Automated structural imaging analysis detects premanifest Huntington's disease neurodegeneration within 1 year
Identifieur interne : 001796 ( Main/Curation ); précédent : 001795; suivant : 001797Automated structural imaging analysis detects premanifest Huntington's disease neurodegeneration within 1 year
Auteurs : D. S. Adnan Majid [États-Unis] ; Diederick Stoffers [Pays-Bas] ; Sarah Sheldon [États-Unis] ; Samar Hamza [États-Unis] ; Wesley K. Thompson [États-Unis] ; Jody Goldstein [États-Unis] ; Jody Corey-Bloom [États-Unis] ; Adam R. Aron [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-07.
English descriptors
- KwdEn :
- Adult, Brain (pathology), Case-Control Studies, Cognition Disorders (diagnosis), Cognition Disorders (etiology), Disease Progression, Female, Humans, Huntington Disease (complications), Huntington Disease (diagnosis), Image Processing, Computer-Assisted, Longitudinal Studies, MRI biomarker, Magnetic Resonance Imaging (methods), Male, Middle Aged, Nerve Degeneration (diagnosis), Nerve Degeneration (etiology), longitudinal atrophy, premanifest HD.
- MESH :
- complications : Huntington Disease.
- diagnosis : Cognition Disorders, Huntington Disease, Nerve Degeneration.
- etiology : Cognition Disorders, Nerve Degeneration.
- methods : Magnetic Resonance Imaging.
- pathology : Brain.
- Adult, Case-Control Studies, Disease Progression, Female, Humans, Image Processing, Computer-Assisted, Longitudinal Studies, Male, Middle Aged.
Abstract
Intense efforts are underway to evaluate neuroimaging measures as biomarkers for neurodegeneration in premanifest Huntington's disease (preHD). We used a completely automated longitudinal analysis method to compare structural scans in preHD individuals and controls. Using a 1‐year longitudinal design, we analyzed T1‐weighted structural scans in 35 preHD individuals and 22 age‐matched controls. We used the SIENA (Structural Image Evaluation, using Normalization, of Atrophy) software tool to yield overall percentage brain volume change (PBVC) and voxel‐level changes in atrophy. We calculated sample sizes for a hypothetical disease‐modifying (neuroprotection) study. We found significantly greater yearly atrophy in preHD individuals versus controls (mean PBVC controls, −0.149%; preHD, −0.388%; P = .031, Cohen's d = .617). For a preHD subgroup closest to disease onset, yearly atrophy was more than 3 times that of controls (mean PBVC close‐to‐onset preHD, −0.510%; P = .019, Cohen's d = .920). This atrophy was evident at the voxel level in periventricular regions, consistent with well‐established preHD basal ganglia atrophy. We estimated that a neuroprotection study using SIENA would only need 74 close‐to‐onset individuals in each arm (treatment vs placebo) to detect a 50% slowing in yearly atrophy with 80% power. Automated whole‐brain analysis of structural MRI can reliably detect preHD disease progression in 1 year. These results were attained with a readily available imaging analysis tool, SIENA, which is observer independent, automated, and robust with respect to image quality, slice thickness, and different pulse sequences. This MRI biomarker approach could be used to evaluate neuroprotection in preHD. © 2011 Movement Disorder Society
Url:
- https://api.istex.fr/document/513EB143EAF43F3EE6C748913627587EA86F73BD/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136652
DOI: 10.1002/mds.23656
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000094
- to stream Istex, to step Curation: Pour aller vers cette notice dans l'étape Curation :000094
- to stream Istex, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000529
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000135
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :000135
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000282
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001294
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :001294
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001462
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :003133
- to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :003133
- to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :003133
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :001850
Links to Exploration step
ISTEX:513EB143EAF43F3EE6C748913627587EA86F73BDLe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Automated structural imaging analysis detects premanifest Huntington's disease neurodegeneration within 1 year</title>
