MovDisordV3, Main, Curation, bibRecord, 001806

Apomorphine effect on pain threshold in Parkinson's disease: A clinical and positron emission tomography study

Identifieur interne : 001806 ( Main/Curation ); précédent : 001805; suivant : 001807

Apomorphine effect on pain threshold in Parkinson's disease: A clinical and positron emission tomography study

Auteurs : Estelle Dellapina [France] ; Angélique Gerdelat-Mas [France] ; Fabienne Ory-Magne [France] ; Laure Pourcel [France] ; Monique Galitzky [France] ; Fabienne Calvas [France] ; Marion Simonetta-Moreau [France] ; Claire Thalamas [France] ; Pierre Payoux [France] ; Christine Brefel-Courbon [France]

Source :

Movement Disorders [ 0885-3185 ] ; 2011-01.

RBID : ISTEX:0FE03C86D5A2B78BBBBBF3C8873095BA4F7F1891

Descripteurs français

Pascal (Inist)
- Apomorphine, Douleur, Maladie de Parkinson, Pathologie du système nerveux, Tomographie par émission de positons, Tomoscintigraphie.

English descriptors

KwdEn :
- Aged, Antiparkinson Agents (pharmacology), Antiparkinson Agents (therapeutic use), Apomorphine (pharmacology), Apomorphine (therapeutic use), Cerebral Cortex (radionuclide imaging), Double-Blind Method, Emission tomography, Female, Humans, H 215O positron emission tomography, Male, Middle Aged, Nervous system diseases, Neuralgia (diagnosis), Neuralgia (etiology), Oxygen Isotopes (diagnostic use), Pain, Pain Threshold (drug effects), Parkinson Disease (complications), Parkinson Disease (drug therapy), Parkinson Disease (pathology), Parkinson Disease (radionuclide imaging), Parkinson disease, Parkinson's disease, Positron emission tomography, Positron-Emission Tomography (methods), apomorphine, pain threshold.
MESH :
- chemical , diagnostic use : Oxygen Isotopes.
- chemical , pharmacology : Antiparkinson Agents, Apomorphine.
- chemical , therapeutic use : Antiparkinson Agents, Apomorphine.
- complications : Parkinson Disease.
- diagnosis : Neuralgia.
- drug effects : Pain Threshold.
- drug therapy : Parkinson Disease.
- etiology : Neuralgia.
- methods : Positron-Emission Tomography.
- pathology : Parkinson Disease.
- radionuclide imaging : Cerebral Cortex, Parkinson Disease.
- Aged, Double-Blind Method, Female, Humans, Male, Middle Aged.

Abstract

Patients with Parkinson's disease (PD) frequently experience pain that could be in part due to central modification of nociception. In this randomized controlled double blind study, we compared the effect of apomorphine versus placebo on pain thresholds and pain‐induced cerebral activity in 25 patients with PD. Subjective pain threshold (using thermal stimulation, thermotest), objective pain threshold (nociceptive flexion reflex), and cerebral activity (H 215O PET) during noxious and innocuous stimulations were performed. Neither subjective nor objective pain thresholds nor pain activation profile were modified by apomorphine compared with placebo in 25 PD patients. Apomorphine has no effect on pain processing in PD. We suggest that other monoamine systems than dopaminergic system could be involved. © 2010 Movement Disorder Society.

Url:

https://api.istex.fr/document/0FE03C86D5A2B78BBBBBF3C8873095BA4F7F1891/fulltext/pdf

DOI: 10.1002/mds.23406

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ISTEX:0FE03C86D5A2B78BBBBBF3C8873095BA4F7F1891

