Impaired habituation of long‐latency stretch reflexes of the wrist muscles in Huntington's disease
Identifieur interne : 003002 ( Istex/Curation ); précédent : 003001; suivant : 003003Impaired habituation of long‐latency stretch reflexes of the wrist muscles in Huntington's disease
Auteurs : Abbruzzese [Italie] ; D. Dall'Agata [Italie] ; M. Morena [Italie] ; L. Spadavecchia [Italie] ; S. Rattod [Italie] ; E. Favale [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 1990.
English descriptors
Abstract
Electromyographic responses to sudden wrist extension were recorded from the forearm and finger flexor muscles in 10 patients with Huntington's disease (HD) and in 10 normal controls. Stretch reflexes were characterized by a short‐latency (SL) and a long‐latency (LL) component both in patients and controls. Latency, duration, and size of the SL component were not different in the two groups, whereas the LL component was delayed in latency and reduced in size in HD patients. Increasing the stretch repetition rate from 0.1 to 0.4 cycles/s did not affect the SL component of either group, whereas the LL stretch reflex was reduced in size and duration in normal controls, but not in HD patients. These findings suggest an impairment of the “gain” mechanisms of the sole LL component, responsible for a desaturation of this component. This study supports the hypothesis that LL stretch reflexes are mediated by a transcortical long loop, possibly damaged in HD.
Url:
DOI: 10.1002/mds.870050108
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :003002
Links to Exploration step
ISTEX:532F2122BD0BB8F4C0C2A4B121D7F5EE4F5C9BC0Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Impaired habituation of long‐latency stretch reflexes of the wrist muscles in Huntington's disease</title>
<author><name sortKey="Abbruzzese" sort="Abbruzzese" uniqKey="Abbruzzese" last="Abbruzzese">Abbruzzese</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University of Genoa, C.N.R., Genoa, Italy</mods:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Neurology, University of Genoa, C.N.R., Genoa</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dall Agata, D" sort="Dall Agata, D" uniqKey="Dall Agata D" first="D." last="Dall'Agata">D. Dall'Agata</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University of Genoa, C.N.R., Genoa, Italy</mods:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Neurology, University of Genoa, C.N.R., Genoa</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Morena, M" sort="Morena, M" uniqKey="Morena M" first="M." last="Morena">M. Morena</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University of Genoa, C.N.R., Genoa, Italy</mods:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Neurology, University of Genoa, C.N.R., Genoa</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Spadavecchia, L" sort="Spadavecchia, L" uniqKey="Spadavecchia L" first="L." last="Spadavecchia">L. Spadavecchia</name>
<affiliation wicri:level="1"><mods:affiliation>Institute of Cybernetics and Biophysics, C.N.R., Genoa, Italy</mods:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Institute of Cybernetics and Biophysics, C.N.R., Genoa</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rattod, S" sort="Rattod, S" uniqKey="Rattod S" first="S." last="Rattod">S. Rattod</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University of Genoa, C.N.R., Genoa, Italy</mods:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Neurology, University of Genoa, C.N.R., Genoa</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Favale, E" sort="Favale, E" uniqKey="Favale E" first="E." last="Favale">E. Favale</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University of Genoa, C.N.R., Genoa, Italy</mods:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Neurology, University of Genoa, C.N.R., Genoa</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:532F2122BD0BB8F4C0C2A4B121D7F5EE4F5C9BC0</idno>
<date when="1990" year="1990">1990</date>
<idno type="doi">10.1002/mds.870050108</idno>
<idno type="url">https://api.istex.fr/document/532F2122BD0BB8F4C0C2A4B121D7F5EE4F5C9BC0/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">003002</idno>
<idno type="wicri:Area/Istex/Curation">003002</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Impaired habituation of long‐latency stretch reflexes of the wrist muscles in Huntington's disease</title>
<author><name sortKey="Abbruzzese" sort="Abbruzzese" uniqKey="Abbruzzese" last="Abbruzzese">Abbruzzese</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University of Genoa, C.N.R., Genoa, Italy</mods:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Neurology, University of Genoa, C.N.R., Genoa</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dall Agata, D" sort="Dall Agata, D" uniqKey="Dall Agata D" first="D." last="Dall'Agata">D. Dall'Agata</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University of Genoa, C.N.R., Genoa, Italy</mods:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Neurology, University of Genoa, C.N.R., Genoa</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Morena, M" sort="Morena, M" uniqKey="Morena M" first="M." last="Morena">M. Morena</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University of Genoa, C.N.R., Genoa, Italy</mods:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Neurology, University of Genoa, C.N.R., Genoa</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Spadavecchia, L" sort="Spadavecchia, L" uniqKey="Spadavecchia L" first="L." last="Spadavecchia">L. Spadavecchia</name>
<affiliation wicri:level="1"><mods:affiliation>Institute of Cybernetics and Biophysics, C.N.R., Genoa, Italy</mods:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Institute of Cybernetics and Biophysics, C.N.R., Genoa</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rattod, S" sort="Rattod, S" uniqKey="Rattod S" first="S." last="Rattod">S. Rattod</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University of Genoa, C.N.R., Genoa, Italy</mods:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Neurology, University of Genoa, C.N.R., Genoa</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Favale, E" sort="Favale, E" uniqKey="Favale E" first="E." last="Favale">E. Favale</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University of Genoa, C.N.R., Genoa, Italy</mods:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Neurology, University of Genoa, C.N.R., Genoa</wicri:regionArea>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="1990">1990</date>
<biblScope unit="vol">5</biblScope>
<biblScope unit="issue">1</biblScope>
<biblScope unit="page" from="32">32</biblScope>
<biblScope unit="page" to="35">35</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">532F2122BD0BB8F4C0C2A4B121D7F5EE4F5C9BC0</idno>
<idno type="DOI">10.1002/mds.870050108</idno>
<idno type="ArticleID">MDS870050108</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Habituation</term>
<term>Huntington's disease</term>
<term>Long‐loop mechanisms</term>
<term>Stretch reflexes</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Electromyographic responses to sudden wrist extension were recorded from the forearm and finger flexor muscles in 10 patients with Huntington's disease (HD) and in 10 normal controls. Stretch reflexes were characterized by a short‐latency (SL) and a long‐latency (LL) component both in patients and controls. Latency, duration, and size of the SL component were not different in the two groups, whereas the LL component was delayed in latency and reduced in size in HD patients. Increasing the stretch repetition rate from 0.1 to 0.4 cycles/s did not affect the SL component of either group, whereas the LL stretch reflex was reduced in size and duration in normal controls, but not in HD patients. These findings suggest an impairment of the “gain” mechanisms of the sole LL component, responsible for a desaturation of this component. This study supports the hypothesis that LL stretch reflexes are mediated by a transcortical long loop, possibly damaged in HD.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Istex/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003002 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Curation/biblio.hfd -nk 003002 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Istex |étape= Curation |type= RBID |clé= ISTEX:532F2122BD0BB8F4C0C2A4B121D7F5EE4F5C9BC0 |texte= Impaired habituation of long‐latency stretch reflexes of the wrist muscles in Huntington's disease }}
![]() | This area was generated with Dilib version V0.6.23. | ![]() |