Associations between family history of Parkinson's disease and dementia and risk of dementia in Parkinson's disease: A community‐based, longitudinal study
Identifieur interne : 003578 ( Main/Curation ); précédent : 003577; suivant : 003579Associations between family history of Parkinson's disease and dementia and risk of dementia in Parkinson's disease: A community‐based, longitudinal study
Auteurs : Martin Wilhelm Kurz [Allemagne, Norvège] ; Jan Petter Larsen [Norvège] ; Jan Terje Kvaloy [Norvège] ; Dag Aarsland [Norvège]Source :
- Movement Disorders [ 0885-3185 ] ; 2006-12.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Age of Onset, Aged, Aged, 80 and over, Dementia, Dementia (complications), Dementia (epidemiology), Dementia (genetics), Family Health, Female, Humans, Longitudinal Studies, Male, Nervous system diseases, Neurologic Examination, Neuropsychological Tests (statistics & numerical data), Parkinson Disease (complications), Parkinson Disease (epidemiology), Parkinson Disease (genetics), Parkinson disease, Parkinson's disease, Pathogenesis, Proportional Hazards Models, Residence Characteristics, Risk, Risk Factors, Risk factor, Time Factors, dementia, family history, genetics, pathogenesis.
- MESH :
- complications : Dementia, Parkinson Disease.
- epidemiology : Dementia, Parkinson Disease.
- genetics : Dementia, Parkinson Disease.
- statistics & numerical data : Neuropsychological Tests.
- Age of Onset, Aged, Aged, 80 and over, Family Health, Female, Humans, Longitudinal Studies, Male, Neurologic Examination, Proportional Hazards Models, Residence Characteristics, Risk, Risk Factors, Time Factors.
Abstract
Dementia is common in patients with Parkinson's disease (PDD). The etiology of PDD is still unclear, but exciting advances have been made in discovering pathogenetic components in Parkinson's disease (PD), implicating the role of genetic factors. It is, however, still controversial whether genetic factors also contribute to the development of dementia in PD. Thus, we investigated the association between development of dementia and a positive family history of PD or dementia in a community‐based study of PD in Rogaland County, Norway (n = 219). The patients were followed prospectively with neurological and neuropsychological assessments. Dementia was more common in patients with a strong family association of PD (first‐degree relatives > second‐degree relatives > no family history; P < 0.05). However, time to dementia did not differ between the two groups. No associations between dementia in PD and familial occurrence of dementia could be shown. Further studies with larger samples are needed to explore a possible relationship between a family history of PD and development of dementia in PD and its potential pathogenetic mechanisms. © 2006 Movement Disorder Society
Url:
DOI: 10.1002/mds.21144
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<front><div type="abstract" xml:lang="en">Dementia is common in patients with Parkinson's disease (PDD). The etiology of PDD is still unclear, but exciting advances have been made in discovering pathogenetic components in Parkinson's disease (PD), implicating the role of genetic factors. It is, however, still controversial whether genetic factors also contribute to the development of dementia in PD. Thus, we investigated the association between development of dementia and a positive family history of PD or dementia in a community-based study of PD in Rogaland County, Norway (n = 219). The patients were followed prospectively with neurological and neuropsychological assessments. Dementia was more common in patients with a strong family association of PD (first-degree relatives > second-degree relatives > no family history; P < 0.05). However, time to dementia did not differ between the two groups. No associations between dementia in PD and familial occurrence of dementia could be shown. Further studies with larger samples are needed to explore a possible relationship between a family history of PD and development of dementia in PD and its potential pathogenetic mechanisms.</div>
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<author><name sortKey="Kvaloy, Jan Terje" sort="Kvaloy, Jan Terje" uniqKey="Kvaloy J" first="Jan Terje" last="Kvaloy">Jan Terje Kvaloy</name>
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<author><name sortKey="Aarsland, Dag" sort="Aarsland, Dag" uniqKey="Aarsland D" first="Dag" last="Aarsland">Dag Aarsland</name>
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<idno type="doi">10.1002/mds.21144</idno>
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<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Associations between family history of Parkinson's disease and dementia and risk of dementia in Parkinson's disease: A community‐based, longitudinal study</title>
<author><name sortKey="Kurz, Martin Wilhelm" sort="Kurz, Martin Wilhelm" uniqKey="Kurz M" first="Martin Wilhelm" last="Kurz">Martin Wilhelm Kurz</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Heinrich‐Heine‐University, Düsseldorf</wicri:regionArea>
<wicri:noRegion>Düsseldorf</wicri:noRegion>
<wicri:noRegion>Düsseldorf</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Norvège</country>
<wicri:regionArea>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger</wicri:regionArea>
<wicri:noRegion>Stavanger</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Larsen, Jan Petter" sort="Larsen, Jan Petter" uniqKey="Larsen J" first="Jan Petter" last="Larsen">Jan Petter Larsen</name>
<affiliation wicri:level="1"><country xml:lang="fr">Norvège</country>
<wicri:regionArea>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger</wicri:regionArea>
<wicri:noRegion>Stavanger</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of Neurology, Stavanger University Hospital, Stavanger</wicri:regionArea>
<wicri:noRegion>Stavanger</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kvaloy, Jan Terje" sort="Kvaloy, Jan Terje" uniqKey="Kvaloy J" first="Jan Terje" last="Kvaloy">Jan Terje Kvaloy</name>
<affiliation wicri:level="1"><country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of Mathematics and Natural Science, University of Stavanger Division of Research and Human Resources, Stavanger University Hospital, Stavanger</wicri:regionArea>
<wicri:noRegion>Stavanger</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Aarsland, Dag" sort="Aarsland, Dag" uniqKey="Aarsland D" first="Dag" last="Aarsland">Dag Aarsland</name>
<affiliation wicri:level="1"><country xml:lang="fr">Norvège</country>
<wicri:regionArea>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger</wicri:regionArea>
<wicri:noRegion>Stavanger</wicri:noRegion>
</affiliation>
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<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2006-12">2006-12</date>
<biblScope unit="vol">21</biblScope>
<biblScope unit="issue">12</biblScope>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age of Onset</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Dementia (complications)</term>
<term>Dementia (epidemiology)</term>
<term>Dementia (genetics)</term>
<term>Family Health</term>
<term>Female</term>
<term>Humans</term>
<term>Longitudinal Studies</term>
<term>Male</term>
<term>Neurologic Examination</term>
<term>Neuropsychological Tests (statistics & numerical data)</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (epidemiology)</term>
<term>Parkinson Disease (genetics)</term>
<term>Parkinson's disease</term>
<term>Proportional Hazards Models</term>
<term>Residence Characteristics</term>
<term>Risk</term>
<term>Risk Factors</term>
<term>Time Factors</term>
<term>dementia</term>
<term>family history</term>
<term>genetics</term>
<term>pathogenesis</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Dementia</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Dementia</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Dementia</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Neuropsychological Tests</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Age of Onset</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Family Health</term>
<term>Female</term>
<term>Humans</term>
<term>Longitudinal Studies</term>
<term>Male</term>
<term>Neurologic Examination</term>
<term>Proportional Hazards Models</term>
<term>Residence Characteristics</term>
<term>Risk</term>
<term>Risk Factors</term>
<term>Time Factors</term>
</keywords>
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<front><div type="abstract" xml:lang="en">Dementia is common in patients with Parkinson's disease (PDD). The etiology of PDD is still unclear, but exciting advances have been made in discovering pathogenetic components in Parkinson's disease (PD), implicating the role of genetic factors. It is, however, still controversial whether genetic factors also contribute to the development of dementia in PD. Thus, we investigated the association between development of dementia and a positive family history of PD or dementia in a community‐based study of PD in Rogaland County, Norway (n = 219). The patients were followed prospectively with neurological and neuropsychological assessments. Dementia was more common in patients with a strong family association of PD (first‐degree relatives > second‐degree relatives > no family history; P < 0.05). However, time to dementia did not differ between the two groups. No associations between dementia in PD and familial occurrence of dementia could be shown. Further studies with larger samples are needed to explore a possible relationship between a family history of PD and development of dementia in PD and its potential pathogenetic mechanisms. © 2006 Movement Disorder Society</div>
</front>
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