MovDisordV3, PubMed, Corpus, bibRecord, 001226

Uric acid as a potential disease modifier in patients with multiple system atrophy.

Identifieur interne : 001226 ( PubMed/Corpus ); précédent : 001225; suivant : 001227

Uric acid as a potential disease modifier in patients with multiple system atrophy.

Auteurs : Ji E. Lee ; Sook K. Song ; Young H. Sohn ; Phil Hyu Lee

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2011.

RBID : pubmed:21542015

English descriptors

KwdEn :
- Enzyme Assays, Female, Humans, Male, Middle Aged, Multiple System Atrophy (blood), Prospective Studies, Regression Analysis, Seasons, Uric Acid (blood).
MESH :
- chemical , blood : Uric Acid.
- blood : Multiple System Atrophy.
- Enzyme Assays, Female, Humans, Male, Middle Aged, Prospective Studies, Regression Analysis, Seasons.

Abstract

Recent studies have suggested that mitochondrial dysfunction and oxidative stress play a key role in the pathogenesis of multiple system atrophy.

DOI: 10.1002/mds.23556
PubMed: 21542015

Links to Exploration step

pubmed:21542015

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Uric acid as a potential disease modifier in patients with multiple system atrophy.</title>
<author><name sortKey="Lee, Ji E" sort="Lee, Ji E" uniqKey="Lee J" first="Ji E" last="Lee">Ji E. Lee</name>
<affiliation><nlm:affiliation>Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Song, Sook K" sort="Song, Sook K" uniqKey="Song S" first="Sook K" last="Song">Sook K. Song</name>
</author>
<author><name sortKey="Sohn, Young H" sort="Sohn, Young H" uniqKey="Sohn Y" first="Young H" last="Sohn">Young H. Sohn</name>
</author>
<author><name sortKey="Lee, Phil Hyu" sort="Lee, Phil Hyu" uniqKey="Lee P" first="Phil Hyu" last="Lee">Phil Hyu Lee</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2011">2011</date>
<idno type="doi">10.1002/mds.23556</idno>
<idno type="RBID">pubmed:21542015</idno>
<idno type="pmid">21542015</idno>
<idno type="wicri:Area/PubMed/Corpus">001226</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Uric acid as a potential disease modifier in patients with multiple system atrophy.</title>
<author><name sortKey="Lee, Ji E" sort="Lee, Ji E" uniqKey="Lee J" first="Ji E" last="Lee">Ji E. Lee</name>
<affiliation><nlm:affiliation>Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Song, Sook K" sort="Song, Sook K" uniqKey="Song S" first="Sook K" last="Song">Sook K. Song</name>
</author>
<author><name sortKey="Sohn, Young H" sort="Sohn, Young H" uniqKey="Sohn Y" first="Young H" last="Sohn">Young H. Sohn</name>
</author>
<author><name sortKey="Lee, Phil Hyu" sort="Lee, Phil Hyu" uniqKey="Lee P" first="Phil Hyu" last="Lee">Phil Hyu Lee</name>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2011" type="published">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Enzyme Assays</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Multiple System Atrophy (blood)</term>
<term>Prospective Studies</term>
<term>Regression Analysis</term>
<term>Seasons</term>
<term>Uric Acid (blood)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Uric Acid</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Multiple System Atrophy</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Enzyme Assays</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Prospective Studies</term>
<term>Regression Analysis</term>
<term>Seasons</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Recent studies have suggested that mitochondrial dysfunction and oxidative stress play a key role in the pathogenesis of multiple system atrophy.</div>
</front>
</TEI>
<pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">21542015</PMID>
<DateCreated><Year>2011</Year>
<Month>11</Month>
<Day>04</Day>
</DateCreated>
<DateCompleted><Year>2012</Year>
<Month>02</Month>
<Day>29</Day>
</DateCompleted>
<DateRevised><Year>2013</Year>
<Month>11</Month>
<Day>21</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>26</Volume>
<Issue>8</Issue>
<PubDate><Year>2011</Year>
<Month>Jul</Month>
</PubDate>
</JournalIssue>
<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
<ISOAbbreviation>Mov. Disord.</ISOAbbreviation>
</Journal>
<ArticleTitle>Uric acid as a potential disease modifier in patients with multiple system atrophy.</ArticleTitle>
<Pagination><MedlinePgn>1533-6</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.23556</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Recent studies have suggested that mitochondrial dysfunction and oxidative stress play a key role in the pathogenesis of multiple system atrophy.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We evaluated the influence of serum uric acid levels on disease progression in 52 patients with multiple system atrophy using changes in the annualized Unified Multiple System Atrophy Rating Scale scores.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">The mean annualized Unified Multiple System Atrophy Rating Scale changes were significantly lower in patients with the highest uric acid quartile compared with those with the lowest quartile (8.4 ± 5.1 vs 20.2 ± 16.0, P = .038). Serum uric acid levels had a significant negative correlation with the annualized Unified Multiple System Atrophy Rating Scale changes (r = -0.40, P = .004). Multiple linear regression analysis showed that only serum uric acid concentration was significantly correlated with the annualized Unified Multiple System Atrophy Rating Scale changes (β = -2.687, P = .011).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">These data suggest that serum uric acid may act as a potential disease modifier in multiple system atrophy.</AbstractText>
<CopyrightInformation>Copyright © 2010 Movement Disorder Society.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lee</LastName>
<ForeName>Ji E</ForeName>
<Initials>JE</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Song</LastName>
<ForeName>Sook K</ForeName>
<Initials>SK</Initials>
</Author>
<Author ValidYN="Y"><LastName>Sohn</LastName>
<ForeName>Young H</ForeName>
<Initials>YH</Initials>
</Author>
<Author ValidYN="Y"><LastName>Lee</LastName>
<ForeName>Phil Hyu</ForeName>
<Initials>PH</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2011</Year>
<Month>05</Month>
<Day>03</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Mov Disord</MedlineTA>
<NlmUniqueID>8610688</NlmUniqueID>
<ISSNLinking>0885-3185</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>268B43MJ25</RegistryNumber>
<NameOfSubstance UI="D014527">Uric Acid</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D057075">Enzyme Assays</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D019578">Multiple System Atrophy</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000097">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D011446">Prospective Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D012044">Regression Analysis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D012621">Seasons</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D014527">Uric Acid</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000097">blood</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2010</Year>
<Month>9</Month>
<Day>8</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2010</Year>
<Month>11</Month>
<Day>3</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2010</Year>
<Month>11</Month>
<Day>4</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="aheadofprint"><Year>2011</Year>
<Month>5</Month>
<Day>3</Day>
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<PubMedPubDate PubStatus="entrez"><Year>2011</Year>
<Month>5</Month>
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<PubMedPubDate PubStatus="medline"><Year>2012</Year>
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</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="doi">10.1002/mds.23556</ArticleId>
<ArticleId IdType="pubmed">21542015</ArticleId>
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</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Uric acid as a potential disease modifier in patients with multiple system atrophy.

Uric acid as a potential disease modifier in patients with multiple system atrophy.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki