MovDisordV3, Main, Curation, bibRecord, 002631

Short‐term effects of coenzyme Q10 in progressive supranuclear palsy: A randomized, placebo‐controlled trial

Identifieur interne : 002631 ( Main/Curation ); précédent : 002630; suivant : 002632

Short‐term effects of coenzyme Q10 in progressive supranuclear palsy: A randomized, placebo‐controlled trial

Auteurs : Maria Stamelou [Allemagne] ; Alexander Reuss [Allemagne] ; Ulrich Pilatus [Allemagne] ; Jörg Magerkurth [Allemagne] ; Petra Niklowitz [Allemagne] ; Karla M. Eggert [Allemagne] ; Andrea Krisp [Allemagne] ; Thomas Menke [Allemagne] ; Carmen Schade-Brittinger [Allemagne] ; Wolfgang H. Oertel [Allemagne] ; Günter U. Höglinger [Allemagne]

Source :

Movement Disorders [ 0885-3185 ] ; 2008-05-15.

RBID : ISTEX:FE411EB6419C546541B9B6910C430C9F66C6F4D4

Descripteurs français

Pascal (Inist)
- Court terme, Essai clinique, Métabolisme énergétique, Pathologie du système nerveux, Placebo, Spectrométrie RMN.

English descriptors

KwdEn :
- Adult, Aged, Basal Ganglia (drug effects), Basal Ganglia (metabolism), Clinical trial, Double-Blind Method, Energy metabolism, Female, Humans, Magnetic Resonance Spectroscopy, Male, Middle Aged, NMR spectrometry, Nervous system diseases, Neuroprotective Agents (pharmacology), Neuroprotective Agents (therapeutic use), Placebo, Short term, Supranuclear Palsy, Progressive (drug therapy), Ubiquinone (analogs & derivatives), Ubiquinone (pharmacology), Ubiquinone (therapeutic use), coenzyme Q10, energy metabolism, magnetic resonance spectroscopy, progressive supranuclear palsy, randomized controlled clinical trial (CONSORT statement).
MESH :
- chemical , analogs & derivatives : Ubiquinone.
- chemical , pharmacology : Neuroprotective Agents, Ubiquinone.
- drug effects : Basal Ganglia.
- drug therapy : Supranuclear Palsy, Progressive.
- metabolism : Basal Ganglia.
- chemical , therapeutic use : Neuroprotective Agents, Ubiquinone.
- Adult, Aged, Double-Blind Method, Female, Humans, Magnetic Resonance Spectroscopy, Male, Middle Aged.

Abstract

Mitochondrial complex I appears to be dysfunctional in progressive supranuclear palsy (PSP). Coenzyme Q10 (CoQ10) is a physiological cofactor of complex I. Therefore, we evaluated the short‐term effects of CoQ10 in PSP. We performed a double‐blind, randomized, placebo‐controlled, phase II trial, including 21 clinically probable PSP patients (stage ≤ III) to receive a liquid nanodispersion of CoQ10 (5 mg/kg/day) or matching placebo. Over a 6‐week period, we determined the change in CoQ10 serum concentration, cerebral energy metabolites (by 31P‐ and 1H‐magnetic resonance spectroscopy), motor and neuropsychological dysfunction (PSP rating scale, UPDRS III, Hoehn and Yahr stage, Frontal Assessment Battery, Mini Mental Status Examination, Montgomery Åsberg Depression Scale). CoQ10 was safe and well tolerated. In patients receiving CoQ10 compared to placebo, the concentration of low‐energy phosphates (adenosine‐diphosphate, unphosphorylated creatine) decreased. Consequently, the ratio of high‐energy phosphates to low‐energy phosphates (adenosine‐triphosphate to adenosine‐diphosphate, phospho‐creatine to unphosphorylated creatine) increased. These changes were significant in the occipital lobe and showed a consistent trend in the basal ganglia. Clinically, the PSP rating scale and the Frontal Assessment Battery improved slightly, but significantly, upon CoQ10 treatment compared to placebo. Since CoQ10 appears to improve cerebral energy metabolism in PSP, long‐term treatment might have a disease‐modifying, neuroprotective effect. © 2008 Movement Disorder Society

Url:

https://api.istex.fr/document/FE411EB6419C546541B9B6910C430C9F66C6F4D4/fulltext/pdf

DOI: 10.1002/mds.22023

Links toward previous steps (curation, corpus...)

to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001338
to stream Istex, to step Curation: Pour aller vers cette notice dans l'étape Curation :001338
to stream Istex, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001187
to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002229
to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :002229
to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :002086
to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :002132
to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :002132
to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :002132
to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :003209
to stream PascalFrancis, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001231
to stream PascalFrancis, to step Curation: Pour aller vers cette notice dans l'étape Curation :001A88
to stream PascalFrancis, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001095
to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :003703

Links to Exploration step

ISTEX:FE411EB6419C546541B9B6910C430C9F66C6F4D4

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Short‐term effects of coenzyme Q10 in progressive supranuclear palsy: A randomized, placebo‐controlled trial</title>
<author><name sortKey="Stamelou, Maria" sort="Stamelou, Maria" uniqKey="Stamelou M" first="Maria" last="Stamelou">Maria Stamelou</name>
</author>
<author><name sortKey="Reuss, Alexander" sort="Reuss, Alexander" uniqKey="Reuss A" first="Alexander" last="Reuss">Alexander Reuss</name>
</author>
<author><name sortKey="Pilatus, Ulrich" sort="Pilatus, Ulrich" uniqKey="Pilatus U" first="Ulrich" last="Pilatus">Ulrich Pilatus</name>
</author>
<author><name sortKey="Magerkurth, Jorg" sort="Magerkurth, Jorg" uniqKey="Magerkurth J" first="Jörg" last="Magerkurth">Jörg Magerkurth</name>
</author>
<author><name sortKey="Niklowitz, Petra" sort="Niklowitz, Petra" uniqKey="Niklowitz P" first="Petra" last="Niklowitz">Petra Niklowitz</name>
</author>
<author><name sortKey="Eggert, Karla M" sort="Eggert, Karla M" uniqKey="Eggert K" first="Karla M." last="Eggert">Karla M. Eggert</name>
</author>
<author><name sortKey="Krisp, Andrea" sort="Krisp, Andrea" uniqKey="Krisp A" first="Andrea" last="Krisp">Andrea Krisp</name>
</author>
<author><name sortKey="Menke, Thomas" sort="Menke, Thomas" uniqKey="Menke T" first="Thomas" last="Menke">Thomas Menke</name>
</author>
<author><name sortKey="Schade Rittinger, Carmen" sort="Schade Rittinger, Carmen" uniqKey="Schade Rittinger C" first="Carmen" last="Schade-Brittinger">Carmen Schade-Brittinger</name>
</author>
<author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name>
</author>
<author><name sortKey="Hoglinger, Gunter U" sort="Hoglinger, Gunter U" uniqKey="Hoglinger G" first="Günter U." last="Höglinger">Günter U. Höglinger</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:FE411EB6419C546541B9B6910C430C9F66C6F4D4</idno>
<date when="2008" year="2008">2008</date>
<idno type="doi">10.1002/mds.22023</idno>
<idno type="url">https://api.istex.fr/document/FE411EB6419C546541B9B6910C430C9F66C6F4D4/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001338</idno>
<idno type="wicri:Area/Istex/Curation">001338</idno>
<idno type="wicri:Area/Istex/Checkpoint">001187</idno>
<idno type="wicri:doubleKey">0885-3185:2008:Stamelou M:short:term:effects</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:18464278</idno>
<idno type="wicri:Area/PubMed/Corpus">002229</idno>
<idno type="wicri:Area/PubMed/Curation">002229</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002086</idno>
<idno type="wicri:Area/Ncbi/Merge">002132</idno>
<idno type="wicri:Area/Ncbi/Curation">002132</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002132</idno>
<idno type="wicri:Area/Main/Merge">003209</idno>
<idno type="wicri:source">INIST</idno>
<idno type="RBID">Pascal:08-0305151</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001231</idno>
<idno type="wicri:Area/PascalFrancis/Curation">001A88</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">001095</idno>
<idno type="wicri:doubleKey">0885-3185:2008:Stamelou M:short:term:effects</idno>
<idno type="wicri:Area/Main/Merge">003703</idno>
<idno type="wicri:Area/Main/Curation">002631</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Short‐term effects of coenzyme Q10 in progressive supranuclear palsy: A randomized, placebo‐controlled trial</title>
