International multicenter pilot study of the first comprehensive self‐completed nonmotor symptoms questionnaire for Parkinson's disease: The NMSQuest study
Identifieur interne : 000910 ( Istex/Curation ); précédent : 000909; suivant : 000911International multicenter pilot study of the first comprehensive self‐completed nonmotor symptoms questionnaire for Parkinson's disease: The NMSQuest study
Auteurs : Kallol Ray Chaudhuri [Royaume-Uni] ; Pablo Martinez-Martin [Espagne] ; Anthony H. V. Schapira [Royaume-Uni] ; Fabrizio Stocchi [Italie] ; Kapil Sethi [États-Unis] ; Per Odin [Allemagne] ; Richard G. Brown [Royaume-Uni] ; William Koller [États-Unis] ; Paolo Barone [Italie] ; Graeme Macphee [Royaume-Uni] ; Linda Kelly [Royaume-Uni] ; Martin Rabey [Israël] ; Doug Macmahon [Royaume-Uni] ; Sue Thomas [Royaume-Uni] ; William Ondo [États-Unis] ; David Rye [États-Unis] ; Alison Forbes [Royaume-Uni] ; Susanne Tluk [Royaume-Uni] ; Vandana Dhawan [Royaume-Uni] ; Annette Bowron [Royaume-Uni] ; Adrian J. Williams [Royaume-Uni] ; Charles W. Olanow [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2006-07.
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Abstract
Nonmotor symptoms (NMS) of Parkinson's disease (PD) are not well recognized in clinical practice, either in primary or in secondary care, and are frequently missed during routine consultations. There is no single instrument (questionnaire or scale) that enables a comprehensive assessment of the range of NMS in PD both for the identification of problems and for the measurement of outcome. Against this background, a multidisciplinary group of experts, including patient group representatives, has developed an NMS screening questionnaire comprising 30 items. This instrument does not provide an overall score of disability and is not a graded or rating instrument. Instead, it is a screening tool designed to draw attention to the presence of NMS and initiate further investigation. In this article, we present the results from an international pilot study assessing feasibility, validity, and acceptability of a nonmotor questionnaire (NMSQuest). Data from 123 PD patients and 96 controls were analyzed. NMS were highly significantly more prevalent in PD compared to controls (PD NMS, median = 9.0, mean = 9.5 vs. control NMS, median = 5.5, mean = 4.0; Mann–Whitney, Kruskal–Wallis, and t test, P < 0.0001), with PD patients reporting at least 10 different NMS on average per patient. In PD, NMS were highly significantly more prevalent across all disease stages and the number of symptoms correlated significantly with advancing disease and duration of disease. Furthermore, frequently, problems such as diplopia, dribbling, apathy, blues, taste and smell problems were never previously disclosed to the health professionals. © 2006 Movement Disorder Society
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DOI: 10.1002/mds.20844
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Rye</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Emory University, Atlanta, Georgia, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Emory University, Atlanta, Georgia</wicri:regionArea></affiliation></author><author><name sortKey="Forbes, Alison" sort="Forbes, Alison" uniqKey="Forbes A" first="Alison" last="Forbes">Alison Forbes</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Hospital Lewisham, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurology, University Hospital Lewisham, London</wicri:regionArea></affiliation></author><author><name sortKey="Tluk, Susanne" sort="Tluk, Susanne" uniqKey="Tluk S" first="Susanne" last="Tluk">Susanne Tluk</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Hospital Lewisham, London, United 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sortKey="Bowron, Annette" sort="Bowron, Annette" uniqKey="Bowron A" first="Annette" last="Bowron">Annette Bowron</name><affiliation wicri:level="1"><mods:affiliation>Department of Medicine, North Tyneside General Hospital, North Shields, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Medicine, North Tyneside General Hospital, North Shields</wicri:regionArea></affiliation></author><author><name sortKey="Williams, Adrian J" sort="Williams, Adrian J" uniqKey="Williams A" first="Adrian J." last="Williams">Adrian J. Williams</name><affiliation wicri:level="1"><mods:affiliation>Lane‐Fox Sleep Centre, St. Thomas' Hospital, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Lane‐Fox Sleep Centre, St. Thomas' Hospital, London</wicri:regionArea></affiliation></author><author><name sortKey="Olanow, Charles W" sort="Olanow, Charles W" uniqKey="Olanow C" first="Charles W." last="Olanow">Charles W. Olanow</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Mount Sinai School of Medicine, New York, New York, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mount Sinai School of Medicine, New York, New York</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:D8434962ECAF86015FB03F915D9586CF01CBD870</idno><date when="2006" year="2006">2006</date><idno type="doi">10.1002/mds.20844</idno><idno type="url">https://api.istex.fr/document/D8434962ECAF86015FB03F915D9586CF01CBD870/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000910</idno><idno type="wicri:Area/Istex/Curation">000910</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">International multicenter pilot study of the first comprehensive self‐completed nonmotor symptoms questionnaire for