MovDisordV3, PascalFrancis, Curation, bibRecord, 002593

Apomorphine Effect on Pain Threshold in Parkinson's Disease: A Clinical and Positron Emission Tomography Study

Identifieur interne : 002593 ( PascalFrancis/Curation ); précédent : 002592; suivant : 002594

Apomorphine Effect on Pain Threshold in Parkinson's Disease: A Clinical and Positron Emission Tomography Study

Auteurs : Estelle Dellapina [France] ; Angélique Gerdelat-Mas [France] ; Fabienne Ory-Magne [France] ; Laure Pourcel [France] ; Monique Galitzky [France] ; Fabienne Calvas [France] ; Marion Simonetta-Moreau [France] ; Claire Thalamas [France] ; Pierre Payoux [France] ; Christine Brefel-Courbon [France]

Source :

Movement disorders [ 0885-3185 ] ; 2011.

RBID : Pascal:11-0143238

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Apomorphine, Douleur, Tomoscintigraphie, Tomographie par émission de positons.

English descriptors

KwdEn :
- Emission tomography, Nervous system diseases, Pain, Parkinson disease, Positron emission tomography.

Abstract

Patients with Parkinson's disease (PD) frequently experience pain that could be in part due to central modification of nociception. In this randomized controlled double blind study, we compared the effect of apomorphine versus placebo on pain thresholds and pain-induced cerebral activity in 25 patients with PD. Subjective pain threshold (using thermal stimulation, thermotest), objective pain threshold (nociceptive flexion reflex), and cerebral activity (H¹⁵₂O PET) during noxious and innocuous stimulations were performed. Neither subjective nor objective pain thresholds nor pain activation profile were modified by apomorphine compared with placebo in 25 PD patients. Apomorphine has no effect on pain processing in PD. We suggest that other monoamine systems than dopaminergic system could be involved.

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A08	`01`	`1`	`ENG`	`@1 Apomorphine Effect on Pain Threshold in Parkinson's Disease: A Clinical and Positron Emission Tomography Study`
A11	`01`	`1`		`@1 DELLAPINA (Estelle)`
A11	`02`	`1`		`@1 GERDELAT-MAS (Angélique)`
A11	`03`	`1`		`@1 ORY-MAGNE (Fabienne)`
A11	`04`	`1`		`@1 POURCEL (Laure)`
A11	`05`	`1`		`@1 GALITZKY (Monique)`
A11	`06`	`1`		`@1 CALVAS (Fabienne)`
A11	`07`	`1`		`@1 SIMONETTA-MOREAU (Marion)`
A11	`08`	`1`		`@1 THALAMAS (Claire)`
A11	`09`	`1`		`@1 PAYOUX (Pierre)`
A11	`10`	`1`		`@1 BREFEL-COURBON (Christine)`
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C01	`01`		`ENG`	@0 Patients with Parkinson's disease (PD) frequently experience pain that could be in part due to central modification of nociception. In this randomized controlled double blind study, we compared the effect of apomorphine versus placebo on pain thresholds and pain-induced cerebral activity in 25 patients with PD. Subjective pain threshold (using thermal stimulation, thermotest), objective pain threshold (nociceptive flexion reflex), and cerebral activity (H¹⁵₂O PET) during noxious and innocuous stimulations were performed. Neither subjective nor objective pain thresholds nor pain activation profile were modified by apomorphine compared with placebo in 25 PD patients. Apomorphine has no effect on pain processing in PD. We suggest that other monoamine systems than dopaminergic system could be involved.
C02	`01`	`X`		`@0 002B17`
C02	`02`	`X`		`@0 002B17G`
C03	`01`	`X`	`FRE`	`@0 Maladie de Parkinson @2 NM @5 01`
C03	`01`	`X`	`ENG`	`@0 Parkinson disease @2 NM @5 01`
C03	`01`	`X`	`SPA`	`@0 Parkinson enfermedad @2 NM @5 01`
C03	`02`	`X`	`FRE`	`@0 Pathologie du système nerveux @5 02`
C03	`02`	`X`	`ENG`	`@0 Nervous system diseases @5 02`
C03	`02`	`X`	`SPA`	`@0 Sistema nervioso patología @5 02`
C03	`03`	`X`	`FRE`	`@0 Apomorphine @2 NK @2 FR @5 09`
C03	`04`	`X`	`FRE`	`@0 Douleur @5 10`
C03	`04`	`X`	`ENG`	`@0 Pain @5 10`
C03	`04`	`X`	`SPA`	`@0 Dolor @5 10`
C03	`05`	`X`	`FRE`	`@0 Tomoscintigraphie @5 11`
C03	`05`	`X`	`ENG`	`@0 Emission tomography @5 11`
C03	`05`	`X`	`SPA`	`@0 Tomocentelleografía @5 11`
C03	`06`	`X`	`FRE`	`@0 Tomographie par émission de positons @5 12`
C03	`06`	`X`	`ENG`	`@0 Positron emission tomography @5 12`
C03	`06`	`X`	`SPA`	`@0 Tomografía emisión positrones @5 12`
C07	`01`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 37`
C07	`01`	`X`	`ENG`	`@0 Cerebral disorder @5 37`
C07	`01`	`X`	`SPA`	`@0 Encéfalo patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Syndrome extrapyramidal @5 38`
C07	`02`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 38`
C07	`02`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 38`
C07	`03`	`X`	`FRE`	`@0 Maladie dégénérative @5 39`
C07	`03`	`X`	`ENG`	`@0 Degenerative disease @5 39`
C07	`03`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 39`
C07	`04`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 40`
C07	`04`	`X`	`ENG`	`@0 Central nervous system disease @5 40`
C07	`04`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 40`
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N44	`01`			`@1 OTO`
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Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Apomorphine Effect on Pain Threshold in Parkinson's Disease: A Clinical and Positron Emission Tomography Study</title>
<author><name sortKey="Dellapina, Estelle" sort="Dellapina, Estelle" uniqKey="Dellapina E" first="Estelle" last="Dellapina">Estelle Dellapina</name>
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<author><name sortKey="Gerdelat Mas, Angelique" sort="Gerdelat Mas, Angelique" uniqKey="Gerdelat Mas A" first="Angélique" last="Gerdelat-Mas">Angélique Gerdelat-Mas</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Centre Hospitalier Universitaire de Toulouse, Service de Neurologie</s1>
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<author><name sortKey="Ory Magne, Fabienne" sort="Ory Magne, Fabienne" uniqKey="Ory Magne F" first="Fabienne" last="Ory-Magne">Fabienne Ory-Magne</name>
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<author><name sortKey="Pourcel, Laure" sort="Pourcel, Laure" uniqKey="Pourcel L" first="Laure" last="Pourcel">Laure Pourcel</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Unité de Pharmacoépidémiologie, Faculté de médecine</s1>
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</inist:fA14>
<country>France</country>
</affiliation>
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<author><name sortKey="Galitzky, Monique" sort="Galitzky, Monique" uniqKey="Galitzky M" first="Monique" last="Galitzky">Monique Galitzky</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Inserm, Centre d' Investigation Clinique, CHU Purpan</s1>
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<author><name sortKey="Calvas, Fabienne" sort="Calvas, Fabienne" uniqKey="Calvas F" first="Fabienne" last="Calvas">Fabienne Calvas</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Inserm, Centre d' Investigation Clinique, CHU Purpan</s1>
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</inist:fA14>
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</author>
<author><name sortKey="Simonetta Moreau, Marion" sort="Simonetta Moreau, Marion" uniqKey="Simonetta Moreau M" first="Marion" last="Simonetta-Moreau">Marion Simonetta-Moreau</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Inserm, Imagerie cérébrale et handicaps neurologiques</s1>
<s2>Toulouse</s2>
<s3>FRA</s3>
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<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Université de Toulouse, UPS, Imagerie cérébrale et handicaps neurologiques</s1>
<s2>Toulouse</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Centre Hospitalier Universitaire de Toulouse, Service de Neurologie</s1>
<s2>Toulouse</s2>
<s3>FRA</s3>
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</inist:fA14>
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</affiliation>
</author>
<author><name sortKey="Thalamas, Claire" sort="Thalamas, Claire" uniqKey="Thalamas C" first="Claire" last="Thalamas">Claire Thalamas</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Inserm, Centre d' Investigation Clinique, CHU Purpan</s1>
<s2>Toulouse</s2>
<s3>FRA</s3>
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<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Payoux, Pierre" sort="Payoux, Pierre" uniqKey="Payoux P" first="Pierre" last="Payoux">Pierre Payoux</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Inserm, Imagerie cérébrale et handicaps neurologiques</s1>
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</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Université de Toulouse, UPS, Imagerie cérébrale et handicaps neurologiques</s1>
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<author><name sortKey="Brefel Courbon, Christine" sort="Brefel Courbon, Christine" uniqKey="Brefel Courbon C" first="Christine" last="Brefel-Courbon">Christine Brefel-Courbon</name>
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<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
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<seriesStmt><title level="j" type="main">Movement disorders</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Emission tomography</term>
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<term>Positron emission tomography</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
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<front><div type="abstract" xml:lang="en">Patients with Parkinson's disease (PD) frequently experience pain that could be in part due to central modification of nociception. In this randomized controlled double blind study, we compared the effect of apomorphine versus placebo on pain thresholds and pain-induced cerebral activity in 25 patients with PD. Subjective pain threshold (using thermal stimulation, thermotest), objective pain threshold (nociceptive flexion reflex), and cerebral activity (H<sup>15</sup>
<sub>2</sub>
O PET) during noxious and innocuous stimulations were performed. Neither subjective nor objective pain thresholds nor pain activation profile were modified by apomorphine compared with placebo in 25 PD patients. Apomorphine has no effect on pain processing in PD. We suggest that other monoamine systems than dopaminergic system could be involved.</div>
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<sub>2</sub>
O PET) during noxious and innocuous stimulations were performed. Neither subjective nor objective pain thresholds nor pain activation profile were modified by apomorphine compared with placebo in 25 PD patients. Apomorphine has no effect on pain processing in PD. We suggest that other monoamine systems than dopaminergic system could be involved.</s0>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Apomorphine Effect on Pain Threshold in Parkinson's Disease: A Clinical and Positron Emission Tomography Study

Apomorphine Effect on Pain Threshold in Parkinson's Disease: A Clinical and Positron Emission Tomography Study

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