<author><name sortKey="Stamelou, Maria" sort="Stamelou, Maria" uniqKey="Stamelou M" first="Maria" last="Stamelou">Maria Stamelou</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Reuss, Alexander" sort="Reuss, Alexander" uniqKey="Reuss A" first="Alexander" last="Reuss">Alexander Reuss</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center for Clinical Trials, Philipps University, Marburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pilatus, Ulrich" sort="Pilatus, Ulrich" uniqKey="Pilatus U" first="Ulrich" last="Pilatus">Ulrich Pilatus</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Brain Imaging Center and Institute of Neuroradiology, J.W. Goethe University, Frankfurt</wicri:regionArea>
<wicri:noRegion>Frankfurt</wicri:noRegion>
<wicri:noRegion>Frankfurt</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Magerkurth, Jorg" sort="Magerkurth, Jorg" uniqKey="Magerkurth J" first="Jörg" last="Magerkurth">Jörg Magerkurth</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Brain Imaging Center and Institute of Neuroradiology, J.W. Goethe University, Frankfurt</wicri:regionArea>
<wicri:noRegion>Frankfurt</wicri:noRegion>
<wicri:noRegion>Frankfurt</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Niklowitz, Petra" sort="Niklowitz, Petra" uniqKey="Niklowitz P" first="Petra" last="Niklowitz">Petra Niklowitz</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Children's Hospital Datteln, Witten‐Herdecke University</wicri:regionArea>
<wicri:noRegion>Witten‐Herdecke University</wicri:noRegion>
<wicri:noRegion>Witten‐Herdecke University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Eggert, Karla M" sort="Eggert, Karla M" uniqKey="Eggert K" first="Karla M." last="Eggert">Karla M. Eggert</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Krisp, Andrea" sort="Krisp, Andrea" uniqKey="Krisp A" first="Andrea" last="Krisp">Andrea Krisp</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Menke, Thomas" sort="Menke, Thomas" uniqKey="Menke T" first="Thomas" last="Menke">Thomas Menke</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Children's Hospital Datteln, Witten‐Herdecke University</wicri:regionArea>
<wicri:noRegion>Witten‐Herdecke University</wicri:noRegion>
<wicri:noRegion>Witten‐Herdecke University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schade Rittinger, Carmen" sort="Schade Rittinger, Carmen" uniqKey="Schade Rittinger C" first="Carmen" last="Schade-Brittinger">Carmen Schade-Brittinger</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center for Clinical Trials, Philipps University, Marburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hoglinger, Gunter U" sort="Hoglinger, Gunter U" uniqKey="Hoglinger G" first="Günter U." last="Höglinger">Günter U. Höglinger</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2008-05-15">2008-05-15</date>
<biblScope unit="vol">23</biblScope>
<biblScope unit="issue">7</biblScope>
<biblScope unit="page" from="942">942</biblScope>
<biblScope unit="page" to="949">949</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">FE411EB6419C546541B9B6910C430C9F66C6F4D4</idno>
<idno type="DOI">10.1002/mds.22023</idno>
<idno type="ArticleID">MDS22023</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Basal Ganglia (drug effects)</term>
<term>Basal Ganglia (metabolism)</term>
<term>Clinical trial</term>
<term>Double-Blind Method</term>
<term>Energy metabolism</term>
<term>Female</term>
<term>Humans</term>
<term>Magnetic Resonance Spectroscopy</term>
<term>Male</term>
<term>Middle Aged</term>
<term>NMR spectrometry</term>
<term>Nervous system diseases</term>
<term>Neuroprotective Agents (pharmacology)</term>
<term>Neuroprotective Agents (therapeutic use)</term>
<term>Placebo</term>
<term>Short term</term>
<term>Supranuclear Palsy, Progressive (drug therapy)</term>
<term>Ubiquinone (analogs & derivatives)</term>
<term>Ubiquinone (pharmacology)</term>
<term>Ubiquinone (therapeutic use)</term>
<term>coenzyme Q10</term>
<term>energy metabolism</term>
<term>magnetic resonance spectroscopy</term>
<term>progressive supranuclear palsy</term>
<term>randomized controlled clinical trial (CONSORT statement)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Ubiquinone</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Neuroprotective Agents</term>
<term>Ubiquinone</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Basal Ganglia</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Supranuclear Palsy, Progressive</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Basal Ganglia</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Neuroprotective Agents</term>