Parkinson's disease: The NMSQuest study</title><author><name sortKey="Chaudhuri, Kallol Ray" sort="Chaudhuri, Kallol Ray" uniqKey="Chaudhuri K" first="Kallol Ray" last="Chaudhuri">Kallol Ray Chaudhuri</name><affiliation wicri:level="1"><mods:affiliation>Movement Disorders Unit, Kings College Hospital, University Hospital Lewisham, Guy's King's and St. Thomas' School of Medicine, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Movement Disorders Unit, Kings College Hospital, University Hospital Lewisham, Guy's King's and St. Thomas' School of Medicine, London</wicri:regionArea></affiliation></author><author><name sortKey="Martinez Artin, Pablo" sort="Martinez Artin, Pablo" uniqKey="Martinez Artin P" first="Pablo" last="Martinez-Martin">Pablo Martinez-Martin</name><affiliation wicri:level="1"><mods:affiliation>Unit of Neuroepidemiology, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unit of Neuroepidemiology, National Center for Epidemiology, Carlos III Institute of Health, Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Schapira, Anthony H V" sort="Schapira, Anthony H V" uniqKey="Schapira A" first="Anthony H. V." last="Schapira">Anthony H. V. Schapira</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Royal Free Hospital Medical School and National Hospital for Neurology, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurology, Royal Free Hospital Medical School and National Hospital for Neurology, London</wicri:regionArea></affiliation></author><author><name sortKey="Stocchi, Fabrizio" sort="Stocchi, Fabrizio" uniqKey="Stocchi F" first="Fabrizio" last="Stocchi">Fabrizio Stocchi</name><affiliation wicri:level="1"><mods:affiliation>Institute of Neurology, IRCCS NEUROMED, Pozzilli, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Neurology, IRCCS NEUROMED, Pozzilli</wicri:regionArea></affiliation></author><author><name sortKey="Sethi, Kapil" sort="Sethi, Kapil" uniqKey="Sethi K" first="Kapil" last="Sethi">Kapil Sethi</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Medical College of Georgia, Augusta, Georgia, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Medical College of Georgia, Augusta, Georgia</wicri:regionArea></affiliation></author><author><name sortKey="Odin, Per" sort="Odin, Per" uniqKey="Odin P" first="Per" last="Odin">Per Odin</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Klinikum‐Bremerhaven Reinkenheide, Bremenhaven, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Klinikum‐Bremerhaven Reinkenheide, Bremenhaven</wicri:regionArea></affiliation></author><author><name sortKey="Brown, Richard G" sort="Brown, Richard G" uniqKey="Brown R" first="Richard G." last="Brown">Richard G. Brown</name><affiliation wicri:level="1"><mods:affiliation>Department of Psychology, Institute of Psychiatry, King's College London, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Psychology, Institute of Psychiatry, King's College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Koller, William" sort="Koller, William" uniqKey="Koller W" first="William" last="Koller">William Koller</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University of North Carolina, Chapel Hill, North Carolina, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of North Carolina, Chapel Hill, North Carolina</wicri:regionArea></affiliation></author><author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University of Napoli, Napoli, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, University of Napoli, Napoli</wicri:regionArea></affiliation></author><author><name sortKey="Macphee, Graeme" sort="Macphee, Graeme" uniqKey="Macphee G" first="Graeme" last="Macphee">Graeme Macphee</name><affiliation wicri:level="1"><mods:affiliation>Department of Care of the Elderly, Southern General Hospital, Glasgow, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Care of the Elderly, Southern General Hospital, Glasgow</wicri:regionArea></affiliation></author><author><name sortKey="Kelly, Linda" sort="Kelly, Linda" uniqKey="Kelly L" first="Linda" last="Kelly">Linda Kelly</name><affiliation wicri:level="1"><mods:affiliation>U.K. Parkinson's Disease Society, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>U.K. Parkinson's Disease Society, London</wicri:regionArea></affiliation></author><author><name sortKey="Rabey, Martin" sort="Rabey, Martin" uniqKey="Rabey M" first="Martin" last="Rabey">Martin Rabey</name><affiliation wicri:level="1"><mods:affiliation>Assaf Harofeh Medical Center, School of Medicine, Tel‐Aviv University, Zerifin, Israel</mods:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Assaf Harofeh Medical Center, School of Medicine, Tel‐Aviv University, Zerifin</wicri:regionArea></affiliation></author><author><name sortKey="Macmahon, Doug" sort="Macmahon, Doug" uniqKey="Macmahon D" first="Doug" last="Macmahon">Doug Macmahon</name><affiliation wicri:level="1"><mods:affiliation>Department of Care of the Elderly, Camborne‐Redruth Hospital, Cornwall, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Care of the Elderly, Camborne‐Redruth Hospital, Cornwall</wicri:regionArea></affiliation></author><author><name sortKey="Thomas, Sue" sort="Thomas, Sue" uniqKey="Thomas S" first="Sue" last="Thomas">Sue Thomas</name><affiliation wicri:level="1"><mods:affiliation>Division of Nursing, Royal College of Nursing, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Nursing, Royal College of Nursing, London</wicri:regionArea></affiliation></author><author><name