MovDisordV3, Main, Curation, bibRecord, 001290

Uric acid as a potential disease modifier in patients with multiple system atrophy

Identifieur interne : 001290 ( Main/Curation ); précédent : 001289; suivant : 001291

Uric acid as a potential disease modifier in patients with multiple system atrophy

Auteurs : Ji E. Lee [Corée du Sud] ; Sook K. Song [Corée du Sud] ; Young H. Sohn [Corée du Sud] ; Phil Hyu Lee [Corée du Sud]

Source :

Movement Disorders [ 0885-3185 ] ; 2011-07.

RBID : ISTEX:9FDA783E1D171D8F0B82711CD9D73384D43B8E33

Descripteurs français

Pascal (Inist)
- Acide urique, Atrophie multisystématisée, Homme, Pathologie du système nerveux.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Enzyme Assays, Female, Human, Humans, Male, Middle Aged, Multiple System Atrophy (blood), Multiple system atrophy, Nervous system diseases, Prospective Studies, Regression Analysis, Seasons, Uric Acid (blood), Uric acid, multiple system atrophy, progression, uric acid.
MESH :
- chemical , blood : Uric Acid.
- blood : Multiple System Atrophy.
- Enzyme Assays, Female, Humans, Male, Middle Aged, Prospective Studies, Regression Analysis, Seasons.

Abstract

Background:: Recent studies have suggested that mitochondrial dysfunction and oxidative stress play a key role in the pathogenesis of multiple system atrophy. Methods:: We evaluated the influence of serum uric acid levels on disease progression in 52 patients with multiple system atrophy using changes in the annualized Unified Multiple System Atrophy Rating Scale scores. Results:: The mean annualized Unified Multiple System Atrophy Rating Scale changes were significantly lower in patients with the highest uric acid quartile compared with those with the lowest quartile (8.4 ± 5.1 vs 20.2 ± 16.0, P = .038). Serum uric acid levels had a significant negative correlation with the annualized Unified Multiple System Atrophy Rating Scale changes (r = −0.40, P = .004). Multiple linear regression analysis showed that only serum uric acid concentration was significantly correlated with the annualized Unified Multiple System Atrophy Rating Scale changes (β = −2.687, P = .011). Conclusions:: These data suggest that serum uric acid may act as a potential disease modifier in multiple system atrophy. © 2011 Movement Disorder Society

Url:

https://api.istex.fr/document/9FDA783E1D171D8F0B82711CD9D73384D43B8E33/fulltext/pdf

DOI: 10.1002/mds.23556

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ISTEX:9FDA783E1D171D8F0B82711CD9D73384D43B8E33

Le document en format XML

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<affiliation wicri:level="3"><country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Severance Biomedical Science Institute, Yonsei University, Seoul</wicri:regionArea>
<placeName><settlement type="city">Séoul</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2011-07">2011-07</date>
<biblScope unit="vol">26</biblScope>
<biblScope unit="issue">8</biblScope>
<biblScope unit="page" from="1533">1533</biblScope>
<biblScope unit="page" to="1536">1536</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">9FDA783E1D171D8F0B82711CD9D73384D43B8E33</idno>
<idno type="DOI">10.1002/mds.23556</idno>
<idno type="ArticleID">MDS23556</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Enzyme Assays</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Multiple System Atrophy (blood)</term>
<term>Prospective Studies</term>
<term>Regression Analysis</term>
<term>Seasons</term>
<term>Uric Acid (blood)</term>
<term>multiple system atrophy</term>
<term>progression</term>
<term>uric acid</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Uric Acid</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Multiple System Atrophy</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Enzyme Assays</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Prospective Studies</term>
<term>Regression Analysis</term>
<term>Seasons</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background:: Recent studies have suggested that mitochondrial dysfunction and oxidative stress play a key role in the pathogenesis of multiple system atrophy. Methods:: We evaluated the influence of serum uric acid levels on disease progression in 52 patients with multiple system atrophy using changes in the annualized Unified Multiple System Atrophy Rating Scale scores. Results:: The mean annualized Unified Multiple System Atrophy Rating Scale changes were significantly lower in patients with the highest uric acid quartile compared with those with the lowest quartile (8.4 ± 5.1 vs 20.2 ± 16.0, P = .038). Serum uric acid levels had a significant negative correlation with the annualized Unified Multiple System Atrophy Rating Scale changes (r = −0.40, P = .004). Multiple linear regression analysis showed that only serum uric acid concentration was significantly correlated with the annualized Unified Multiple System Atrophy Rating Scale changes (β = −2.687, P = .011). Conclusions:: These data suggest that serum uric acid may act as a potential disease modifier in multiple system atrophy. © 2011 Movement Disorder Society</div>
</front>
</TEI>
</ISTEX>
</double>
</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Uric acid as a potential disease modifier in patients with multiple system atrophy

Uric acid as a potential disease modifier in patients with multiple system atrophy

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