<term>Ubiquinone</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Humans</term>
<term>Magnetic Resonance Spectroscopy</term>
<term>Male</term>
<term>Middle Aged</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Court terme</term>
<term>Essai clinique</term>
<term>Métabolisme énergétique</term>
<term>Pathologie du   système nerveux</term>
<term>Placebo</term>
<term>Spectrométrie RMN</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Mitochondrial complex I appears to be dysfunctional in progressive supranuclear palsy (PSP). Coenzyme Q10 (CoQ10) is a physiological cofactor of complex I. Therefore, we evaluated the short‐term effects of CoQ10 in PSP. We performed a double‐blind, randomized, placebo‐controlled, phase II trial, including 21 clinically probable PSP patients (stage ≤ III) to receive a liquid nanodispersion of CoQ10 (5 mg/kg/day) or matching placebo. Over a 6‐week period, we determined the change in CoQ10 serum concentration, cerebral energy metabolites (by 31P‐ and 1H‐magnetic resonance spectroscopy), motor and neuropsychological dysfunction (PSP rating scale, UPDRS III, Hoehn and Yahr stage, Frontal Assessment Battery, Mini Mental Status Examination, Montgomery Åsberg Depression Scale). CoQ10 was safe and well tolerated. In patients receiving CoQ10 compared to placebo, the concentration of low‐energy phosphates (adenosine‐diphosphate, unphosphorylated creatine) decreased. Consequently, the ratio of high‐energy phosphates to low‐energy phosphates (adenosine‐triphosphate to adenosine‐diphosphate, phospho‐creatine to unphosphorylated creatine) increased. These changes were significant in the occipital lobe and showed a consistent trend in the basal ganglia. Clinically, the PSP rating scale and the Frontal Assessment Battery improved slightly, but significantly, upon CoQ10 treatment compared to placebo. Since CoQ10 appears to improve cerebral energy metabolism in PSP, long‐term treatment might have a disease‐modifying, neuroprotective effect. © 2008 Movement Disorder Society</div>
</front>
</TEI>
<double idat="0885-3185:2008:Stamelou M:short:term:effects"><INIST><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Short-Term Effects of Coenzyme Q<sub>10</sub>
 in Progressive Supranuclear Palsy : A Randomized, Placebo-Controlled Trial</title>
<author><name sortKey="Stamelou, Maria" sort="Stamelou, Maria" uniqKey="Stamelou M" first="Maria" last="Stamelou">Maria Stamelou</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Philipps University</s1>
<s2>Marburg</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Reuss, Alexander" sort="Reuss, Alexander" uniqKey="Reuss A" first="Alexander" last="Reuss">Alexander Reuss</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Center for Clinical Trials, Philipps University</s1>
<s2>Marburg</s2>
<s3>DEU</s3>
<sZ>2 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pilatus, Ulrich" sort="Pilatus, Ulrich" uniqKey="Pilatus U" first="Ulrich" last="Pilatus">Ulrich Pilatus</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Brain Imaging Center and Institute of Neuroradiology, J.W. Goethe University</s1>
<s2>Frankfurt</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Frankfurt</wicri:noRegion>
<wicri:noRegion>J.W. Goethe University</wicri:noRegion>
<wicri:noRegion>Frankfurt</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Magerkurth, Jorg" sort="Magerkurth, Jorg" uniqKey="Magerkurth J" first="Jörg" last="Magerkurth">Jörg Magerkurth</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Brain Imaging Center and Institute of Neuroradiology, J.W. Goethe University</s1>
<s2>Frankfurt</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Frankfurt</wicri:noRegion>
<wicri:noRegion>J.W. Goethe University</wicri:noRegion>
<wicri:noRegion>Frankfurt</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Niklowitz, Petra" sort="Niklowitz, Petra" uniqKey="Niklowitz P" first="Petra" last="Niklowitz">Petra Niklowitz</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Children's Hospital Datteln, Witten-Herdecke University</s1>
<s3>DEU</s3>
<sZ>5 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Witten-Herdecke University</wicri:noRegion>
<wicri:noRegion>Children's Hospital Datteln, Witten-Herdecke University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Eggert, Karla M" sort="Eggert, Karla M" uniqKey="Eggert K" first="Karla M." last="Eggert">Karla M. Eggert</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Philipps University</s1>
