Impaired habituation of long‐latency stretch reflexes of the wrist muscles in Huntington's disease
Identifieur interne : 003002 ( Istex/Corpus ); précédent : 003001; suivant : 003003Impaired habituation of long‐latency stretch reflexes of the wrist muscles in Huntington's disease
Auteurs : Abbruzzese ; D. Dall'Agata ; M. Morena ; L. Spadavecchia ; S. Rattod ; E. FavaleSource :
- Movement Disorders [ 0885-3185 ] ; 1990.
English descriptors
Abstract
Electromyographic responses to sudden wrist extension were recorded from the forearm and finger flexor muscles in 10 patients with Huntington's disease (HD) and in 10 normal controls. Stretch reflexes were characterized by a short‐latency (SL) and a long‐latency (LL) component both in patients and controls. Latency, duration, and size of the SL component were not different in the two groups, whereas the LL component was delayed in latency and reduced in size in HD patients. Increasing the stretch repetition rate from 0.1 to 0.4 cycles/s did not affect the SL component of either group, whereas the LL stretch reflex was reduced in size and duration in normal controls, but not in HD patients. These findings suggest an impairment of the “gain” mechanisms of the sole LL component, responsible for a desaturation of this component. This study supports the hypothesis that LL stretch reflexes are mediated by a transcortical long loop, possibly damaged in HD.
Url:
DOI: 10.1002/mds.870050108
Links to Exploration step
ISTEX:532F2122BD0BB8F4C0C2A4B121D7F5EE4F5C9BC0Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Impaired habituation of long‐latency stretch reflexes of the wrist muscles in Huntington's disease</title><author><name sortKey="Abbruzzese" sort="Abbruzzese" uniqKey="Abbruzzese" last="Abbruzzese">Abbruzzese</name><affiliation><mods:affiliation>Department of Neurology, University of Genoa, C.N.R., Genoa, Italy</mods:affiliation></affiliation></author><author><name sortKey="Dall Agata, D" sort="Dall Agata, D" uniqKey="Dall Agata D" first="D." last="Dall'Agata">D. Dall'Agata</name><affiliation><mods:affiliation>Department of Neurology, University of Genoa, C.N.R., Genoa, Italy</mods:affiliation></affiliation></author><author><name sortKey="Morena, M" sort="Morena, M" uniqKey="Morena M" first="M." last="Morena">M. Morena</name><affiliation><mods:affiliation>Department of Neurology, University of Genoa, C.N.R., Genoa, Italy</mods:affiliation></affiliation></author><author><name sortKey="Spadavecchia, L" sort="Spadavecchia, L" uniqKey="Spadavecchia L" first="L." last="Spadavecchia">L. Spadavecchia</name><affiliation><mods:affiliation>Institute of Cybernetics and Biophysics, C.N.R., Genoa, Italy</mods:affiliation></affiliation></author><author><name sortKey="Rattod, S" sort="Rattod, S" uniqKey="Rattod S" first="S." last="Rattod">S. Rattod</name><affiliation><mods:affiliation>Department of Neurology, University of Genoa, C.N.R., Genoa, Italy</mods:affiliation></affiliation></author><author><name sortKey="Favale, E" sort="Favale, E" uniqKey="Favale E" first="E." last="Favale">E. Favale</name><affiliation><mods:affiliation>Department of Neurology, University of Genoa, C.N.R., Genoa, Italy</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:532F2122BD0BB8F4C0C2A4B121D7F5EE4F5C9BC0</idno><date when="1990" year="1990">1990</date><idno type="doi">10.1002/mds.870050108</idno><idno type="url">https://api.istex.fr/document/532F2122BD0BB8F4C0C2A4B121D7F5EE4F5C9BC0/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">003002</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Impaired habituation of long‐latency stretch reflexes of the wrist muscles in Huntington's disease</title><author><name sortKey="Abbruzzese" sort="Abbruzzese" uniqKey="Abbruzzese" last="Abbruzzese">Abbruzzese</name><affiliation><mods:affiliation>Department of Neurology, University of Genoa, C.N.R., Genoa, Italy</mods:affiliation></affiliation></author><author><name sortKey="Dall Agata, D" sort="Dall Agata, D" uniqKey="Dall Agata D" first="D." last="Dall'Agata">D. Dall'Agata</name><affiliation><mods:affiliation>Department of Neurology, University of Genoa, C.N.R., Genoa, Italy</mods:affiliation></affiliation></author><author><name sortKey="Morena, M" sort="Morena, M" uniqKey="Morena M" first="M." last="Morena">M. Morena</name><affiliation><mods:affiliation>Department of Neurology, University of Genoa, C.N.R., Genoa, Italy</mods:affiliation></affiliation></author><author><name sortKey="Spadavecchia, L" sort="Spadavecchia, L" uniqKey="Spadavecchia L" first="L." last="Spadavecchia">L. Spadavecchia</name><affiliation><mods:affiliation>Institute of Cybernetics and Biophysics, C.N.R., Genoa, Italy</mods:affiliation></affiliation></author><author><name sortKey="Rattod, S" sort="Rattod, S" uniqKey="Rattod S" first="S." last="Rattod">S. Rattod</name><affiliation><mods:affiliation>Department of Neurology, University of Genoa, C.N.R., Genoa, Italy</mods:affiliation></affiliation></author><author><name sortKey="Favale, E" sort="Favale, E" uniqKey="Favale E" first="E." last="Favale">E. Favale</name><affiliation><mods:affiliation>Department of Neurology, University of Genoa, C.N.R., Genoa, Italy</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1990">1990</date><biblScope unit="vol">5</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="32">32</biblScope><biblScope