Tremor severity and age: A cross‐sectional, population‐based study of 2,524 young and midlife normal adults
Identifieur interne : 000911 ( Istex/Curation ); précédent : 000910; suivant : 000912Tremor severity and age: A cross‐sectional, population‐based study of 2,524 young and midlife normal adults
Auteurs : Elan D. Louis [États-Unis] ; Danella Hafeman [États-Unis] ; Faruque Parvez [États-Unis] ; Xinhua Liu [États-Unis] ; Roy N. Alcalay [États-Unis] ; Tariqul Islam [Bangladesh] ; Alauddin Ahmed [Bangladesh] ; Abu Bakar Siddique [Bangladesh] ; Tazul Islam Patwary [Bangladesh] ; Stephanie Melkonian [États-Unis] ; Maria Argos [États-Unis] ; Diane Levy [États-Unis] ; Habibul Ahsan [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-07.
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Abstract
Mild action tremor occurs in most normal people. Yet this tremor mainly has been studied within the context of advanced age rather than among the vast bulk of adults who are not elderly. Whether this tremor worsens during young and middle age is unknown. Using cross‐sectional data from a large population‐based study of young and midlife normal adults (age range, 18–60 years), we assessed whether increasing age is associated with more severe action tremor. Two thousand five hundred and twenty‐four adults in Araihazar, Bangladesh, drew an Archimedes spiral with each hand. Tremor in spirals was rated (0–3) by a blinded neurologist, and a spiral score (range, 0–6) was assigned. Spiral score was correlated with age (r = 0.06, P = .004). With each advancing decade, the spiral score increased (P = .002) so that the spiral score in participants in the highest age group (age 60) was approximately twice that of participants in the youngest age group (age 18–19); P = .003. In the regression model that adjusted for potential confounders (sex, cigarettes, medications, asthma inhalers, and tea and betel nut use), spiral score was associated with age (P = .0045). In this cross‐sectional, population‐based study of more than 2500 young and midlife normal adults, there was a clear association between age and tremor severity. Although the magnitude of the correlation coefficient was modest, tremor severity was higher with each passing decade. These data suggest that age‐dependent increase in tremor amplitude is not restricted to older people but occurs in all adult age groups. © 2011 Movement Disorder Society
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DOI: 10.1002/mds.23674
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Louis</name><affiliation wicri:level="1"><mods:affiliation>GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York</wicri:regionArea></affiliation></author><author><name sortKey="Hafeman, Danella" sort="Hafeman, Danella" uniqKey="Hafeman D" first="Danella" last="Hafeman">Danella Hafeman</name><affiliation wicri:level="1"><mods:affiliation>Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania</wicri:regionArea></affiliation></author><author><name sortKey="Parvez, Faruque" sort="Parvez, Faruque" uniqKey="Parvez F" first="Faruque" last="Parvez">Faruque Parvez</name><affiliation wicri:level="1"><mods:affiliation>Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Xinhua" sort="Liu, Xinhua" uniqKey="Liu X" first="Xinhua" last="Liu">Xinhua Liu</name><affiliation wicri:level="1"><mods:affiliation>Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York</wicri:regionArea></affiliation></author><author><name sortKey="Alcalay, Roy N" sort="Alcalay, Roy N" uniqKey="Alcalay R" first="Roy N." last="Alcalay">Roy N. 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xml:lang="en">Tremor severity and age: A cross‐sectional, population‐based study of 2,524 young and midlife normal adults</title><author><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D." last="Louis">Elan D. Louis</name><affiliation wicri:level="1"><mods:affiliation>GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York</wicri:regionArea></affiliation></author><author><name sortKey="Hafeman, Danella" sort="Hafeman, Danella" uniqKey="Hafeman D" first="Danella" last="Hafeman">Danella Hafeman</name><affiliation wicri:level="1"><mods:affiliation>Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania</wicri:regionArea></affiliation></author><author><name sortKey="Parvez, Faruque" sort="Parvez, Faruque" uniqKey="Parvez F" first="Faruque" last="Parvez">Faruque Parvez</name><affiliation wicri:level="1"><mods:affiliation>Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Xinhua" sort="Liu, Xinhua" uniqKey="Liu X" first="Xinhua" last="Liu">Xinhua Liu</name><affiliation wicri:level="1"><mods:affiliation>Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York</wicri:regionArea></affiliation></author><author><name sortKey="Alcalay, Roy N" sort="Alcalay, Roy N" uniqKey="Alcalay R" first="Roy N." last="Alcalay">Roy N. Alcalay</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York</wicri:regionArea></affiliation></author><author><name sortKey="Islam, Tariqul" sort="Islam, Tariqul" uniqKey="Islam T" first="Tariqul" last="Islam">Tariqul Islam</name><affiliation wicri:level="1"><mods:affiliation>Columbia University/University of Chicago Arsenic Research Office in Bangladesh, Dhaka, Bangladesh</mods:affiliation><country xml:lang="fr">Bangladesh</country><wicri:regionArea>Columbia University/University of Chicago Arsenic Research Office in Bangladesh, Dhaka</wicri:regionArea></affiliation></author><author><name sortKey="Ahmed, Alauddin" sort="Ahmed, Alauddin" uniqKey="Ahmed