<s2>Marburg</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Krisp, Andrea" sort="Krisp, Andrea" uniqKey="Krisp A" first="Andrea" last="Krisp">Andrea Krisp</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Philipps University</s1>
<s2>Marburg</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Menke, Thomas" sort="Menke, Thomas" uniqKey="Menke T" first="Thomas" last="Menke">Thomas Menke</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Children's Hospital Datteln, Witten-Herdecke University</s1>
<s3>DEU</s3>
<sZ>5 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Witten-Herdecke University</wicri:noRegion>
<wicri:noRegion>Children's Hospital Datteln, Witten-Herdecke University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schade Brittinger, Carmen" sort="Schade Brittinger, Carmen" uniqKey="Schade Brittinger C" first="Carmen" last="Schade-Brittinger">Carmen Schade-Brittinger</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Center for Clinical Trials, Philipps University</s1>
<s2>Marburg</s2>
<s3>DEU</s3>
<sZ>2 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Philipps University</s1>
<s2>Marburg</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hoglinger, Gunter U" sort="Hoglinger, Gunter U" uniqKey="Hoglinger G" first="Günter U." last="Höglinger">Günter U. Höglinger</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Philipps University</s1>
<s2>Marburg</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">08-0305151</idno>
<date when="2008">2008</date>
<idno type="stanalyst">PASCAL 08-0305151 INIST</idno>
<idno type="RBID">Pascal:08-0305151</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001231</idno>
<idno type="wicri:Area/PascalFrancis/Curation">001A88</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">001095</idno>
<idno type="wicri:doubleKey">0885-3185:2008:Stamelou M:short:term:effects</idno>
<idno type="wicri:Area/Main/Merge">003703</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Short-Term Effects of Coenzyme Q<sub>10</sub>
 in Progressive Supranuclear Palsy : A Randomized, Placebo-Controlled Trial</title>
<author><name sortKey="Stamelou, Maria" sort="Stamelou, Maria" uniqKey="Stamelou M" first="Maria" last="Stamelou">Maria Stamelou</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Philipps University</s1>
<s2>Marburg</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Reuss, Alexander" sort="Reuss, Alexander" uniqKey="Reuss A" first="Alexander" last="Reuss">Alexander Reuss</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Center for Clinical Trials, Philipps University</s1>
<s2>Marburg</s2>
<s3>DEU</s3>
<sZ>2 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pilatus, Ulrich" sort="Pilatus, Ulrich" uniqKey="Pilatus U" first="Ulrich" last="Pilatus">Ulrich Pilatus</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Brain Imaging Center and Institute of Neuroradiology, J.W. Goethe University</s1>
<s2>Frankfurt</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Frankfurt</wicri:noRegion>
<wicri:noRegion>J.W. Goethe University</wicri:noRegion>
<wicri:noRegion>Frankfurt</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Magerkurth, Jorg" sort="Magerkurth, Jorg" uniqKey="Magerkurth J" first="Jörg" last="Magerkurth">Jörg Magerkurth</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Brain Imaging Center and Institute of Neuroradiology, J.W. Goethe University</s1>
<s2>Frankfurt</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Frankfurt</wicri:noRegion>
<wicri:noRegion>J.W. Goethe University</wicri:noRegion>
<wicri:noRegion>Frankfurt</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Niklowitz, Petra" sort="Niklowitz, Petra" uniqKey="Niklowitz P" first="Petra" last="Niklowitz">Petra Niklowitz</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Children's Hospital Datteln, Witten-Herdecke University</s1>
<s3>DEU</s3>
<sZ>5 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Witten-Herdecke University</wicri:noRegion>
<wicri:noRegion>Children's Hospital Datteln, Witten-Herdecke University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Eggert, Karla M" sort="Eggert, Karla M" uniqKey="Eggert K" first="Karla M." last="Eggert">Karla M. Eggert</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Philipps University</s1>
<s2>Marburg</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Krisp, Andrea" sort="Krisp, Andrea" uniqKey="Krisp A" first="Andrea" last="Krisp">Andrea Krisp</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Philipps University</s1>