unit="page" to="35">35</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">532F2122BD0BB8F4C0C2A4B121D7F5EE4F5C9BC0</idno><idno type="DOI">10.1002/mds.870050108</idno><idno type="ArticleID">MDS870050108</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Habituation</term><term>Huntington's disease</term><term>Long‐loop mechanisms</term><term>Stretch reflexes</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Electromyographic responses to sudden wrist extension were recorded from the forearm and finger flexor muscles in 10 patients with Huntington's disease (HD) and in 10 normal controls. Stretch reflexes were characterized by a short‐latency (SL) and a long‐latency (LL) component both in patients and controls. Latency, duration, and size of the SL component were not different in the two groups, whereas the LL component was delayed in latency and reduced in size in HD patients. Increasing the stretch repetition rate from 0.1 to 0.4 cycles/s did not affect the SL component of either group, whereas the LL stretch reflex was reduced in size and duration in normal controls, but not in HD patients. These findings suggest an impairment of the “gain” mechanisms of the sole LL component, responsible for a desaturation of this component. This study supports the hypothesis that LL stretch reflexes are mediated by a transcortical long loop, possibly damaged in HD.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Dr. Abbruzzese</name><affiliations><json:string>Department of Neurology, University of Genoa, C.N.R., Genoa, Italy</json:string></affiliations></json:item><json:item><name>D. Dall'Agata</name><affiliations><json:string>Department of Neurology, University of Genoa, C.N.R., Genoa, Italy</json:string></affiliations></json:item><json:item><name>M. Morena</name><affiliations><json:string>Department of Neurology, University of Genoa, C.N.R., Genoa, Italy</json:string></affiliations></json:item><json:item><name>L. Spadavecchia</name><affiliations><json:string>Institute of Cybernetics and Biophysics, C.N.R., Genoa, Italy</json:string></affiliations></json:item><json:item><name>S. Rattod</name><affiliations><json:string>Department of Neurology, University of Genoa, C.N.R., Genoa, Italy</json:string></affiliations></json:item><json:item><name>E. Favale</name><affiliations><json:string>Department of Neurology, University of Genoa, C.N.R., Genoa, Italy</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Stretch reflexes</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Habituation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Huntington's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Long‐loop mechanisms</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Electromyographic responses to sudden wrist extension were recorded from the forearm and finger flexor muscles in 10 patients with Huntington's disease (HD) and in 10 normal controls. Stretch reflexes were characterized by a short‐latency (SL) and a long‐latency (LL) component both in patients and controls. Latency, duration, and size of the SL component were not different in the two groups, whereas the LL component was delayed in latency and reduced in size in HD patients. Increasing the stretch repetition rate from 0.1 to 0.4 cycles/s did not affect the SL component of either group, whereas the LL stretch reflex was reduced in size and duration in normal controls, but not in HD patients. These findings suggest an impairment of the “gain” mechanisms of the sole LL component, responsible for a desaturation of this component. This study supports the hypothesis that LL stretch reflexes are mediated by a transcortical long loop, possibly damaged in HD.</abstract><qualityIndicators><score>3.96</score><pdfVersion>1.3</pdfVersion><pdfPageSize>576 x 828 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>963</abstractCharCount><pdfWordCount>2112</pdfWordCount><pdfCharCount>12971</pdfCharCount><pdfPageCount>4</pdfPageCount><abstractWordCount>154</abstractWordCount></qualityIndicators><title>Impaired habituation of long‐latency stretch reflexes of the wrist muscles in Huntington's disease</title><genre><json:string>Serial article</json:string></genre><host><volume>5</volume><pages><total>4</total><last>35</last><first>32</first></pages><issn><json:string>0885-3185</json:string></issn><issue>1</issue><subject><json:item><value>Article</value></json:item></subject><genre></genre><language><json:string>unknown</json:string></language><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>1990</publicationDate><copyrightDate>1990</copyrightDate><doi><json:string>10.1002/mds.870050108</json:string></doi><id>532F2122BD0BB8F4C0C2A4B121D7F5EE4F5C9BC0</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/532F2122BD0BB8F4C0C2A4B121D7F5EE4F5C9BC0/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/532F2122BD0BB8F4C0C2A4B121D7F5EE4F5C9BC0/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/532F2122BD0BB8F4C0C2A4B121D7F5EE4F5C9BC0/fulltext/tei"><teiHeader type="text"><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Impaired habituation of long‐latency stretch reflexes of the wrist muscles in Huntington's disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>Wiley Subscription Services, Inc., A Wiley Company</p></availability><date>1990</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Impaired habituation of long‐latency stretch reflexes of the wrist muscles in Huntington's disease</title><author><persName><surname>Abbruzzese</surname><roleName type="degree">Dr.