Movement Disorders (revue)

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Predictors of freezing in Parkinson's disease: A survey of 6,620 patients

Identifieur interne : 002C64 ( Main/Curation ); précédent : 002C63; suivant : 002C65

Predictors of freezing in Parkinson's disease: A survey of 6,620 patients

Auteurs : Michael Macht [Allemagne] ; Yvonne Kaussner [Allemagne] ; Jens Carsten Möller [Allemagne] ; Karin Stiasny-Kolster [Allemagne] ; Karla Maria Eggert [Allemagne] ; Hans-Peter Krüger [Allemagne] ; Heiner Ellgring [Allemagne]

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RBID : ISTEX:89B070ED9458B1A4BBB1E9108C9C5AAB3E2F9274

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English descriptors

Abstract

Data from a survey of 6,620 Parkinson's disease patients were examined for correlation of freezing with age, sex, duration, subjective severity of Parkinson's disease, and antiparkinsonian medication. Forty‐seven percent of the patients reported experiencing freezing regularly. Logistic regression analysis showed that freezing was significantly associated with a longer disease duration and a more advanced stage of the disease. Freezing episodes were more likely in men than in women and in patients taking, in addition to levodopa, Entacapone, Amantadine, or dopamine agonists. Finally, patients considering tremor as their main symptom reported freezing less frequently. Common antiparkinsonian drugs given in combination with levodopa were not negatively correlated with freezing. The results underline the necessity to develop appropriate countermeasures against this phenomenon, which is widely known to cause significant impairment of patients' quality of life and—as our data also showed—may cause traffic accidents in licensed patients. © 2007 Movement Disorder Society

Url:
DOI: 10.1002/mds.21458

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ISTEX:89B070ED9458B1A4BBB1E9108C9C5AAB3E2F9274

Le document en format XML

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<div type="abstract" xml:lang="en">Data from a survey of 6,620 Parkinson's disease patients were examined for correlation of freezing with age, sex, duration, subjective severity of Parkinson's disease, and antiparkinsonian medication. Forty‐seven percent of the patients reported experiencing freezing regularly. Logistic regression analysis showed that freezing was significantly associated with a longer disease duration and a more advanced stage of the disease. Freezing episodes were more likely in men than in women and in patients taking, in addition to levodopa, Entacapone, Amantadine, or dopamine agonists. Finally, patients considering tremor as their main symptom reported freezing less frequently. Common antiparkinsonian drugs given in combination with levodopa were not negatively correlated with freezing. The results underline the necessity to develop appropriate countermeasures against this phenomenon, which is widely known to cause significant impairment of patients' quality of life and—as our data also showed—may cause traffic accidents in licensed patients. © 2007 Movement Disorder Society</div>
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