<s2>Marburg</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Menke, Thomas" sort="Menke, Thomas" uniqKey="Menke T" first="Thomas" last="Menke">Thomas Menke</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Children's Hospital Datteln, Witten-Herdecke University</s1>
<s3>DEU</s3>
<sZ>5 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Witten-Herdecke University</wicri:noRegion>
<wicri:noRegion>Children's Hospital Datteln, Witten-Herdecke University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schade Brittinger, Carmen" sort="Schade Brittinger, Carmen" uniqKey="Schade Brittinger C" first="Carmen" last="Schade-Brittinger">Carmen Schade-Brittinger</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Center for Clinical Trials, Philipps University</s1>
<s2>Marburg</s2>
<s3>DEU</s3>
<sZ>2 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Philipps University</s1>
<s2>Marburg</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hoglinger, Gunter U" sort="Hoglinger, Gunter U" uniqKey="Hoglinger G" first="Günter U." last="Höglinger">Günter U. Höglinger</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Philipps University</s1>
<s2>Marburg</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2008">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Clinical trial</term>
<term>Energy metabolism</term>
<term>NMR spectrometry</term>
<term>Nervous system diseases</term>
<term>Placebo</term>
<term>Short term</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Pathologie du   système nerveux</term>
<term>Court terme</term>
<term>Placebo</term>
<term>Métabolisme énergétique</term>
<term>Spectrométrie RMN</term>
<term>Essai clinique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Mitochondrial complex I appears to be dysfunctional in progressive supranuclear palsy (PSP). Coenzyme Q<sub>10</sub>
 (CoQ<sub>10</sub>
) is a physiological cofactor of complex I. Therefore, we evaluated the short-term effects of CoQ<sub>10</sub>
 in PSP. We performed a double-blind, randomized, placebo-controlled, phase II trial, including 21 clinically probable PSP patients (stage < III) to receive a liquid nanodispersion of CoQ<sub>10</sub>
 (5 mg/kg/day) or matching placebo. Over a 6-week period, we determined the change in CoQ<sub>10</sub>
 serum concentration, cerebral energy metabolites (by <sup>31</sup>
P- and <sup>1</sup>
H-magnetic resonance spectroscopy), motor and neuropsychological dysfunction (PSP rating scale, UPDRS III, Hoehn and Yahr stage, Frontal Assessment Battery, Mini Mental Status Examination, Montgomery Åsberg Depression Scale). CoQ<sub>10</sub>
 was safe and well tolerated. In patients receiving CoQ<sub>10</sub>
 compared to placebo, the concentration of low-energy phosphates (adenosine-diphosphate, unphosphorylated creatine) decreased. Consequently, the ratio of high-energy phosphates to low-energy phosphates (adenosine-triphosphate to adenosine-diphosphate, phospho-creatine to unphosphorylated creatine) increased. These changes were significant in the occipital lobe and showed a consistent trend in the basal ganglia. Clinically, the PSP rating scale and the Frontal Assessment Battery improved slightly, but significantly, upon CoQ<sub>10</sub>
 treatment compared to placebo. Since CoQ<sub>10</sub>
 appears to improve cerebral energy metabolism in PSP, long-term treatment might have a disease-modifying, neuroprotective effect.</div>
</front>
</TEI>
</INIST>
<ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Short‐term effects of coenzyme Q10 in progressive supranuclear palsy: A randomized, placebo‐controlled trial</title>
<author><name sortKey="Stamelou, Maria" sort="Stamelou, Maria" uniqKey="Stamelou M" first="Maria" last="Stamelou">Maria Stamelou</name>
</author>
<author><name sortKey="Reuss, Alexander" sort="Reuss, Alexander" uniqKey="Reuss A" first="Alexander" last="Reuss">Alexander Reuss</name>
</author>
<author><name sortKey="Pilatus, Ulrich" sort="Pilatus, Ulrich" uniqKey="Pilatus U" first="Ulrich" last="Pilatus">Ulrich Pilatus</name>
</author>
<author><name sortKey="Magerkurth, Jorg" sort="Magerkurth, Jorg" uniqKey="Magerkurth J" first="Jörg" last="Magerkurth">Jörg Magerkurth</name>
</author>
<author><name sortKey="Niklowitz, Petra" sort="Niklowitz, Petra" uniqKey="Niklowitz P" first="Petra" last="Niklowitz">Petra Niklowitz</name>
</author>