<author><name sortKey="Majid, D S Adnan" sort="Majid, D S Adnan" uniqKey="Majid D" first="D. S. Adnan" last="Majid">D. S. Adnan Majid</name>
</author>
<author><name sortKey="Stoffers, Diederick" sort="Stoffers, Diederick" uniqKey="Stoffers D" first="Diederick" last="Stoffers">Diederick Stoffers</name>
</author>
<author><name sortKey="Sheldon, Sarah" sort="Sheldon, Sarah" uniqKey="Sheldon S" first="Sarah" last="Sheldon">Sarah Sheldon</name>
</author>
<author><name sortKey="Hamza, Samar" sort="Hamza, Samar" uniqKey="Hamza S" first="Samar" last="Hamza">Samar Hamza</name>
</author>
<author><name sortKey="Thompson, Wesley K" sort="Thompson, Wesley K" uniqKey="Thompson W" first="Wesley K." last="Thompson">Wesley K. Thompson</name>
</author>
<author><name sortKey="Goldstein, Jody" sort="Goldstein, Jody" uniqKey="Goldstein J" first="Jody" last="Goldstein">Jody Goldstein</name>
</author>
<author><name sortKey="Corey Loom, Jody" sort="Corey Loom, Jody" uniqKey="Corey Loom J" first="Jody" last="Corey-Bloom">Jody Corey-Bloom</name>
</author>
<author><name sortKey="Aron, Adam R" sort="Aron, Adam R" uniqKey="Aron A" first="Adam R." last="Aron">Adam R. Aron</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:513EB143EAF43F3EE6C748913627587EA86F73BD</idno>
<date when="2011" year="2011">2011</date>
<idno type="doi">10.1002/mds.23656</idno>
<idno type="url">https://api.istex.fr/document/513EB143EAF43F3EE6C748913627587EA86F73BD/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000094</idno>
<idno type="wicri:Area/Istex/Curation">000094</idno>
<idno type="wicri:Area/Istex/Checkpoint">000529</idno>
<idno type="wicri:doubleKey">0885-3185:2011:Majid D:automated:structural:imaging</idno>
<idno type="wicri:source">PMC</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136652</idno>
<idno type="RBID">PMC:3136652</idno>
<idno type="wicri:Area/Pmc/Corpus">000135</idno>
<idno type="wicri:Area/Pmc/Curation">000135</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000282</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">001294</idno>
<idno type="wicri:Area/PubMed/Curation">001294</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001462</idno>
<idno type="wicri:Area/Ncbi/Merge">003133</idno>
<idno type="wicri:Area/Ncbi/Curation">003133</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">003133</idno>
<idno type="wicri:doubleKey">0885-3185:2011:Majid D:automated:structural:imaging</idno>
<idno type="wicri:Area/Main/Merge">001850</idno>
<idno type="wicri:Area/Main/Curation">001796</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Automated structural imaging analysis detects premanifest Huntington's disease neurodegeneration within 1 year</title>
<author><name sortKey="Majid, D S Adnan" sort="Majid, D S Adnan" uniqKey="Majid D" first="D. S. Adnan" last="Majid">D. S. Adnan Majid</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychology, University of California, San Diego (UCSD), San Diego, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Neurosciences Graduate Program, University of California, San Diego (UCSD), San Diego, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stoffers, Diederick" sort="Stoffers, Diederick" uniqKey="Stoffers D" first="Diederick" last="Stoffers">Diederick Stoffers</name>
<affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Institute for Neuroscience, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sheldon, Sarah" sort="Sheldon, Sarah" uniqKey="Sheldon S" first="Sarah" last="Sheldon">Sarah Sheldon</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurosciences, University of California, San Diego (UCSD), San Diego, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hamza, Samar" sort="Hamza, Samar" uniqKey="Hamza S" first="Samar" last="Hamza">Samar Hamza</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurosciences, University of California, San Diego (UCSD), San Diego, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thompson, Wesley K" sort="Thompson, Wesley K" uniqKey="Thompson W" first="Wesley K." last="Thompson">Wesley K. Thompson</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of California, San Diego (UCSD), San Diego, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Goldstein, Jody" sort="Goldstein, Jody" uniqKey="Goldstein J" first="Jody" last="Goldstein">Jody Goldstein</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurosciences, University of California, San Diego (UCSD), San Diego, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Corey Loom, Jody" sort="Corey Loom, Jody" uniqKey="Corey Loom J" first="Jody" last="Corey-Bloom">Jody Corey-Bloom</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurosciences, University of California, San Diego (UCSD), San Diego, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Aron, Adam R" sort="Aron, Adam R" uniqKey="Aron A" first="Adam R." last="Aron">Adam R. Aron</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychology, University of California, San Diego (UCSD), San Diego, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Neurosciences Graduate Program, University of California, San Diego (UCSD), San Diego, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2011-07">2011-07</date>
