Homocysteine and cognitive impairment in Parkinson's disease: A biochemical, neuroimaging, and genetic study
Identifieur interne : 000823 ( Istex/Curation ); précédent : 000822; suivant : 000824Homocysteine and cognitive impairment in Parkinson's disease: A biochemical, neuroimaging, and genetic study
Auteurs : Maria C. Rodriguez-Oroz [Espagne] ; Pablo Martínez Lage [Espagne] ; Jose Sanchez-Mut [Espagne] ; Isabel Lamet [Espagne] ; Javier Pagonabarraga [Espagne] ; Jon B. Toledo [Espagne] ; David García-Garcia [Espagne] ; Pedro Clavero [Espagne] ; Lluis Samaranch [Espagne] ; Cecilia Irurzun [Espagne] ; Juan M. Matsubara [Espagne] ; Jaione Irigoien [Espagne] ; Emilia Bescos [Espagne] ; Jaime Kulisevsky [Espagne] ; Jordi Pérez-Tur [Espagne] ; Jose A. Obeso [Espagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-07-30.
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Abstract
The role of the plasma level of homocysteine (Hcy), as a primary outcome, and the effect of silent cerebrovascular lesions and genetic variants related to Hcy metabolism, as secondary outcomes, in the cognitive decline and dementia in Parkinson's disease (PD) were studied. This case–control study focused on 89 PD patients of minimum 10 years of evolution and older than 60 years, who were neuropsychologically classified either as cognitively normal (n = 37), having mild cognitive impairment (Petersen criteria) (n = 22), or suffering from dementia (DSM‐IV) (n = 30), compared with cognitively normal age‐matched control subjects (n = 30). Plasma levels of Hcy, vitamins B12 and B6, folic acid, polymorphisms in genes related to Hcy metabolism (MTHFR, MTR, MTRR, and CBS) and silent cerebrovascular events were analyzed. Plasma levels of Hcy were increased in PD patients (P = 0.0001). There were no differences between the groups of patients. The brain vascular burden was similar among PD groups. There was no association between polymorphisms in the studied genes and the Hcy plasma levels or cognitive status in PD patients. We found no evidence for a direct relationship between Hcy plasma levels and cognitive impairment and dementia in PD. No indirect effect through cerebrovascular disease or genetic background was found either. © 2009 Movement Disorder Society
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DOI: 10.1002/mds.22522
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Jose Sanchez-Mut<affiliation><mods:affiliation>Current Address: Cancer Epigenetics and Biology Program (PEBC), Catalan Institute of Oncology (ICO), Hospital Duran i Reynals, L'Hospitalet de Llobregat (Barcelona) Spain</mods:affiliation><wicri:noCountry code="subField">L'Hospitalet de Llobregat (Barcelona) Spain</wicri:noCountry></affiliation>Le document en format XML
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Matsubara</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Clinic and Medical School of Navarra, Pamplona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, University Clinic and Medical School of Navarra, Pamplona</wicri:regionArea></affiliation></author><author><name sortKey="Irigoien, Jaione" sort="Irigoien, Jaione" uniqKey="Irigoien J" first="Jaione" last="Irigoien">Jaione Irigoien</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Clinic and Medical School of Navarra, Pamplona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, University Clinic and Medical School of Navarra, Pamplona</wicri:regionArea></affiliation></author><author><name sortKey="Bescos, Emilia" sort="Bescos, Emilia" uniqKey="Bescos E" first="Emilia" last="Bescos">Emilia Bescos</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Clinic and Medical School of Navarra, Pamplona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, University Clinic and Medical School of Navarra, Pamplona</wicri:regionArea></affiliation></author><author><name sortKey="Kulisevsky, Jaime" sort="Kulisevsky, Jaime" uniqKey="Kulisevsky J" first="Jaime" last="Kulisevsky">Jaime Kulisevsky</name><affiliation wicri:level="1"><mods:affiliation>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Hospital Sant Pau, Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital Sant Pau, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Perez Ur, Jordi" sort="Perez Ur, Jordi" uniqKey="Perez Ur J" first="Jordi" last="Pérez-Tur">Jordi Pérez-Tur</name><affiliation wicri:level="1"><mods:affiliation>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Unitat de Genética Molecular, Institut de Biomedicina de València‐CSIC, Valencia, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unitat de Genética Molecular, Institut de Biomedicina de València‐CSIC, Valencia</wicri:regionArea></affiliation></author><author><name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="Jose A." last="Obeso">Jose A. Obeso</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Clinic and Medical School of Navarra, Pamplona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, University Clinic and Medical School of Navarra, Pamplona</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Neuroscience Center, CIMA, Pamplona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Neuroscience