FP‐CIT and MIBG scintigraphy in early Parkinson's disease
Identifieur interne : 000537 ( Istex/Corpus ); précédent : 000536; suivant : 000538FP‐CIT and MIBG scintigraphy in early Parkinson's disease
Auteurs : Jörg Spiegel ; Marc-Oliver Möllers ; Wolfgang H. Jost ; Gerhard Fuss ; Samuel Samnick ; Ulrich Dillmann ; Georg Becker ; Carl-Martin KirschSource :
- Movement Disorders [ 0885-3185 ] ; 2005-05.
English descriptors
Abstract
Methods provided by nuclear medicine may be helpful in diagnosis of Parkinson's disease (PD). For that purpose, the sensitivity of iodine‐123 metaiodobenzylguanidine ([123I]MIBG) scintigraphy and [123I]FP‐CIT single photon emission computed tomography (SPECT) was studied in patients with PD onset (Hoehn and Yahr Stage 1). Cerebral [123I]FP‐CIT and cardiac [123I]MIBG scintigraphy were carried out in 18 patients with idiopathic Parkinson's disease, according to Hoehn and Yahr Stage 1. For quantification purposes, we calculated the striatum/posterior lobe binding of FP‐CIT and the heart‐to‐mediastinum (H/M) count ratio regarding MIBG scintigraphy. In 15 of 18 patients, we observed markedly reduced or asymmetric striatal FP‐CIT tracer accumulation. FP‐CIT binding of the affected striatum was significantly lower as compared with that of the unaffected side. Striatal FP‐CIT binding correlated significantly with the motor part of the Unified Parkinson's disease rating scale (UPDRS) but not with age, disease duration, or gender. MIBG scintigraphy delivered significant pathological results in 13 of 18 patients. There was no significant correlation between the H/M ratio relating to MIBG scintigraphy and the motor part of UPDRS, age, disease duration, or gender; however, binding of striatal FP‐CIT correlated significantly with cardiac MIBG accumulation. According to the clinical criteria, it might be difficult to prove the diagnosis of PD in patients with slight symptoms and in these cases, FP‐CIT SPECT and MIBG scintigraphy may contribute to the early diagnosis of PD. In addition, the functional loss of nigrostriatal and cardiac sympathetic neurons seems to be coupled closely. © 2005 Movement Disorder Society
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DOI: 10.1002/mds.20369
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2005-05">2005-05</date><biblScope unit="vol">20</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="552">552</biblScope><biblScope unit="page" to="561">561</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">46C9714EE76CE07B7C4B3720149380844D1C9D17</idno><idno type="DOI">10.1002/mds.20369</idno><idno type="ArticleID">MDS20369</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>dopamine transporters</term><term>noradrenaline transporters</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Methods provided by nuclear medicine may be helpful in diagnosis of Parkinson's disease (PD). For that purpose, the sensitivity of iodine‐123 metaiodobenzylguanidine ([123I]MIBG) scintigraphy and [123I]FP‐CIT single photon emission computed tomography (SPECT) was studied in patients with PD onset (Hoehn and Yahr Stage 1). Cerebral [123I]FP‐CIT and cardiac [123I]MIBG scintigraphy were carried out in 18 patients with idiopathic Parkinson's disease, according to Hoehn and Yahr Stage 1. For quantification purposes, we calculated the striatum/posterior lobe binding of FP‐CIT and the heart‐to‐mediastinum (H/M) count ratio regarding MIBG scintigraphy. In 15 of 18 patients, we observed markedly reduced or asymmetric striatal FP‐CIT tracer accumulation. FP‐CIT binding of the affected striatum was significantly lower as compared with that of the unaffected side. Striatal FP‐CIT binding correlated significantly with the motor part of the Unified Parkinson's disease rating scale (UPDRS) but not with age, disease duration, or gender. MIBG scintigraphy delivered significant pathological results in 13 of 18 patients. There was no significant correlation between the H/M ratio relating to MIBG scintigraphy and the motor part of UPDRS, age, disease duration, or gender; however, binding of striatal FP‐CIT correlated significantly with cardiac MIBG accumulation. According to the clinical criteria, it might be difficult to prove the diagnosis of PD in patients with slight symptoms and in these cases, FP‐CIT SPECT and MIBG scintigraphy may contribute to the early diagnosis of PD. In addition, the functional loss of nigrostriatal and cardiac sympathetic neurons seems to be coupled closely. © 2005 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Jörg Spiegel MD</name><affiliations><json:string>Department of Neurology, Saarland University, Homburg/Saar, Germany</json:string></affiliations></json:item><json:item><name>Marc‐Oliver Möllers MD</name><affiliations><json:string>Department of Nuclear Medicine, Saarland University, Homburg/Saar, Germany</json:string></affiliations></json:item><json:item><name>Wolfgang H. Jost MD</name><affiliations><json:string>Department of Neurology, Deutsche Klinik für Diagnostik, Wiesbaden, Germany</json:string></affiliations></json:item><json:item><name>Gerhard Fuss MD</name><affiliations><json:string>Department of Neurology, Saarland University, Homburg/Saar, Germany</json:string></affiliations></json:item><json:item><name>Samuel Samnick MD</name><affiliations><json:string>Department of Nuclear Medicine, Saarland University, Homburg/Saar, Germany</json:string></affiliations></json:item><json:item><name>Ulrich Dillmann MD</name><affiliations><json:string>Department of Neurology, Saarland University, Homburg/Saar, Germany</json:string></affiliations></json:item><json:item><name>Georg Becker MD</name><affiliations><json:string>Department of Neurology, Saarland University, Homburg/Saar, Germany</json:string></affiliations></json:item><json:item><name>Carl‐Martin Kirsch MD, PhD</name><affiliations><json:string>Department of Nuclear Medicine, Saarland University, Homburg/Saar, Germany</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>dopamine transporters</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>noradrenaline transporters</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Methods provided by nuclear medicine may be helpful in diagnosis of Parkinson's disease (PD). For that purpose, the sensitivity of iodine‐123 metaiodobenzylguanidine ([123I]MIBG) scintigraphy and [123I]FP‐CIT single photon emission computed tomography (SPECT) was studied in patients with PD onset (Hoehn and Yahr Stage 1). Cerebral [123I]FP‐CIT and cardiac [123I]MIBG scintigraphy were carried out in 18 patients with idiopathic Parkinson's disease, according to Hoehn and Yahr Stage 1. For quantification purposes, we calculated the striatum/posterior lobe binding of FP‐CIT and the heart‐to‐mediastinum (H/M) count ratio regarding MIBG scintigraphy. In 15 of 18 patients, we observed markedly reduced or asymmetric striatal FP‐CIT tracer accumulation. FP‐CIT binding of the affected striatum was significantly lower as compared with that of the unaffected side. Striatal FP‐CIT binding correlated significantly with the motor part of the Unified Parkinson's disease rating scale (UPDRS) but not with age, disease duration, or gender. MIBG scintigraphy delivered significant pathological results in 13 of 18 patients. There was no significant correlation between the H/M ratio relating to MIBG scintigraphy and the motor part of UPDRS, age, disease duration, or gender; however, binding of striatal FP‐CIT correlated significantly with cardiac MIBG accumulation. According to the clinical criteria, it might be difficult to prove the diagnosis of PD in patients with slight symptoms and in these cases, FP‐CIT SPECT and MIBG scintigraphy may contribute to the early diagnosis of PD. In addition, the functional loss of nigrostriatal and cardiac sympathetic neurons seems to be coupled closely. © 2005 Movement Disorder Society</abstract><qualityIndicators><score>7.477</score><pdfVersion>1.3</pdfVersion><pdfPageSize>594 x 792 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>1728</abstractCharCount><pdfWordCount>4501</pdfWordCount><pdfCharCount>30090</pdfCharCount><pdfPageCount>10</pdfPageCount><abstractWordCount>248</abstractWordCount></qualityIndicators><title>FP‐CIT and MIBG scintigraphy in early Parkinson's disease</title><genre><json:string>Serial article</json:string></genre><host><volume>20</volume><pages><total>10</total><last>561</last><first>552</first></pages><issn><json:string>0885-3185</json:string></issn><issue>5</issue><subject><json:item><value>Research Article</value></json:item></subject><genre></genre><language><json:string>unknown</json:string></language><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2005</publicationDate><copyrightDate>2005</copyrightDate><doi><json:string>10.1002/mds.20369</json:string></doi><id>46C9714EE76CE07B7C4B3720149380844D1C9D17</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/46C9714EE76CE07B7C4B3720149380844D1C9D17/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/46C9714EE76CE07B7C4B3720149380844D1C9D17/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/46C9714EE76CE07B7C4B3720149380844D1C9D17/fulltext/tei"><teiHeader type="text"><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">FP‐CIT and MIBG scintigraphy in early Parkinson's disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>Wiley Subscription Services, Inc., A Wiley Company</p></availability><date>2005</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">FP‐CIT and MIBG scintigraphy in early Parkinson's disease</title><author><persName><forename type="first">Jörg</forename><surname>Spiegel</surname><roleName type="degree">MD</roleName></persName><note type="correspondence"><p>Correspondence: Neurologische Klinik, Universitätskliniken des Saarlandes, Kirrberger Straße, D‐66421 Homburg/Saar, Germany</p></note><affiliation>Department of Neurology, Saarland University, Homburg/Saar, Germany</affiliation></author><author><persName><forename type="first">Marc‐Oliver</forename><surname>Möllers</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Nuclear Medicine, Saarland University, Homburg/Saar, Germany</affiliation></author><author><persName><forename type="first">Wolfgang H.