Cardiovascular risk factors in restless legs syndrome
Identifieur interne : 002415 ( Main/Curation ); précédent : 002414; suivant : 002416Cardiovascular risk factors in restless legs syndrome
Auteurs : Ilana Schlesinger [Israël] ; Ilana Erikh [Israël] ; Ophir Avizohar [Israël] ; Elliot Sprecher [Israël] ; David Yarnitsky [Israël]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-08-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Anemia (epidemiology), Anthropometry, BMI, Body Mass Index, Cardiovascular Diseases (epidemiology), Cardiovascular disease, Comorbidity, Cross-Sectional Studies, Female, Hematocrit, Humans, Hypercholesterolemia (epidemiology), Hyperglycemia (epidemiology), Hyperlipemia, Hypertension (epidemiology), Kidney Diseases (epidemiology), Lipids, Male, Middle Aged, Nervous system diseases, Physical Fitness, Prevalence, Questionnaires, Restless Legs Syndrome (blood), Restless Legs Syndrome (epidemiology), Restless legs syndrome, Risk Factors, Risk factor, Sex Distribution, Smoking (epidemiology), cardiovascular, hyperlipidemia, prevalence, restless legs syndrome.
- MESH :
- blood : Restless Legs Syndrome.
- epidemiology : Anemia, Cardiovascular Diseases, Hypercholesterolemia, Hyperglycemia, Hypertension, Kidney Diseases, Restless Legs Syndrome, Smoking.
- Anthropometry, Body Mass Index, Comorbidity, Cross-Sectional Studies, Female, Hematocrit, Humans, Male, Middle Aged, Physical Fitness, Questionnaires, Risk Factors, Sex Distribution.
Abstract
We conducted a population‐based cross‐sectional study to assess prevalence of cardiovascular risk factors in subjects with and without restless legs syndrome (RLS). Adults attending their annual checkup completed the International RLS Study Group questionnaire and underwent an interview by a neurologist. Data from the annual checkup were compared between subjects with and without RLS. The prevalence of RLS was 6.7% (95% CI 5.45–7.95) among 1,537 responders. RLS subjects' blood tests showed significantly higher fasting blood glucose level (P = 0.029), higher prevalence of hypercholesterolemia (P = 0.029) and reduced renal function (P = 0.013), and increased prevalence of low hematocrit (P = 0.008). RLS subjects weighed more (P = 0.029), had a higher BMI (P = 0.033), larger hip circumference (P = 0.033), and were less fit (P = 0.010). To control for interactions among statistical predictors, we also employed multivariate logistic regression models adjusted for age, gender, smoking, BMI, hemoglobin, glucose, HDL/LDL cholesterol, triglycerides, and creatinine. We found that female gender (OR 2.16; 95% CI 1.11–4.17), smoking (OR 1.82; 95% CI, 1.10–3.00), and HDL/LDL cholesterol (OR 0.18; 95% CI 0.034–0.90) were significantly associated with RLS compared with subjects without RLS. RLS was associated with cardiovascular risk factors. © 2009 Movement Disorder Society
Url:
DOI: 10.1002/mds.22486
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-08-15">2009-08-15</date><biblScope unit="vol">24</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1587">1587</biblScope><biblScope unit="page" to="1592">1592</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">718DA255A861341B421DE3F70EC55407E6AEDB86</idno><idno type="DOI">10.1002/mds.22486</idno><idno type="ArticleID">MDS22486</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anemia (epidemiology)</term><term>Anthropometry</term><term>BMI</term><term>Body Mass Index</term><term>Cardiovascular Diseases (epidemiology)</term><term>Cardiovascular disease</term><term>Comorbidity</term><term>Cross-Sectional Studies</term><term>Female</term><term>Hematocrit</term><term>Humans</term><term>Hypercholesterolemia (epidemiology)</term><term>Hyperglycemia (epidemiology)</term><term>Hyperlipemia</term><term>Hypertension (epidemiology)</term><term>Kidney Diseases (epidemiology)</term><term>Lipids</term><term>Male</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Physical Fitness</term><term>Prevalence</term><term>Questionnaires</term><term>Restless Legs Syndrome (blood)</term><term>Restless Legs Syndrome (epidemiology)</term><term>Restless legs syndrome</term><term>Risk Factors</term><term>Risk factor</term><term>Sex Distribution</term><term>Smoking (epidemiology)</term><term>cardiovascular</term><term>hyperlipidemia</term><term>prevalence</term><term>restless legs syndrome</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Anemia</term><term>Cardiovascular Diseases</term><term>Hypercholesterolemia</term><term>Hyperglycemia</term><term>Hypertension</term><term>Kidney Diseases</term><term>Restless Legs Syndrome</term><term>Smoking</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Anthropometry</term><term>Body Mass Index</term><term>Comorbidity</term><term>Cross-Sectional Studies</term><term>Female</term><term>Hematocrit</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Physical Fitness</term><term>Questionnaires</term><term>Risk Factors</term><term>Sex Distribution</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Facteur risque</term><term>Hyperlipémie</term><term>Lipide</term><term>Pathologie de l'appareil circulatoire</term><term>Pathologie du système nerveux</term><term>Prévalence</term><term>Syndrome des jambes sans repos</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We conducted a population‐based cross‐sectional study to assess prevalence of cardiovascular risk factors in subjects with and without restless legs syndrome (RLS). Adults attending their annual checkup completed the International RLS Study Group questionnaire and underwent an interview by a neurologist. Data from the annual checkup were compared between subjects with and without RLS. The prevalence of RLS was 6.7% (95% CI 5.45–7.95) among 1,537 responders. RLS subjects' blood tests showed significantly higher fasting blood glucose level (P = 0.029), higher prevalence of hypercholesterolemia (P = 0.029) and reduced renal function (P = 0.013), and increased prevalence of low hematocrit (P = 0.008). RLS subjects weighed more (P = 0.029), had a higher BMI (P = 0.033), larger hip circumference (P = 0.033), and were less fit (P = 0.010). To control for interactions among statistical predictors, we also employed multivariate logistic regression models adjusted for age, gender, smoking, BMI, hemoglobin, glucose, HDL/LDL cholesterol, triglycerides, and creatinine. We found that female gender (OR 2.16; 95% CI 1.11–4.17), smoking (OR 1.82; 95% CI, 1.10–3.00), and HDL/LDL cholesterol (OR 0.18; 95% CI 0.034–0.90) were significantly associated with RLS compared with subjects without RLS. RLS was associated with cardiovascular risk factors. © 2009 Movement Disorder Society</div></front></TEI><double idat="0885-3185:2009:Schlesinger I:cardiovascular:risk:factors"><INIST><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Cardiovascular Risk Factors in Restless Legs Syndrome</title><author><name sortKey="Schlesinger, Ilana" sort="Schlesinger, Ilana" uniqKey="Schlesinger I" first="Ilana" last="Schlesinger">Ilana Schlesinger</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Rambam Health Care Campus</s1><s2>Haifa</s2><s3>ISR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Israël</country><wicri:noRegion>Haifa</wicri:noRegion></affiliation></author><author><name sortKey="Erikh, Ilana" sort="Erikh, Ilana" uniqKey="Erikh I" first="Ilana" last="Erikh">Ilana Erikh</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Rambam Health Care Campus</s1><s2>Haifa</s2><s3>ISR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Israël</country><wicri:noRegion>Haifa</wicri:noRegion></affiliation></author><author><name sortKey="Avizohar, Ophir" sort="Avizohar, Ophir" uniqKey="Avizohar O" first="Ophir" last="Avizohar">Ophir Avizohar</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Ramham Center for Preventive Medicine, Rambam Health Care Campus</s1><s2>Haifa</s2><s3>ISR</s3><sZ>3 aut.