Predictors of freezing in Parkinson's disease: a survey of 6,620 patients.
Identifieur interne : 001B44 ( Ncbi/Checkpoint ); précédent : 001B43; suivant : 001B45Predictors of freezing in Parkinson's disease: a survey of 6,620 patients.
Auteurs : Michael Macht [Allemagne] ; Yvonne Kaussner ; Jens Carsten Möller ; Karin Stiasny-Kolster ; Karla Maria Eggert ; Hans-Peter Krüger ; Heiner EllgringSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
English descriptors
- KwdEn :
- Adult, Age Factors, Aged, Aged, 80 and over, Antiparkinson Agents (therapeutic use), Chi-Square Distribution, Female, Forecasting, Freezing Reaction, Cataleptic (drug effects), Freezing Reaction, Cataleptic (physiology), Health Surveys, Humans, Male, Middle Aged, Parkinson Disease (diet therapy), Parkinson Disease (epidemiology), Parkinson Disease (physiopathology), Severity of Illness Index, Sex Factors.
- MESH :
- chemical , therapeutic use : Antiparkinson Agents.
- diet therapy : Parkinson Disease.
- drug effects : Freezing Reaction, Cataleptic.
- epidemiology : Parkinson Disease.
- physiology : Freezing Reaction, Cataleptic.
- physiopathology : Parkinson Disease.
- Adult, Age Factors, Aged, Aged, 80 and over, Chi-Square Distribution, Female, Forecasting, Health Surveys, Humans, Male, Middle Aged, Severity of Illness Index, Sex Factors.
Abstract
Data from a survey of 6,620 Parkinson's disease patients were examined for correlation of freezing with age, sex, duration, subjective severity of Parkinson's disease, and antiparkinsonian medication. Forty-seven percent of the patients reported experiencing freezing regularly. Logistic regression analysis showed that freezing was significantly associated with a longer disease duration and a more advanced stage of the disease. Freezing episodes were more likely in men than in women and in patients taking, in addition to levodopa, Entacapone, Amantadine, or dopamine agonists. Finally, patients considering tremor as their main symptom reported freezing less frequently. Common antiparkinsonian drugs given in combination with levodopa were not negatively correlated with freezing. The results underline the necessity to develop appropriate countermeasures against this phenomenon, which is widely known to cause significant impairment of patients' quality of life and - as our data also showed - may cause traffic accidents in licensed patients.
DOI: 10.1002/mds.21458
PubMed: 17377927
Affiliations:
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last="Möller">Jens Carsten Möller</name></author><author><name sortKey="Stiasny Kolster, Karin" sort="Stiasny Kolster, Karin" uniqKey="Stiasny Kolster K" first="Karin" last="Stiasny-Kolster">Karin Stiasny-Kolster</name></author><author><name sortKey="Eggert, Karla Maria" sort="Eggert, Karla Maria" uniqKey="Eggert K" first="Karla Maria" last="Eggert">Karla Maria Eggert</name></author><author><name sortKey="Kruger, Hans Peter" sort="Kruger, Hans Peter" uniqKey="Kruger H" first="Hans-Peter" last="Krüger">Hans-Peter Krüger</name></author><author><name sortKey="Ellgring, Heiner" sort="Ellgring, Heiner" uniqKey="Ellgring H" first="Heiner" last="Ellgring">Heiner Ellgring</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="doi">10.1002/mds.21458</idno><idno type="RBID">pubmed:17377927</idno><idno type="pmid">17377927</idno><idno type="wicri:Area/PubMed/Corpus">002795</idno><idno 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sortKey="Kaussner, Yvonne" sort="Kaussner, Yvonne" uniqKey="Kaussner Y" first="Yvonne" last="Kaussner">Yvonne Kaussner</name></author><author><name sortKey="Moller, Jens Carsten" sort="Moller, Jens Carsten" uniqKey="Moller J" first="Jens Carsten" last="Möller">Jens Carsten Möller</name></author><author><name sortKey="Stiasny Kolster, Karin" sort="Stiasny Kolster, Karin" uniqKey="Stiasny Kolster K" first="Karin" last="Stiasny-Kolster">Karin Stiasny-Kolster</name></author><author><name sortKey="Eggert, Karla Maria" sort="Eggert, Karla Maria" uniqKey="Eggert K" first="Karla Maria" last="Eggert">Karla Maria Eggert</name></author><author><name sortKey="Kruger, Hans Peter" sort="Kruger, Hans Peter" uniqKey="Kruger H" first="Hans-Peter" last="Krüger">Hans-Peter Krüger</name></author><author><name sortKey="Ellgring, Heiner" sort="Ellgring, Heiner" uniqKey="Ellgring H" first="Heiner" last="Ellgring">Heiner Ellgring</name></author></analytic><series><title level="j">Movement disorders : official 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xml:lang="en">Data from a survey of 6,620 Parkinson's disease patients were examined for correlation of freezing with age, sex, duration, subjective severity of Parkinson's disease, and antiparkinsonian medication. Forty-seven percent of the patients reported experiencing freezing regularly. Logistic regression analysis showed that freezing was significantly associated with a longer disease duration and a more advanced stage of the disease. Freezing episodes were more likely in men than in women and in patients taking, in addition to levodopa, Entacapone, Amantadine, or dopamine agonists. Finally, patients considering tremor as their main symptom reported freezing less frequently. Common antiparkinsonian drugs given in combination with levodopa were not negatively correlated with freezing. The results underline the necessity to develop appropriate countermeasures against this phenomenon, which is widely known to cause significant impairment of patients' quality of life and - as our data also showed - may cause traffic accidents in licensed patients.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country></list><tree><noCountry><name sortKey="Eggert, Karla Maria" sort="Eggert, Karla Maria" uniqKey="Eggert K" first="Karla Maria" last="Eggert">Karla Maria Eggert</name><name sortKey="Ellgring, Heiner" sort="Ellgring, Heiner" uniqKey="Ellgring H" first="Heiner" last="Ellgring">Heiner Ellgring</name><name sortKey="Kaussner, Yvonne" sort="Kaussner, Yvonne" uniqKey="Kaussner Y" first="Yvonne" last="Kaussner">Yvonne Kaussner</name><name sortKey="Kruger, Hans Peter" sort="Kruger, Hans Peter" uniqKey="Kruger H" first="Hans-Peter" last="Krüger">Hans-Peter Krüger</name><name sortKey="Moller, Jens Carsten" sort="Moller, Jens Carsten" uniqKey="Moller J" first="Jens Carsten" last="Möller">Jens Carsten Möller</name><name sortKey="Stiasny Kolster, Karin" sort="Stiasny Kolster, Karin" uniqKey="Stiasny Kolster K" first="Karin" last="Stiasny-Kolster">Karin Stiasny-Kolster</name></noCountry><country name="Allemagne"><noRegion><name sortKey="Macht, Michael" sort="Macht, Michael" uniqKey="Macht M" first="Michael" last="Macht">Michael Macht</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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