MovDisordV3, PascalFrancis, Corpus, bibRecord, 001745

Transcranial imaging of substantia nigra hyperechogenicity in a Taiwanese cohort of Parkinson's disease

Identifieur interne : 001745 ( PascalFrancis/Corpus ); précédent : 001744; suivant : 001746

Transcranial imaging of substantia nigra hyperechogenicity in a Taiwanese cohort of Parkinson's disease

Auteurs : Yu-Wen Huang ; Jiann-Shing Jeng ; Chung-Fen Tsai ; Li-Ling Chen ; Ruey-Meei Wu

Source :

Movement disorders [ 0885-3185 ] ; 2007.

RBID : Pascal:07-0210957

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Parkinson maladie, Locus niger, Dopplérométrie, Mésencéphale.

English descriptors

KwdEn :
- Doppler ultrasound study, Locus niger, Midbrain, Nervous system diseases, Parkinson disease.

Abstract

Transcranial Doppler imaging (TCDI) has been used as a noninvasive diagnostic tool to differentiate Parkinson's disease (PD) from atypical parkinsonism by detecting hyperechogenicity in the substantia nigra (SN). To our knowledge, no TCDI data are available for Asian populations, and TCDI sensitivity is uncertain across populations. Early-onset PD (EOPD) represents a specific PD subtype based on clinical features and pathogenic mechanisms. It is not known if EOPD patients have abnormal echogenicity in SN comparable to late-onset PD (LOPD) patients. We assessed the area of SN hyperechogenicity (hyper-SN) and a ratio of hyper-SN over ipsilateral midbrain (S/M ratio) with TCDI in 164 healthy Taiwanese, 40 EOPD patients, and 40 LOPD patients. The upper 95th percentile values for hyper-SN and S/M ratio were 0.20 cm²and 0.07. Our results indicate that S/M ratio is a more sensitive measure than hyper-SN in diagnosing PD. Approximately 92.5% of the LOPD patients and 57.5% of the EOPD patients had S/M ratios ≥ 0.07. Enlarged hyperechogenicity of SN is a common finding in LOPD, but not in EOPD. Iron-independent mechanisms of SN cell degeneration in EOPD distinct from that in LOPD might contribute to the sonographic findings.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A08	`01`	`1`	`ENG`	`@1 Transcranial imaging of substantia nigra hyperechogenicity in a Taiwanese cohort of Parkinson's disease`
A11	`01`	`1`		`@1 HUANG (Yu-Wen)`
A11	`02`	`1`		`@1 JENG (Jiann-Shing)`
A11	`03`	`1`		`@1 TSAI (Chung-Fen)`
A11	`04`	`1`		`@1 CHEN (Li-Ling)`
A11	`05`	`1`		`@1 WU (Ruey-Meei)`
A14	`01`			`@1 Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University @2 Taipei @3 TWN @Z 1 aut. @Z 2 aut. @Z 4 aut. @Z 5 aut.`
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A21				`@1 2007`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 20953 @5 354000145702210160`
A44				`@0 0000 @1 © 2007 INIST-CNRS. All rights reserved.`
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C01	`01`		`ENG`	@0 Transcranial Doppler imaging (TCDI) has been used as a noninvasive diagnostic tool to differentiate Parkinson's disease (PD) from atypical parkinsonism by detecting hyperechogenicity in the substantia nigra (SN). To our knowledge, no TCDI data are available for Asian populations, and TCDI sensitivity is uncertain across populations. Early-onset PD (EOPD) represents a specific PD subtype based on clinical features and pathogenic mechanisms. It is not known if EOPD patients have abnormal echogenicity in SN comparable to late-onset PD (LOPD) patients. We assessed the area of SN hyperechogenicity (hyper-SN) and a ratio of hyper-SN over ipsilateral midbrain (S/M ratio) with TCDI in 164 healthy Taiwanese, 40 EOPD patients, and 40 LOPD patients. The upper 95th percentile values for hyper-SN and S/M ratio were 0.20 cm²and 0.07. Our results indicate that S/M ratio is a more sensitive measure than hyper-SN in diagnosing PD. Approximately 92.5% of the LOPD patients and 57.5% of the EOPD patients had S/M ratios ≥ 0.07. Enlarged hyperechogenicity of SN is a common finding in LOPD, but not in EOPD. Iron-independent mechanisms of SN cell degeneration in EOPD distinct from that in LOPD might contribute to the sonographic findings.
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C07	`01`	`X`	`ENG`	`@0 Cerebral disorder @5 37`
C07	`01`	`X`	`SPA`	`@0 Encéfalo patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Système nerveux central @5 38`
C07	`02`	`X`	`ENG`	`@0 Central nervous system @5 38`
C07	`02`	`X`	`SPA`	`@0 Sistema nervioso central @5 38`
C07	`03`	`X`	`FRE`	`@0 Extrapyramidal syndrome @5 39`
C07	`03`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 39`
C07	`03`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 39`
C07	`04`	`X`	`FRE`	`@0 Maladie dégénérative @5 40`
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Format Inist (serveur)