</sZ></inist:fA14><country>Israël</country><wicri:noRegion>Haifa</wicri:noRegion></affiliation></author><author><name sortKey="Sprecher, Elliot" sort="Sprecher, Elliot" uniqKey="Sprecher E" first="Elliot" last="Sprecher">Elliot Sprecher</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Rambam Health Care Campus</s1><s2>Haifa</s2><s3>ISR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Israël</country><wicri:noRegion>Haifa</wicri:noRegion></affiliation></author><author><name sortKey="Yamitsky, David" sort="Yamitsky, David" uniqKey="Yamitsky D" first="David" last="Yamitsky">David Yamitsky</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, Rambam Health Care Campus, Technion Faculty of Medicine</s1><s2>Haifa</s2><s3>ISR</s3><sZ>5 aut.</sZ></inist:fA14><country>Israël</country><wicri:noRegion>Haifa</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">09-0386510</idno><date when="2009">2009</date><idno type="stanalyst">PASCAL 09-0386510 INIST</idno><idno type="RBID">Pascal:09-0386510</idno><idno type="wicri:Area/PascalFrancis/Corpus">000D89</idno><idno type="wicri:Area/PascalFrancis/Curation">001F30</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000F57</idno><idno type="wicri:doubleKey">0885-3185:2009:Schlesinger I:cardiovascular:risk:factors</idno><idno type="wicri:Area/Main/Merge">003054</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Cardiovascular Risk Factors in Restless Legs Syndrome</title><author><name sortKey="Schlesinger, Ilana" sort="Schlesinger, Ilana" uniqKey="Schlesinger I" first="Ilana" last="Schlesinger">Ilana Schlesinger</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Rambam Health Care Campus</s1><s2>Haifa</s2><s3>ISR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Israël</country><wicri:noRegion>Haifa</wicri:noRegion></affiliation></author><author><name sortKey="Erikh, Ilana" sort="Erikh, Ilana" uniqKey="Erikh I" first="Ilana" last="Erikh">Ilana Erikh</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Rambam Health Care Campus</s1><s2>Haifa</s2><s3>ISR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Israël</country><wicri:noRegion>Haifa</wicri:noRegion></affiliation></author><author><name sortKey="Avizohar, Ophir" sort="Avizohar, Ophir" uniqKey="Avizohar O" first="Ophir" last="Avizohar">Ophir Avizohar</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Ramham Center for Preventive Medicine, Rambam Health Care Campus</s1><s2>Haifa</s2><s3>ISR</s3><sZ>3 aut.</sZ></inist:fA14><country>Israël</country><wicri:noRegion>Haifa</wicri:noRegion></affiliation></author><author><name sortKey="Sprecher, Elliot" sort="Sprecher, Elliot" uniqKey="Sprecher E" first="Elliot" last="Sprecher">Elliot Sprecher</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Rambam Health Care Campus</s1><s2>Haifa</s2><s3>ISR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Israël</country><wicri:noRegion>Haifa</wicri:noRegion></affiliation></author><author><name sortKey="Yamitsky, David" sort="Yamitsky, David" uniqKey="Yamitsky D" first="David" last="Yamitsky">David Yamitsky</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, Rambam Health Care Campus, Technion Faculty of Medicine</s1><s2>Haifa</s2><s3>ISR</s3><sZ>5 aut.</sZ></inist:fA14><country>Israël</country><wicri:noRegion>Haifa</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cardiovascular disease</term><term>Hyperlipemia</term><term>Lipids</term><term>Nervous system diseases</term><term>Prevalence</term><term>Restless legs syndrome</term><term>Risk factor</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Pathologie de l'appareil circulatoire</term><term>Syndrome des jambes sans repos</term><term>Hyperlipémie</term><term>Pathologie du système nerveux</term><term>Facteur risque</term><term>Prévalence</term><term>Lipide</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We conducted a population-based cross-sectional study to assess prevalence of cardiovascular risk factors in subjects with and without restless legs syndrome (RLS). Adults attending their annual checkup completed the International RLS Study Group questionnaire and underwent an interview by a neurologist. Data from the annual checkup were compared between subjects with and without