</roleName></persName><note type="correspondence"><p>Correspondence: Clinica Neurologica dell'Universita', Via De Toni 5, I‐16132 Genoa, Italy</p></note><affiliation>Department of Neurology, University of Genoa, C.N.R., Genoa, Italy</affiliation></author><author><persName><forename type="first">D.</forename><surname>Dall'Agata</surname></persName><affiliation>Department of Neurology, University of Genoa, C.N.R., Genoa, Italy</affiliation></author><author><persName><forename type="first">M.</forename><surname>Morena</surname></persName><affiliation>Department of Neurology, University of Genoa, C.N.R., Genoa, Italy</affiliation></author><author><persName><forename type="first">L.</forename><surname>Spadavecchia</surname></persName><affiliation>Institute of Cybernetics and Biophysics, C.N.R., Genoa, Italy</affiliation></author><author><persName><forename type="first">S.</forename><surname>Rattod</surname></persName><affiliation>Department of Neurology, University of Genoa, C.N.R., Genoa, Italy</affiliation></author><author><persName><forename type="first">E.</forename><surname>Favale</surname></persName><affiliation>Department of Neurology, University of Genoa, C.N.R., Genoa, Italy</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1990"></date><biblScope unit="vol">5</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="32">32</biblScope><biblScope unit="page" to="35">35</biblScope></imprint></monogr><idno type="istex">532F2122BD0BB8F4C0C2A4B121D7F5EE4F5C9BC0</idno><idno type="DOI">10.1002/mds.870050108</idno><idno type="ArticleID">MDS870050108</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1990</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Electromyographic responses to sudden wrist extension were recorded from the forearm and finger flexor muscles in 10 patients with Huntington's disease (HD) and in 10 normal controls. Stretch reflexes were characterized by a short‐latency (SL) and a long‐latency (LL) component both in patients and controls. Latency, duration, and size of the SL component were not different in the two groups, whereas the LL component was delayed in latency and reduced in size in HD patients. Increasing the stretch repetition rate from 0.1 to 0.4 cycles/s did not affect the SL component of either group, whereas the LL stretch reflex was reduced in size and duration in normal controls, but not in HD patients. These findings suggest an impairment of the “gain” mechanisms of the sole LL component, responsible for a desaturation of this component. This study supports the hypothesis that LL stretch reflexes are mediated by a transcortical long loop, possibly damaged in HD.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Stretch reflexes</term></item><item><term>Habituation</term></item><item><term>Huntington's disease</term></item><item><term>Long‐loop mechanisms</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1990">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/532F2122BD0BB8F4C0C2A4B121D7F5EE4F5C9BC0/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="subtitle">Official Journal of the Movement Disorder Society</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="10"><doi origin="wiley" registered="yes">10.1002/mds.v5:1</doi><numberingGroup><numbering type="journalVolume" number="5">5</numbering><numbering type="journalIssue">1</numbering></numberingGroup><coverDate startDate="1990">1990</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="8" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.870050108</doi><idGroup><id type="unit" value="MDS870050108"></id></idGroup><countGroup><count type="pageTotal" number="4"></count></countGroup><titleGroup><title type="articleCategory">Article</title><title type="tocHeading1">Articles</title></titleGroup><copyright ownership="thirdParty">Copyright © 1990 Movement Disorder Society</copyright><eventGroup><event type="firstOnline" date="2004-10-12"></event><event type="publishedOnlineFinalForm" date="2004-10-12"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.2 mode:FullText source:HeaderRef result:HeaderRef" date="2010-03-09"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">32</numbering><numbering type="pageLast">35</numbering></numberingGroup><correspondenceTo>Clinica Neurologica dell'Universita', Via De Toni 5, I‐16132 Genoa, Italy</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS870050108.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="2"></count><count type="tableTotal" number="2"></count><count type="referenceTotal" number="16"></count></countGroup><titleGroup><title type="main" xml:lang="en">Impaired habituation of long‐latency stretch reflexes of the wrist muscles in Huntington's disease</title><title type="short" xml:lang="en">STRETCH REFLEX HABITUATION IN HUNTINGTON</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><honorifics>Dr.</honorifics><givenNames>G.</givenNames><familyName>Abbruzzese</familyName></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>D.</givenNames><familyName>Dall'Agata</familyName></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1"><personName><givenNames>M.</givenNames><familyName>Morena</familyName></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af2"><personName><givenNames>L.</givenNames><familyName>Spadavecchia</familyName></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1"><personName><givenNames>S.</givenNames><familyName>Rattod</familyName></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1"><personName><givenNames>E.</givenNames><familyName>Favale</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="IT" type="organization"><unparsedAffiliation>Department of Neurology, University of Genoa, C.N.R., Genoa, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="IT" type="organization"><unparsedAffiliation>Institute of Cybernetics and Biophysics, C.N.R., Genoa, Italy</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Stretch reflexes</keyword><keyword xml:id="kwd2">Habituation</keyword><keyword xml:id="kwd3">Huntington's disease</keyword><keyword xml:id="kwd4">Long‐loop mechanisms</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Electromyographic responses to sudden wrist extension were recorded from the forearm and finger flexor muscles in 10 patients with Huntington's disease (HD) and in 10 normal controls. Stretch reflexes were characterized by a short‐latency (SL) and a long‐latency (LL) component both in patients and controls. Latency, duration, and size of the SL component were not different in the two groups, whereas the LL component was delayed in latency and reduced in size in HD patients. Increasing the stretch repetition rate from 0.1 to 0.4 cycles/s did not affect the SL component of either group, whereas the LL stretch reflex was reduced in size and duration in normal controls, but not in HD patients. These findings suggest an impairment of the “gain” mechanisms of the sole LL component, responsible for a desaturation of this component. This study supports the hypothesis that LL stretch reflexes are mediated by a transcortical long loop, possibly damaged in HD.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 4-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Impaired habituation of long‐latency stretch reflexes of the wrist muscles in Huntington's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>STRETCH REFLEX HABITUATION IN HUNTINGTON</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Impaired habituation of long‐latency stretch reflexes of the wrist muscles in Huntington's disease</title></titleInfo><name type="personal"><namePart type="termsOfAddress">Dr.</namePart><namePart type="family">Abbruzzese</namePart><affiliation>Department of Neurology, University of Genoa, C.N.R., Genoa, Italy</affiliation><description>Correspondence: Clinica Neurologica dell'Universita', Via De Toni 5, I‐16132 Genoa, Italy</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Dall'Agata</namePart><affiliation>Department of Neurology, University of Genoa, C.N.R., Genoa, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Morena</namePart><affiliation>Department of Neurology, University of Genoa, C.N.R., Genoa, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Spadavecchia</namePart><affiliation>Institute of Cybernetics and Biophysics, C.N.R., Genoa, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Rattod</namePart><affiliation>Department of Neurology, University of Genoa, C.N.R., Genoa, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Favale</namePart><affiliation>Department of Neurology, University of Genoa, C.N.R., Genoa, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">1990</dateIssued><copyrightDate encoding="w3cdtf">1990</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="tables">2</extent><extent unit="references">16</extent></physicalDescription><abstract lang="en">Electromyographic responses to sudden wrist extension were recorded from the forearm and finger flexor muscles in 10 patients with Huntington's disease (HD) and in 10 normal controls. Stretch reflexes were characterized by a short‐latency (SL) and a long‐latency (LL) component both in patients and controls. Latency, duration, and size of the SL component were not different in the two groups, whereas the LL component was delayed in latency and reduced in size in HD patients. Increasing the stretch repetition rate from 0.1 to 0.4 cycles/s did not affect the SL component of either group, whereas the LL stretch reflex was reduced in size and duration in normal controls, but not in HD patients. These findings suggest an impairment of the “gain” mechanisms of the sole LL component, responsible for a desaturation of this component. This study supports the hypothesis that LL stretch reflexes are mediated by a transcortical long loop, possibly damaged in HD.</abstract><subject lang="en"><genre>Keywords</genre><topic>Stretch reflexes</topic><topic>Habituation</topic><topic>Huntington's disease</topic><topic>Long‐loop mechanisms</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>5</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>32</start><end>35</end><total>4</total></extent></part></relatedItem><identifier type="istex">532F2122BD0BB8F4C0C2A4B121D7F5EE4F5C9BC0</identifier><identifier type="DOI">10.1002/mds.870050108</identifier><identifier type="ArticleID">MDS870050108</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 1990 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003002 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 003002 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:532F2122BD0BB8F4C0C2A4B121D7F5EE4F5C9BC0
|texte= Impaired habituation of long‐latency stretch reflexes of the wrist muscles in Huntington's disease
}}
| This area was generated with Dilib version V0.6.23. |  |