Transcranial imaging of substantia nigra hyperechogenicity in a Taiwanese cohort of Parkinson's disease
Identifieur interne : 002B17 ( Main/Curation ); précédent : 002B16; suivant : 002B18Transcranial imaging of substantia nigra hyperechogenicity in a Taiwanese cohort of Parkinson's disease
Auteurs : Yu-Wen Huang [Taïwan] ; Jiann-Shing Jeng [Taïwan] ; Chung-Fen Tsai [Taïwan] ; Li-Ling Chen [Taïwan] ; Ruey-Meei Wu [Taïwan]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-03-15.
Descripteurs français
- Pascal (Inist)
- Wicri :
- geographic : Taïwan.
English descriptors
- KwdEn :
- Aged, Cohort Studies, Demography, Doppler ultrasound study, Female, Humans, Locus niger, Male, Mesencephalon (physiopathology), Mesencephalon (ultrasonography), Midbrain, Middle Aged, Nervous system diseases, Observer Variation, Parkinson Disease (epidemiology), Parkinson Disease (physiopathology), Parkinson Disease (ultrasonography), Parkinson disease, Parkinson's disease, Severity of Illness Index, Substantia Nigra (physiopathology), Substantia Nigra (ultrasonography), Taiwan (epidemiology), Taiwanese, Ultrasonography, Doppler, Transcranial (methods), echogenicity, midbrain, substantia nigra, transcranial doppler image.
- MESH :
- geographic , epidemiology : Taiwan.
- epidemiology : Parkinson Disease.
- methods : Ultrasonography, Doppler, Transcranial.
- physiopathology : Mesencephalon, Parkinson Disease, Substantia Nigra.
- ultrasonography : Mesencephalon, Parkinson Disease, Substantia Nigra.
- Aged, Cohort Studies, Demography, Female, Humans, Male, Middle Aged, Observer Variation, Severity of Illness Index.
Abstract
Transcranial Doppler imaging (TCDI) has been used as a noninvasive diagnostic tool to differentiate Parkinson's disease (PD) from atypical parkinsonism by detecting hyperechogenicity in the substantia nigra (SN). To our knowledge, no TCDI data are available for Asian populations, and TCDI sensitivity is uncertain across populations. Early‐onset PD (EOPD) represents a specific PD subtype based on clinical features and pathogenic mechanisms. It is not known if EOPD patients have abnormal echogenicity in SN comparable to late‐onset PD (LOPD) patients. We assessed the area of SN hyperechogenicity (hyper‐SN) and a ratio of hyper‐SN over ipsilateral midbrain (S/M ratio) with TCDI in 164 healthy Taiwanese, 40 EOPD patients, and 40 LOPD patients. The upper 95th percentile values for hyper‐SN and S/M ratio were 0.20 cm2 and 0.07. Our results indicate that S/M ratio is a more sensitive measure than hyper‐SN in diagnosing PD. Approximately 92.5% of the LOPD patients and 57.5% of the EOPD patients had S/M ratios ≥ 0.07. Enlarged hyperechogenicity of SN is a common finding in LOPD, but not in EOPD. Iron‐independent mechanisms of SN cell degeneration in EOPD distinct from that in LOPD might contribute to the sonographic findings. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21372
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<front><div type="abstract" xml:lang="en">Transcranial Doppler imaging (TCDI) has been used as a noninvasive diagnostic tool to differentiate Parkinson's disease (PD) from atypical parkinsonism by detecting hyperechogenicity in the substantia nigra (SN). To our knowledge, no TCDI data are available for Asian populations, and TCDI sensitivity is uncertain across populations. Early‐onset PD (EOPD) represents a specific PD subtype based on clinical features and pathogenic mechanisms. It is not known if EOPD patients have abnormal echogenicity in SN comparable to late‐onset PD (LOPD) patients. We assessed the area of SN hyperechogenicity (hyper‐SN) and a ratio of hyper‐SN over ipsilateral midbrain (S/M ratio) with TCDI in 164 healthy Taiwanese, 40 EOPD patients, and 40 LOPD patients. The upper 95th percentile values for hyper‐SN and S/M ratio were 0.20 cm2 and 0.07. Our results indicate that S/M ratio is a more sensitive measure than hyper‐SN in diagnosing PD. Approximately 92.5% of the LOPD patients and 57.5% of the EOPD patients had S/M ratios ≥ 0.07. Enlarged hyperechogenicity of SN is a common finding in LOPD, but not in EOPD. Iron‐independent mechanisms of SN cell degeneration in EOPD distinct from that in LOPD might contribute to the sonographic findings. © 2007 Movement Disorder Society</div>
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<front><div type="abstract" xml:lang="en">Transcranial Doppler imaging (TCDI) has been used as a noninvasive diagnostic tool to differentiate Parkinson's disease (PD) from atypical parkinsonism by detecting hyperechogenicity in the substantia nigra (SN). To our knowledge, no TCDI data are available for Asian populations, and TCDI sensitivity is uncertain across populations. Early-onset PD (EOPD) represents a specific PD subtype based on clinical features and pathogenic mechanisms. It is not known if EOPD patients have abnormal echogenicity in SN comparable to late-onset PD (LOPD) patients. We assessed the area of SN hyperechogenicity (hyper-SN) and a ratio of hyper-SN over ipsilateral midbrain (S/M ratio) with TCDI in 164 healthy Taiwanese, 40 EOPD patients, and 40 LOPD patients. The upper 95th percentile values for hyper-SN and S/M ratio were 0.20 cm<sup>2</sup>
and 0.07. Our results indicate that S/M ratio is a more sensitive measure than hyper-SN in diagnosing PD. Approximately 92.5% of the LOPD patients and 57.5% of the EOPD patients had S/M ratios ≥ 0.07. Enlarged hyperechogenicity of SN is a common finding in LOPD, but not in EOPD. Iron-independent mechanisms of SN cell degeneration in EOPD distinct from that in LOPD might contribute to the sonographic findings.</div>