Le document en format XML

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<term>Antiparkinson Agents (pharmacology)</term>
<term>Antiparkinson Agents (therapeutic use)</term>
<term>Apomorphine (pharmacology)</term>
<term>Apomorphine (therapeutic use)</term>
<term>Cerebral Cortex (radionuclide imaging)</term>
<term>Double-Blind Method</term>
<term>Emission tomography</term>
<term>Female</term>
<term>Humans</term>
<term>H 215O positron emission tomography</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Nervous system diseases</term>
<term>Neuralgia (diagnosis)</term>
<term>Neuralgia (etiology)</term>
<term>Oxygen Isotopes (diagnostic use)</term>
<term>Pain</term>
<term>Pain Threshold (drug effects)</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson Disease (pathology)</term>
<term>Parkinson Disease (radionuclide imaging)</term>
<term>Parkinson disease</term>
<term>Parkinson's disease</term>
<term>Positron emission tomography</term>
<term>Positron-Emission Tomography (methods)</term>
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<term>pain threshold</term>
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<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Pain Threshold</term>
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<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term>
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<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Neuralgia</term>
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<term>Douleur</term>
<term>Maladie de Parkinson</term>
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<front><div type="abstract" xml:lang="en">Patients with Parkinson's disease (PD) frequently experience pain that could be in part due to central modification of nociception. In this randomized controlled double blind study, we compared the effect of apomorphine versus placebo on pain thresholds and pain‐induced cerebral activity in 25 patients with PD. Subjective pain threshold (using thermal stimulation, thermotest), objective pain threshold (nociceptive flexion reflex), and cerebral activity (H 215O PET) during noxious and innocuous stimulations were performed. Neither subjective nor objective pain thresholds nor pain activation profile were modified by apomorphine compared with placebo in 25 PD patients. Apomorphine has no effect on pain processing in PD. We suggest that other monoamine systems than dopaminergic system could be involved. © 2010 Movement Disorder Society.</div>
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<author><name sortKey="Simonetta Moreau, Marion" sort="Simonetta Moreau, Marion" uniqKey="Simonetta Moreau M" first="Marion" last="Simonetta-Moreau">Marion Simonetta-Moreau</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Inserm, Imagerie cérébrale et handicaps neurologiques</s1>
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<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Université de Toulouse, UPS, Imagerie cérébrale et handicaps neurologiques</s1>
<s2>Toulouse</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Centre Hospitalier Universitaire de Toulouse, Service de Neurologie</s1>
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<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thalamas, Claire" sort="Thalamas, Claire" uniqKey="Thalamas C" first="Claire" last="Thalamas">Claire Thalamas</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Inserm, Centre d' Investigation Clinique, CHU Purpan</s1>
<s2>Toulouse</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Payoux, Pierre" sort="Payoux, Pierre" uniqKey="Payoux P" first="Pierre" last="Payoux">Pierre Payoux</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Inserm, Imagerie cérébrale et handicaps neurologiques</s1>
<s2>Toulouse</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Université de Toulouse, UPS, Imagerie cérébrale et handicaps neurologiques</s1>
<s2>Toulouse</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Brefel Courbon, Christine" sort="Brefel Courbon, Christine" uniqKey="Brefel Courbon C" first="Christine" last="Brefel-Courbon">Christine Brefel-Courbon</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Inserm, Imagerie cérébrale et handicaps neurologiques</s1>
<s2>Toulouse</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Université de Toulouse, UPS, Imagerie cérébrale et handicaps neurologiques</s1>
<s2>Toulouse</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Centre Hospitalier Universitaire de Toulouse, Service de Neurologie</s1>
<s2>Toulouse</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Service de Pharmacologie Clinique, Faculté de médecine</s1>
<s2>Toulouse</s2>
<s3>FRA</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">11-0143238</idno>
<date when="2011">2011</date>
<idno type="stanalyst">PASCAL 11-0143238 INIST</idno>
<idno type="RBID">Pascal:11-0143238</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000725</idno>
<idno type="wicri:Area/PascalFrancis/Curation">002593</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000711</idno>
<idno type="wicri:doubleKey">0885-3185:2011:Dellapina E:apomorphine:effect:on</idno>
<idno type="wicri:Area/Main/Merge">001D01</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Apomorphine Effect on Pain Threshold in Parkinson's Disease: A Clinical and Positron Emission Tomography Study</title>
<author><name sortKey="Dellapina, Estelle" sort="Dellapina, Estelle" uniqKey="Dellapina E" first="Estelle" last="Dellapina">Estelle Dellapina</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Inserm, Imagerie cérébrale et handicaps neurologiques</s1>
<s2>Toulouse</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Université de Toulouse, UPS, Imagerie cérébrale et handicaps neurologiques</s1>
<s2>Toulouse</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gerdelat Mas, Angelique" sort="Gerdelat Mas, Angelique" uniqKey="Gerdelat Mas A" first="Angélique" last="Gerdelat-Mas">Angélique Gerdelat-Mas</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Centre Hospitalier Universitaire de Toulouse, Service de Neurologie</s1>
<s2>Toulouse</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ory Magne, Fabienne" sort="Ory Magne, Fabienne" uniqKey="Ory Magne F" first="Fabienne" last="Ory-Magne">Fabienne Ory-Magne</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Centre Hospitalier Universitaire de Toulouse, Service de Neurologie</s1>
<s2>Toulouse</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pourcel, Laure" sort="Pourcel, Laure" uniqKey="Pourcel L" first="Laure" last="Pourcel">Laure Pourcel</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Unité de Pharmacoépidémiologie, Faculté de médecine</s1>
<s2>Toulouse</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Galitzky, Monique" sort="Galitzky, Monique" uniqKey="Galitzky M" first="Monique" last="Galitzky">Monique Galitzky</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Inserm, Centre d' Investigation Clinique, CHU Purpan</s1>
<s2>Toulouse</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Calvas, Fabienne" sort="Calvas, Fabienne" uniqKey="Calvas F" first="Fabienne" last="Calvas">Fabienne Calvas</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Inserm, Centre d' Investigation Clinique, CHU Purpan</s1>
<s2>Toulouse</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Simonetta Moreau, Marion" sort="Simonetta Moreau, Marion" uniqKey="Simonetta Moreau M" first="Marion" last="Simonetta-Moreau">Marion Simonetta-Moreau</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Inserm, Imagerie cérébrale et handicaps neurologiques</s1>
<s2>Toulouse</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Université de Toulouse, UPS, Imagerie cérébrale et handicaps neurologiques</s1>
<s2>Toulouse</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Centre Hospitalier Universitaire de Toulouse, Service de Neurologie</s1>
<s2>Toulouse</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thalamas, Claire" sort="Thalamas, Claire" uniqKey="Thalamas C" first="Claire" last="Thalamas">Claire Thalamas</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Inserm, Centre d' Investigation Clinique, CHU Purpan</s1>
<s2>Toulouse</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Payoux, Pierre" sort="Payoux, Pierre" uniqKey="Payoux P" first="Pierre" last="Payoux">Pierre Payoux</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Inserm, Imagerie cérébrale et handicaps neurologiques</s1>
<s2>Toulouse</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Université de Toulouse, UPS, Imagerie cérébrale et handicaps neurologiques</s1>
<s2>Toulouse</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Brefel Courbon, Christine" sort="Brefel Courbon, Christine" uniqKey="Brefel Courbon C" first="Christine" last="Brefel-Courbon">Christine Brefel-Courbon</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Inserm, Imagerie cérébrale et handicaps neurologiques</s1>
<s2>Toulouse</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Université de Toulouse, UPS, Imagerie cérébrale et handicaps neurologiques</s1>
<s2>Toulouse</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Centre Hospitalier Universitaire de Toulouse, Service de Neurologie</s1>
<s2>Toulouse</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Service de Pharmacologie Clinique, Faculté de médecine</s1>
<s2>Toulouse</s2>
<s3>FRA</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Emission tomography</term>
<term>Nervous system diseases</term>
<term>Pain</term>
<term>Parkinson disease</term>
<term>Positron emission tomography</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Pathologie du   système nerveux</term>
<term>Apomorphine</term>
<term>Douleur</term>
<term>Tomoscintigraphie</term>
<term>Tomographie par émission de positons</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Patients with Parkinson's disease (PD) frequently experience pain that could be in part due to central modification of nociception. In this randomized controlled double blind study, we compared the effect of apomorphine versus placebo on pain thresholds and pain-induced cerebral activity in 25 patients with PD. Subjective pain threshold (using thermal stimulation, thermotest), objective pain threshold (nociceptive flexion reflex), and cerebral activity (H<sup>15</sup>
<sub>2</sub>
O PET) during noxious and innocuous stimulations were performed. Neither subjective nor objective pain thresholds nor pain activation profile were modified by apomorphine compared with placebo in 25 PD patients. Apomorphine has no effect on pain processing in PD. We suggest that other monoamine systems than dopaminergic system could be involved.</div>
