNJ‐Robert Wood Johnson Medical School, New Brunswick, New Jersey</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lazzarini, Alice M" sort="Lazzarini, Alice M" uniqKey="Lazzarini A" first="Alice M." last="Lazzarini">Alice M. Lazzarini</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, UMDNJ‐Robert Wood Johnson Medical School, New Brunswick, New Jersey</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Spychala, John R" sort="Spychala, John R" uniqKey="Spychala J" first="John R." last="Spychala">John R. Spychala</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, UMDNJ‐Robert Wood Johnson Medical School, New Brunswick, New Jersey</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Johnson, William G" sort="Johnson, William G" uniqKey="Johnson W" first="William G." last="Johnson">William G. Johnson</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, UMDNJ‐Robert Wood Johnson Medical School, New Brunswick, New Jersey</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stenroos, Edward S" sort="Stenroos, Edward S" uniqKey="Stenroos E" first="Edward S." last="Stenroos">Edward S. Stenroos</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, UMDNJ‐Robert Wood Johnson Medical School, New Brunswick, New Jersey</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mark, Margery H" sort="Mark, Margery H" uniqKey="Mark M" first="Margery H." last="Mark">Margery H. Mark</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, UMDNJ‐Robert Wood Johnson Medical School, New Brunswick, New Jersey</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sage, Jacob I" sort="Sage, Jacob I" uniqKey="Sage J" first="Jacob I." last="Sage">Jacob I. Sage</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, UMDNJ‐Robert Wood Johnson Medical School, New Brunswick, New Jersey</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>John Wiley & Sons, Inc.</publisher>
<pubPlace>New York</pubPlace>
<date type="published" when="2001-05">2001-05</date>
<biblScope unit="vol">16</biblScope>
<biblScope unit="issue">3</biblScope>
<biblScope unit="page" from="442">442</biblScope>
<biblScope unit="page" to="447">447</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">785EF73A2A3DAB87D2F6CC4C9448E17C2F2C4804</idno>
<idno type="DOI">10.1002/mds.1087</idno>
<idno type="ArticleID">MDS1087</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term>
<term>genetics</term>
<term>progressive supranuclear palsy</term>
<term>tau</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Parkinson's disease (PD) is primarily an α‐synucle‐ inopathy, rather than a tauopathy, but there is evidence for an indirect association of tau with the pathogenetic process in PD. We therefore assessed the frequency in PD of the tau A0 allele, a dinucleotide repeat marker that has been associated with a sporadic tauopathy, progressive supranuclear palsy (PSP). We found the A0 allele to comprise 79.2% of 758 alleles from PD patients and 71.2% of 264 control alleles (P = 0.008). We also performed a meta‐analysis of three previous reports, two of which failed to produce statistically significant results. Taken together, they also support a PD/A0 allelic association, even after correction for misdiagnosis of PSP as PD (P< 0.001). The A0/A0 genotype frequency in our patients (62.3%) did not differ significantly from that in controls (53.0%, P = 0.062), but the meta‐analysis, even after correction for misdiagnosis, showed a significant result, with P = 0.002. The frequency of A0 allele and the A0/A0 genotype were compatible with Hardy‐Weinberg equilibrium. The frequency of the A0 allele and the A0/A0 genotype in our patients with familial PD was not significantly greater than in those with sporadic PD. We conclude that the tau protein may play a small role in the pathogenesis of PD and that biochemical characterization of this role may suggest opportunities for PD prophylaxis. © 2001 Movement Disorder Society.</div>
</front>
</TEI>
</ISTEX>
<PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The tau A0 allele in Parkinson's disease.</title>
<author><name sortKey="Golbe, L I" sort="Golbe, L I" uniqKey="Golbe L" first="L I" last="Golbe">L I Golbe</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, New Jersey 08901, USA. golbe@umdnj.edu</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, New Jersey 08901</wicri:regionArea>
<wicri:noRegion>New Jersey 08901</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lazzarini, A M" sort="Lazzarini, A M" uniqKey="Lazzarini A" first="A M" last="Lazzarini">A M Lazzarini</name>
</author>
<author><name sortKey="Spychala, J R" sort="Spychala, J R" uniqKey="Spychala J" first="J R" last="Spychala">J R Spychala</name>
</author>
<author><name sortKey="Johnson, W G" sort="Johnson, W G" uniqKey="Johnson W" first="W G" last="Johnson">W G Johnson</name>
</author>
<author><name sortKey="Stenroos, E S" sort="Stenroos, E S" uniqKey="Stenroos E" first="E S" last="Stenroos">E S Stenroos</name>