<biblScope unit="vol">26</biblScope>
<biblScope unit="issue">8</biblScope>
<biblScope unit="page" from="1481">1481</biblScope>
<biblScope unit="page" to="1488">1488</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">513EB143EAF43F3EE6C748913627587EA86F73BD</idno>
<idno type="DOI">10.1002/mds.23656</idno>
<idno type="ArticleID">MDS23656</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Brain (pathology)</term>
<term>Case-Control Studies</term>
<term>Cognition Disorders (diagnosis)</term>
<term>Cognition Disorders (etiology)</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Humans</term>
<term>Huntington Disease (complications)</term>
<term>Huntington Disease (diagnosis)</term>
<term>Image Processing, Computer-Assisted</term>
<term>Longitudinal Studies</term>
<term>MRI biomarker</term>
<term>Magnetic Resonance Imaging (methods)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Nerve Degeneration (diagnosis)</term>
<term>Nerve Degeneration (etiology)</term>
<term>longitudinal atrophy</term>
<term>premanifest HD</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Huntington Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Cognition Disorders</term>
<term>Huntington Disease</term>
<term>Nerve Degeneration</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term>
<term>Nerve Degeneration</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Magnetic Resonance Imaging</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Case-Control Studies</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Humans</term>
<term>Image Processing, Computer-Assisted</term>
<term>Longitudinal Studies</term>
<term>Male</term>
<term>Middle Aged</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Intense efforts are underway to evaluate neuroimaging measures as biomarkers for neurodegeneration in premanifest Huntington's disease (preHD). We used a completely automated longitudinal analysis method to compare structural scans in preHD individuals and controls. Using a 1‐year longitudinal design, we analyzed T1‐weighted structural scans in 35 preHD individuals and 22 age‐matched controls. We used the SIENA (Structural Image Evaluation, using Normalization, of Atrophy) software tool to yield overall percentage brain volume change (PBVC) and voxel‐level changes in atrophy. We calculated sample sizes for a hypothetical disease‐modifying (neuroprotection) study. We found significantly greater yearly atrophy in preHD individuals versus controls (mean PBVC controls, −0.149%; preHD, −0.388%; P = .031, Cohen's d = .617). For a preHD subgroup closest to disease onset, yearly atrophy was more than 3 times that of controls (mean PBVC close‐to‐onset preHD, −0.510%; P = .019, Cohen's d = .920). This atrophy was evident at the voxel level in periventricular regions, consistent with well‐established preHD basal ganglia atrophy. We estimated that a neuroprotection study using SIENA would only need 74 close‐to‐onset individuals in each arm (treatment vs placebo) to detect a 50% slowing in yearly atrophy with 80% power. Automated whole‐brain analysis of structural MRI can reliably detect preHD disease progression in 1 year. These results were attained with a readily available imaging analysis tool, SIENA, which is observer independent, automated, and robust with respect to image quality, slice thickness, and different pulse sequences. This MRI biomarker approach could be used to evaluate neuroprotection in preHD. © 2011 Movement Disorder Society</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001796 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 001796 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Main |étape= Curation |type= RBID |clé= ISTEX:513EB143EAF43F3EE6C748913627587EA86F73BD |texte= Automated structural imaging analysis detects premanifest Huntington's disease neurodegeneration within 1 year }}
![]() | This area was generated with Dilib version V0.6.23. | ![]() |