</front>
</TEI>
</INIST>
<ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Apomorphine effect on pain threshold in Parkinson's disease: A clinical and positron emission tomography study</title>
<author><name sortKey="Dellapina, Estelle" sort="Dellapina, Estelle" uniqKey="Dellapina E" first="Estelle" last="Dellapina">Estelle Dellapina</name>
</author>
<author><name sortKey="Gerdelat As, Angelique" sort="Gerdelat As, Angelique" uniqKey="Gerdelat As A" first="Angélique" last="Gerdelat-Mas">Angélique Gerdelat-Mas</name>
</author>
<author><name sortKey="Ory Agne, Fabienne" sort="Ory Agne, Fabienne" uniqKey="Ory Agne F" first="Fabienne" last="Ory-Magne">Fabienne Ory-Magne</name>
</author>
<author><name sortKey="Pourcel, Laure" sort="Pourcel, Laure" uniqKey="Pourcel L" first="Laure" last="Pourcel">Laure Pourcel</name>
</author>
<author><name sortKey="Galitzky, Monique" sort="Galitzky, Monique" uniqKey="Galitzky M" first="Monique" last="Galitzky">Monique Galitzky</name>
</author>
<author><name sortKey="Calvas, Fabienne" sort="Calvas, Fabienne" uniqKey="Calvas F" first="Fabienne" last="Calvas">Fabienne Calvas</name>
</author>
<author><name sortKey="Simonetta Oreau, Marion" sort="Simonetta Oreau, Marion" uniqKey="Simonetta Oreau M" first="Marion" last="Simonetta-Moreau">Marion Simonetta-Moreau</name>
</author>
<author><name sortKey="Thalamas, Claire" sort="Thalamas, Claire" uniqKey="Thalamas C" first="Claire" last="Thalamas">Claire Thalamas</name>
</author>
<author><name sortKey="Payoux, Pierre" sort="Payoux, Pierre" uniqKey="Payoux P" first="Pierre" last="Payoux">Pierre Payoux</name>
</author>
<author><name sortKey="Brefel Ourbon, Christine" sort="Brefel Ourbon, Christine" uniqKey="Brefel Ourbon C" first="Christine" last="Brefel-Courbon">Christine Brefel-Courbon</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:0FE03C86D5A2B78BBBBBF3C8873095BA4F7F1891</idno>
<date when="2011" year="2011">2011</date>
<idno type="doi">10.1002/mds.23406</idno>
<idno type="url">https://api.istex.fr/document/0FE03C86D5A2B78BBBBBF3C8873095BA4F7F1891/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001252</idno>
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<idno type="wicri:Area/Istex/Checkpoint">000539</idno>
<idno type="wicri:doubleKey">0885-3185:2011:Dellapina E:apomorphine:effect:on</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:20960436</idno>
<idno type="wicri:Area/PubMed/Corpus">001508</idno>
<idno type="wicri:Area/PubMed/Curation">001508</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001472</idno>
<idno type="wicri:Area/Ncbi/Merge">002F09</idno>
<idno type="wicri:Area/Ncbi/Curation">002F09</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002F09</idno>
<idno type="wicri:Area/Main/Merge">001860</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Apomorphine effect on pain threshold in Parkinson's disease: A clinical and positron emission tomography study</title>
<author><name sortKey="Dellapina, Estelle" sort="Dellapina, Estelle" uniqKey="Dellapina E" first="Estelle" last="Dellapina">Estelle Dellapina</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Inserm, Imagerie cérébrale et handicaps neurologiques, Toulouse</wicri:regionArea>
<placeName><settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Université de Toulouse, UPS, Imagerie cérébrale et handicaps neurologiques, Toulouse</wicri:regionArea>
<placeName><settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gerdelat As, Angelique" sort="Gerdelat As, Angelique" uniqKey="Gerdelat As A" first="Angélique" last="Gerdelat-Mas">Angélique Gerdelat-Mas</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Centre Hospitalier Universitaire de Toulouse, Service de Neurologie, Toulouse</wicri:regionArea>
<placeName><settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ory Agne, Fabienne" sort="Ory Agne, Fabienne" uniqKey="Ory Agne F" first="Fabienne" last="Ory-Magne">Fabienne Ory-Magne</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Centre Hospitalier Universitaire de Toulouse, Service de Neurologie, Toulouse</wicri:regionArea>
<placeName><settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pourcel, Laure" sort="Pourcel, Laure" uniqKey="Pourcel L" first="Laure" last="Pourcel">Laure Pourcel</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Unité de Pharmacoépidémiologie, Faculté de médecine, Toulouse</wicri:regionArea>
<placeName><settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Galitzky, Monique" sort="Galitzky, Monique" uniqKey="Galitzky M" first="Monique" last="Galitzky">Monique Galitzky</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Inserm, Centre d'Investigation Clinique, CHU Purpan, Toulouse</wicri:regionArea>
<placeName><settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Calvas, Fabienne" sort="Calvas, Fabienne" uniqKey="Calvas F" first="Fabienne" last="Calvas">Fabienne Calvas</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Inserm, Centre d'Investigation Clinique, CHU Purpan, Toulouse</wicri:regionArea>
<placeName><settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Simonetta Oreau, Marion" sort="Simonetta Oreau, Marion" uniqKey="Simonetta Oreau M" first="Marion" last="Simonetta-Moreau">Marion Simonetta-Moreau</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Inserm, Imagerie cérébrale et handicaps neurologiques, Toulouse</wicri:regionArea>
