Associations between family history of Parkinson's disease and dementia and risk of dementia in Parkinson's disease: A community-based, longitudinal study.
Identifieur interne : 001888 ( Ncbi/Checkpoint ); précédent : 001887; suivant : 001889Associations between family history of Parkinson's disease and dementia and risk of dementia in Parkinson's disease: A community-based, longitudinal study.
Auteurs : Martin Wilhelm Kurz [Allemagne] ; Jan Petter Larsen ; Jan Terje Kvaloy ; Dag AarslandSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2006.
English descriptors
- KwdEn :
- Age of Onset, Aged, Aged, 80 and over, Dementia (complications), Dementia (epidemiology), Dementia (genetics), Family Health, Female, Humans, Longitudinal Studies, Male, Neurologic Examination, Neuropsychological Tests (statistics & numerical data), Parkinson Disease (complications), Parkinson Disease (epidemiology), Parkinson Disease (genetics), Proportional Hazards Models, Residence Characteristics, Risk, Risk Factors, Time Factors.
- MESH :
- complications : Dementia, Parkinson Disease.
- epidemiology : Dementia, Parkinson Disease.
- genetics : Dementia, Parkinson Disease.
- statistics & numerical data : Neuropsychological Tests.
- Age of Onset, Aged, Aged, 80 and over, Family Health, Female, Humans, Longitudinal Studies, Male, Neurologic Examination, Proportional Hazards Models, Residence Characteristics, Risk, Risk Factors, Time Factors.
Abstract
Dementia is common in patients with Parkinson's disease (PDD). The etiology of PDD is still unclear, but exciting advances have been made in discovering pathogenetic components in Parkinson's disease (PD), implicating the role of genetic factors. It is, however, still controversial whether genetic factors also contribute to the development of dementia in PD. Thus, we investigated the association between development of dementia and a positive family history of PD or dementia in a community-based study of PD in Rogaland County, Norway (n = 219). The patients were followed prospectively with neurological and neuropsychological assessments. Dementia was more common in patients with a strong family association of PD (first-degree relatives > second-degree relatives > no family history; P < 0.05). However, time to dementia did not differ between the two groups. No associations between dementia in PD and familial occurrence of dementia could be shown. Further studies with larger samples are needed to explore a possible relationship between a family history of PD and development of dementia in PD and its potential pathogenetic mechanisms.
DOI: 10.1002/mds.21144
PubMed: 17029273
Affiliations:
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pubmed:17029273Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Associations between family history of Parkinson's disease and dementia and risk of dementia in Parkinson's disease: A community-based, longitudinal study.</title>
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<term>Dementia (epidemiology)</term>
<term>Dementia (genetics)</term>
<term>Family Health</term>
<term>Female</term>
<term>Humans</term>
<term>Longitudinal Studies</term>
<term>Male</term>
<term>Neurologic Examination</term>
<term>Neuropsychological Tests (statistics & numerical data)</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (epidemiology)</term>
<term>Parkinson Disease (genetics)</term>
<term>Proportional Hazards Models</term>
<term>Residence Characteristics</term>
<term>Risk</term>
<term>Risk Factors</term>
<term>Time Factors</term>
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<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Dementia</term>
<term>Parkinson Disease</term>
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<term>Parkinson Disease</term>
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<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Dementia</term>
<term>Parkinson Disease</term>
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<term>Aged</term>
<term>Aged, 80 and over</term>
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<term>Humans</term>
<term>Longitudinal Studies</term>
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<front><div type="abstract" xml:lang="en">Dementia is common in patients with Parkinson's disease (PDD). The etiology of PDD is still unclear, but exciting advances have been made in discovering pathogenetic components in Parkinson's disease (PD), implicating the role of genetic factors. It is, however, still controversial whether genetic factors also contribute to the development of dementia in PD. Thus, we investigated the association between development of dementia and a positive family history of PD or dementia in a community-based study of PD in Rogaland County, Norway (n = 219). The patients were followed prospectively with neurological and neuropsychological assessments. Dementia was more common in patients with a strong family association of PD (first-degree relatives > second-degree relatives > no family history; P < 0.05). However, time to dementia did not differ between the two groups. No associations between dementia in PD and familial occurrence of dementia could be shown. Further studies with larger samples are needed to explore a possible relationship between a family history of PD and development of dementia in PD and its potential pathogenetic mechanisms.</div>
</front>
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<name sortKey="Larsen, Jan Petter" sort="Larsen, Jan Petter" uniqKey="Larsen J" first="Jan Petter" last="Larsen">Jan Petter Larsen</name>
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<country name="Allemagne"><noRegion><name sortKey="Kurz, Martin Wilhelm" sort="Kurz, Martin Wilhelm" uniqKey="Kurz M" first="Martin Wilhelm" last="Kurz">Martin Wilhelm Kurz</name>
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