Center, CIMA, Pamplona</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:623F6888A7B960F1E7BF39FC9094613747719D6C</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1002/mds.22522</idno><idno type="url">https://api.istex.fr/document/623F6888A7B960F1E7BF39FC9094613747719D6C/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000823</idno><idno type="wicri:Area/Istex/Curation">000823</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Homocysteine and cognitive impairment in Parkinson's disease: A biochemical, neuroimaging, and genetic study</title><author><name sortKey="Rodriguez Roz, Maria C" sort="Rodriguez Roz, Maria C" uniqKey="Rodriguez Roz M" first="Maria C." last="Rodriguez-Oroz">Maria C. Rodriguez-Oroz</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Clinic and Medical School of Navarra, Pamplona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, University Clinic and Medical School of Navarra, Pamplona</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Neuroscience Center, CIMA, Pamplona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Neuroscience Center, CIMA, Pamplona</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</wicri:regionArea></affiliation></author><author><name sortKey="Lage, Pablo Martinez" sort="Lage, Pablo Martinez" uniqKey="Lage P" first="Pablo Martínez" last="Lage">Pablo Martínez Lage</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Clinic and Medical School of Navarra, Pamplona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, University Clinic and Medical School of Navarra, Pamplona</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Current Address: Fundación ACE, Instituto Catalán de Neurociencias Aplicadas, Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Current Address: Fundación ACE, Instituto Catalán de Neurociencias Aplicadas, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Sanchez Ut, Jose" sort="Sanchez Ut, Jose" uniqKey="Sanchez Ut J" first="Jose" last="Sanchez-Mut">Jose Sanchez-Mut</name><affiliation wicri:level="1"><mods:affiliation>Unitat de Genética Molecular, Institut de Biomedicina de València‐CSIC, Valencia, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unitat de Genética Molecular, Institut de Biomedicina de València‐CSIC, Valencia</wicri:regionArea></affiliation><affiliation><mods:affiliation>Current Address: Cancer Epigenetics and Biology Program (PEBC), Catalan Institute of Oncology (ICO), Hospital Duran i Reynals, L'Hospitalet de Llobregat (Barcelona) Spain</mods:affiliation><wicri:noCountry code="subField">L'Hospitalet de Llobregat (Barcelona) Spain</wicri:noCountry></affiliation></author><author><name sortKey="Lamet, Isabel" sort="Lamet, Isabel" uniqKey="Lamet I" first="Isabel" last="Lamet">Isabel Lamet</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Clinic and Medical School of Navarra, Pamplona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, University Clinic and Medical School of Navarra, Pamplona</wicri:regionArea></affiliation></author><author><name sortKey="Pagonabarraga, Javier" sort="Pagonabarraga, Javier" uniqKey="Pagonabarraga J" first="Javier" last="Pagonabarraga">Javier Pagonabarraga</name><affiliation wicri:level="1"><mods:affiliation>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Hospital Sant Pau, Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital Sant Pau, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Toledo, Jon B" sort="Toledo, Jon B" uniqKey="Toledo J" first="Jon B." last="Toledo">Jon B. Toledo</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Clinic and Medical School of Navarra, Pamplona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, University Clinic and Medical School of Navarra, Pamplona</wicri:regionArea></affiliation></author><author><name sortKey="Garcia Arcia, David" sort="Garcia Arcia, David" uniqKey="Garcia Arcia D" first="David" last="García-Garcia">David García-Garcia</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Clinic and Medical School of Navarra, Pamplona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, University Clinic and Medical School of Navarra, Pamplona</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Neuroscience Center, CIMA, Pamplona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Neuroscience Center, CIMA, Pamplona</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</wicri:regionArea></affiliation></author><author><name sortKey="Clavero, Pedro" sort="Clavero, Pedro" uniqKey="Clavero P" first="Pedro" last="Clavero">Pedro Clavero</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Clinic and Medical School of Navarra, Pamplona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, University Clinic and Medical School of Navarra, Pamplona</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Neuroscience Center, CIMA, Pamplona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Neuroscience Center, CIMA, Pamplona</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</wicri:regionArea></affiliation></author><author><name sortKey="Samaranch, Lluis" sort="Samaranch, Lluis" uniqKey="Samaranch L" first="Lluis" last="Samaranch">Lluis Samaranch</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Clinic and Medical