</forename><surname>Jost</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, Deutsche Klinik für Diagnostik, Wiesbaden, Germany</affiliation></author><author><persName><forename type="first">Gerhard</forename><surname>Fuss</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, Saarland University, Homburg/Saar, Germany</affiliation></author><author><persName><forename type="first">Samuel</forename><surname>Samnick</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Nuclear Medicine, Saarland University, Homburg/Saar, Germany</affiliation></author><author><persName><forename type="first">Ulrich</forename><surname>Dillmann</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, Saarland University, Homburg/Saar, Germany</affiliation></author><author><persName><forename type="first">Georg</forename><surname>Becker</surname><roleName type="degree">MD</roleName></persName><note type="biography">Deceased</note><affiliation>Deceased</affiliation><affiliation>Department of Neurology, Saarland University, Homburg/Saar, Germany</affiliation></author><author><persName><forename type="first">Carl‐Martin</forename><surname>Kirsch</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Department of Nuclear Medicine, Saarland University, Homburg/Saar, Germany</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. 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For that purpose, the sensitivity of iodine‐123 metaiodobenzylguanidine ([123I]MIBG) scintigraphy and [123I]FP‐CIT single photon emission computed tomography (SPECT) was studied in patients with PD onset (Hoehn and Yahr Stage 1). Cerebral [123I]FP‐CIT and cardiac [123I]MIBG scintigraphy were carried out in 18 patients with idiopathic Parkinson's disease, according to Hoehn and Yahr Stage 1. For quantification purposes, we calculated the striatum/posterior lobe binding of FP‐CIT and the heart‐to‐mediastinum (H/M) count ratio regarding MIBG scintigraphy. In 15 of 18 patients, we observed markedly reduced or asymmetric striatal FP‐CIT tracer accumulation. FP‐CIT binding of the affected striatum was significantly lower as compared with that of the unaffected side. Striatal FP‐CIT binding correlated significantly with the motor part of the Unified Parkinson's disease rating scale (UPDRS) but not with age, disease duration, or gender. MIBG scintigraphy delivered significant pathological results in 13 of 18 patients. There was no significant correlation between the H/M ratio relating to MIBG scintigraphy and the motor part of UPDRS, age, disease duration, or gender; however, binding of striatal FP‐CIT correlated significantly with cardiac MIBG accumulation. According to the clinical criteria, it might be difficult to prove the diagnosis of PD in patients with slight symptoms and in these cases, FP‐CIT SPECT and MIBG scintigraphy may contribute to the early diagnosis of PD. 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noteRef="#fn1"><personName><givenNames>Georg</givenNames><familyName>Becker</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Carl‐Martin</givenNames><familyName>Kirsch</familyName><degrees>MD, PhD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="DE" type="organization"><unparsedAffiliation>Department of Neurology, Saarland University, Homburg/Saar, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="DE" type="organization"><unparsedAffiliation>Department of Nuclear Medicine, Saarland University, Homburg/Saar, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="DE" type="organization"><unparsedAffiliation>Department of Neurology, Deutsche Klinik für Diagnostik, Wiesbaden, Germany</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">dopamine transporters</keyword><keyword xml:id="kwd3">noradrenaline transporters</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Methods provided by nuclear medicine may be helpful in diagnosis of Parkinson's disease (PD). For that purpose, the sensitivity of iodine‐123 metaiodobenzylguanidine ([123I]MIBG) scintigraphy and [123I]FP‐CIT single photon emission computed tomography (SPECT) was studied in patients with PD onset (Hoehn and Yahr Stage 1). Cerebral [123I]FP‐CIT and cardiac [123I]MIBG scintigraphy were carried out in 18 patients with idiopathic Parkinson's disease, according to Hoehn and Yahr Stage 1. For quantification purposes, we calculated the striatum/posterior lobe binding of FP‐CIT and the heart‐to‐mediastinum (H/M) count ratio regarding MIBG scintigraphy. In 15 of 18 patients, we observed markedly reduced or asymmetric striatal FP‐CIT tracer accumulation. FP‐CIT binding of the affected striatum was significantly lower as compared with that of the unaffected side. Striatal FP‐CIT binding correlated significantly with the motor part of the Unified Parkinson's disease rating scale (UPDRS) but not with age, disease duration, or gender. MIBG scintigraphy delivered significant pathological results in 13 of 18 patients. There was no significant correlation between the H/M ratio relating to MIBG scintigraphy and the motor part of UPDRS, age, disease duration, or gender; however, binding of striatal FP‐CIT correlated significantly with cardiac MIBG accumulation. According to the clinical criteria, it might be difficult to prove the diagnosis of PD in patients with slight symptoms