<author><name sortKey="Eggert, Karla M" sort="Eggert, Karla M" uniqKey="Eggert K" first="Karla M." last="Eggert">Karla M. Eggert</name>
</author>
<author><name sortKey="Krisp, Andrea" sort="Krisp, Andrea" uniqKey="Krisp A" first="Andrea" last="Krisp">Andrea Krisp</name>
</author>
<author><name sortKey="Menke, Thomas" sort="Menke, Thomas" uniqKey="Menke T" first="Thomas" last="Menke">Thomas Menke</name>
</author>
<author><name sortKey="Schade Rittinger, Carmen" sort="Schade Rittinger, Carmen" uniqKey="Schade Rittinger C" first="Carmen" last="Schade-Brittinger">Carmen Schade-Brittinger</name>
</author>
<author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name>
</author>
<author><name sortKey="Hoglinger, Gunter U" sort="Hoglinger, Gunter U" uniqKey="Hoglinger G" first="Günter U." last="Höglinger">Günter U. Höglinger</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:FE411EB6419C546541B9B6910C430C9F66C6F4D4</idno>
<date when="2008" year="2008">2008</date>
<idno type="doi">10.1002/mds.22023</idno>
<idno type="url">https://api.istex.fr/document/FE411EB6419C546541B9B6910C430C9F66C6F4D4/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001338</idno>
<idno type="wicri:Area/Istex/Curation">001338</idno>
<idno type="wicri:Area/Istex/Checkpoint">001187</idno>
<idno type="wicri:doubleKey">0885-3185:2008:Stamelou M:short:term:effects</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:18464278</idno>
<idno type="wicri:Area/PubMed/Corpus">002229</idno>
<idno type="wicri:Area/PubMed/Curation">002229</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002086</idno>
<idno type="wicri:Area/Ncbi/Merge">002132</idno>
<idno type="wicri:Area/Ncbi/Curation">002132</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002132</idno>
<idno type="wicri:Area/Main/Merge">003209</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Short‐term effects of coenzyme Q10 in progressive supranuclear palsy: A randomized, placebo‐controlled trial</title>
<author><name sortKey="Stamelou, Maria" sort="Stamelou, Maria" uniqKey="Stamelou M" first="Maria" last="Stamelou">Maria Stamelou</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Reuss, Alexander" sort="Reuss, Alexander" uniqKey="Reuss A" first="Alexander" last="Reuss">Alexander Reuss</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center for Clinical Trials, Philipps University, Marburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pilatus, Ulrich" sort="Pilatus, Ulrich" uniqKey="Pilatus U" first="Ulrich" last="Pilatus">Ulrich Pilatus</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Brain Imaging Center and Institute of Neuroradiology, J.W. Goethe University, Frankfurt</wicri:regionArea>
<wicri:noRegion>Frankfurt</wicri:noRegion>
<wicri:noRegion>Frankfurt</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Magerkurth, Jorg" sort="Magerkurth, Jorg" uniqKey="Magerkurth J" first="Jörg" last="Magerkurth">Jörg Magerkurth</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Brain Imaging Center and Institute of Neuroradiology, J.W. Goethe University, Frankfurt</wicri:regionArea>
<wicri:noRegion>Frankfurt</wicri:noRegion>
<wicri:noRegion>Frankfurt</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Niklowitz, Petra" sort="Niklowitz, Petra" uniqKey="Niklowitz P" first="Petra" last="Niklowitz">Petra Niklowitz</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Children's Hospital Datteln, Witten‐Herdecke University</wicri:regionArea>
<wicri:noRegion>Witten‐Herdecke University</wicri:noRegion>
<wicri:noRegion>Witten‐Herdecke University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Eggert, Karla M" sort="Eggert, Karla M" uniqKey="Eggert K" first="Karla M." last="Eggert">Karla M. Eggert</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Krisp, Andrea" sort="Krisp, Andrea" uniqKey="Krisp A" first="Andrea" last="Krisp">Andrea Krisp</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Menke, Thomas" sort="Menke, Thomas" uniqKey="Menke T" first="Thomas" last="Menke">Thomas Menke</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Children's Hospital Datteln, Witten‐Herdecke University</wicri:regionArea>
<wicri:noRegion>Witten‐Herdecke University</wicri:noRegion>
<wicri:noRegion>Witten‐Herdecke University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schade Rittinger, Carmen" sort="Schade Rittinger, Carmen" uniqKey="Schade Rittinger C" first="Carmen" last="Schade-Brittinger">Carmen Schade-Brittinger</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center for Clinical Trials, Philipps University, Marburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hoglinger, Gunter U" sort="Hoglinger, Gunter U" uniqKey="Hoglinger G" first="Günter U." last="Höglinger">Günter U. Höglinger</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2008-05-15">2008-05-15</date>
