Long‐term follow‐up of DYT1 dystonia patients treated by deep brain stimulation: An open‐label study
Identifieur interne : 000C42 ( Istex/Corpus ); précédent : 000C41; suivant : 000C43Long‐term follow‐up of DYT1 dystonia patients treated by deep brain stimulation: An open‐label study
Auteurs : Laura Cif ; Xavier Vasques ; Victoria Gonzalez ; Patrice Ravel ; Brigitte Biolsi ; Gwenaelle Collod-Beroud ; Sylvie Tuffery-Giraud ; Hassan Elfertit ; Mireille Claustres ; Philippe CoubesSource :
- Movement Disorders [ 0885-3185 ] ; 2010-02-15.
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Abstract
Long‐term efficacy of internal globus pallidus (GPi) deep‐brain stimulation (DBS) in DYT1 dystonia and disease progression under DBS was studied. Twenty‐six patients of this open‐label study were divided into two groups: (A) with single bilateral GPi lead, (B) with a second bilateral GPi lead implanted owning to subsequent worsening of symptomatology. Dystonia was assessed with the Burke Scale. Appearance of new symptoms and distribution according to body region were recorded. In the whole cohort, significant decreases in motor and disability subscores (P < 0.0001) were observed at 1 year and maintained up to 10 years. Group B showed worsening of the symptoms. At 1 year, there were no significant differences between Groups A (without subsequent worsening) and B; at 5 years, a significant difference was found for motor and disability scores. Within Group B, four patients exhibited additional improvement after the second DBS surgery. In the 26 patients, significant difference (P = 0.001) was found between the number of body regions affected by dystonia preoperatively and over the whole follow‐up. DBS efficacy in DYT1 dystonia can be maintained up to 10 years (two patients). New symptoms appear with long‐term follow‐up and may improve with additional leads in a subgroup of patients. © 2009 Movement Disorder Society
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DOI: 10.1002/mds.22802
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year="2010">2010</date><idno type="doi">10.1002/mds.22802</idno><idno type="url">https://api.istex.fr/document/C9AE796F8705D2EBD0732ECEFED18513E9AB9CCD/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000C42</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Long‐term follow‐up of DYT1 dystonia patients treated by deep brain stimulation: An open‐label study</title><author><name sortKey="Cif, Laura" sort="Cif, Laura" uniqKey="Cif L" first="Laura" last="Cif">Laura Cif</name><affiliation><mods:affiliation>CHRU Montpellier, Hôpital Gui de Chauliac, Service de Neurochirurgie, Montpellier, France</mods:affiliation></affiliation><affiliation><mods:affiliation>INSERM, U661, Montpellier, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Université de Montpellier 1, Montpellier, France</mods:affiliation></affiliation><affiliation><mods:affiliation>CNRS UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France</mods:affiliation></affiliation></author><author><name sortKey="Vasques, Xavier" sort="Vasques, Xavier" uniqKey="Vasques X" first="Xavier" last="Vasques">Xavier Vasques</name><affiliation><mods:affiliation>INSERM, U661, Montpellier, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Université de Montpellier 1, Montpellier, France</mods:affiliation></affiliation><affiliation><mods:affiliation>CNRS UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France</mods:affiliation></affiliation></author><author><name sortKey="Gonzalez, Victoria" sort="Gonzalez, Victoria" uniqKey="Gonzalez V" first="Victoria" last="Gonzalez">Victoria Gonzalez</name><affiliation><mods:affiliation>CHRU Montpellier, Hôpital Gui de Chauliac, Service de Neurochirurgie, Montpellier, France</mods:affiliation></affiliation><affiliation><mods:affiliation>INSERM, U661, Montpellier, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Université de Montpellier 1, Montpellier, France</mods:affiliation></affiliation><affiliation><mods:affiliation>CNRS UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France</mods:affiliation></affiliation></author><author><name sortKey="Ravel, Patrice" sort="Ravel, Patrice" uniqKey="Ravel P" first="Patrice" last="Ravel">Patrice Ravel</name><affiliation><mods:affiliation>Université de Montpellier 1, Montpellier, France</mods:affiliation></affiliation><affiliation><mods:affiliation>CNRS UMR5048, Centre de Biochimie Structurale, Montpellier, France</mods:affiliation></affiliation><affiliation><mods:affiliation>INSERM, U554, Montpellier, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Université de Montpellier 2, Montpellier, France</mods:affiliation></affiliation></author><author><name