Short‐term effects of coenzyme Q10 in progressive supranuclear palsy: A randomized, placebo‐controlled trial
Identifieur interne : 002631 ( Main/Curation ); précédent : 002630; suivant : 002632Short‐term effects of coenzyme Q10 in progressive supranuclear palsy: A randomized, placebo‐controlled trial
Auteurs : Maria Stamelou [Allemagne] ; Alexander Reuss [Allemagne] ; Ulrich Pilatus [Allemagne] ; Jörg Magerkurth [Allemagne] ; Petra Niklowitz [Allemagne] ; Karla M. Eggert [Allemagne] ; Andrea Krisp [Allemagne] ; Thomas Menke [Allemagne] ; Carmen Schade-Brittinger [Allemagne] ; Wolfgang H. Oertel [Allemagne] ; Günter U. Höglinger [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-05-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Aged, Basal Ganglia (drug effects), Basal Ganglia (metabolism), Clinical trial, Double-Blind Method, Energy metabolism, Female, Humans, Magnetic Resonance Spectroscopy, Male, Middle Aged, NMR spectrometry, Nervous system diseases, Neuroprotective Agents (pharmacology), Neuroprotective Agents (therapeutic use), Placebo, Short term, Supranuclear Palsy, Progressive (drug therapy), Ubiquinone (analogs & derivatives), Ubiquinone (pharmacology), Ubiquinone (therapeutic use), coenzyme Q10, energy metabolism, magnetic resonance spectroscopy, progressive supranuclear palsy, randomized controlled clinical trial (CONSORT statement).
- MESH :
- chemical , analogs & derivatives : Ubiquinone.
- chemical , pharmacology : Neuroprotective Agents, Ubiquinone.
- drug effects : Basal Ganglia.
- drug therapy : Supranuclear Palsy, Progressive.
- metabolism : Basal Ganglia.
- chemical , therapeutic use : Neuroprotective Agents, Ubiquinone.
- Adult, Aged, Double-Blind Method, Female, Humans, Magnetic Resonance Spectroscopy, Male, Middle Aged.
Abstract
Mitochondrial complex I appears to be dysfunctional in progressive supranuclear palsy (PSP). Coenzyme Q10 (CoQ10) is a physiological cofactor of complex I. Therefore, we evaluated the short‐term effects of CoQ10 in PSP. We performed a double‐blind, randomized, placebo‐controlled, phase II trial, including 21 clinically probable PSP patients (stage ≤ III) to receive a liquid nanodispersion of CoQ10 (5 mg/kg/day) or matching placebo. Over a 6‐week period, we determined the change in CoQ10 serum concentration, cerebral energy metabolites (by 31P‐ and 1H‐magnetic resonance spectroscopy), motor and neuropsychological dysfunction (PSP rating scale, UPDRS III, Hoehn and Yahr stage, Frontal Assessment Battery, Mini Mental Status Examination, Montgomery Åsberg Depression Scale). CoQ10 was safe and well tolerated. In patients receiving CoQ10 compared to placebo, the concentration of low‐energy phosphates (adenosine‐diphosphate, unphosphorylated creatine) decreased. Consequently, the ratio of high‐energy phosphates to low‐energy phosphates (adenosine‐triphosphate to adenosine‐diphosphate, phospho‐creatine to unphosphorylated creatine) increased. These changes were significant in the occipital lobe and showed a consistent trend in the basal ganglia. Clinically, the PSP rating scale and the Frontal Assessment Battery improved slightly, but significantly, upon CoQ10 treatment compared to placebo. Since CoQ10 appears to improve cerebral energy metabolism in PSP, long‐term treatment might have a disease‐modifying, neuroprotective effect. © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.22023
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<front><div type="abstract" xml:lang="en">Mitochondrial complex I appears to be dysfunctional in progressive supranuclear palsy (PSP). Coenzyme Q10 (CoQ10) is a physiological cofactor of complex I. Therefore, we evaluated the short‐term effects of CoQ10 in PSP. We performed a double‐blind, randomized, placebo‐controlled, phase II trial, including 21 clinically probable PSP patients (stage ≤ III) to receive a liquid nanodispersion of CoQ10 (5 mg/kg/day) or matching placebo. Over a 6‐week period, we determined the change in CoQ10 serum concentration, cerebral energy metabolites (by 31P‐ and 1H‐magnetic resonance spectroscopy), motor and neuropsychological dysfunction (PSP rating scale, UPDRS III, Hoehn and Yahr stage, Frontal Assessment Battery, Mini Mental Status Examination, Montgomery Åsberg Depression Scale). CoQ10 was safe and well tolerated. In patients receiving CoQ10 compared to placebo, the concentration of low‐energy phosphates (adenosine‐diphosphate, unphosphorylated creatine) decreased. Consequently, the ratio of high‐energy phosphates to low‐energy phosphates (adenosine‐triphosphate to adenosine‐diphosphate, phospho‐creatine to unphosphorylated creatine) increased. These changes were significant in the occipital lobe and showed a consistent trend in the basal ganglia. Clinically, the PSP rating scale and the Frontal Assessment Battery improved slightly, but significantly, upon CoQ10 treatment compared to placebo. Since CoQ10 appears to improve cerebral energy metabolism in PSP, long‐term treatment might have a disease‐modifying, neuroprotective effect. © 2008 Movement Disorder Society</div>
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</placeName>
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</author>
<author><name sortKey="Menke, Thomas" sort="Menke, Thomas" uniqKey="Menke T" first="Thomas" last="Menke">Thomas Menke</name>
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</affiliation>
</author>
<author><name sortKey="Schade Brittinger, Carmen" sort="Schade Brittinger, Carmen" uniqKey="Schade Brittinger C" first="Carmen" last="Schade-Brittinger">Carmen Schade-Brittinger</name>
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<country>Allemagne</country>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name>
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<country>Allemagne</country>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hoglinger, Gunter U" sort="Hoglinger, Gunter U" uniqKey="Hoglinger G" first="Günter U." last="Höglinger">Günter U. Höglinger</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Philipps University</s1>
<s2>Marburg</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
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</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">08-0305151</idno>
<date when="2008">2008</date>
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<idno type="RBID">Pascal:08-0305151</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001231</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Short-Term Effects of Coenzyme Q<sub>10</sub>
in Progressive Supranuclear Palsy : A Randomized, Placebo-Controlled Trial</title>
<author><name sortKey="Stamelou, Maria" sort="Stamelou, Maria" uniqKey="Stamelou M" first="Maria" last="Stamelou">Maria Stamelou</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Philipps University</s1>
<s2>Marburg</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Reuss, Alexander" sort="Reuss, Alexander" uniqKey="Reuss A" first="Alexander" last="Reuss">Alexander Reuss</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Center for Clinical Trials, Philipps University</s1>
<s2>Marburg</s2>
<s3>DEU</s3>
<sZ>2 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pilatus, Ulrich" sort="Pilatus, Ulrich" uniqKey="Pilatus U" first="Ulrich" last="Pilatus">Ulrich Pilatus</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Brain Imaging Center and Institute of Neuroradiology, J.W. Goethe University</s1>
<s2>Frankfurt</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Frankfurt</wicri:noRegion>
<wicri:noRegion>J.W. Goethe University</wicri:noRegion>
<wicri:noRegion>Frankfurt</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Magerkurth, Jorg" sort="Magerkurth, Jorg" uniqKey="Magerkurth J" first="Jörg" last="Magerkurth">Jörg Magerkurth</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Brain Imaging Center and Institute of Neuroradiology, J.W. Goethe University</s1>
<s2>Frankfurt</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Frankfurt</wicri:noRegion>
<wicri:noRegion>J.W. Goethe University</wicri:noRegion>
<wicri:noRegion>Frankfurt</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Niklowitz, Petra" sort="Niklowitz, Petra" uniqKey="Niklowitz P" first="Petra" last="Niklowitz">Petra Niklowitz</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Children's Hospital Datteln, Witten-Herdecke University</s1>
<s3>DEU</s3>
<sZ>5 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Witten-Herdecke University</wicri:noRegion>
<wicri:noRegion>Children's Hospital Datteln, Witten-Herdecke University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Eggert, Karla M" sort="Eggert, Karla M" uniqKey="Eggert K" first="Karla M." last="Eggert">Karla M. Eggert</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Philipps University</s1>
<s2>Marburg</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
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</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Krisp, Andrea" sort="Krisp, Andrea" uniqKey="Krisp A" first="Andrea" last="Krisp">Andrea Krisp</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Philipps University</s1>
<s2>Marburg</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Menke, Thomas" sort="Menke, Thomas" uniqKey="Menke T" first="Thomas" last="Menke">Thomas Menke</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Children's Hospital Datteln, Witten-Herdecke University</s1>
<s3>DEU</s3>
<sZ>5 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Witten-Herdecke University</wicri:noRegion>
<wicri:noRegion>Children's Hospital Datteln, Witten-Herdecke University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schade Brittinger, Carmen" sort="Schade Brittinger, Carmen" uniqKey="Schade Brittinger C" first="Carmen" last="Schade-Brittinger">Carmen Schade-Brittinger</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Center for Clinical Trials, Philipps University</s1>
<s2>Marburg</s2>
<s3>DEU</s3>
<sZ>2 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Philipps University</s1>
<s2>Marburg</s2>
<s3>DEU</s3>
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<sZ>10 aut.</sZ>
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</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hoglinger, Gunter U" sort="Hoglinger, Gunter U" uniqKey="Hoglinger G" first="Günter U." last="Höglinger">Günter U. Höglinger</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Philipps University</s1>
<s2>Marburg</s2>
<s3>DEU</s3>
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<country>Allemagne</country>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2008">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Clinical trial</term>
<term>Energy metabolism</term>
<term>NMR spectrometry</term>
<term>Nervous system diseases</term>
<term>Placebo</term>
<term>Short term</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Pathologie du système nerveux</term>
<term>Court terme</term>
<term>Placebo</term>
<term>Métabolisme énergétique</term>
<term>Spectrométrie RMN</term>
<term>Essai clinique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Mitochondrial complex I appears to be dysfunctional in progressive supranuclear palsy (PSP). Coenzyme Q<sub>10</sub>
(CoQ<sub>10</sub>
) is a physiological cofactor of complex I. Therefore, we evaluated the short-term effects of CoQ<sub>10</sub>
in PSP. We performed a double-blind, randomized, placebo-controlled, phase II trial, including 21 clinically probable PSP patients (stage < III) to receive a liquid nanodispersion of CoQ<sub>10</sub>
(5 mg/kg/day) or matching placebo. Over a 6-week period, we determined the change in CoQ<sub>10</sub>
serum concentration, cerebral energy metabolites (by <sup>31</sup>
P- and <sup>1</sup>
H-magnetic resonance spectroscopy), motor and neuropsychological dysfunction (PSP rating scale, UPDRS III, Hoehn and Yahr stage, Frontal Assessment Battery, Mini Mental Status Examination, Montgomery Åsberg Depression Scale). CoQ<sub>10</sub>
was safe and well tolerated. In patients receiving CoQ<sub>10</sub>
compared to placebo, the concentration of low-energy phosphates (adenosine-diphosphate, unphosphorylated creatine) decreased. Consequently, the ratio of high-energy phosphates to low-energy phosphates (adenosine-triphosphate to adenosine-diphosphate, phospho-creatine to unphosphorylated creatine) increased. These changes were significant in the occipital lobe and showed a consistent trend in the basal ganglia. Clinically, the PSP rating scale and the Frontal Assessment Battery improved slightly, but significantly, upon CoQ<sub>10</sub>
treatment compared to placebo. Since CoQ<sub>10</sub>
appears to improve cerebral energy metabolism in PSP, long-term treatment might have a disease-modifying, neuroprotective effect.</div>
</front>
</TEI>
</INIST>
<ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Short‐term effects of coenzyme Q10 in progressive supranuclear palsy: A randomized, placebo‐controlled trial</title>
<author><name sortKey="Stamelou, Maria" sort="Stamelou, Maria" uniqKey="Stamelou M" first="Maria" last="Stamelou">Maria Stamelou</name>
</author>
<author><name sortKey="Reuss, Alexander" sort="Reuss, Alexander" uniqKey="Reuss A" first="Alexander" last="Reuss">Alexander Reuss</name>
</author>
<author><name sortKey="Pilatus, Ulrich" sort="Pilatus, Ulrich" uniqKey="Pilatus U" first="Ulrich" last="Pilatus">Ulrich Pilatus</name>
</author>
<author><name sortKey="Magerkurth, Jorg" sort="Magerkurth, Jorg" uniqKey="Magerkurth J" first="Jörg" last="Magerkurth">Jörg Magerkurth</name>
</author>
<author><name sortKey="Niklowitz, Petra" sort="Niklowitz, Petra" uniqKey="Niklowitz P" first="Petra" last="Niklowitz">Petra Niklowitz</name>
</author>
<author><name sortKey="Eggert, Karla M" sort="Eggert, Karla M" uniqKey="Eggert K" first="Karla M." last="Eggert">Karla M. Eggert</name>
</author>
<author><name sortKey="Krisp, Andrea" sort="Krisp, Andrea" uniqKey="Krisp A" first="Andrea" last="Krisp">Andrea Krisp</name>
</author>
<author><name sortKey="Menke, Thomas" sort="Menke, Thomas" uniqKey="Menke T" first="Thomas" last="Menke">Thomas Menke</name>
</author>
<author><name sortKey="Schade Rittinger, Carmen" sort="Schade Rittinger, Carmen" uniqKey="Schade Rittinger C" first="Carmen" last="Schade-Brittinger">Carmen Schade-Brittinger</name>
</author>
<author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name>
</author>
<author><name sortKey="Hoglinger, Gunter U" sort="Hoglinger, Gunter U" uniqKey="Hoglinger G" first="Günter U." last="Höglinger">Günter U. Höglinger</name>
</author>
</titleStmt>
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<idno type="RBID">ISTEX:FE411EB6419C546541B9B6910C430C9F66C6F4D4</idno>
<date when="2008" year="2008">2008</date>
<idno type="doi">10.1002/mds.22023</idno>
<idno type="url">https://api.istex.fr/document/FE411EB6419C546541B9B6910C430C9F66C6F4D4/fulltext/pdf</idno>
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<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:18464278</idno>
<idno type="wicri:Area/PubMed/Corpus">002229</idno>
<idno type="wicri:Area/PubMed/Curation">002229</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002086</idno>
<idno type="wicri:Area/Ncbi/Merge">002132</idno>
<idno type="wicri:Area/Ncbi/Curation">002132</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002132</idno>
<idno type="wicri:Area/Main/Merge">003209</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Short‐term effects of coenzyme Q10 in progressive supranuclear palsy: A randomized, placebo‐controlled trial</title>
<author><name sortKey="Stamelou, Maria" sort="Stamelou, Maria" uniqKey="Stamelou M" first="Maria" last="Stamelou">Maria Stamelou</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Reuss, Alexander" sort="Reuss, Alexander" uniqKey="Reuss A" first="Alexander" last="Reuss">Alexander Reuss</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center for Clinical Trials, Philipps University, Marburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pilatus, Ulrich" sort="Pilatus, Ulrich" uniqKey="Pilatus U" first="Ulrich" last="Pilatus">Ulrich Pilatus</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Brain Imaging Center and Institute of Neuroradiology, J.W. Goethe University, Frankfurt</wicri:regionArea>
<wicri:noRegion>Frankfurt</wicri:noRegion>
<wicri:noRegion>Frankfurt</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Magerkurth, Jorg" sort="Magerkurth, Jorg" uniqKey="Magerkurth J" first="Jörg" last="Magerkurth">Jörg Magerkurth</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Brain Imaging Center and Institute of Neuroradiology, J.W. Goethe University, Frankfurt</wicri:regionArea>
<wicri:noRegion>Frankfurt</wicri:noRegion>
<wicri:noRegion>Frankfurt</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Niklowitz, Petra" sort="Niklowitz, Petra" uniqKey="Niklowitz P" first="Petra" last="Niklowitz">Petra Niklowitz</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Children's Hospital Datteln, Witten‐Herdecke University</wicri:regionArea>
<wicri:noRegion>Witten‐Herdecke University</wicri:noRegion>
<wicri:noRegion>Witten‐Herdecke University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Eggert, Karla M" sort="Eggert, Karla M" uniqKey="Eggert K" first="Karla M." last="Eggert">Karla M. Eggert</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Krisp, Andrea" sort="Krisp, Andrea" uniqKey="Krisp A" first="Andrea" last="Krisp">Andrea Krisp</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Menke, Thomas" sort="Menke, Thomas" uniqKey="Menke T" first="Thomas" last="Menke">Thomas Menke</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Children's Hospital Datteln, Witten‐Herdecke University</wicri:regionArea>
<wicri:noRegion>Witten‐Herdecke University</wicri:noRegion>
<wicri:noRegion>Witten‐Herdecke University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schade Rittinger, Carmen" sort="Schade Rittinger, Carmen" uniqKey="Schade Rittinger C" first="Carmen" last="Schade-Brittinger">Carmen Schade-Brittinger</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center for Clinical Trials, Philipps University, Marburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hoglinger, Gunter U" sort="Hoglinger, Gunter U" uniqKey="Hoglinger G" first="Günter U." last="Höglinger">Günter U. Höglinger</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2008-05-15">2008-05-15</date>
<biblScope unit="vol">23</biblScope>
<biblScope unit="issue">7</biblScope>
<biblScope unit="page" from="942">942</biblScope>
<biblScope unit="page" to="949">949</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">FE411EB6419C546541B9B6910C430C9F66C6F4D4</idno>
<idno type="DOI">10.1002/mds.22023</idno>
<idno type="ArticleID">MDS22023</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Basal Ganglia (drug effects)</term>
<term>Basal Ganglia (metabolism)</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Humans</term>
<term>Magnetic Resonance Spectroscopy</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neuroprotective Agents (pharmacology)</term>
<term>Neuroprotective Agents (therapeutic use)</term>
<term>Supranuclear Palsy, Progressive (drug therapy)</term>
<term>Ubiquinone (analogs & derivatives)</term>
<term>Ubiquinone (pharmacology)</term>
<term>Ubiquinone (therapeutic use)</term>
<term>coenzyme Q10</term>
<term>energy metabolism</term>
<term>magnetic resonance spectroscopy</term>
<term>progressive supranuclear palsy</term>
<term>randomized controlled clinical trial (CONSORT statement)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Ubiquinone</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Neuroprotective Agents</term>
<term>Ubiquinone</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Basal Ganglia</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Supranuclear Palsy, Progressive</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Basal Ganglia</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Neuroprotective Agents</term>
<term>Ubiquinone</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Humans</term>
<term>Magnetic Resonance Spectroscopy</term>
<term>Male</term>
<term>Middle Aged</term>
</keywords>
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<langUsage><language ident="en">en</language>
</langUsage>
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<front><div type="abstract" xml:lang="en">Mitochondrial complex I appears to be dysfunctional in progressive supranuclear palsy (PSP). Coenzyme Q10 (CoQ10) is a physiological cofactor of complex I. Therefore, we evaluated the short‐term effects of CoQ10 in PSP. We performed a double‐blind, randomized, placebo‐controlled, phase II trial, including 21 clinically probable PSP patients (stage ≤ III) to receive a liquid nanodispersion of CoQ10 (5 mg/kg/day) or matching placebo. Over a 6‐week period, we determined the change in CoQ10 serum concentration, cerebral energy metabolites (by 31P‐ and 1H‐magnetic resonance spectroscopy), motor and neuropsychological dysfunction (PSP rating scale, UPDRS III, Hoehn and Yahr stage, Frontal Assessment Battery, Mini Mental Status Examination, Montgomery Åsberg Depression Scale). CoQ10 was safe and well tolerated. In patients receiving CoQ10 compared to placebo, the concentration of low‐energy phosphates (adenosine‐diphosphate, unphosphorylated creatine) decreased. Consequently, the ratio of high‐energy phosphates to low‐energy phosphates (adenosine‐triphosphate to adenosine‐diphosphate, phospho‐creatine to unphosphorylated creatine) increased. These changes were significant in the occipital lobe and showed a consistent trend in the basal ganglia. Clinically, the PSP rating scale and the Frontal Assessment Battery improved slightly, but significantly, upon CoQ10 treatment compared to placebo. Since CoQ10 appears to improve cerebral energy metabolism in PSP, long‐term treatment might have a disease‐modifying, neuroprotective effect. © 2008 Movement Disorder Society</div>
</front>
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