Long‐term follow‐up of DYT1 dystonia patients treated by deep brain stimulation: An open‐label study
Identifieur interne : 000C42 ( Istex/Curation ); précédent : 000C41; suivant : 000C43Long‐term follow‐up of DYT1 dystonia patients treated by deep brain stimulation: An open‐label study
Auteurs : Laura Cif [France] ; Xavier Vasques [France] ; Victoria Gonzalez [France] ; Patrice Ravel [France] ; Brigitte Biolsi [France] ; Gwenaelle Collod-Beroud [France] ; Sylvie Tuffery-Giraud [France] ; Hassan Elfertit [France] ; Mireille Claustres [France] ; Philippe Coubes [France]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-02-15.
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Abstract
Long‐term efficacy of internal globus pallidus (GPi) deep‐brain stimulation (DBS) in DYT1 dystonia and disease progression under DBS was studied. Twenty‐six patients of this open‐label study were divided into two groups: (A) with single bilateral GPi lead, (B) with a second bilateral GPi lead implanted owning to subsequent worsening of symptomatology. Dystonia was assessed with the Burke Scale. Appearance of new symptoms and distribution according to body region were recorded. In the whole cohort, significant decreases in motor and disability subscores (P < 0.0001) were observed at 1 year and maintained up to 10 years. Group B showed worsening of the symptoms. At 1 year, there were no significant differences between Groups A (without subsequent worsening) and B; at 5 years, a significant difference was found for motor and disability scores. Within Group B, four patients exhibited additional improvement after the second DBS surgery. In the 26 patients, significant difference (P = 0.001) was found between the number of body regions affected by dystonia preoperatively and over the whole follow‐up. DBS efficacy in DYT1 dystonia can be maintained up to 10 years (two patients). New symptoms appear with long‐term follow‐up and may improve with additional leads in a subgroup of patients. © 2009 Movement Disorder Society
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DOI: 10.1002/mds.22802
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wicri:level="1"><mods:affiliation>CNRS UMR5048, Centre de Biochimie Structurale, Montpellier, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS UMR5048, Centre de Biochimie Structurale, Montpellier</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>INSERM, U554, Montpellier, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U554, Montpellier</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Université de Montpellier 2, Montpellier, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Montpellier 2, Montpellier</wicri:regionArea></affiliation></author><author><name sortKey="Biolsi, Brigitte" sort="Biolsi, Brigitte" uniqKey="Biolsi B" first="Brigitte" last="Biolsi">Brigitte Biolsi</name><affiliation wicri:level="1"><mods:affiliation>CHRU Montpellier, Hôpital Gui de Chauliac, Service de Neurochirurgie, Montpellier, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CHRU Montpellier, Hôpital Gui de Chauliac, Service de Neurochirurgie, Montpellier</wicri:regionArea></affiliation></author><author><name sortKey="Collod Eroud, Gwenaelle" sort="Collod Eroud, Gwenaelle" uniqKey="Collod Eroud G" first="Gwenaelle" last="Collod-Beroud">Gwenaelle Collod-Beroud</name><affiliation wicri:level="1"><mods:affiliation>Université de Montpellier 1, Montpellier, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Montpellier 1, Montpellier</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>INSERM, U827, Montpellier, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U827, Montpellier</wicri:regionArea></affiliation></author><author><name sortKey="Tuffery Iraud, Sylvie" sort="Tuffery Iraud, Sylvie" uniqKey="Tuffery Iraud S" first="Sylvie" last="Tuffery-Giraud">Sylvie Tuffery-Giraud</name><affiliation wicri:level="1"><mods:affiliation>Université de Montpellier 1, Montpellier, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Montpellier 1, Montpellier</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>INSERM, U827, Montpellier, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U827, Montpellier</wicri:regionArea></affiliation></author><author><name sortKey="Elfertit, Hassan" sort="Elfertit, Hassan" uniqKey="Elfertit H" first="Hassan" last="Elfertit">Hassan Elfertit</name><affiliation wicri:level="1"><mods:affiliation>CHRU Montpellier, Hôpital Gui de Chauliac, Service de Neurochirurgie, Montpellier, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CHRU Montpellier, Hôpital Gui de Chauliac, Service de Neurochirurgie, Montpellier</wicri:regionArea></affiliation></author><author><name sortKey="Claustres, Mireille" sort="Claustres, Mireille" uniqKey="Claustres M" first="Mireille" last="Claustres">Mireille Claustres</name><affiliation wicri:level="1"><mods:affiliation>Université de Montpellier 1, Montpellier, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Montpellier 1, Montpellier</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>INSERM, U827, Montpellier, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U827, Montpellier</wicri:regionArea></affiliation></author><author><name sortKey="Coubes, Philippe" sort="Coubes, Philippe" uniqKey="Coubes P" first="Philippe" last="Coubes">Philippe Coubes</name><affiliation wicri:level="1"><mods:affiliation>CHRU Montpellier, Hôpital Gui de Chauliac, Service de Neurochirurgie, Montpellier, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CHRU Montpellier, Hôpital Gui de Chauliac, Service de Neurochirurgie, Montpellier</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>INSERM, U661, Montpellier, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U661, Montpellier</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Université de Montpellier 1, Montpellier, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Montpellier 1, Montpellier</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-02-15">2010-02-15</date><biblScope unit="vol">25</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="289">289</biblScope><biblScope unit="page" to="299">299</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">C9AE796F8705D2EBD0732ECEFED18513E9AB9CCD</idno><idno type="DOI">10.1002/mds.22802</idno><idno type="ArticleID">MDS22802</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>DBS</term><term>DYT1 dystonia</term><term>disease progression</term><term>internal pallidum</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Long‐term efficacy of internal globus pallidus (GPi) deep‐brain stimulation (DBS) in DYT1 dystonia and disease progression under DBS was studied. Twenty‐six patients of this open‐label study were divided into two groups: (A) with single bilateral GPi lead, (B) with a second bilateral GPi lead implanted owning to subsequent worsening of symptomatology. Dystonia was assessed with the Burke Scale. Appearance of new symptoms and distribution according to body region were recorded. In the whole cohort, significant decreases in motor and disability subscores (P < 0.0001) were observed at 1 year and maintained up to 10 years. Group B showed worsening of the symptoms. At 1 year, there were no significant differences between Groups A (without subsequent worsening) and B; at 5 years, a significant difference was found for motor and disability scores. Within Group B, four patients exhibited additional improvement after the second DBS surgery. In the 26 patients, significant difference (P = 0.001) was found between the number of body regions affected by dystonia preoperatively and over the whole follow‐up. DBS efficacy in DYT1 dystonia can be maintained up to 10 years (two patients). New symptoms appear with long‐term follow‐up and may improve with additional leads in a subgroup of patients. © 2009 Movement Disorder Society</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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