and in these cases, FP‐CIT SPECT and MIBG scintigraphy may contribute to the early diagnosis of PD. In addition, the functional loss of nigrostriatal and cardiac sympathetic neurons seems to be coupled closely. © 2005 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Deceased</p></note></noteGroup></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>FP‐CIT and MIBG scintigraphy in early Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Scintigraphy in Early Parkinson's Disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>FP‐CIT and MIBG scintigraphy in early Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Jörg</namePart><namePart type="family">Spiegel</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Saarland University, Homburg/Saar, Germany</affiliation><description>Correspondence: Neurologische Klinik, Universitätskliniken des Saarlandes, Kirrberger Straße, D‐66421 Homburg/Saar, Germany</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marc‐Oliver</namePart><namePart type="family">Möllers</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Nuclear Medicine, Saarland University, Homburg/Saar, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Wolfgang H.</namePart><namePart type="family">Jost</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Deutsche Klinik für Diagnostik, Wiesbaden, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gerhard</namePart><namePart type="family">Fuss</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Saarland University, Homburg/Saar, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Samuel</namePart><namePart type="family">Samnick</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Nuclear Medicine, Saarland University, Homburg/Saar, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ulrich</namePart><namePart type="family">Dillmann</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Saarland University, Homburg/Saar, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Georg</namePart><namePart type="family">Becker</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Saarland University, Homburg/Saar, Germany</affiliation><description>Deceased</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Carl‐Martin</namePart><namePart type="family">Kirsch</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Nuclear Medicine, Saarland University, Homburg/Saar, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2005-05</dateIssued><dateCaptured encoding="w3cdtf">2004-03-14</dateCaptured><dateValid encoding="w3cdtf">2004-08-15</dateValid><copyrightDate encoding="w3cdtf">2005</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">6</extent><extent unit="tables">2</extent><extent unit="references">38</extent><extent unit="words">5336</extent></physicalDescription><abstract lang="en">Methods provided by nuclear medicine may be helpful in diagnosis of Parkinson's disease (PD). For that purpose, the sensitivity of iodine‐123 metaiodobenzylguanidine ([123I]MIBG) scintigraphy and [123I]FP‐CIT single photon emission computed tomography (SPECT) was studied in patients with PD onset (Hoehn and Yahr Stage 1). Cerebral [123I]FP‐CIT and cardiac [123I]MIBG scintigraphy were carried out in 18 patients with idiopathic Parkinson's disease, according to Hoehn and Yahr Stage 1. For quantification purposes, we calculated the striatum/posterior lobe binding of FP‐CIT and the heart‐to‐mediastinum (H/M) count ratio regarding MIBG scintigraphy. In 15 of 18 patients, we observed markedly reduced or asymmetric striatal FP‐CIT tracer accumulation. FP‐CIT binding of the affected striatum was significantly lower as compared with that of the unaffected side. Striatal FP‐CIT binding correlated significantly with the motor part of the Unified Parkinson's disease rating scale (UPDRS) but not with age, disease duration, or gender. MIBG scintigraphy delivered significant pathological results in 13 of 18 patients. There was no significant correlation between the H/M ratio relating to MIBG scintigraphy and the motor part of UPDRS, age, disease duration, or gender; however, binding of striatal FP‐CIT correlated significantly with cardiac MIBG accumulation. According to the clinical criteria, it might be difficult to prove the diagnosis of PD in patients with slight symptoms and in these cases, FP‐CIT SPECT and MIBG scintigraphy may contribute to the early diagnosis of PD. In addition, the functional loss of nigrostriatal and cardiac sympathetic neurons seems to be coupled closely. © 2005 Movement Disorder Society</abstract><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>dopamine transporters</topic><topic>noradrenaline transporters</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>20</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>552</start><end>561</end><total>10</total></extent></part></relatedItem><identifier type="istex">46C9714EE76CE07B7C4B3720149380844D1C9D17</identifier><identifier type="DOI">10.1002/mds.20369</identifier><identifier type="ArticleID">MDS20369</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2005 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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