sortKey="Ondo, William" sort="Ondo, William" uniqKey="Ondo W" first="William" last="Ondo">William Ondo</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Baylor College of Medicine, Houston, Texas, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Baylor College of Medicine, Houston, Texas</wicri:regionArea></affiliation></author><author><name sortKey="Rye, David" sort="Rye, David" uniqKey="Rye D" first="David" last="Rye">David Rye</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Emory University, Atlanta, Georgia, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Emory University, Atlanta, Georgia</wicri:regionArea></affiliation></author><author><name sortKey="Forbes, Alison" sort="Forbes, Alison" uniqKey="Forbes A" first="Alison" last="Forbes">Alison Forbes</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Hospital Lewisham, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurology, University Hospital Lewisham, London</wicri:regionArea></affiliation></author><author><name sortKey="Tluk, Susanne" sort="Tluk, Susanne" uniqKey="Tluk S" first="Susanne" last="Tluk">Susanne Tluk</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Hospital Lewisham, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurology, University Hospital Lewisham, London</wicri:regionArea></affiliation></author><author><name sortKey="Dhawan, Vandana" sort="Dhawan, Vandana" uniqKey="Dhawan V" first="Vandana" last="Dhawan">Vandana Dhawan</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Hospital Lewisham, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurology, University Hospital Lewisham, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Movement Disorders Section, Department of Neurology, King's College Hospital, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Movement Disorders Section, Department of Neurology, King's College Hospital, London</wicri:regionArea></affiliation></author><author><name sortKey="Bowron, Annette" sort="Bowron, Annette" uniqKey="Bowron A" first="Annette" last="Bowron">Annette Bowron</name><affiliation wicri:level="1"><mods:affiliation>Department of Medicine, North Tyneside General Hospital, North Shields, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Medicine, North Tyneside General Hospital, North Shields</wicri:regionArea></affiliation></author><author><name sortKey="Williams, Adrian J" sort="Williams, Adrian J" uniqKey="Williams A" first="Adrian J." last="Williams">Adrian J. Williams</name><affiliation wicri:level="1"><mods:affiliation>Lane‐Fox Sleep Centre, St. Thomas' Hospital, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Lane‐Fox Sleep Centre, St. Thomas' Hospital, London</wicri:regionArea></affiliation></author><author><name sortKey="Olanow, Charles W" sort="Olanow, Charles W" uniqKey="Olanow C" first="Charles W." last="Olanow">Charles W. Olanow</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Mount Sinai School of Medicine, New York, New York, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mount Sinai School of Medicine, New York, New York</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2006-07">2006-07</date><biblScope unit="vol">21</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="916">916</biblScope><biblScope unit="page" to="923">923</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">D8434962ECAF86015FB03F915D9586CF01CBD870</idno><idno type="DOI">10.1002/mds.20844</idno><idno type="ArticleID">MDS20844</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>Unified Parkinson's Disease Rating Scale</term><term>nonmotor</term><term>quality of life</term><term>questionnaire</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Nonmotor symptoms (NMS) of Parkinson's disease (PD) are not well recognized in clinical practice, either in primary or in secondary care, and are frequently missed during routine consultations. There is no single instrument (questionnaire or scale) that enables a comprehensive assessment of the range of NMS in PD both for the identification of problems and for the measurement of outcome. Against this background, a multidisciplinary group of experts, including patient group representatives, has developed an NMS screening questionnaire comprising 30 items. This instrument does not provide an overall score of disability and is not a graded or rating instrument. Instead, it is a screening tool designed to draw attention to the presence of NMS and initiate further investigation. In this article, we present the results from an international pilot study assessing feasibility, validity, and acceptability of a nonmotor questionnaire (NMSQuest). Data from 123 PD patients and 96 controls were analyzed. NMS were highly significantly more prevalent in PD compared to controls (PD NMS, median = 9.0, mean = 9.5 vs. control NMS, median = 5.5, mean = 4.0; Mann–Whitney, Kruskal–Wallis, and t test, P < 0.0001), with PD patients reporting at least 10 different NMS on average per patient. In PD, NMS were highly significantly more prevalent across all disease stages and the number of symptoms correlated significantly with advancing disease and duration of disease. Furthermore, frequently, problems such as diplopia, dribbling, apathy, blues, taste and smell problems were never previously disclosed to the health professionals. © 2006 Movement Disorder Society</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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