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<author><name sortKey="Huang, Yu En" sort="Huang, Yu En" uniqKey="Huang Y" first="Yu-Wen" last="Huang">Yu-Wen Huang</name>
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<author><name sortKey="Jeng, Jiann Hing" sort="Jeng, Jiann Hing" uniqKey="Jeng J" first="Jiann-Shing" last="Jeng">Jiann-Shing Jeng</name>
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<author><name sortKey="Tsai, Chung En" sort="Tsai, Chung En" uniqKey="Tsai C" first="Chung-Fen" last="Tsai">Chung-Fen Tsai</name>
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<author><name sortKey="Chen, Li Ing" sort="Chen, Li Ing" uniqKey="Chen L" first="Li-Ling" last="Chen">Li-Ling Chen</name>
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<author><name sortKey="Wu, Ruey Eei" sort="Wu, Ruey Eei" uniqKey="Wu R" first="Ruey-Meei" last="Wu">Ruey-Meei Wu</name>
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<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Transcranial imaging of substantia nigra hyperechogenicity in a Taiwanese cohort of Parkinson's disease</title>
<author><name sortKey="Huang, Yu En" sort="Huang, Yu En" uniqKey="Huang Y" first="Yu-Wen" last="Huang">Yu-Wen Huang</name>
<affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei</wicri:regionArea>
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<author><name sortKey="Jeng, Jiann Hing" sort="Jeng, Jiann Hing" uniqKey="Jeng J" first="Jiann-Shing" last="Jeng">Jiann-Shing Jeng</name>
<affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei</wicri:regionArea>
<wicri:noRegion>Taipei</wicri:noRegion>
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<author><name sortKey="Tsai, Chung En" sort="Tsai, Chung En" uniqKey="Tsai C" first="Chung-Fen" last="Tsai">Chung-Fen Tsai</name>
<affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Neurology, Cardinal‐Tien Hospital, Taipei</wicri:regionArea>
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<author><name sortKey="Chen, Li Ing" sort="Chen, Li Ing" uniqKey="Chen L" first="Li-Ling" last="Chen">Li-Ling Chen</name>
<affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei</wicri:regionArea>
<wicri:noRegion>Taipei</wicri:noRegion>
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<author><name sortKey="Wu, Ruey Eei" sort="Wu, Ruey Eei" uniqKey="Wu R" first="Ruey-Meei" last="Wu">Ruey-Meei Wu</name>
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<wicri:regionArea>Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei</wicri:regionArea>
<wicri:noRegion>Taipei</wicri:noRegion>
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<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
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<pubPlace>Hoboken</pubPlace>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Cohort Studies</term>
<term>Demography</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Mesencephalon (physiopathology)</term>
<term>Mesencephalon (ultrasonography)</term>
<term>Middle Aged</term>
<term>Observer Variation</term>
<term>Parkinson Disease (epidemiology)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson Disease (ultrasonography)</term>
<term>Parkinson's disease</term>
<term>Severity of Illness Index</term>
<term>Substantia Nigra (physiopathology)</term>
<term>Substantia Nigra (ultrasonography)</term>
<term>Taiwan (epidemiology)</term>
<term>Taiwanese</term>
<term>Ultrasonography, Doppler, Transcranial (methods)</term>
<term>echogenicity</term>
<term>midbrain</term>
<term>substantia nigra</term>
<term>transcranial doppler image</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Taiwan</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Ultrasonography, Doppler, Transcranial</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Mesencephalon</term>
<term>Parkinson Disease</term>
<term>Substantia Nigra</term>
</keywords>
<keywords scheme="MESH" qualifier="ultrasonography" xml:lang="en"><term>Mesencephalon</term>
<term>Parkinson Disease</term>
<term>Substantia Nigra</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Cohort Studies</term>
<term>Demography</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Observer Variation</term>
<term>Severity of Illness Index</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Taïwan</term>
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<front><div type="abstract" xml:lang="en">Transcranial Doppler imaging (TCDI) has been used as a noninvasive diagnostic tool to differentiate Parkinson's disease (PD) from atypical parkinsonism by detecting hyperechogenicity in the substantia nigra (SN). To our knowledge, no TCDI data are available for Asian populations, and TCDI sensitivity is uncertain across populations. Early‐onset PD (EOPD) represents a specific PD subtype based on clinical features and pathogenic mechanisms. It is not known if EOPD patients have abnormal echogenicity in SN comparable to late‐onset PD (LOPD) patients. We assessed the area of SN hyperechogenicity (hyper‐SN) and a ratio of hyper‐SN over ipsilateral midbrain (S/M ratio) with TCDI in 164 healthy Taiwanese, 40 EOPD patients, and 40 LOPD patients. The upper 95th percentile values for hyper‐SN and S/M ratio were 0.20 cm2 and 0.07. Our results indicate that S/M ratio is a more sensitive measure than hyper‐SN in diagnosing PD. Approximately 92.5% of the LOPD patients and 57.5% of the EOPD patients had S/M ratios ≥ 0.07. Enlarged hyperechogenicity of SN is a common finding in LOPD, but not in EOPD. Iron‐independent mechanisms of SN cell degeneration in EOPD distinct from that in LOPD might contribute to the sonographic findings. © 2007 Movement Disorder Society</div>
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