sortKey="Biolsi, Brigitte" sort="Biolsi, Brigitte" uniqKey="Biolsi B" first="Brigitte" last="Biolsi">Brigitte Biolsi</name><affiliation><mods:affiliation>CHRU Montpellier, Hôpital Gui de Chauliac, Service de Neurochirurgie, Montpellier, France</mods:affiliation></affiliation></author><author><name sortKey="Collod Eroud, Gwenaelle" sort="Collod Eroud, Gwenaelle" uniqKey="Collod Eroud G" first="Gwenaelle" last="Collod-Beroud">Gwenaelle Collod-Beroud</name><affiliation><mods:affiliation>Université de Montpellier 1, Montpellier, France</mods:affiliation></affiliation><affiliation><mods:affiliation>INSERM, U827, Montpellier, France</mods:affiliation></affiliation></author><author><name sortKey="Tuffery Iraud, Sylvie" sort="Tuffery Iraud, Sylvie" uniqKey="Tuffery Iraud S" first="Sylvie" last="Tuffery-Giraud">Sylvie Tuffery-Giraud</name><affiliation><mods:affiliation>Université de Montpellier 1, Montpellier, France</mods:affiliation></affiliation><affiliation><mods:affiliation>INSERM, U827, Montpellier, France</mods:affiliation></affiliation></author><author><name sortKey="Elfertit, Hassan" sort="Elfertit, Hassan" uniqKey="Elfertit H" first="Hassan" last="Elfertit">Hassan Elfertit</name><affiliation><mods:affiliation>CHRU Montpellier, Hôpital Gui de Chauliac, Service de Neurochirurgie, Montpellier, France</mods:affiliation></affiliation></author><author><name sortKey="Claustres, Mireille" sort="Claustres, Mireille" uniqKey="Claustres M" first="Mireille" last="Claustres">Mireille Claustres</name><affiliation><mods:affiliation>Université de Montpellier 1, Montpellier, France</mods:affiliation></affiliation><affiliation><mods:affiliation>INSERM, U827, Montpellier, France</mods:affiliation></affiliation></author><author><name sortKey="Coubes, Philippe" sort="Coubes, Philippe" uniqKey="Coubes P" first="Philippe" last="Coubes">Philippe Coubes</name><affiliation><mods:affiliation>CHRU Montpellier, Hôpital Gui de Chauliac, Service de Neurochirurgie, Montpellier, France</mods:affiliation></affiliation><affiliation><mods:affiliation>INSERM, U661, Montpellier, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Université de Montpellier 1, Montpellier, France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-02-15">2010-02-15</date><biblScope unit="vol">25</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="289">289</biblScope><biblScope unit="page" to="299">299</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">C9AE796F8705D2EBD0732ECEFED18513E9AB9CCD</idno><idno type="DOI">10.1002/mds.22802</idno><idno type="ArticleID">MDS22802</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>DBS</term><term>DYT1 dystonia</term><term>disease progression</term><term>internal pallidum</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Long‐term efficacy of internal globus pallidus (GPi) deep‐brain stimulation (DBS) in DYT1 dystonia and disease progression under DBS was studied. Twenty‐six patients of this open‐label study were divided into two groups: (A) with single bilateral GPi lead, (B) with a second bilateral GPi lead implanted owning to subsequent worsening of symptomatology. Dystonia was assessed with the Burke Scale. Appearance of new symptoms and distribution according to body region were recorded. In the whole cohort, significant decreases in motor and disability subscores (P < 0.0001) were observed at 1 year and maintained up to 10 years. Group B showed worsening of the symptoms. At 1 year, there were no significant differences between Groups A (without subsequent worsening) and B; at 5 years, a significant difference was found for motor and disability scores. Within Group B, four patients exhibited additional improvement after the second DBS surgery. In the 26 patients, significant difference (P = 0.001) was found between the number of body regions affected by dystonia preoperatively and over the whole follow‐up. DBS efficacy in DYT1 dystonia can be maintained up to 10 years (two patients). New symptoms appear with long‐term follow‐up and may improve with additional leads in a subgroup of patients. © 2009 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Laura Cif MD</name><affiliations><json:string>CHRU Montpellier, Hôpital Gui de Chauliac, Service de Neurochirurgie, Montpellier, France</json:string><json:string>INSERM, U661, Montpellier, France</json:string><json:string>Université de Montpellier 1, Montpellier, France</json:string><json:string>CNRS UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France</json:string></affiliations></json:item><json:item><name>Xavier Vasques PhD</name><affiliations><json:string>INSERM, U661, Montpellier, France</json:string><json:string>Université