School of Navarra, Pamplona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, University Clinic and Medical School of Navarra, Pamplona</wicri:regionArea></affiliation></author><author><name sortKey="Irurzun, Cecilia" sort="Irurzun, Cecilia" uniqKey="Irurzun C" first="Cecilia" last="Irurzun">Cecilia Irurzun</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Clinic and Medical School of Navarra, Pamplona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, University Clinic and Medical School of Navarra, Pamplona</wicri:regionArea></affiliation></author><author><name sortKey="Matsubara, Juan M" sort="Matsubara, Juan M" uniqKey="Matsubara J" first="Juan M." last="Matsubara">Juan M. Matsubara</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Clinic and Medical School of Navarra, Pamplona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, University Clinic and Medical School of Navarra, Pamplona</wicri:regionArea></affiliation></author><author><name sortKey="Irigoien, Jaione" sort="Irigoien, Jaione" uniqKey="Irigoien J" first="Jaione" last="Irigoien">Jaione Irigoien</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Clinic and Medical School of Navarra, Pamplona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, University Clinic and Medical School of Navarra, Pamplona</wicri:regionArea></affiliation></author><author><name sortKey="Bescos, Emilia" sort="Bescos, Emilia" uniqKey="Bescos E" first="Emilia" last="Bescos">Emilia Bescos</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Clinic and Medical School of Navarra, Pamplona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, University Clinic and Medical School of Navarra, Pamplona</wicri:regionArea></affiliation></author><author><name sortKey="Kulisevsky, Jaime" sort="Kulisevsky, Jaime" uniqKey="Kulisevsky J" first="Jaime" last="Kulisevsky">Jaime Kulisevsky</name><affiliation wicri:level="1"><mods:affiliation>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Hospital Sant Pau, Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital Sant Pau, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Perez Ur, Jordi" sort="Perez Ur, Jordi" uniqKey="Perez Ur J" first="Jordi" last="Pérez-Tur">Jordi Pérez-Tur</name><affiliation wicri:level="1"><mods:affiliation>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Unitat de Genética Molecular, Institut de Biomedicina de València‐CSIC, Valencia, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unitat de Genética Molecular, Institut de Biomedicina de València‐CSIC, Valencia</wicri:regionArea></affiliation></author><author><name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="Jose A." last="Obeso">Jose A. Obeso</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Clinic and Medical School of Navarra, Pamplona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, University Clinic and Medical School of Navarra, Pamplona</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Neuroscience Center, CIMA, Pamplona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Neuroscience Center, CIMA, Pamplona</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-07-30">2009-07-30</date><biblScope unit="vol">24</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1437">1437</biblScope><biblScope unit="page" to="1444">1444</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">623F6888A7B960F1E7BF39FC9094613747719D6C</idno><idno type="DOI">10.1002/mds.22522</idno><idno type="ArticleID">MDS22522</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>dementia</term><term>genetics</term><term>homocysteine</term><term>mild cognitive impairment</term><term>white matter hyperintensities</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The role of the plasma level of homocysteine (Hcy), as a primary outcome, and the effect of silent cerebrovascular lesions and genetic variants related to Hcy metabolism, as secondary outcomes, in the cognitive decline and dementia in Parkinson's disease (PD) were studied. This case–control study focused on 89 PD patients of minimum 10 years of evolution and older than 60 years, who were neuropsychologically classified either as cognitively normal (n = 37), having mild cognitive impairment (Petersen criteria) (n = 22), or suffering from dementia (DSM‐IV) (n = 30), compared with cognitively normal age‐matched control subjects (n = 30). Plasma levels of Hcy, vitamins B12 and B6, folic acid, polymorphisms in genes related to Hcy metabolism (MTHFR, MTR, MTRR, and CBS) and silent cerebrovascular events were analyzed. Plasma levels of Hcy were increased in PD patients (P = 0.0001). There were no differences between the groups of patients. The brain vascular burden was similar among PD groups. There was no association between polymorphisms in the studied genes and the Hcy plasma levels or cognitive status in PD patients. We found no evidence for a direct relationship between Hcy plasma levels and cognitive impairment and dementia in PD. No indirect effect through cerebrovascular disease or genetic background was found either. © 2009 Movement Disorder Society</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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