</author>
<author><name sortKey="Mark, M H" sort="Mark, M H" uniqKey="Mark M" first="M H" last="Mark">M H Mark</name>
</author>
<author><name sortKey="Sage, J I" sort="Sage, J I" uniqKey="Sage J" first="J I" last="Sage">J I Sage</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2001">2001</date>
<idno type="RBID">pubmed:11391737</idno>
<idno type="pmid">11391737</idno>
<idno type="wicri:Area/PubMed/Corpus">003D50</idno>
<idno type="wicri:Area/PubMed/Curation">003D50</idno>
<idno type="wicri:Area/PubMed/Checkpoint">003C23</idno>
<idno type="wicri:Area/Ncbi/Merge">000501</idno>
<idno type="wicri:Area/Ncbi/Curation">000501</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000501</idno>
<idno type="wicri:doubleKey">0885-3185:2001:Golbe L:the:tau:a</idno>
<idno type="wicri:Area/Main/Merge">006925</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">The tau A0 allele in Parkinson's disease.</title>
<author><name sortKey="Golbe, L I" sort="Golbe, L I" uniqKey="Golbe L" first="L I" last="Golbe">L I Golbe</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, New Jersey 08901, USA. golbe@umdnj.edu</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, New Jersey 08901</wicri:regionArea>
<wicri:noRegion>New Jersey 08901</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lazzarini, A M" sort="Lazzarini, A M" uniqKey="Lazzarini A" first="A M" last="Lazzarini">A M Lazzarini</name>
</author>
<author><name sortKey="Spychala, J R" sort="Spychala, J R" uniqKey="Spychala J" first="J R" last="Spychala">J R Spychala</name>
</author>
<author><name sortKey="Johnson, W G" sort="Johnson, W G" uniqKey="Johnson W" first="W G" last="Johnson">W G Johnson</name>
</author>
<author><name sortKey="Stenroos, E S" sort="Stenroos, E S" uniqKey="Stenroos E" first="E S" last="Stenroos">E S Stenroos</name>
</author>
<author><name sortKey="Mark, M H" sort="Mark, M H" uniqKey="Mark M" first="M H" last="Mark">M H Mark</name>
</author>
<author><name sortKey="Sage, J I" sort="Sage, J I" uniqKey="Sage J" first="J I" last="Sage">J I Sage</name>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2001" type="published">2001</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Alleles</term>
<term>Case-Control Studies</term>
<term>Female</term>
<term>Gene Frequency</term>
<term>Genetic Markers</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Nerve Tissue Proteins (genetics)</term>
<term>Parkinson Disease (classification)</term>
<term>Parkinson Disease (genetics)</term>
<term>Protein Isoforms</term>
<term>Supranuclear Palsy, Progressive (genetics)</term>
<term>Synucleins</term>
<term>tau Proteins (genetics)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Nerve Tissue Proteins</term>
<term>tau Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Genetic Markers</term>
<term>Protein Isoforms</term>
<term>Synucleins</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term>
<term>Supranuclear Palsy, Progressive</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Alleles</term>
<term>Case-Control Studies</term>
<term>Female</term>
<term>Gene Frequency</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Parkinson's disease (PD) is primarily an alpha-synucleinopathy, rather than a tauopathy, but there is evidence for an indirect association of tau with the pathogenetic process in PD. We therefore assessed the frequency in PD of the tau A0 allele, a dinucleotide repeat marker that has been associated with a sporadic tauopathy, progressive supranuclear palsy (PSP). We found the A0 allele to comprise 79.2% of 758 alleles from PD patients and 71.2% of 264 control alleles (P = 0.008). We also performed a meta-analysis of three previous reports, two of which failed to produce statistically significant results. Taken together, they also support a PD/A0 allelic association, even after correction for misdiagnosis of PSP as PD (P< 0.001). The A0/A0 genotype frequency in our patients (62.3%) did not differ significantly from that in controls (53.0%, P = 0.062), but the meta-analysis, even after correction for misdiagnosis, showed a significant result, with P = 0.002. The frequency of A0 allele and the A0/A0 genotype were compatible with Hardy-Weinberg equilibrium. The frequency of the A0 allele and the A0/A0 genotype in our patients with familial PD was not significantly greater than in those with sporadic PD. We conclude that the tau protein may play a small role in the pathogenesis of PD and that biochemical characterization of this role may suggest opportunities for PD prophylaxis.</div>
</front>
</TEI>
</PubMed>
</double>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004667 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 004667 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Main |étape= Curation |type= RBID |clé= ISTEX:785EF73A2A3DAB87D2F6CC4C9448E17C2F2C4804 |texte= The tau A0 allele in Parkinson's disease }}
![]() | This area was generated with Dilib version V0.6.23. | ![]() |