de Montpellier 1, Montpellier, France</json:string><json:string>CNRS UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France</json:string></affiliations></json:item><json:item><name>Victoria Gonzalez MD</name><affiliations><json:string>CHRU Montpellier, Hôpital Gui de Chauliac, Service de Neurochirurgie, Montpellier, France</json:string><json:string>INSERM, U661, Montpellier, France</json:string><json:string>Université de Montpellier 1, Montpellier, France</json:string><json:string>CNRS UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France</json:string></affiliations></json:item><json:item><name>Patrice Ravel PhD</name><affiliations><json:string>Université de Montpellier 1, Montpellier, France</json:string><json:string>CNRS UMR5048, Centre de Biochimie Structurale, Montpellier, France</json:string><json:string>INSERM, U554, Montpellier, France</json:string><json:string>Université de Montpellier 2, Montpellier, France</json:string></affiliations></json:item><json:item><name>Brigitte Biolsi MD</name><affiliations><json:string>CHRU Montpellier, Hôpital Gui de Chauliac, Service de Neurochirurgie, Montpellier, France</json:string></affiliations></json:item><json:item><name>Gwenaelle Collod‐Beroud PhD</name><affiliations><json:string>Université de Montpellier 1, Montpellier, France</json:string><json:string>INSERM, U827, Montpellier, France</json:string></affiliations></json:item><json:item><name>Sylvie Tuffery‐Giraud PhD</name><affiliations><json:string>Université de Montpellier 1, Montpellier, France</json:string><json:string>INSERM, U827, Montpellier, France</json:string></affiliations></json:item><json:item><name>Hassan Elfertit MD</name><affiliations><json:string>CHRU Montpellier, Hôpital Gui de Chauliac, Service de Neurochirurgie, Montpellier, France</json:string></affiliations></json:item><json:item><name>Mireille Claustres MD, PhD</name><affiliations><json:string>Université de Montpellier 1, Montpellier, France</json:string><json:string>INSERM, U827, Montpellier, France</json:string></affiliations></json:item><json:item><name>Philippe Coubes MD, PhD</name><affiliations><json:string>CHRU Montpellier, Hôpital Gui de Chauliac, Service de Neurochirurgie, Montpellier, France</json:string><json:string>INSERM, U661, Montpellier, France</json:string><json:string>Université de Montpellier 1, Montpellier, France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>DYT1 dystonia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>DBS</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>internal pallidum</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>disease progression</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Long‐term efficacy of internal globus pallidus (GPi) deep‐brain stimulation (DBS) in DYT1 dystonia and disease progression under DBS was studied. Twenty‐six patients of this open‐label study were divided into two groups: (A) with single bilateral GPi lead, (B) with a second bilateral GPi lead implanted owning to subsequent worsening of symptomatology. Dystonia was assessed with the Burke Scale. Appearance of new symptoms and distribution according to body region were recorded. In the whole cohort, significant decreases in motor and disability subscores (P > 0.0001) were observed at 1 year and maintained up to 10 years. Group B showed worsening of the symptoms. At 1 year, there were no significant differences between Groups A (without subsequent worsening) and B; at 5 years, a significant difference was found for motor and disability scores. Within Group B, four patients exhibited additional improvement after the second DBS surgery. In the 26 patients, significant difference (P = 0.001) was found between the number of body regions affected by dystonia preoperatively and over the whole follow‐up. DBS efficacy in DYT1 dystonia can be maintained up to 10 years (two patients). New symptoms appear with long‐term follow‐up and may improve with additional leads in a subgroup of patients. © 2009 Movement Disorder Society</abstract><qualityIndicators><score>6.874</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>1333</abstractCharCount><pdfWordCount>4402</pdfWordCount><pdfCharCount>28200</pdfCharCount><pdfPageCount>11</pdfPageCount><abstractWordCount>206</abstractWordCount></qualityIndicators><title>Long‐term follow‐up of DYT1 dystonia patients treated by deep brain stimulation: An open‐label study</title><genre><json:string>Serial article</json:string></genre><host><volume>25</volume><pages><total>11</total><last>299</last><first>289</first></pages><issn><json:string>0885-3185</json:string></issn><issue>3</issue><subject><json:item><value>Research