FP‐CIT and MIBG scintigraphy in early Parkinson's disease
Identifieur interne : 000537 ( Istex/Curation ); précédent : 000536; suivant : 000538FP‐CIT and MIBG scintigraphy in early Parkinson's disease
Auteurs : Jörg Spiegel [Allemagne] ; Marc-Oliver Möllers [Allemagne] ; Wolfgang H. Jost [Allemagne] ; Gerhard Fuss [Allemagne] ; Samuel Samnick [Allemagne] ; Ulrich Dillmann [Allemagne] ; Georg Becker [Allemagne] ; Carl-Martin Kirsch [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2005-05.
English descriptors
Abstract
Methods provided by nuclear medicine may be helpful in diagnosis of Parkinson's disease (PD). For that purpose, the sensitivity of iodine‐123 metaiodobenzylguanidine ([123I]MIBG) scintigraphy and [123I]FP‐CIT single photon emission computed tomography (SPECT) was studied in patients with PD onset (Hoehn and Yahr Stage 1). Cerebral [123I]FP‐CIT and cardiac [123I]MIBG scintigraphy were carried out in 18 patients with idiopathic Parkinson's disease, according to Hoehn and Yahr Stage 1. For quantification purposes, we calculated the striatum/posterior lobe binding of FP‐CIT and the heart‐to‐mediastinum (H/M) count ratio regarding MIBG scintigraphy. In 15 of 18 patients, we observed markedly reduced or asymmetric striatal FP‐CIT tracer accumulation. FP‐CIT binding of the affected striatum was significantly lower as compared with that of the unaffected side. Striatal FP‐CIT binding correlated significantly with the motor part of the Unified Parkinson's disease rating scale (UPDRS) but not with age, disease duration, or gender. MIBG scintigraphy delivered significant pathological results in 13 of 18 patients. There was no significant correlation between the H/M ratio relating to MIBG scintigraphy and the motor part of UPDRS, age, disease duration, or gender; however, binding of striatal FP‐CIT correlated significantly with cardiac MIBG accumulation. According to the clinical criteria, it might be difficult to prove the diagnosis of PD in patients with slight symptoms and in these cases, FP‐CIT SPECT and MIBG scintigraphy may contribute to the early diagnosis of PD. In addition, the functional loss of nigrostriatal and cardiac sympathetic neurons seems to be coupled closely. © 2005 Movement Disorder Society
Url:
DOI: 10.1002/mds.20369
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000537
Links to Exploration step
ISTEX:46C9714EE76CE07B7C4B3720149380844D1C9D17Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">FP‐CIT and MIBG scintigraphy in early Parkinson's disease</title><author><name sortKey="Spiegel, Jorg" sort="Spiegel, Jorg" uniqKey="Spiegel J" first="Jörg" last="Spiegel">Jörg Spiegel</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Saarland University, Homburg/Saar, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Saarland University, Homburg/Saar</wicri:regionArea></affiliation></author><author><name sortKey="Mollers, Marc Liver" sort="Mollers, Marc Liver" uniqKey="Mollers M" first="Marc-Oliver" last="Möllers">Marc-Oliver Möllers</name><affiliation wicri:level="1"><mods:affiliation>Department of Nuclear Medicine, Saarland University, Homburg/Saar, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Nuclear Medicine, Saarland University, Homburg/Saar</wicri:regionArea></affiliation></author><author><name sortKey="Jost, Wolfgang H" sort="Jost, Wolfgang H" uniqKey="Jost W" first="Wolfgang H." last="Jost">Wolfgang H. Jost</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Deutsche Klinik für Diagnostik, Wiesbaden, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Deutsche Klinik für Diagnostik, Wiesbaden</wicri:regionArea></affiliation></author><author><name sortKey="Fuss, Gerhard" sort="Fuss, Gerhard" uniqKey="Fuss G" first="Gerhard" last="Fuss">Gerhard Fuss</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Saarland University, Homburg/Saar, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Saarland University, Homburg/Saar</wicri:regionArea></affiliation></author><author><name sortKey="Samnick, Samuel" sort="Samnick, Samuel" uniqKey="Samnick S" first="Samuel" last="Samnick">Samuel Samnick</name><affiliation wicri:level="1"><mods:affiliation>Department of Nuclear Medicine, Saarland University, Homburg/Saar, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Nuclear Medicine, Saarland University, Homburg/Saar</wicri:regionArea></affiliation></author><author><name sortKey="Dillmann, Ulrich" sort="Dillmann, Ulrich" uniqKey="Dillmann U" first="Ulrich" last="Dillmann">Ulrich Dillmann</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Saarland University, Homburg/Saar, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Saarland University, Homburg/Saar</wicri:regionArea></affiliation></author><author><name sortKey="Becker, Georg" sort="Becker, Georg" uniqKey="Becker G" first="Georg" last="Becker">Georg Becker</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Saarland University, Homburg/Saar, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Saarland University, Homburg/Saar</wicri:regionArea></affiliation></author><author><name sortKey="Kirsch, Carl Artin" sort="Kirsch, Carl Artin" uniqKey="Kirsch C" first="Carl-Martin" last="Kirsch">Carl-Martin Kirsch</name><affiliation wicri:level="1"><mods:affiliation>Department of Nuclear Medicine, Saarland University, Homburg/Saar, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Nuclear Medicine, Saarland University, Homburg/Saar</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:46C9714EE76CE07B7C4B3720149380844D1C9D17</idno><date when="2005" year="2005">2005</date><idno type="doi">10.1002/mds.20369</idno><idno type="url">https://api.istex.fr/document/46C9714EE76CE07B7C4B3720149380844D1C9D17/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000537</idno><idno