<placeName><settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Université de Toulouse, UPS, Imagerie cérébrale et handicaps neurologiques, Toulouse</wicri:regionArea>
<placeName><settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Centre Hospitalier Universitaire de Toulouse, Service de Neurologie, Toulouse</wicri:regionArea>
<placeName><settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thalamas, Claire" sort="Thalamas, Claire" uniqKey="Thalamas C" first="Claire" last="Thalamas">Claire Thalamas</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Inserm, Centre d'Investigation Clinique, CHU Purpan, Toulouse</wicri:regionArea>
<placeName><settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Payoux, Pierre" sort="Payoux, Pierre" uniqKey="Payoux P" first="Pierre" last="Payoux">Pierre Payoux</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Inserm, Imagerie cérébrale et handicaps neurologiques, Toulouse</wicri:regionArea>
<placeName><settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Université de Toulouse, UPS, Imagerie cérébrale et handicaps neurologiques, Toulouse</wicri:regionArea>
<placeName><settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Brefel Ourbon, Christine" sort="Brefel Ourbon, Christine" uniqKey="Brefel Ourbon C" first="Christine" last="Brefel-Courbon">Christine Brefel-Courbon</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Inserm, Imagerie cérébrale et handicaps neurologiques, Toulouse</wicri:regionArea>
<placeName><settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Université de Toulouse, UPS, Imagerie cérébrale et handicaps neurologiques, Toulouse</wicri:regionArea>
<placeName><settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Centre Hospitalier Universitaire de Toulouse, Service de Neurologie, Toulouse</wicri:regionArea>
<placeName><settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Service de Pharmacologie Clinique, Faculté de médecine, Toulouse</wicri:regionArea>
<placeName><settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2011-01">2011-01</date>
<biblScope unit="vol">26</biblScope>
<biblScope unit="issue">1</biblScope>
<biblScope unit="page" from="153">153</biblScope>
<biblScope unit="page" to="157">157</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">0FE03C86D5A2B78BBBBBF3C8873095BA4F7F1891</idno>
<idno type="DOI">10.1002/mds.23406</idno>
<idno type="ArticleID">MDS23406</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Antiparkinson Agents (pharmacology)</term>
<term>Antiparkinson Agents (therapeutic use)</term>
<term>Apomorphine (pharmacology)</term>
<term>Apomorphine (therapeutic use)</term>
<term>Cerebral Cortex (radionuclide imaging)</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Humans</term>
<term>H 215O positron emission tomography</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neuralgia (diagnosis)</term>
<term>Neuralgia (etiology)</term>
<term>Oxygen Isotopes (diagnostic use)</term>
<term>Pain Threshold (drug effects)</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson Disease (pathology)</term>
<term>Parkinson Disease (radionuclide imaging)</term>
<term>Parkinson's disease</term>
<term>Positron-Emission Tomography (methods)</term>
<term>apomorphine</term>
<term>pain threshold</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Oxygen Isotopes</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiparkinson Agents</term>
<term>Apomorphine</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term>
<term>Apomorphine</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Neuralgia</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Pain Threshold</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Neuralgia</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Positron-Emission Tomography</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Cerebral Cortex</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Patients with Parkinson's disease (PD) frequently experience pain that could be in part due to central modification of nociception. In this randomized controlled double blind study, we compared the effect of apomorphine versus placebo on pain thresholds and pain‐induced cerebral activity in 25 patients with PD. Subjective pain threshold (using thermal stimulation, thermotest), objective pain threshold (nociceptive flexion reflex), and cerebral activity (H 215O PET) during noxious and innocuous stimulations were performed. Neither subjective nor objective pain thresholds nor pain activation profile were modified by apomorphine compared with placebo in 25 PD patients. Apomorphine has no effect on pain processing in PD. We suggest that other monoamine systems than dopaminergic system could be involved. © 2010 Movement Disorder Society.</div>
</front>
</TEI>
</ISTEX>
</double>
</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Apomorphine effect on pain threshold in Parkinson's disease: A clinical and positron emission tomography study

Apomorphine effect on pain threshold in Parkinson's disease: A clinical and positron emission tomography study

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