Article</value></json:item></subject><genre></genre><language><json:string>unknown</json:string></language><title>Movement 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study</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>Wiley Subscription Services, Inc., A Wiley Company</p></availability><date>2010</date></publicationStmt><notesStmt><note type="content">*Potential conflict of interest: Nothing to report</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Long‐term follow‐up of DYT1 dystonia patients treated by deep brain stimulation: An open‐label study</title><author><persName><forename type="first">Laura</forename><surname>Cif</surname><roleName type="degree">MD</roleName></persName><note type="correspondence"><p>Correspondence: Service de Neurochirurgie, Hôpital Gui de Chauliac, 80, Avenue Augustin Fliche, Montepellier, 34295 Cedex 5, France===</p></note><affiliation>CHRU Montpellier, Hôpital Gui de Chauliac, Service de Neurochirurgie, Montpellier, France</affiliation><affiliation>INSERM, U661, Montpellier, France</affiliation><affiliation>Université de Montpellier 1, Montpellier, France</affiliation><affiliation>CNRS UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France</affiliation></author><author><persName><forename type="first">Xavier</forename><surname>Vasques</surname><roleName type="degree">PhD</roleName></persName><affiliation>INSERM, U661, Montpellier, France</affiliation><affiliation>Université de Montpellier 1, Montpellier, France</affiliation><affiliation>CNRS UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France</affiliation></author><author><persName><forename type="first">Victoria</forename><surname>Gonzalez</surname><roleName type="degree">MD</roleName></persName><affiliation>CHRU Montpellier, Hôpital Gui de Chauliac, Service de Neurochirurgie, Montpellier, France</affiliation><affiliation>INSERM, U661, Montpellier, France</affiliation><affiliation>Université de Montpellier 1, Montpellier, France</affiliation><affiliation>CNRS UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France</affiliation></author><author><persName><forename type="first">Patrice</forename><surname>Ravel</surname><roleName type="degree">PhD</roleName></persName><affiliation>Université de Montpellier 1, Montpellier, France</affiliation><affiliation>CNRS UMR5048, Centre de Biochimie Structurale, Montpellier, France</affiliation><affiliation>INSERM, U554, Montpellier, France</affiliation><affiliation>Université de Montpellier 2, Montpellier, France</affiliation></author><author><persName><forename type="first">Brigitte</forename><surname>Biolsi</surname><roleName type="degree">MD</roleName></persName><affiliation>CHRU Montpellier, Hôpital Gui de Chauliac, Service de Neurochirurgie, Montpellier, France</affiliation></author><author><persName><forename type="first">Gwenaelle</forename><surname>Collod‐Beroud</surname><roleName type="degree">PhD</roleName></persName><affiliation>Université de Montpellier 1, Montpellier, France</affiliation><affiliation>INSERM, U827, Montpellier, France</affiliation></author><author><persName><forename type="first">Sylvie</forename><surname>Tuffery‐Giraud</surname><roleName type="degree">PhD</roleName></persName><affiliation>Université de Montpellier 1, Montpellier, France</affiliation><affiliation>INSERM, U827, Montpellier, France</affiliation></author><author><persName><forename type="first">Hassan</forename><surname>Elfertit</surname><roleName type="degree">MD</roleName></persName><affiliation>CHRU Montpellier, Hôpital Gui de Chauliac, Service de Neurochirurgie, Montpellier, France</affiliation></author><author><persName><forename type="first">Mireille</forename><surname>Claustres</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Université de Montpellier 1, Montpellier, France</affiliation><affiliation>INSERM, U827, Montpellier, France</affiliation></author><author><persName><forename type="first">Philippe</forename><surname>Coubes</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>CHRU Montpellier, Hôpital Gui de Chauliac, Service de Neurochirurgie, Montpellier, France</affiliation><affiliation>INSERM, U661, Montpellier, France</affiliation><affiliation>Université de Montpellier 1, Montpellier, France</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-02-15"></date><biblScope unit="vol">25</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="289">289</biblScope><biblScope unit="page" to="299">299</biblScope></imprint></monogr><idno type="istex">C9AE796F8705D2EBD0732ECEFED18513E9AB9CCD</idno><idno type="DOI">10.1002/mds.22802</idno><idno