Cardiovascular risk factors in restless legs syndrome.
Identifieur interne : 001F18 ( PubMed/Checkpoint ); précédent : 001F17; suivant : 001F19Cardiovascular risk factors in restless legs syndrome.
Auteurs : Ilana Schlesinger [Israël] ; Ilana Erikh ; Ophir Avizohar ; Elliot Sprecher ; David YarnitskySource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2009.
English descriptors
- KwdEn :
- Anemia (epidemiology), Anthropometry, Body Mass Index, Cardiovascular Diseases (epidemiology), Comorbidity, Cross-Sectional Studies, Female, Hematocrit, Humans, Hypercholesterolemia (epidemiology), Hyperglycemia (epidemiology), Hypertension (epidemiology), Kidney Diseases (epidemiology), Male, Middle Aged, Physical Fitness, Questionnaires, Restless Legs Syndrome (blood), Restless Legs Syndrome (epidemiology), Risk Factors, Sex Distribution, Smoking (epidemiology).
- MESH :
- blood : Restless Legs Syndrome.
- epidemiology : Anemia, Cardiovascular Diseases, Hypercholesterolemia, Hyperglycemia, Hypertension, Kidney Diseases, Restless Legs Syndrome, Smoking.
- Anthropometry, Body Mass Index, Comorbidity, Cross-Sectional Studies, Female, Hematocrit, Humans, Male, Middle Aged, Physical Fitness, Questionnaires, Risk Factors, Sex Distribution.
Abstract
We conducted a population-based cross-sectional study to assess prevalence of cardiovascular risk factors in subjects with and without restless legs syndrome (RLS). Adults attending their annual checkup completed the International RLS Study Group questionnaire and underwent an interview by a neurologist. Data from the annual checkup were compared between subjects with and without RLS. The prevalence of RLS was 6.7% (95% CI 5.45-7.95) among 1,537 responders. RLS subjects' blood tests showed significantly higher fasting blood glucose level (P = 0.029), higher prevalence of hypercholesterolemia (P = 0.029) and reduced renal function (P = 0.013), and increased prevalence of low hematocrit (P = 0.008). RLS subjects weighed more (P = 0.029), had a higher BMI (P = 0.033), larger hip circumference (P = 0.033), and were less fit (P = 0.010). To control for interactions among statistical predictors, we also employed multivariate logistic regression models adjusted for age, gender, smoking, BMI, hemoglobin, glucose, HDL/LDL cholesterol, triglycerides, and creatinine. We found that female gender (OR 2.16; 95% CI 1.11-4.17), smoking (OR 1.82; 95% CI, 1.10-3.00), and HDL/LDL cholesterol (OR 0.18; 95% CI 0.034-0.90) were significantly associated with RLS compared with subjects without RLS. RLS was associated with cardiovascular risk factors.
DOI: 10.1002/mds.22486
PubMed: 19526583
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cardiovascular risk factors in restless legs syndrome.</title><author><name sortKey="Schlesinger, Ilana" sort="Schlesinger, Ilana" uniqKey="Schlesinger I" first="Ilana" last="Schlesinger">Ilana Schlesinger</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Rambam Health Care Campus, Haifa, Israel. i_schles@rambam.health.gov.il</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Neurology, Rambam Health Care Campus, Haifa</wicri:regionArea><wicri:noRegion>Haifa</wicri:noRegion></affiliation></author><author><name sortKey="Erikh, Ilana" sort="Erikh, Ilana" uniqKey="Erikh I" first="Ilana" last="Erikh">Ilana Erikh</name></author><author><name sortKey="Avizohar, Ophir" sort="Avizohar, Ophir" uniqKey="Avizohar O" first="Ophir" last="Avizohar">Ophir Avizohar</name></author><author><name sortKey="Sprecher, Elliot" sort="Sprecher, Elliot" uniqKey="Sprecher E" first="Elliot" last="Sprecher">Elliot Sprecher</name></author><author><name sortKey="Yarnitsky, David" sort="Yarnitsky, David" uniqKey="Yarnitsky D" first="David" last="Yarnitsky">David Yarnitsky</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="doi">10.1002/mds.22486</idno><idno type="RBID">pubmed:19526583</idno><idno type="pmid">19526583</idno><idno type="wicri:Area/PubMed/Corpus">001C56</idno><idno type="wicri:Area/PubMed/Curation">001C56</idno><idno type="wicri:Area/PubMed/Checkpoint">001F18</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Cardiovascular risk factors in restless legs syndrome.</title><author><name sortKey="Schlesinger, Ilana" sort="Schlesinger, Ilana" uniqKey="Schlesinger I" first="Ilana" last="Schlesinger">Ilana Schlesinger</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Rambam Health Care Campus, Haifa, Israel. i_schles@rambam.health.gov.il</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Neurology, Rambam Health Care Campus, Haifa</wicri:regionArea><wicri:noRegion>Haifa</wicri:noRegion></affiliation></author><author><name sortKey="Erikh, Ilana" sort="Erikh, Ilana" uniqKey="Erikh I" first="Ilana" last="Erikh">Ilana Erikh</name></author><author><name sortKey="Avizohar, Ophir" sort="Avizohar, Ophir" uniqKey="Avizohar O" first="Ophir" last="Avizohar">Ophir Avizohar</name></author><author><name sortKey="Sprecher, Elliot" sort="Sprecher, Elliot" uniqKey="Sprecher E" first="Elliot" last="Sprecher">Elliot Sprecher</name></author><author><name sortKey="Yarnitsky, David" sort="Yarnitsky, David" uniqKey="Yarnitsky D" first="David" last="Yarnitsky">David Yarnitsky</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anemia (epidemiology)</term><term>Anthropometry</term><term>Body Mass Index</term><term>Cardiovascular Diseases (epidemiology)</term><term>Comorbidity</term><term>Cross-Sectional Studies</term><term>Female</term><term>Hematocrit</term><term>Humans</term><term>Hypercholesterolemia (epidemiology)</term><term>Hyperglycemia (epidemiology)</term><term>Hypertension (epidemiology)</term><term>Kidney Diseases (epidemiology)</term><term>Male</term><term>Middle Aged</term><term>Physical Fitness</term><term>Questionnaires</term><term>Restless Legs Syndrome (blood)</term><term>Restless Legs Syndrome (epidemiology)</term><term>Risk Factors</term><term>Sex Distribution</term><term>Smoking (epidemiology)</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Anemia</term><term>Cardiovascular Diseases</term><term>Hypercholesterolemia</term><term>Hyperglycemia</term><term>Hypertension</term><term>Kidney Diseases</term><term>Restless Legs Syndrome</term><term>Smoking</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Anthropometry</term><term>Body Mass Index</term><term>Comorbidity</term><term>Cross-Sectional Studies</term><term>Female</term><term>Hematocrit</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Physical Fitness</term><term>Questionnaires</term><term>Risk Factors</term><term>Sex Distribution</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We conducted a population-based cross-sectional study to assess prevalence of cardiovascular risk factors in subjects with and without restless legs syndrome (RLS). Adults attending their annual checkup completed the International RLS Study Group questionnaire and underwent an interview by a neurologist. Data from the annual checkup were compared between subjects with and without RLS. The prevalence of RLS was 6.7% (95% CI 5.45-7.95) among 1,537 responders. RLS subjects' blood tests showed significantly higher fasting blood glucose level (P = 0.029), higher prevalence of hypercholesterolemia (P = 0.029) and reduced renal function (P = 0.013), and increased prevalence of low hematocrit (P = 0.008). RLS subjects weighed more (P = 0.029), had a higher BMI (P = 0.033), larger hip circumference (P = 0.033), and were less fit (P = 0.010). To control for interactions among statistical predictors, we also employed multivariate logistic regression models adjusted for age, gender, smoking, BMI, hemoglobin, glucose, HDL/LDL cholesterol, triglycerides, and creatinine. We found that female gender (OR 2.16; 95% CI 1.11-4.17), smoking (OR 1.82; 95% CI, 1.10-3.00), and HDL/LDL cholesterol (OR 0.18; 95% CI 0.034-0.90) were significantly associated with RLS compared with subjects without RLS. RLS was associated with cardiovascular risk factors.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">19526583</PMID><DateCreated><Year>2009</Year><Month>09</Month><Day>01</Day></DateCreated><DateCompleted><Year>2010</Year><Month>01</Month><Day>15</Day></DateCompleted><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>24</Volume><Issue>11</Issue><PubDate><Year>2009</Year><Month>Aug</Month><Day>15</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Cardiovascular risk factors in restless legs syndrome.</ArticleTitle><Pagination><MedlinePgn>1587-92</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.22486</ELocationID><Abstract><AbstractText>We conducted a population-based cross-sectional study to assess prevalence of cardiovascular risk factors in subjects with and without restless legs syndrome (RLS). Adults attending their annual checkup completed the International RLS Study Group questionnaire and underwent an interview by a neurologist. Data from the annual checkup were compared between subjects with and without RLS. The prevalence of RLS was 6.7% (95% CI 5.45-7.95) among 1,537 responders. RLS subjects' blood tests showed significantly higher fasting blood glucose level (P = 0.029), higher prevalence of hypercholesterolemia (P = 0.029) and reduced renal function (P = 0.013), and increased prevalence of low hematocrit (P = 0.008). RLS subjects weighed more (P = 0.029), had a higher BMI (P = 0.033), larger hip circumference (P = 0.033), and were less fit (P = 0.010). To control for interactions among statistical predictors, we also employed multivariate logistic regression models adjusted for age, gender, smoking, BMI, hemoglobin, glucose, HDL/LDL cholesterol, triglycerides, and creatinine. We found that female gender (OR 2.16; 95% CI 1.11-4.17), smoking (OR 1.82; 95% CI, 1.10-3.00), and HDL/LDL cholesterol (OR 0.18; 95% CI 0.034-0.90) were significantly associated with RLS compared with subjects without RLS. RLS was associated with cardiovascular risk factors.</AbstractText><CopyrightInformation>2009 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Schlesinger</LastName><ForeName>Ilana</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Neurology, Rambam Health Care Campus, Haifa, Israel. i_schles@rambam.health.gov.il</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Erikh</LastName><ForeName>Ilana</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Avizohar</LastName><ForeName>Ophir</ForeName><Initials>O</Initials></Author><Author ValidYN="Y"><LastName>Sprecher</LastName><ForeName>Elliot</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Yarnitsky</LastName><ForeName>David</ForeName><Initials>D</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000740">Anemia</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000453">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000886">Anthropometry</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015992">Body Mass Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002318">Cardiovascular Diseases</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000453">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015897">Comorbidity</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D003430">Cross-Sectional Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006400">Hematocrit</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006937">Hypercholesterolemia</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000453">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006943">Hyperglycemia</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000453">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006973">Hypertension</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000453">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007674">Kidney Diseases</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000453">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010809">Physical Fitness</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011795">Questionnaires</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012148">Restless Legs Syndrome</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000097">blood</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000453">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012307">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D017678">Sex Distribution</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012907">Smoking</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000453">epidemiology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2009</Year><Month>6</Month><Day>16</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2009</Year><Month>6</Month><Day>16</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2010</Year><Month>1</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.22486</ArticleId><ArticleId IdType="pubmed">19526583</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Israël</li></country></list><tree><noCountry><name sortKey="Avizohar, Ophir" sort="Avizohar, Ophir" uniqKey="Avizohar O" first="Ophir" last="Avizohar">Ophir Avizohar</name><name sortKey="Erikh, Ilana" sort="Erikh, Ilana" uniqKey="Erikh I" first="Ilana" last="Erikh">Ilana Erikh</name><name sortKey="Sprecher, Elliot" sort="Sprecher, Elliot" uniqKey="Sprecher E" first="Elliot" last="Sprecher">Elliot Sprecher</name><name sortKey="Yarnitsky, David" sort="Yarnitsky, David" uniqKey="Yarnitsky D" first="David" last="Yarnitsky">David Yarnitsky</name></noCountry><country name="Israël"><noRegion><name sortKey="Schlesinger, Ilana" sort="Schlesinger, Ilana" uniqKey="Schlesinger I" first="Ilana" last="Schlesinger">Ilana Schlesinger</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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