RLS. The prevalence of RLS was 6.7% (95% CI 5.45-7.95) among 1,537 responders. RLS subjects' blood tests showed significantly higher fasting blood glucose level (P = 0.029), higher prevalence of hyper-cholesterolemia (P = 0.029) and reduced renal function (P = 0.013), and increased prevalence of low hematocrit (P = 0.008). RLS subjects weighed more (P = 0.029), had a higher BMI (P = 0.033), larger hip circumference (P = 0.033), and were less fit (P = 0.010). To control for interactions among statistical predictors, we also employed multivariate logistic regression models adjusted for age, gender, smoking, BMI, hemoglobin, glucose, HDL/LDL cholesterol, triglycerides, and creatinine. We found that female gender (OR 2.16; 95% CI 1.11-4.17), smoking (OR 1.82; 95% CI, 1.10-3.00), and HDL/ LDL cholesterol (OR 0.18; 95% CI 0.034-0.90) were significantly associated with RLS compared with subjects without RLS. RLS was associated with cardiovascular risk factors.</div></front></TEI></INIST><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cardiovascular risk factors in restless legs syndrome</title><author><name sortKey="Schlesinger, Ilana" sort="Schlesinger, Ilana" uniqKey="Schlesinger I" first="Ilana" last="Schlesinger">Ilana Schlesinger</name></author><author><name sortKey="Erikh, Ilana" sort="Erikh, Ilana" uniqKey="Erikh I" first="Ilana" last="Erikh">Ilana Erikh</name></author><author><name sortKey="Avizohar, Ophir" sort="Avizohar, Ophir" uniqKey="Avizohar O" first="Ophir" last="Avizohar">Ophir Avizohar</name></author><author><name sortKey="Sprecher, Elliot" sort="Sprecher, Elliot" uniqKey="Sprecher E" first="Elliot" last="Sprecher">Elliot Sprecher</name></author><author><name sortKey="Yarnitsky, David" sort="Yarnitsky, David" uniqKey="Yarnitsky D" first="David" last="Yarnitsky">David Yarnitsky</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:718DA255A861341B421DE3F70EC55407E6AEDB86</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1002/mds.22486</idno><idno type="url">https://api.istex.fr/document/718DA255A861341B421DE3F70EC55407E6AEDB86/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001775</idno><idno type="wicri:Area/Istex/Curation">001775</idno><idno type="wicri:Area/Istex/Checkpoint">001017</idno><idno type="wicri:doubleKey">0885-3185:2009:Schlesinger I:cardiovascular:risk:factors</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:19526583</idno><idno type="wicri:Area/PubMed/Corpus">001C56</idno><idno type="wicri:Area/PubMed/Curation">001C56</idno><idno type="wicri:Area/PubMed/Checkpoint">001F18</idno><idno type="wicri:Area/Ncbi/Merge">002721</idno><idno type="wicri:Area/Ncbi/Curation">002721</idno><idno type="wicri:Area/Ncbi/Checkpoint">002721</idno><idno type="wicri:Area/Main/Merge">002C76</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Cardiovascular risk factors in restless legs syndrome</title><author><name sortKey="Schlesinger, Ilana" sort="Schlesinger, Ilana" uniqKey="Schlesinger I" first="Ilana" last="Schlesinger">Ilana Schlesinger</name><affiliation wicri:level="1"><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Neurology, Rambam Health Care Campus, Haifa</wicri:regionArea><wicri:noRegion>Haifa</wicri:noRegion></affiliation></author><author><name sortKey="Erikh, Ilana" sort="Erikh, Ilana" uniqKey="Erikh I" first="Ilana" last="Erikh">Ilana Erikh</name><affiliation wicri:level="1"><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Neurology, Rambam Health Care Campus, Haifa</wicri:regionArea><wicri:noRegion>Haifa</wicri:noRegion></affiliation></author><author><name sortKey="Avizohar, Ophir" sort="Avizohar, Ophir" uniqKey="Avizohar O" first="Ophir" last="Avizohar">Ophir Avizohar</name><affiliation wicri:level="1"><country xml:lang="fr">Israël</country><wicri:regionArea>Rambam Center for Preventive Medicine, Rambam Health Care Campus, Haifa</wicri:regionArea><wicri:noRegion>Haifa</wicri:noRegion></affiliation></author><author><name sortKey="Sprecher, Elliot" sort="Sprecher, Elliot" uniqKey="Sprecher E" first="Elliot" last="Sprecher">Elliot Sprecher</name><affiliation wicri:level="1"><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Neurology, Rambam Health Care Campus, Haifa</wicri:regionArea><wicri:noRegion>Haifa</wicri:noRegion></affiliation></author><author><name sortKey="Yarnitsky, David" sort="Yarnitsky, David" uniqKey="Yarnitsky D" first="David" last="Yarnitsky">David Yarnitsky</name><affiliation wicri:level="1"><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Neurology, Rambam Health Care Campus, Technion Faculty of Medicine, Haifa</wicri:regionArea><wicri:noRegion>Haifa</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-08-15">2009-08-15</date><biblScope unit="vol">24</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1587">1587</biblScope><biblScope unit="page" to="1592">1592</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">718DA255A861341B421DE3F70EC55407E6AEDB86</idno><idno type="DOI">10.1002/mds.22486</idno><idno type="ArticleID">MDS22486</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anemia (epidemiology)</term><term>Anthropometry</term><term>BMI</term><term>Body Mass Index</term><term>Cardiovascular Diseases (epidemiology)</term><term>Comorbidity</term><term>Cross-Sectional Studies</term><term>Female</term><term>Hematocrit</term><term>Humans</term><term>Hypercholesterolemia (epidemiology)</term><term>Hyperglycemia (epidemiology)</term><term>Hypertension (epidemiology)</term><term>Kidney Diseases (epidemiology)</term><term>Male</term><term>Middle Aged</term><term>Physical Fitness</term><term>Questionnaires</term><term>Restless Legs Syndrome (blood)</term><term>Restless Legs Syndrome (epidemiology)</term><term>Risk Factors</term><term>Sex Distribution</term><term>Smoking (epidemiology)</term><term>cardiovascular</term><term>hyperlipidemia</term><term>prevalence</term><term>restless legs syndrome</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Anemia</term><term>Cardiovascular Diseases</term><term>Hypercholesterolemia</term><term>Hyperglycemia</term><term>Hypertension</term><term>Kidney Diseases</term><term>Restless Legs Syndrome</term><term>Smoking</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Anthropometry</term><term>Body Mass Index</term><term>Comorbidity</term><term>Cross-Sectional Studies</term><term>Female</term><term>Hematocrit</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Physical Fitness</term><term>Questionnaires</term><term>Risk Factors</term><term>Sex Distribution</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We conducted a population‐based cross‐sectional study to assess prevalence of cardiovascular risk factors in subjects with and without restless legs syndrome (RLS). Adults attending their annual checkup completed the International RLS Study Group questionnaire and underwent an interview by a neurologist. Data from the annual checkup were compared between subjects with and without RLS. The prevalence of RLS was 6.7% (95% CI 5.45–7.95) among 1,537 responders. RLS subjects' blood tests showed significantly higher fasting blood glucose level (P = 0.029), higher prevalence of hypercholesterolemia (P = 0.029) and reduced renal function (P = 0.013), and increased prevalence of low hematocrit (P = 0.008). RLS subjects weighed more (P = 0.029), had a higher BMI (P = 0.033), larger hip circumference (P = 0.033), and were less fit (P = 0.010). To control for interactions among statistical predictors, we also employed multivariate logistic regression models adjusted for age, gender, smoking, BMI, hemoglobin, glucose, HDL/LDL cholesterol, triglycerides, and creatinine. We found that female gender (OR 2.16; 95% CI 1.11–4.17), smoking (OR 1.82; 95% CI, 1.10–3.00), and HDL/LDL cholesterol (OR 0.18; 95% CI 0.034–0.90) were significantly associated with RLS compared with subjects without RLS. RLS was associated with cardiovascular risk factors. © 2009 Movement Disorder Society</div></front></TEI></ISTEX></double></record>Pour manipuler ce document sous Unix (Dilib)
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