type="ArticleID">MDS22802</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2010</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Long‐term efficacy of internal globus pallidus (GPi) deep‐brain stimulation (DBS) in DYT1 dystonia and disease progression under DBS was studied. Twenty‐six patients of this open‐label study were divided into two groups: (A) with single bilateral GPi lead, (B) with a second bilateral GPi lead implanted owning to subsequent worsening of symptomatology. Dystonia was assessed with the Burke Scale. Appearance of new symptoms and distribution according to body region were recorded. In the whole cohort, significant decreases in motor and disability subscores (P < 0.0001) were observed at 1 year and maintained up to 10 years. Group B showed worsening of the symptoms. At 1 year, there were no significant differences between Groups A (without subsequent worsening) and B; at 5 years, a significant difference was found for motor and disability scores. Within Group B, four patients exhibited additional improvement after the second DBS surgery. In the 26 patients, significant difference (P = 0.001) was found between the number of body regions affected by dystonia preoperatively and over the whole follow‐up. DBS efficacy in DYT1 dystonia can be maintained up to 10 years (two patients). New symptoms appear with long‐term follow‐up and may improve with additional leads in a subgroup of patients. © 2009 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>DYT1 dystonia</term></item><item><term>DBS</term></item><item><term>internal pallidum</term></item><item><term>disease progression</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2008-11-14">Received</change><change when="2009-08-20">Registration</change><change when="2010-02-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/C9AE796F8705D2EBD0732ECEFED18513E9AB9CCD/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="30"><doi origin="wiley" registered="yes">10.1002/mds.v25:3</doi><numberingGroup><numbering type="journalVolume" number="25">25</numbering><numbering type="journalIssue">3</numbering></numberingGroup><coverDate startDate="2010-02-15">15 February 2010</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="70" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.22802</doi><idGroup><id type="unit" value="MDS22802"></id></idGroup><countGroup><count type="pageTotal" number="11"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="thirdParty">Copyright © 2009 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2008-11-14"></event><event type="manuscriptAccepted" date="2009-08-20"></event><event type="firstOnline" date="2010-01-08"></event><event type="publishedOnlineFinalForm" date="2010-02-24"></event><event type="publishedOnlineAcceptedOrEarlyUnpaginated" date="2010-01-08"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:3.3.2 mode:FullText" date="2014-07-01"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.3.2 mode:FullText" date="2014-07-01"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">289</numbering><numbering type="pageLast">299</numbering></numberingGroup><correspondenceTo>Service de Neurochirurgie, Hôpital Gui de Chauliac, 80, Avenue Augustin Fliche, Montepellier, 34295 Cedex 5, France===</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS22802.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="2"></count><count type="tableTotal" number="3"></count><count type="referenceTotal" number="30"></count><count type="wordTotal" number="7931"></count></countGroup><titleGroup><title type="main" xml:lang="en">Long‐term follow‐up of DYT1 dystonia patients treated by deep brain stimulation: An open‐label study<link href="#fn9"></link></title><title type="short" xml:lang="en">Clinical Course of DYT1 Dystonia with DBS</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1 #af2 #af3 #af4" corresponding="yes"><personName><givenNames>Laura</givenNames><familyName>Cif</familyName><degrees>MD</degrees></personName><contactDetails><email normalForm="a-cif@chu-montpellier.fr">a‐cif@chu‐montpellier.fr</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2 #af3 #af4"><personName><givenNames>Xavier</givenNames><familyName>Vasques</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1 #af2 #af3 #af4"><personName><givenNames>Victoria</givenNames><familyName>Gonzalez</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af3 #af5 #af6 #af7"><personName><givenNames>Patrice</givenNames><familyName>Ravel</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Brigitte</givenNames><familyName>Biolsi</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af3 #af8"><personName><givenNames>Gwenaelle</givenNames><familyName>Collod‐Beroud</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af3 #af8"><personName><givenNames>Sylvie</givenNames><familyName>Tuffery‐Giraud</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Hassan</givenNames><familyName>Elfertit</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af3 #af8"><personName><givenNames>Mireille</givenNames><familyName>Claustres</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au10" creatorRole="author" affiliationRef="#af1 #af2 #af3"><personName><givenNames>Philippe</givenNames><familyName>Coubes</familyName><degrees>MD, PhD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="FR" type="organization"><unparsedAffiliation>CHRU Montpellier, Hôpital Gui de Chauliac, Service de Neurochirurgie, Montpellier, France</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="FR" type="organization"><unparsedAffiliation>INSERM, U661, Montpellier, France</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="FR" type="organization"><unparsedAffiliation>Université de Montpellier 1, Montpellier, France</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="FR" type="organization"><unparsedAffiliation>CNRS UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="FR" type="organization"><unparsedAffiliation>CNRS UMR5048, Centre de Biochimie Structurale, Montpellier, France</unparsedAffiliation></affiliation><affiliation xml:id="af6" countryCode="FR" type="organization"><unparsedAffiliation>INSERM, U554, Montpellier, France</unparsedAffiliation></affiliation><affiliation xml:id="af7" countryCode="FR" type="organization"><unparsedAffiliation>Université de Montpellier 2, Montpellier, France</unparsedAffiliation></affiliation><affiliation xml:id="af8" countryCode="FR" type="organization"><unparsedAffiliation>INSERM, U827, Montpellier, France</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">DYT1 dystonia</keyword><keyword xml:id="kwd2">DBS</keyword><keyword xml:id="kwd3">internal pallidum</keyword><keyword xml:id="kwd4">disease progression</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Long‐term efficacy of internal globus pallidus (GPi) deep‐brain stimulation (DBS) in DYT1 dystonia and disease progression under DBS was studied. Twenty‐six patients of this open‐label study were divided into two groups: (A) with single bilateral GPi lead, (B) with a second bilateral GPi lead implanted owning to subsequent worsening of symptomatology. Dystonia was assessed with the Burke Scale. Appearance of new symptoms and distribution according to body region were recorded. In the whole cohort, significant decreases in motor and disability subscores (<i>P</i> < 0.0001) were observed at 1 year and maintained up to 10 years. Group B showed worsening of the symptoms. At 1 year, there were no significant differences between Groups A (without subsequent worsening) and B; at 5 years, a significant difference was found for motor and disability scores. Within Group B, four patients exhibited additional improvement after the second DBS surgery. In the 26 patients, significant difference (<i>P</i> = 0.001) was found between the number of body regions affected by dystonia preoperatively and over the whole follow‐up. DBS efficacy in DYT1 dystonia can be maintained up to 10 years (two patients). New symptoms appear with long‐term follow‐up and may improve with additional leads in a subgroup of patients. © 2009 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn9"><p>Potential conflict of interest: Nothing to report</p></note></noteGroup></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Long‐term follow‐up of DYT1 dystonia patients treated by deep brain stimulation: An open‐label study</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Clinical Course of DYT1 Dystonia with DBS</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Long‐term follow‐up of DYT1 dystonia patients treated by deep brain stimulation: An open‐label study</title></titleInfo><name type="personal"><namePart type="given">Laura</namePart><namePart type="family">Cif</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>CHRU Montpellier, Hôpital Gui de Chauliac, Service de Neurochirurgie, Montpellier, France</affiliation><affiliation>INSERM, U661, Montpellier, France</affiliation><affiliation>Université de Montpellier 1, Montpellier, France</affiliation><affiliation>CNRS UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France</affiliation><description>Correspondence: Service de Neurochirurgie, Hôpital Gui de Chauliac, 80, Avenue Augustin Fliche, Montepellier, 34295 Cedex 5, France===</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Xavier</namePart><namePart