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The tau A0 allele in Parkinson's disease

Identifieur interne : 006D85 ( Main/Merge ); précédent : 006D84; suivant : 006D86

The tau A0 allele in Parkinson's disease

Auteurs : Lawrence I. Golbe [États-Unis] ; Alice M. Lazzarini [États-Unis] ; John R. Spychala [États-Unis] ; William G. Johnson [États-Unis] ; Edward S. Stenroos [États-Unis] ; Margery H. Mark [États-Unis] ; Jacob I. Sage [États-Unis]

Source :

Movement disorders [ 0885-3185 ] ; 2001.

RBID : Pascal:01-0377453

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Réaction chaîne polymérase, Protéine tau, Métaanalyse, Physiopathologie, Homme.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Human, Metaanalysis, Parkinson disease, Pathophysiology, Polymerase chain reaction, Tau protein.

Abstract

Parkinson's disease (PD) is primarily an α-synucleinopathy, rather than a tauopathy, but there is evidence for an indirect association of tau with the pathogenetic process in PD. We therefore assessed the frequency in PD of the tau A0 allele, a dinucleotide repeat marker that has been associated with a sporadic tauopathy, progressive supranuclear palsy (PSP). We found the A0 allele to comprise 79.2% of 758 alleles from PD patients and 71.2% of 264 control alleles (P = 0.008), We also performed a meta-analysis of three previous reports, two of which failed to produce statistically significant results. Taken together, they also support a PD/A0 allelic association, even after correction for misdiagnosis of PSP as PD (P< 0.001). The A0/A0 genotype frequency in our patients (62.3%) did not differ significantly from that in controls (53.0%, P = 0.062), but the meta-analysis, even after correction for misdiagnosis, showed a significant result, with P = 0.002. The frequency of A0 allele and the A0/A0 genotype were compatible with Hardy-Weinberg equilibrium. The frequency of the A0 allele and the A0/A0 genotype in our patients with familial PD was not significantly greater than in those with sporadic PD. We conclude that the tau protein may play a small role in the pathogenesis of PD and that biochemical characterization of this role may suggest opportunities for PD prophylaxis.

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Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Human</term>
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<front><div type="abstract" xml:lang="en">Parkinson's disease (PD) is primarily an α-synucleinopathy, rather than a tauopathy, but there is evidence for an indirect association of tau with the pathogenetic process in PD. We therefore assessed the frequency in PD of the tau A0 allele, a dinucleotide repeat marker that has been associated with a sporadic tauopathy, progressive supranuclear palsy (PSP). We found the A0 allele to comprise 79.2% of 758 alleles from PD patients and 71.2% of 264 control alleles (P = 0.008), We also performed a meta-analysis of three previous reports, two of which failed to produce statistically significant results. Taken together, they also support a PD/A0 allelic association, even after correction for misdiagnosis of PSP as PD (P< 0.001). The A0/A0 genotype frequency in our patients (62.3%) did not differ significantly from that in controls (53.0%, P = 0.062), but the meta-analysis, even after correction for misdiagnosis, showed a significant result, with P = 0.002. The frequency of A0 allele and the A0/A0 genotype were compatible with Hardy-Weinberg equilibrium. The frequency of the A0 allele and the A0/A0 genotype in our patients with familial PD was not significantly greater than in those with sporadic PD. We conclude that the tau protein may play a small role in the pathogenesis of PD and that biochemical characterization of this role may suggest opportunities for PD prophylaxis.</div>
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<name sortKey="Johnson, William G" sort="Johnson, William G" uniqKey="Johnson W" first="William G." last="Johnson">William G. Johnson</name>
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<name sortKey="Mark, Margery H" sort="Mark, Margery H" uniqKey="Mark M" first="Margery H." last="Mark">Margery H. Mark</name>
<name sortKey="Sage, Jacob I" sort="Sage, Jacob I" uniqKey="Sage J" first="Jacob I." last="Sage">Jacob I. Sage</name>
<name sortKey="Spychala, John R" sort="Spychala, John R" uniqKey="Spychala J" first="John R." last="Spychala">John R. Spychala</name>
<name sortKey="Stenroos, Edward S" sort="Stenroos, Edward S" uniqKey="Stenroos E" first="Edward S." last="Stenroos">Edward S. Stenroos</name>
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	Movement Disorders (revue)
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Movement Disorders (revue)

The tau A0 allele in Parkinson's disease

The tau A0 allele in Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri