MovDisordV3, Main, Curation, bibRecord, 002935

Combined effects of smoking, coffee, and NSAIDs on Parkinson's disease risk

Identifieur interne : 002935 ( Main/Curation ); précédent : 002934; suivant : 002936

Combined effects of smoking, coffee, and NSAIDs on Parkinson's disease risk

Auteurs : Karen M. Powers [États-Unis] ; Denise M. Kay [États-Unis] ; Stewart A. Factor [Géorgie (pays), États-Unis] ; Cyrus P. Zabetian [États-Unis] ; Donald S. Higgins [États-Unis] ; Ali Samii [États-Unis] ; John G. Nutt [États-Unis] ; Alida Griffith [États-Unis] ; Berta Leis [États-Unis] ; John W. Roberts [États-Unis] ; Erica D. Martinez [États-Unis] ; Jennifer S. Montimurro [États-Unis] ; Harvey Checkoway [États-Unis] ; Haydeh Payami [États-Unis]

Source :

Movement Disorders [ 0885-3185 ] ; 2008-01.

RBID : ISTEX:9F081ACA8389C52ECB10F3BCD72D64CBE95F4A1D

Descripteurs français

Pascal (Inist)
- Antiinflammatoire non stéroïde, Facteur risque, Maladie de Parkinson, Pathologie du système nerveux, Tabagisme.
Wicri :
- topic : Tabagisme.

English descriptors

KwdEn :
- Aged, Anti-Inflammatory Agents, Non-Steroidal (administration & dosage), Anti-Inflammatory Agents, Non-Steroidal (pharmacology), Caffeine (administration & dosage), Caffeine (pharmacology), Central Nervous System Stimulants (administration & dosage), Central Nervous System Stimulants (pharmacology), Coffee, Cognition (drug effects), Drinking Behavior, Female, Humans, Male, NSAIDs, Nervous system diseases, Nicotine (administration & dosage), Nicotine (pharmacology), Non steroidal antiinflammatory agent, Parkinson Disease (epidemiology), Parkinson Disease (physiopathology), Parkinson Disease (prevention & control), Parkinson disease, Parkinson's disease, Prevalence, Questionnaires, Risk factor, Smoking (epidemiology), Tobacco smoking, coffee, nonsteroidal anti‐inflammatory drugs, smoking.
MESH :
- chemical , administration & dosage : Anti-Inflammatory Agents, Non-Steroidal, Caffeine, Central Nervous System Stimulants, Nicotine.
- chemical , pharmacology : Anti-Inflammatory Agents, Non-Steroidal, Caffeine, Central Nervous System Stimulants, Nicotine.
- drug effects : Cognition.
- epidemiology : Parkinson Disease, Smoking.
- physiopathology : Parkinson Disease.
- prevention & control : Parkinson Disease.
- Aged, Coffee, Drinking Behavior, Female, Humans, Male, Prevalence, Questionnaires.

Abstract

Inverse associations of Parkinson's disease (PD) with cigarette smoking, coffee drinking, and nonsteroidal anti‐inflammatory drug (NSAID) use have been reported individually, but their joint effects have not been examined. To quantify associations with PD for the individual, two‐way and three‐way combinations of these factors, a case–control association study with 1,186 PD patients and 928 controls was conducted. The study setting was the NeuroGenetics Research Consortium. Subjects completed a structured questionnaire regarding smoking, coffee, and NSAID consumption. Odds ratios were calculated using unconditional logistic regression. Smoking, coffee, and over the counter NSAID use as individual factors exhibited significantly reduced risks of 20% to 30%. The two‐way and three‐way combinations were associated with risk reduction of 37% to 49%, and 62%, respectively. Smoking and coffee exhibited significant inverse risk trends with increasing cumulative exposures, suggesting dose–response relations. With respect to the combination of all three exposures, persons who were at the highest exposure strata for smoking and coffee and used NSAIDs had an estimated 87% reduction in risk (OR = 0.13, 95% CI = 0.06–0.29). Whether this finding reflects true biologic protection needs to be investigated. © 2007 Movement Disorder Society

Url:

https://api.istex.fr/document/9F081ACA8389C52ECB10F3BCD72D64CBE95F4A1D/fulltext/pdf

DOI: 10.1002/mds.21782

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Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Anti-Inflammatory Agents, Non-Steroidal (administration & dosage)</term>
<term>Anti-Inflammatory Agents, Non-Steroidal (pharmacology)</term>
<term>Caffeine (administration & dosage)</term>
<term>Caffeine (pharmacology)</term>
<term>Central Nervous System Stimulants (administration & dosage)</term>
<term>Central Nervous System Stimulants (pharmacology)</term>
<term>Coffee</term>
<term>Cognition (drug effects)</term>
<term>Drinking Behavior</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>NSAIDs</term>
<term>Nervous system diseases</term>
<term>Nicotine (administration & dosage)</term>
<term>Nicotine (pharmacology)</term>
<term>Non steroidal antiinflammatory agent</term>
<term>Parkinson Disease (epidemiology)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson Disease (prevention & control)</term>
<term>Parkinson disease</term>
<term>Parkinson's disease</term>
<term>Prevalence</term>
<term>Questionnaires</term>
<term>Risk factor</term>
<term>Smoking (epidemiology)</term>
<term>Tobacco smoking</term>
<term>coffee</term>
<term>nonsteroidal anti‐inflammatory drugs</term>
<term>smoking</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Anti-Inflammatory Agents, Non-Steroidal</term>
<term>Caffeine</term>
<term>Central Nervous System Stimulants</term>
<term>Nicotine</term>
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<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Inflammatory Agents, Non-Steroidal</term>
<term>Caffeine</term>
<term>Central Nervous System Stimulants</term>
<term>Nicotine</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cognition</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Parkinson Disease</term>
<term>Smoking</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term>
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<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Parkinson Disease</term>
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<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Coffee</term>
<term>Drinking Behavior</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Prevalence</term>
<term>Questionnaires</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Antiinflammatoire non stéroïde</term>
<term>Facteur risque</term>
<term>Maladie de Parkinson</term>
<term>Pathologie du   système nerveux</term>
<term>Tabagisme</term>
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<front><div type="abstract" xml:lang="en">Inverse associations of Parkinson's disease (PD) with cigarette smoking, coffee drinking, and nonsteroidal anti‐inflammatory drug (NSAID) use have been reported individually, but their joint effects have not been examined. To quantify associations with PD for the individual, two‐way and three‐way combinations of these factors, a case–control association study with 1,186 PD patients and 928 controls was conducted. The study setting was the NeuroGenetics Research Consortium. Subjects completed a structured questionnaire regarding smoking, coffee, and NSAID consumption. Odds ratios were calculated using unconditional logistic regression. Smoking, coffee, and over the counter NSAID use as individual factors exhibited significantly reduced risks of 20% to 30%. The two‐way and three‐way combinations were associated with risk reduction of 37% to 49%, and 62%, respectively. Smoking and coffee exhibited significant inverse risk trends with increasing cumulative exposures, suggesting dose–response relations. With respect to the combination of all three exposures, persons who were at the highest exposure strata for smoking and coffee and used NSAIDs had an estimated 87% reduction in risk (OR = 0.13, 95% CI = 0.06–0.29). Whether this finding reflects true biologic protection needs to be investigated. © 2007 Movement Disorder Society</div>
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<placeName><region type="state">Washington (État)</region>
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<affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Department of Neurology, University of Washington School of Medicine</s1>
<s2>Seattle, Washington</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
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<country>États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Higgins, Donald S" sort="Higgins, Donald S" uniqKey="Higgins D" first="Donald S." last="Higgins">Donald S. Higgins</name>
<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Parkinson's Disease and Movement Disorder Center, Albany Medical Center</s1>
<s2>Albany, New York</s2>
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</placeName>
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</author>
<author><name sortKey="Samii, Ali" sort="Samii, Ali" uniqKey="Samii A" first="Ali" last="Samii">Ali Samii</name>
<affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Department of Neurology, University of Washington School of Medicine</s1>
<s2>Seattle, Washington</s2>
<s3>USA</s3>
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<s2>Seattle, Washington</s2>
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<placeName><region type="state">Washington (État)</region>
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<author><name sortKey="Nutt, John G" sort="Nutt, John G" uniqKey="Nutt J" first="John G." last="Nutt">John G. Nutt</name>
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<s2>Portland, Oregon</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Oregon</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Griffith, Alida" sort="Griffith, Alida" uniqKey="Griffith A" first="Alida" last="Griffith">Alida Griffith</name>
<affiliation wicri:level="2"><inist:fA14 i1="09"><s1>Booth Gardner Parkinson's Care Center, Evergreen Hospital Medical Center</s1>
<s2>Kirkland, Washington</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
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<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Leis, Berta" sort="Leis, Berta" uniqKey="Leis B" first="Berta" last="Leis">Berta Leis</name>
<affiliation wicri:level="2"><inist:fA14 i1="09"><s1>Booth Gardner Parkinson's Care Center, Evergreen Hospital Medical Center</s1>
<s2>Kirkland, Washington</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Roberts, John W" sort="Roberts, John W" uniqKey="Roberts J" first="John W." last="Roberts">John W. Roberts</name>
<affiliation wicri:level="2"><inist:fA14 i1="10"><s1>Virginia Mason Medical Center</s1>
<s2>Seattle, Washington</s2>
<s3>USA</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Martinez, Erica D" sort="Martinez, Erica D" uniqKey="Martinez E" first="Erica D." last="Martinez">Erica D. Martinez</name>
<affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Geriatric Research Education and Clinical Center, VA Puget Sound Health Care System</s1>
<s2>Seattle, Washington</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Department of Neurology, University of Washington School of Medicine</s1>
<s2>Seattle, Washington</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
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<country>États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Montimurro, Jennifer S" sort="Montimurro, Jennifer S" uniqKey="Montimurro J" first="Jennifer S." last="Montimurro">Jennifer S. Montimurro</name>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Genomics Institute, Wadsworth Center, New York State Department of Health</s1>
<s2>Albany, New York</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
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<country>États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Checkoway, Harvey" sort="Checkoway, Harvey" uniqKey="Checkoway H" first="Harvey" last="Checkoway">Harvey Checkoway</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Environmental and Occupational Health Sciences, School of Public Health and Community Medicine, University of Washington</s1>
<s2>Seattle, Washington</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Payami, Haydeh" sort="Payami, Haydeh" uniqKey="Payami H" first="Haydeh" last="Payami">Haydeh Payami</name>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Genomics Institute, Wadsworth Center, New York State Department of Health</s1>
<s2>Albany, New York</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
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<idno type="inist">08-0115901</idno>
<date when="2008">2008</date>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Combined Effects of Smoking, Coffee, and NSAIDs on Parkinson's Disease Risk</title>
<author><name sortKey="Powers, Karen M" sort="Powers, Karen M" uniqKey="Powers K" first="Karen M." last="Powers">Karen M. Powers</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Environmental and Occupational Health Sciences, School of Public Health and Community Medicine, University of Washington</s1>
<s2>Seattle, Washington</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Kay, Denise M" sort="Kay, Denise M" uniqKey="Kay D" first="Denise M." last="Kay">Denise M. Kay</name>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Genomics Institute, Wadsworth Center, New York State Department of Health</s1>
<s2>Albany, New York</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Factor, Stewart A" sort="Factor, Stewart A" uniqKey="Factor S" first="Stewart A." last="Factor">Stewart A. Factor</name>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Neurology, Emory University School of Medicine</s1>
<s2>Atlanta, Georgia</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Parkinson's Disease and Movement Disorder Center, Albany Medical Center</s1>
<s2>Albany, New York</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zabetian, Cyrus P" sort="Zabetian, Cyrus P" uniqKey="Zabetian C" first="Cyrus P." last="Zabetian">Cyrus P. Zabetian</name>
<affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Geriatric Research Education and Clinical Center, VA Puget Sound Health Care System</s1>
<s2>Seattle, Washington</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Department of Neurology, University of Washington School of Medicine</s1>
<s2>Seattle, Washington</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Higgins, Donald S" sort="Higgins, Donald S" uniqKey="Higgins D" first="Donald S." last="Higgins">Donald S. Higgins</name>
<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Parkinson's Disease and Movement Disorder Center, Albany Medical Center</s1>
<s2>Albany, New York</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Samii, Ali" sort="Samii, Ali" uniqKey="Samii A" first="Ali" last="Samii">Ali Samii</name>
<affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Department of Neurology, University of Washington School of Medicine</s1>
<s2>Seattle, Washington</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="07"><s1>Parkinson's Disease Research Education and Clinical Center, VA Puget Sound Health Care System</s1>
<s2>Seattle, Washington</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nutt, John G" sort="Nutt, John G" uniqKey="Nutt J" first="John G." last="Nutt">John G. Nutt</name>
<affiliation wicri:level="2"><inist:fA14 i1="08"><s1>Department of Neurology, Oregon Health and Science University</s1>
<s2>Portland, Oregon</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Oregon</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Griffith, Alida" sort="Griffith, Alida" uniqKey="Griffith A" first="Alida" last="Griffith">Alida Griffith</name>
<affiliation wicri:level="2"><inist:fA14 i1="09"><s1>Booth Gardner Parkinson's Care Center, Evergreen Hospital Medical Center</s1>
<s2>Kirkland, Washington</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Leis, Berta" sort="Leis, Berta" uniqKey="Leis B" first="Berta" last="Leis">Berta Leis</name>
<affiliation wicri:level="2"><inist:fA14 i1="09"><s1>Booth Gardner Parkinson's Care Center, Evergreen Hospital Medical Center</s1>
<s2>Kirkland, Washington</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Roberts, John W" sort="Roberts, John W" uniqKey="Roberts J" first="John W." last="Roberts">John W. Roberts</name>
<affiliation wicri:level="2"><inist:fA14 i1="10"><s1>Virginia Mason Medical Center</s1>
<s2>Seattle, Washington</s2>
<s3>USA</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Martinez, Erica D" sort="Martinez, Erica D" uniqKey="Martinez E" first="Erica D." last="Martinez">Erica D. Martinez</name>
<affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Geriatric Research Education and Clinical Center, VA Puget Sound Health Care System</s1>
<s2>Seattle, Washington</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Department of Neurology, University of Washington School of Medicine</s1>
<s2>Seattle, Washington</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Montimurro, Jennifer S" sort="Montimurro, Jennifer S" uniqKey="Montimurro J" first="Jennifer S." last="Montimurro">Jennifer S. Montimurro</name>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Genomics Institute, Wadsworth Center, New York State Department of Health</s1>
<s2>Albany, New York</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Checkoway, Harvey" sort="Checkoway, Harvey" uniqKey="Checkoway H" first="Harvey" last="Checkoway">Harvey Checkoway</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Environmental and Occupational Health Sciences, School of Public Health and Community Medicine, University of Washington</s1>
<s2>Seattle, Washington</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Payami, Haydeh" sort="Payami, Haydeh" uniqKey="Payami H" first="Haydeh" last="Payami">Haydeh Payami</name>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Genomics Institute, Wadsworth Center, New York State Department of Health</s1>
<s2>Albany, New York</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2008">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Nervous system diseases</term>
<term>Non steroidal antiinflammatory agent</term>
<term>Parkinson disease</term>
<term>Risk factor</term>
<term>Tobacco smoking</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Tabagisme</term>
<term>Maladie de Parkinson</term>
<term>Pathologie du   système nerveux</term>
<term>Antiinflammatoire non stéroïde</term>
<term>Facteur risque</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Tabagisme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Inverse associations of Parkinson's disease (PD) with cigarette smoking, coffee drinking, and nonsteroidal anti-inflammatory drug (NSAID) use have been reported individually, but their joint effects have not been examined. To quantify associations with PD for the individual, two-way and three-way combinations of these factors, a case-control association study with 1,186 PD patients and 928 controls was conducted. The study setting was the NeuroGenetics Research Consortium. Subjects completed a structured questionnaire regarding smoking, coffee, and NSAID consumption. Odds ratios were calculated using unconditional logistic regression. Smoking, coffee, and over the counter NSAID use as individual factors exhibited significantly reduced risks of 20% to 30%. The two-way and three-way combinations were associated with risk reduction of 37% to 49%, and 62%, respectively. Smoking and coffee exhibited significant inverse risk trends with increasing cumulative exposures, suggesting dose-response relations. With respect to the combination of all three exposures, persons who were at the highest exposure strata for smoking and coffee and used NSAIDs had an estimated 87% reduction in risk (OR = 0.13, 95% CI = 0.06-0.29). Whether this finding reflects true biologic protection needs to be investigated.</div>
</front>
</TEI>
</INIST>
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<author><name sortKey="Powers, Karen M" sort="Powers, Karen M" uniqKey="Powers K" first="Karen M." last="Powers">Karen M. Powers</name>
</author>
<author><name sortKey="Kay, Denise M" sort="Kay, Denise M" uniqKey="Kay D" first="Denise M." last="Kay">Denise M. Kay</name>
</author>
<author><name sortKey="Factor, Stewart A" sort="Factor, Stewart A" uniqKey="Factor S" first="Stewart A." last="Factor">Stewart A. Factor</name>
</author>
<author><name sortKey="Zabetian, Cyrus P" sort="Zabetian, Cyrus P" uniqKey="Zabetian C" first="Cyrus P." last="Zabetian">Cyrus P. Zabetian</name>
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<author><name sortKey="Higgins, Donald S" sort="Higgins, Donald S" uniqKey="Higgins D" first="Donald S." last="Higgins">Donald S. Higgins</name>
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<author><name sortKey="Samii, Ali" sort="Samii, Ali" uniqKey="Samii A" first="Ali" last="Samii">Ali Samii</name>
</author>
<author><name sortKey="Nutt, John G" sort="Nutt, John G" uniqKey="Nutt J" first="John G." last="Nutt">John G. Nutt</name>
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<author><name sortKey="Griffith, Alida" sort="Griffith, Alida" uniqKey="Griffith A" first="Alida" last="Griffith">Alida Griffith</name>
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<author><name sortKey="Leis, Berta" sort="Leis, Berta" uniqKey="Leis B" first="Berta" last="Leis">Berta Leis</name>
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<author><name sortKey="Roberts, John W" sort="Roberts, John W" uniqKey="Roberts J" first="John W." last="Roberts">John W. Roberts</name>
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<author><name sortKey="Martinez, Erica D" sort="Martinez, Erica D" uniqKey="Martinez E" first="Erica D." last="Martinez">Erica D. Martinez</name>
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<author><name sortKey="Montimurro, Jennifer S" sort="Montimurro, Jennifer S" uniqKey="Montimurro J" first="Jennifer S." last="Montimurro">Jennifer S. Montimurro</name>
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<author><name sortKey="Checkoway, Harvey" sort="Checkoway, Harvey" uniqKey="Checkoway H" first="Harvey" last="Checkoway">Harvey Checkoway</name>
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<author><name sortKey="Payami, Haydeh" sort="Payami, Haydeh" uniqKey="Payami H" first="Haydeh" last="Payami">Haydeh Payami</name>
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<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Combined effects of smoking, coffee, and NSAIDs on Parkinson's disease risk</title>
<author><name sortKey="Powers, Karen M" sort="Powers, Karen M" uniqKey="Powers K" first="Karen M." last="Powers">Karen M. Powers</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Department of Environmental and Occupational Health Sciences, School of Public Health and Community Medicine, University of Washington, Seattle</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kay, Denise M" sort="Kay, Denise M" uniqKey="Kay D" first="Denise M." last="Kay">Denise M. Kay</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Genomics Institute, Wadsworth Center, New York State Department of Health, Albany</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Factor, Stewart A" sort="Factor, Stewart A" uniqKey="Factor S" first="Stewart A." last="Factor">Stewart A. Factor</name>
<affiliation wicri:level="1"><country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Department of Neurology, Emory University School of Medicine, Atlanta</wicri:regionArea>
<wicri:noRegion>Atlanta</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Parkinson's Disease and Movement Disorder Center, Albany Medical Center, Albany</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Zabetian, Cyrus P" sort="Zabetian, Cyrus P" uniqKey="Zabetian C" first="Cyrus P." last="Zabetian">Cyrus P. Zabetian</name>
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<placeName><region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Geriatric Research Education and Clinical Center, VA Puget Sound Health Care System, Seattle</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Washington School of Medicine, Seattle</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Higgins, Donald S" sort="Higgins, Donald S" uniqKey="Higgins D" first="Donald S." last="Higgins">Donald S. Higgins</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Parkinson's Disease and Movement Disorder Center, Albany Medical Center, Albany</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Samii, Ali" sort="Samii, Ali" uniqKey="Samii A" first="Ali" last="Samii">Ali Samii</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Washington School of Medicine, Seattle</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Parkinson's Disease Research Education and Clinical Center, VA Puget Sound Health Care System, Seattle</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Nutt, John G" sort="Nutt, John G" uniqKey="Nutt J" first="John G." last="Nutt">John G. Nutt</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Oregon</region>
</placeName>
<wicri:cityArea>Department of Neurology, Oregon Health and Science University, Portland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Griffith, Alida" sort="Griffith, Alida" uniqKey="Griffith A" first="Alida" last="Griffith">Alida Griffith</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Booth Gardner Parkinson's Care Center, Evergreen Hospital Medical Center, Kirkland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Leis, Berta" sort="Leis, Berta" uniqKey="Leis B" first="Berta" last="Leis">Berta Leis</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Booth Gardner Parkinson's Care Center, Evergreen Hospital Medical Center, Kirkland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Roberts, John W" sort="Roberts, John W" uniqKey="Roberts J" first="John W." last="Roberts">John W. Roberts</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Virginia Mason Medical Center, Seattle</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Martinez, Erica D" sort="Martinez, Erica D" uniqKey="Martinez E" first="Erica D." last="Martinez">Erica D. Martinez</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Geriatric Research Education and Clinical Center, VA Puget Sound Health Care System, Seattle</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Washington School of Medicine, Seattle</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Montimurro, Jennifer S" sort="Montimurro, Jennifer S" uniqKey="Montimurro J" first="Jennifer S." last="Montimurro">Jennifer S. Montimurro</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Genomics Institute, Wadsworth Center, New York State Department of Health, Albany</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Checkoway, Harvey" sort="Checkoway, Harvey" uniqKey="Checkoway H" first="Harvey" last="Checkoway">Harvey Checkoway</name>
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<placeName><region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Department of Environmental and Occupational Health Sciences, School of Public Health and Community Medicine, University of Washington, Seattle</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Payami, Haydeh" sort="Payami, Haydeh" uniqKey="Payami H" first="Haydeh" last="Payami">Haydeh Payami</name>
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<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Genomics Institute, Wadsworth Center, New York State Department of Health, Albany</wicri:cityArea>
</affiliation>
</author>
</analytic>
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<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Anti-Inflammatory Agents, Non-Steroidal (administration & dosage)</term>
<term>Anti-Inflammatory Agents, Non-Steroidal (pharmacology)</term>
<term>Caffeine (administration & dosage)</term>
<term>Caffeine (pharmacology)</term>
<term>Central Nervous System Stimulants (administration & dosage)</term>
<term>Central Nervous System Stimulants (pharmacology)</term>
<term>Coffee</term>
<term>Cognition (drug effects)</term>
<term>Drinking Behavior</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>NSAIDs</term>
<term>Nicotine (administration & dosage)</term>
<term>Nicotine (pharmacology)</term>
<term>Parkinson Disease (epidemiology)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson Disease (prevention & control)</term>
<term>Parkinson's disease</term>
<term>Prevalence</term>
<term>Questionnaires</term>
<term>Smoking (epidemiology)</term>
<term>coffee</term>
<term>nonsteroidal anti‐inflammatory drugs</term>
<term>smoking</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Anti-Inflammatory Agents, Non-Steroidal</term>
<term>Caffeine</term>
<term>Central Nervous System Stimulants</term>
<term>Nicotine</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Inflammatory Agents, Non-Steroidal</term>
<term>Caffeine</term>
<term>Central Nervous System Stimulants</term>
<term>Nicotine</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cognition</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Parkinson Disease</term>
<term>Smoking</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Coffee</term>
<term>Drinking Behavior</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Prevalence</term>
<term>Questionnaires</term>
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<front><div type="abstract" xml:lang="en">Inverse associations of Parkinson's disease (PD) with cigarette smoking, coffee drinking, and nonsteroidal anti‐inflammatory drug (NSAID) use have been reported individually, but their joint effects have not been examined. To quantify associations with PD for the individual, two‐way and three‐way combinations of these factors, a case–control association study with 1,186 PD patients and 928 controls was conducted. The study setting was the NeuroGenetics Research Consortium. Subjects completed a structured questionnaire regarding smoking, coffee, and NSAID consumption. Odds ratios were calculated using unconditional logistic regression. Smoking, coffee, and over the counter NSAID use as individual factors exhibited significantly reduced risks of 20% to 30%. The two‐way and three‐way combinations were associated with risk reduction of 37% to 49%, and 62%, respectively. Smoking and coffee exhibited significant inverse risk trends with increasing cumulative exposures, suggesting dose–response relations. With respect to the combination of all three exposures, persons who were at the highest exposure strata for smoking and coffee and used NSAIDs had an estimated 87% reduction in risk (OR = 0.13, 95% CI = 0.06–0.29). Whether this finding reflects true biologic protection needs to be investigated. © 2007 Movement Disorder Society</div>
</front>
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Movement Disorders (revue)

Combined effects of smoking, coffee, and NSAIDs on Parkinson's disease risk

Combined effects of smoking, coffee, and NSAIDs on Parkinson's disease risk

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