NO :	PASCAL 07-0210957 INIST
ET :	Transcranial imaging of substantia nigra hyperechogenicity in a Taiwanese cohort of Parkinson's disease
AU :	HUANG (Yu-Wen); JENG (Jiann-Shing); TSAI (Chung-Fen); CHEN (Li-Ling); WU (Ruey-Meei)
AF :	Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University/Taipei/Taïwan (1 aut., 2 aut., 4 aut., 5 aut.); Department of Neurology, Cardinal-Tien Hospital/Taipei/Taïwan (3 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. 4; Pp. 550-555; Bibl. 26 ref.
LA :	Anglais
EA :	Transcranial Doppler imaging (TCDI) has been used as a noninvasive diagnostic tool to differentiate Parkinson's disease (PD) from atypical parkinsonism by detecting hyperechogenicity in the substantia nigra (SN). To our knowledge, no TCDI data are available for Asian populations, and TCDI sensitivity is uncertain across populations. Early-onset PD (EOPD) represents a specific PD subtype based on clinical features and pathogenic mechanisms. It is not known if EOPD patients have abnormal echogenicity in SN comparable to late-onset PD (LOPD) patients. We assessed the area of SN hyperechogenicity (hyper-SN) and a ratio of hyper-SN over ipsilateral midbrain (S/M ratio) with TCDI in 164 healthy Taiwanese, 40 EOPD patients, and 40 LOPD patients. The upper 95th percentile values for hyper-SN and S/M ratio were 0.20 cm²and 0.07. Our results indicate that S/M ratio is a more sensitive measure than hyper-SN in diagnosing PD. Approximately 92.5% of the LOPD patients and 57.5% of the EOPD patients had S/M ratios ≥ 0.07. Enlarged hyperechogenicity of SN is a common finding in LOPD, but not in EOPD. Iron-independent mechanisms of SN cell degeneration in EOPD distinct from that in LOPD might contribute to the sonographic findings.
CC :	002B17; 002B17G; 002B24A06
FD :	Système nerveux pathologie; Parkinson maladie; Locus niger; Dopplérométrie; Mésencéphale
FG :	Encéphale pathologie; Système nerveux central; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie; Exploration ultrason
ED :	Nervous system diseases; Parkinson disease; Locus niger; Doppler ultrasound study; Midbrain
EG :	Cerebral disorder; Central nervous system; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Sonography
SD :	Sistema nervioso patología; Parkinson enfermedad; Locus níger; Dopplerometría; Mesencéfalo
LO :	INIST-20953.354000145702210160
ID :	07-0210957