<biblScope unit="vol">23</biblScope>
<biblScope unit="issue">7</biblScope>
<biblScope unit="page" from="942">942</biblScope>
<biblScope unit="page" to="949">949</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">FE411EB6419C546541B9B6910C430C9F66C6F4D4</idno>
<idno type="DOI">10.1002/mds.22023</idno>
<idno type="ArticleID">MDS22023</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Basal Ganglia (drug effects)</term>
<term>Basal Ganglia (metabolism)</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Humans</term>
<term>Magnetic Resonance Spectroscopy</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neuroprotective Agents (pharmacology)</term>
<term>Neuroprotective Agents (therapeutic use)</term>
<term>Supranuclear Palsy, Progressive (drug therapy)</term>
<term>Ubiquinone (analogs & derivatives)</term>
<term>Ubiquinone (pharmacology)</term>
<term>Ubiquinone (therapeutic use)</term>
<term>coenzyme Q10</term>
<term>energy metabolism</term>
<term>magnetic resonance spectroscopy</term>
<term>progressive supranuclear palsy</term>
<term>randomized controlled clinical trial (CONSORT statement)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Ubiquinone</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Neuroprotective Agents</term>
<term>Ubiquinone</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Basal Ganglia</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Supranuclear Palsy, Progressive</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Basal Ganglia</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Neuroprotective Agents</term>
<term>Ubiquinone</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Humans</term>
<term>Magnetic Resonance Spectroscopy</term>
<term>Male</term>
<term>Middle Aged</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Mitochondrial complex I appears to be dysfunctional in progressive supranuclear palsy (PSP). Coenzyme Q10 (CoQ10) is a physiological cofactor of complex I. Therefore, we evaluated the short‐term effects of CoQ10 in PSP. We performed a double‐blind, randomized, placebo‐controlled, phase II trial, including 21 clinically probable PSP patients (stage ≤ III) to receive a liquid nanodispersion of CoQ10 (5 mg/kg/day) or matching placebo. Over a 6‐week period, we determined the change in CoQ10 serum concentration, cerebral energy metabolites (by 31P‐ and 1H‐magnetic resonance spectroscopy), motor and neuropsychological dysfunction (PSP rating scale, UPDRS III, Hoehn and Yahr stage, Frontal Assessment Battery, Mini Mental Status Examination, Montgomery Åsberg Depression Scale). CoQ10 was safe and well tolerated. In patients receiving CoQ10 compared to placebo, the concentration of low‐energy phosphates (adenosine‐diphosphate, unphosphorylated creatine) decreased. Consequently, the ratio of high‐energy phosphates to low‐energy phosphates (adenosine‐triphosphate to adenosine‐diphosphate, phospho‐creatine to unphosphorylated creatine) increased. These changes were significant in the occipital lobe and showed a consistent trend in the basal ganglia. Clinically, the PSP rating scale and the Frontal Assessment Battery improved slightly, but significantly, upon CoQ10 treatment compared to placebo. Since CoQ10 appears to improve cerebral energy metabolism in PSP, long‐term treatment might have a disease‐modifying, neuroprotective effect. © 2008 Movement Disorder Society</div>
</front>
</TEI>
</ISTEX>
</double>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Curation

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002631 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 002631 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    Main
   |étape=   Curation
   |type=    RBID
   |clé=     ISTEX:FE411EB6419C546541B9B6910C430C9F66C6F4D4
   |texte=   Short‐term effects of coenzyme Q10 in progressive supranuclear palsy: A randomized, placebo‐controlled trial
}}

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Movement Disorders (revue)

Short‐term effects of coenzyme Q10 in progressive supranuclear palsy: A randomized, placebo‐controlled trial

Short‐term effects of coenzyme Q10 in progressive supranuclear palsy: A randomized, placebo‐controlled trial

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri