Associations between family history of Parkinson's disease and dementia and risk of dementia in Parkinson's disease: A community-based, longitudinal study.
Identifieur interne : 001888 ( Ncbi/Checkpoint ); précédent : 001887; suivant : 001889Associations between family history of Parkinson's disease and dementia and risk of dementia in Parkinson's disease: A community-based, longitudinal study.
Auteurs : Martin Wilhelm Kurz [Allemagne] ; Jan Petter Larsen ; Jan Terje Kvaloy ; Dag AarslandSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2006.
English descriptors
- KwdEn :
- Age of Onset, Aged, Aged, 80 and over, Dementia (complications), Dementia (epidemiology), Dementia (genetics), Family Health, Female, Humans, Longitudinal Studies, Male, Neurologic Examination, Neuropsychological Tests (statistics & numerical data), Parkinson Disease (complications), Parkinson Disease (epidemiology), Parkinson Disease (genetics), Proportional Hazards Models, Residence Characteristics, Risk, Risk Factors, Time Factors.
- MESH :
- complications : Dementia, Parkinson Disease.
- epidemiology : Dementia, Parkinson Disease.
- genetics : Dementia, Parkinson Disease.
- statistics & numerical data : Neuropsychological Tests.
- Age of Onset, Aged, Aged, 80 and over, Family Health, Female, Humans, Longitudinal Studies, Male, Neurologic Examination, Proportional Hazards Models, Residence Characteristics, Risk, Risk Factors, Time Factors.
Abstract
Dementia is common in patients with Parkinson's disease (PDD). The etiology of PDD is still unclear, but exciting advances have been made in discovering pathogenetic components in Parkinson's disease (PD), implicating the role of genetic factors. It is, however, still controversial whether genetic factors also contribute to the development of dementia in PD. Thus, we investigated the association between development of dementia and a positive family history of PD or dementia in a community-based study of PD in Rogaland County, Norway (n = 219). The patients were followed prospectively with neurological and neuropsychological assessments. Dementia was more common in patients with a strong family association of PD (first-degree relatives > second-degree relatives > no family history; P < 0.05). However, time to dementia did not differ between the two groups. No associations between dementia in PD and familial occurrence of dementia could be shown. Further studies with larger samples are needed to explore a possible relationship between a family history of PD and development of dementia in PD and its potential pathogenetic mechanisms.
DOI: 10.1002/mds.21144
PubMed: 17029273
Affiliations:
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Terje" sort="Kvaloy, Jan Terje" uniqKey="Kvaloy J" first="Jan Terje" last="Kvaloy">Jan Terje Kvaloy</name></author><author><name sortKey="Aarsland, Dag" sort="Aarsland, Dag" uniqKey="Aarsland D" first="Dag" last="Aarsland">Dag Aarsland</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2006">2006</date><idno type="doi">10.1002/mds.21144</idno><idno type="RBID">pubmed:17029273</idno><idno type="pmid">17029273</idno><idno type="wicri:Area/PubMed/Corpus">002A51</idno><idno type="wicri:Area/PubMed/Curation">002A51</idno><idno type="wicri:Area/PubMed/Checkpoint">002E67</idno><idno type="wicri:Area/Ncbi/Merge">001888</idno><idno type="wicri:Area/Ncbi/Curation">001888</idno><idno type="wicri:Area/Ncbi/Checkpoint">001888</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Associations between family history of Parkinson's disease and dementia and risk of dementia in Parkinson's disease: A community-based, longitudinal study.</title><author><name sortKey="Kurz, Martin Wilhelm" sort="Kurz, Martin Wilhelm" uniqKey="Kurz M" first="Martin Wilhelm" last="Kurz">Martin Wilhelm Kurz</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Heinrich-Heine-University, Düsseldorf, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Heinrich-Heine-University, Düsseldorf</wicri:regionArea><wicri:noRegion>Düsseldorf</wicri:noRegion><wicri:noRegion>Düsseldorf</wicri:noRegion><wicri:noRegion>Düsseldorf</wicri:noRegion></affiliation></author><author><name sortKey="Larsen, Jan Petter" sort="Larsen, Jan Petter" uniqKey="Larsen J" first="Jan Petter" last="Larsen">Jan Petter Larsen</name></author><author><name sortKey="Kvaloy, Jan Terje" sort="Kvaloy, Jan Terje" uniqKey="Kvaloy J" first="Jan Terje" last="Kvaloy">Jan Terje Kvaloy</name></author><author><name sortKey="Aarsland, Dag" sort="Aarsland, Dag" uniqKey="Aarsland D" first="Dag" last="Aarsland">Dag Aarsland</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age of Onset</term><term>Aged</term><term>Aged, 80 and over</term><term>Dementia (complications)</term><term>Dementia (epidemiology)</term><term>Dementia (genetics)</term><term>Family Health</term><term>Female</term><term>Humans</term><term>Longitudinal Studies</term><term>Male</term><term>Neurologic Examination</term><term>Neuropsychological Tests (statistics & numerical data)</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (epidemiology)</term><term>Parkinson Disease (genetics)</term><term>Proportional Hazards Models</term><term>Residence Characteristics</term><term>Risk</term><term>Risk Factors</term><term>Time Factors</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Dementia</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Dementia</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Dementia</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Neuropsychological Tests</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Age of Onset</term><term>Aged</term><term>Aged, 80 and over</term><term>Family Health</term><term>Female</term><term>Humans</term><term>Longitudinal Studies</term><term>Male</term><term>Neurologic Examination</term><term>Proportional Hazards Models</term><term>Residence Characteristics</term><term>Risk</term><term>Risk Factors</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Dementia is common in patients with Parkinson's disease (PDD). The etiology of PDD is still unclear, but exciting advances have been made in discovering pathogenetic components in Parkinson's disease (PD), implicating the role of genetic factors. It is, however, still controversial whether genetic factors also contribute to the development of dementia in PD. Thus, we investigated the association between development of dementia and a positive family history of PD or dementia in a community-based study of PD in Rogaland County, Norway (n = 219). The patients were followed prospectively with neurological and neuropsychological assessments. Dementia was more common in patients with a strong family association of PD (first-degree relatives > second-degree relatives > no family history; P < 0.05). However, time to dementia did not differ between the two groups. No associations between dementia in PD and familial occurrence of dementia could be shown. Further studies with larger samples are needed to explore a possible relationship between a family history of PD and development of dementia in PD and its potential pathogenetic mechanisms.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country></list><tree><noCountry><name sortKey="Aarsland, Dag" sort="Aarsland, Dag" uniqKey="Aarsland D" first="Dag" last="Aarsland">Dag Aarsland</name><name sortKey="Kvaloy, Jan Terje" sort="Kvaloy, Jan Terje" uniqKey="Kvaloy J" first="Jan Terje" last="Kvaloy">Jan Terje Kvaloy</name><name sortKey="Larsen, Jan Petter" sort="Larsen, Jan Petter" uniqKey="Larsen J" first="Jan Petter" last="Larsen">Jan Petter Larsen</name></noCountry><country name="Allemagne"><noRegion><name sortKey="Kurz, Martin Wilhelm" sort="Kurz, Martin Wilhelm" uniqKey="Kurz M" first="Martin Wilhelm" last="Kurz">Martin Wilhelm Kurz</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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