A" first="Alauddin" last="Ahmed">Alauddin Ahmed</name><affiliation wicri:level="1"><mods:affiliation>Columbia University/University of Chicago Arsenic Research Office in Bangladesh, Dhaka, Bangladesh</mods:affiliation><country xml:lang="fr">Bangladesh</country><wicri:regionArea>Columbia University/University of Chicago Arsenic Research Office in Bangladesh, Dhaka</wicri:regionArea></affiliation></author><author><name sortKey="Siddique, Abu Bakar" sort="Siddique, Abu Bakar" uniqKey="Siddique A" first="Abu Bakar" last="Siddique">Abu Bakar Siddique</name><affiliation wicri:level="1"><mods:affiliation>Columbia University/University of Chicago Arsenic Research Office in Bangladesh, Dhaka, Bangladesh</mods:affiliation><country xml:lang="fr">Bangladesh</country><wicri:regionArea>Columbia University/University of Chicago Arsenic Research Office in Bangladesh, Dhaka</wicri:regionArea></affiliation></author><author><name sortKey="Patwary, Tazul Islam" sort="Patwary, Tazul Islam" uniqKey="Patwary T" first="Tazul Islam" last="Patwary">Tazul Islam Patwary</name><affiliation wicri:level="1"><mods:affiliation>Columbia University/University of Chicago Arsenic Research Office in Bangladesh, Dhaka, Bangladesh</mods:affiliation><country xml:lang="fr">Bangladesh</country><wicri:regionArea>Columbia University/University of Chicago Arsenic Research Office in Bangladesh, Dhaka</wicri:regionArea></affiliation></author><author><name sortKey="Melkonian, Stephanie" sort="Melkonian, Stephanie" uniqKey="Melkonian S" first="Stephanie" last="Melkonian">Stephanie Melkonian</name><affiliation wicri:level="1"><mods:affiliation>Departments of Health Studies, Medicine and Human Genetics and Comprehensive Cancer Center, University of Chicago, Chicago, Illinois, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Health Studies, Medicine and Human Genetics and Comprehensive Cancer Center, University of Chicago, Chicago, Illinois</wicri:regionArea></affiliation></author><author><name sortKey="Argos, Maria" sort="Argos, Maria" uniqKey="Argos M" first="Maria" last="Argos">Maria Argos</name><affiliation wicri:level="1"><mods:affiliation>Departments of Health Studies, Medicine and Human Genetics and Comprehensive Cancer Center, University of Chicago, Chicago, Illinois, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Health Studies, Medicine and Human Genetics and Comprehensive Cancer Center, University of Chicago, Chicago, Illinois</wicri:regionArea></affiliation></author><author><name sortKey="Levy, Diane" sort="Levy, Diane" uniqKey="Levy D" first="Diane" last="Levy">Diane Levy</name><affiliation wicri:level="1"><mods:affiliation>Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York</wicri:regionArea></affiliation></author><author><name sortKey="Ahsan, Habibul" sort="Ahsan, Habibul" uniqKey="Ahsan H" first="Habibul" last="Ahsan">Habibul Ahsan</name><affiliation wicri:level="1"><mods:affiliation>Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Departments of Health Studies, Medicine and Human Genetics and Comprehensive Cancer Center, University of Chicago, Chicago, Illinois, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Health Studies, Medicine and Human Genetics and Comprehensive Cancer Center, University of Chicago, Chicago, Illinois</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-07">2011-07</date><biblScope unit="vol">26</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1515">1515</biblScope><biblScope unit="page" to="1520">1520</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">7376BE373F0450F58E54453E77D5C35AFEF7F98A</idno><idno type="DOI">10.1002/mds.23674</idno><idno type="ArticleID">MDS23674</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>age</term><term>clinical</term><term>epidemiology</term><term>tremor</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Mild action tremor occurs in most normal people. Yet this tremor mainly has been studied within the context of advanced age rather than among the vast bulk of adults who are not elderly. Whether this tremor worsens during young and middle age is unknown. Using cross‐sectional data from a large population‐based study of young and midlife normal adults (age range, 18–60 years), we assessed whether increasing age is associated with more severe action tremor. Two thousand five hundred and twenty‐four adults in Araihazar, Bangladesh, drew an Archimedes spiral with each hand. Tremor in spirals was rated (0–3) by a blinded neurologist, and a spiral score (range, 0–6) was assigned. Spiral score was correlated with age (r = 0.06, P = .004). With each advancing decade, the spiral score increased (P = .002) so that the spiral score in participants in the highest age group (age 60) was approximately twice that of participants in the youngest age group (age 18–19); P = .003. In the regression model that adjusted for potential confounders (sex, cigarettes, medications, asthma inhalers, and tea and betel nut use), spiral score was associated with age (P = .0045). In this cross‐sectional, population‐based study of more than 2500 young and midlife normal adults, there was a clear association between age and tremor severity. Although the magnitude of the correlation coefficient was modest, tremor severity was higher with each passing decade. These data suggest that age‐dependent increase in tremor amplitude is not restricted to older people but occurs in all adult age groups. © 2011 Movement Disorder Society</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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