type="family">Vasques</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>INSERM, U661, Montpellier, France</affiliation><affiliation>Université de Montpellier 1, Montpellier, France</affiliation><affiliation>CNRS UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Victoria</namePart><namePart type="family">Gonzalez</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>CHRU Montpellier, Hôpital Gui de Chauliac, Service de Neurochirurgie, Montpellier, France</affiliation><affiliation>INSERM, U661, Montpellier, France</affiliation><affiliation>Université de Montpellier 1, Montpellier, France</affiliation><affiliation>CNRS UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Patrice</namePart><namePart type="family">Ravel</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Université de Montpellier 1, Montpellier, France</affiliation><affiliation>CNRS UMR5048, Centre de Biochimie Structurale, Montpellier, France</affiliation><affiliation>INSERM, U554, Montpellier, France</affiliation><affiliation>Université de Montpellier 2, Montpellier, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Brigitte</namePart><namePart type="family">Biolsi</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>CHRU Montpellier, Hôpital Gui de Chauliac, Service de Neurochirurgie, Montpellier, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gwenaelle</namePart><namePart type="family">Collod‐Beroud</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Université de Montpellier 1, Montpellier, France</affiliation><affiliation>INSERM, U827, Montpellier, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sylvie</namePart><namePart type="family">Tuffery‐Giraud</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Université de Montpellier 1, Montpellier, France</affiliation><affiliation>INSERM, U827, Montpellier, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hassan</namePart><namePart type="family">Elfertit</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>CHRU Montpellier, Hôpital Gui de Chauliac, Service de Neurochirurgie, Montpellier, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mireille</namePart><namePart type="family">Claustres</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Université de Montpellier 1, Montpellier, France</affiliation><affiliation>INSERM, U827, Montpellier, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Philippe</namePart><namePart type="family">Coubes</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>CHRU Montpellier, Hôpital Gui de Chauliac, Service de Neurochirurgie, Montpellier, France</affiliation><affiliation>INSERM, U661, Montpellier, France</affiliation><affiliation>Université de Montpellier 1, Montpellier, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2010-02-15</dateIssued><dateCaptured encoding="w3cdtf">2008-11-14</dateCaptured><dateValid encoding="w3cdtf">2009-08-20</dateValid><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="tables">3</extent><extent unit="references">30</extent><extent unit="words">7931</extent></physicalDescription><abstract lang="en">Long‐term efficacy of internal globus pallidus (GPi) deep‐brain stimulation (DBS) in DYT1 dystonia and disease progression under DBS was studied. Twenty‐six patients of this open‐label study were divided into two groups: (A) with single bilateral GPi lead, (B) with a second bilateral GPi lead implanted owning to subsequent worsening of symptomatology. Dystonia was assessed with the Burke Scale. Appearance of new symptoms and distribution according to body region were recorded. In the whole cohort, significant decreases in motor and disability subscores (P < 0.0001) were observed at 1 year and maintained up to 10 years. Group B showed worsening of the symptoms. At 1 year, there were no significant differences between Groups A (without subsequent worsening) and B; at 5 years, a significant difference was found for motor and disability scores. Within Group B, four patients exhibited additional improvement after the second DBS surgery. In the 26 patients, significant difference (P = 0.001) was found between the number of body regions affected by dystonia preoperatively and over the whole follow‐up. DBS efficacy in DYT1 dystonia can be maintained up to 10 years (two patients). New symptoms appear with long‐term follow‐up and may improve with additional leads in a subgroup of patients. © 2009 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: Nothing to report</note><subject lang="en"><genre>Keywords</genre><topic>DYT1 dystonia</topic><topic>DBS</topic><topic>internal pallidum</topic><topic>disease progression</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. 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