Links to Exploration step

Pascal:07-0210957

Le document en format XML

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<front><div type="abstract" xml:lang="en">Transcranial Doppler imaging (TCDI) has been used as a noninvasive diagnostic tool to differentiate Parkinson's disease (PD) from atypical parkinsonism by detecting hyperechogenicity in the substantia nigra (SN). To our knowledge, no TCDI data are available for Asian populations, and TCDI sensitivity is uncertain across populations. Early-onset PD (EOPD) represents a specific PD subtype based on clinical features and pathogenic mechanisms. It is not known if EOPD patients have abnormal echogenicity in SN comparable to late-onset PD (LOPD) patients. We assessed the area of SN hyperechogenicity (hyper-SN) and a ratio of hyper-SN over ipsilateral midbrain (S/M ratio) with TCDI in 164 healthy Taiwanese, 40 EOPD patients, and 40 LOPD patients. The upper 95th percentile values for hyper-SN and S/M ratio were 0.20 cm<sup>2</sup>
and 0.07. Our results indicate that S/M ratio is a more sensitive measure than hyper-SN in diagnosing PD. Approximately 92.5% of the LOPD patients and 57.5% of the EOPD patients had S/M ratios ≥ 0.07. Enlarged hyperechogenicity of SN is a common finding in LOPD, but not in EOPD. Iron-independent mechanisms of SN cell degeneration in EOPD distinct from that in LOPD might contribute to the sonographic findings.</div>
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<fC01 i1="01" l="ENG"><s0>Transcranial Doppler imaging (TCDI) has been used as a noninvasive diagnostic tool to differentiate Parkinson's disease (PD) from atypical parkinsonism by detecting hyperechogenicity in the substantia nigra (SN). To our knowledge, no TCDI data are available for Asian populations, and TCDI sensitivity is uncertain across populations. Early-onset PD (EOPD) represents a specific PD subtype based on clinical features and pathogenic mechanisms. It is not known if EOPD patients have abnormal echogenicity in SN comparable to late-onset PD (LOPD) patients. We assessed the area of SN hyperechogenicity (hyper-SN) and a ratio of hyper-SN over ipsilateral midbrain (S/M ratio) with TCDI in 164 healthy Taiwanese, 40 EOPD patients, and 40 LOPD patients. The upper 95th percentile values for hyper-SN and S/M ratio were 0.20 cm<sup>2</sup>
and 0.07. Our results indicate that S/M ratio is a more sensitive measure than hyper-SN in diagnosing PD. Approximately 92.5% of the LOPD patients and 57.5% of the EOPD patients had S/M ratios ≥ 0.07. Enlarged hyperechogenicity of SN is a common finding in LOPD, but not in EOPD. Iron-independent mechanisms of SN cell degeneration in EOPD distinct from that in LOPD might contribute to the sonographic findings.</s0>
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<s5>38</s5>
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<s5>38</s5>
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<s5>39</s5>
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<fC07 i1="03" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
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<fC07 i1="04" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0>
<s5>41</s5>
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<fC07 i1="05" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>41</s5>
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<fC07 i1="06" i2="X" l="FRE"><s0>Exploration ultrason</s0>
<s5>42</s5>
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<fC07 i1="06" i2="X" l="ENG"><s0>Sonography</s0>
<s5>42</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Exploración ultrasonido</s0>
<s5>42</s5>
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<fN44 i1="01"><s1>OTO</s1>
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<fN82><s1>OTO</s1>
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<server><NO>PASCAL 07-0210957 INIST</NO>
<ET>Transcranial imaging of substantia nigra hyperechogenicity in a Taiwanese cohort of Parkinson's disease</ET>
<AU>HUANG (Yu-Wen); JENG (Jiann-Shing); TSAI (Chung-Fen); CHEN (Li-Ling); WU (Ruey-Meei)</AU>
<AF>Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University/Taipei/Taïwan (1 aut., 2 aut., 4 aut., 5 aut.); Department of Neurology, Cardinal-Tien Hospital/Taipei/Taïwan (3 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. 4; Pp. 550-555; Bibl. 26 ref.</SO>
<LA>Anglais</LA>
<EA>Transcranial Doppler imaging (TCDI) has been used as a noninvasive diagnostic tool to differentiate Parkinson's disease (PD) from atypical parkinsonism by detecting hyperechogenicity in the substantia nigra (SN). To our knowledge, no TCDI data are available for Asian populations, and TCDI sensitivity is uncertain across populations. Early-onset PD (EOPD) represents a specific PD subtype based on clinical features and pathogenic mechanisms. It is not known if EOPD patients have abnormal echogenicity in SN comparable to late-onset PD (LOPD) patients. We assessed the area of SN hyperechogenicity (hyper-SN) and a ratio of hyper-SN over ipsilateral midbrain (S/M ratio) with TCDI in 164 healthy Taiwanese, 40 EOPD patients, and 40 LOPD patients. The upper 95th percentile values for hyper-SN and S/M ratio were 0.20 cm<sup>2</sup>
and 0.07. Our results indicate that S/M ratio is a more sensitive measure than hyper-SN in diagnosing PD. Approximately 92.5% of the LOPD patients and 57.5% of the EOPD patients had S/M ratios ≥ 0.07. Enlarged hyperechogenicity of SN is a common finding in LOPD, but not in EOPD. Iron-independent mechanisms of SN cell degeneration in EOPD distinct from that in LOPD might contribute to the sonographic findings.</EA>
<CC>002B17; 002B17G; 002B24A06</CC>
<FD>Système nerveux pathologie; Parkinson maladie; Locus niger; Dopplérométrie; Mésencéphale</FD>
<FG>Encéphale pathologie; Système nerveux central; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie; Exploration ultrason</FG>
<ED>Nervous system diseases; Parkinson disease; Locus niger; Doppler ultrasound study; Midbrain</ED>
<EG>Cerebral disorder; Central nervous system; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Sonography</EG>
<SD>Sistema nervioso patología; Parkinson enfermedad; Locus níger; Dopplerometría; Mesencéfalo</SD>
<LO>INIST-20953.354000145702210160</LO>
<ID>07-0210957</ID>
</server>
</inist>
</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Transcranial imaging of substantia nigra hyperechogenicity in a Taiwanese cohort of Parkinson's disease

Transcranial imaging of substantia nigra hyperechogenicity in a Taiwanese cohort of Parkinson's disease

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