type="wicri:Area/Istex/Curation">000537</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">FP‐CIT and MIBG scintigraphy in early Parkinson's disease</title><author><name sortKey="Spiegel, Jorg" sort="Spiegel, Jorg" uniqKey="Spiegel J" first="Jörg" last="Spiegel">Jörg Spiegel</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Saarland University, Homburg/Saar, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Saarland University, Homburg/Saar</wicri:regionArea></affiliation></author><author><name sortKey="Mollers, Marc Liver" sort="Mollers, Marc Liver" uniqKey="Mollers M" first="Marc-Oliver" last="Möllers">Marc-Oliver Möllers</name><affiliation wicri:level="1"><mods:affiliation>Department of Nuclear Medicine, Saarland University, Homburg/Saar, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Nuclear Medicine, Saarland University, Homburg/Saar</wicri:regionArea></affiliation></author><author><name sortKey="Jost, Wolfgang H" sort="Jost, Wolfgang H" uniqKey="Jost W" first="Wolfgang H." last="Jost">Wolfgang H. Jost</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Deutsche Klinik für Diagnostik, Wiesbaden, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Deutsche Klinik für Diagnostik, Wiesbaden</wicri:regionArea></affiliation></author><author><name sortKey="Fuss, Gerhard" sort="Fuss, Gerhard" uniqKey="Fuss G" first="Gerhard" last="Fuss">Gerhard Fuss</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Saarland University, Homburg/Saar, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Saarland University, Homburg/Saar</wicri:regionArea></affiliation></author><author><name sortKey="Samnick, Samuel" sort="Samnick, Samuel" uniqKey="Samnick S" first="Samuel" last="Samnick">Samuel Samnick</name><affiliation wicri:level="1"><mods:affiliation>Department of Nuclear Medicine, Saarland University, Homburg/Saar, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Nuclear Medicine, Saarland University, Homburg/Saar</wicri:regionArea></affiliation></author><author><name sortKey="Dillmann, Ulrich" sort="Dillmann, Ulrich" uniqKey="Dillmann U" first="Ulrich" last="Dillmann">Ulrich Dillmann</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Saarland University, Homburg/Saar, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Saarland University, Homburg/Saar</wicri:regionArea></affiliation></author><author><name sortKey="Becker, Georg" sort="Becker, Georg" uniqKey="Becker G" first="Georg" last="Becker">Georg Becker</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Saarland University, Homburg/Saar, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Saarland University, Homburg/Saar</wicri:regionArea></affiliation></author><author><name sortKey="Kirsch, Carl Artin" sort="Kirsch, Carl Artin" uniqKey="Kirsch C" first="Carl-Martin" last="Kirsch">Carl-Martin Kirsch</name><affiliation wicri:level="1"><mods:affiliation>Department of Nuclear Medicine, Saarland University, Homburg/Saar, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Nuclear Medicine, Saarland University, Homburg/Saar</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2005-05">2005-05</date><biblScope unit="vol">20</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="552">552</biblScope><biblScope unit="page" to="561">561</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">46C9714EE76CE07B7C4B3720149380844D1C9D17</idno><idno type="DOI">10.1002/mds.20369</idno><idno type="ArticleID">MDS20369</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>dopamine transporters</term><term>noradrenaline transporters</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Methods provided by nuclear medicine may be helpful in diagnosis of Parkinson's disease (PD). For that purpose, the sensitivity of iodine‐123 metaiodobenzylguanidine ([123I]MIBG) scintigraphy and [123I]FP‐CIT single photon emission computed tomography (SPECT) was studied in patients with PD onset (Hoehn and Yahr Stage 1). Cerebral [123I]FP‐CIT and cardiac [123I]MIBG scintigraphy were carried out in 18 patients with idiopathic Parkinson's disease, according to Hoehn and Yahr Stage 1. For quantification purposes, we calculated the striatum/posterior lobe binding of FP‐CIT and the heart‐to‐mediastinum (H/M) count ratio regarding MIBG scintigraphy. In 15 of 18 patients, we observed markedly reduced or asymmetric striatal FP‐CIT tracer accumulation. FP‐CIT binding of the affected striatum was significantly lower as compared with that of the unaffected side. Striatal FP‐CIT binding correlated significantly with the motor part of the Unified Parkinson's disease rating scale (UPDRS) but not with age, disease duration, or gender. MIBG scintigraphy delivered significant pathological results in 13 of 18 patients. There was no significant correlation between the H/M ratio relating to MIBG scintigraphy and the motor part of UPDRS, age, disease duration, or gender; however, binding of striatal FP‐CIT correlated significantly with cardiac MIBG accumulation. According to the clinical criteria, it might be difficult to prove the diagnosis of PD in patients with slight symptoms and in these cases, FP‐CIT SPECT and MIBG scintigraphy may contribute to the early diagnosis of PD. In addition, the functional loss of nigrostriatal and cardiac sympathetic neurons seems to be coupled closely. © 2005 Movement Disorder Society</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Istex/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000537 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Curation/biblio.hfd -nk 000537 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Istex
|étape= Curation
|type= RBID
|clé= ISTEX:46C9714EE76CE07B7C4B3720149380844D1C9D17
|texte= FP‐CIT and MIBG scintigraphy in early Parkinson's disease
}}
| This area was generated with Dilib version V0.6.23. |  |