Movement Disorders (revue)

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Parkinson's disease, subthalamic stimulation, and selection of candidates: A pathological study

Identifieur interne : 003348 ( Istex/Curation ); précédent : 003347; suivant : 003349

Parkinson's disease, subthalamic stimulation, and selection of candidates: A pathological study

Auteurs : Bechir Jarraya [France] ; Anne-Marie Bonnet [France] ; Charles Duyckaerts [France] ; Jean-Luc Houeto [France] ; Philippe Cornu [France] ; Jean-Jacques Hauw [France] ; Yves Agid [France]

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RBID : ISTEX:9C7A8C4B14DAAE696BC221EB779B4ACCF6AD3E7B

English descriptors

Abstract

We report on a patient with Parkinson's disease (PD) who was moderately improved by stimulation of the subthalamic nucleus (STN) and died 2 years after electrode implantation. After neurosurgery, symptoms that had responded to levodopa treatment preoperatively continued to improve. Postural instability, dysarthria, and cognitive impairment continued to worsen, despite STN stimulation and levodopa treatment. Postmortem examination of the brain confirmed the diagnosis of PD and showed that the electrodes had been correctly positioned within the STN. The failure of STN stimulation in this patient confirms the importance of screening and excluding patients from surgery with evolving parkinsonian axial symptoms or cognitive impairment. © 2003 Movement Disorder Society

Url:
DOI: 10.1002/mds.10607

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ISTEX:9C7A8C4B14DAAE696BC221EB779B4ACCF6AD3E7B

Le document en format XML

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<div type="abstract" xml:lang="en">We report on a patient with Parkinson's disease (PD) who was moderately improved by stimulation of the subthalamic nucleus (STN) and died 2 years after electrode implantation. After neurosurgery, symptoms that had responded to levodopa treatment preoperatively continued to improve. Postural instability, dysarthria, and cognitive impairment continued to worsen, despite STN stimulation and levodopa treatment. Postmortem examination of the brain confirmed the diagnosis of PD and showed that the electrodes had been correctly positioned within the STN. The failure of STN stimulation in this patient confirms the importance of screening and excluding patients from surgery with evolving parkinsonian axial symptoms or cognitive impairment. © 2003 Movement Disorder Society</div>
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