Depression comorbidity in spinocerebellar ataxia
Identifieur interne : 000522 ( Istex/Curation ); précédent : 000521; suivant : 000523Depression comorbidity in spinocerebellar ataxia
Auteurs : Tanja Schmitz-Hübsch [Allemagne] ; Mathieu Coudert [France] ; Sophie Tezenas Du Montcel [France] ; Paola Giunti [Royaume-Uni] ; Robyn Labrum [Royaume-Uni] ; Alexandra Dürr [France] ; Pascale Ribai [France] ; Perrine Charles [France] ; Christoph Linnemann [Allemagne] ; Ludger Schöls [Allemagne] ; Maryla Rakowicz [Pologne] ; Rafal Rola [Pologne] ; Elszbieta Zdzienicka [Pologne] ; Roberto Fancellu [Italie] ; Caterina Mariotti [Italie] ; Lazlo Baliko [Hongrie] ; Bela Melegh [Hongrie] ; Alessandro Filla [Italie] ; Elena Salvatore [Italie] ; Bart P. C. Van De Warrenburg [Pays-Bas] ; Sandra Szymanski [Allemagne] ; Jon Infante [Espagne] ; Dagmar Timmann [Allemagne] ; Sylvia Boesch [Autriche] ; Chantal Depondt [Belgique] ; Jun-Suk Kang [Allemagne] ; Jörg B. Schulz [Allemagne] ; Thomas Klopstock [Allemagne] ; Nicole Lossnitzer [Allemagne] ; Bernd Löwe [Allemagne] ; Caroline Frick [Allemagne] ; Daniela Rottl Nder [Allemagne] ; Thomas E. Schlaepfer [Allemagne, États-Unis] ; Thomas Klockgether [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-04.
English descriptors
Abstract
This is a description of the prevalence and profile of depressive symptoms in dominant spinocerebellar ataxia (SCA). Depressive symptoms were assessed in a convenience sample of 526 genetically confirmed and clinically affected patients (117 SCA1, 163 SCA2, 139 SCA3, and 107 SCA6) using the Patient Health Questionnaire (PHQ). In addition, depressive status according to the examiner and the use of antidepressants was recorded. Depression self‐assessment was compared with an interview‐based psychiatric assessment in a subset of 26 patients. Depression prevalence estimates were 17.1% according to the PHQ algorithm and 15.4% when assessed clinically. The sensitivity of clinical impression compared with PHQ classification was low (0.35), whereas diagnostic accuracy of PHQ compared with psychiatric interview in the subset was high. Antidepressants were used by 17.7% of patients and in >10% of patients without current clinically relevant depressive symptoms. Depression profile in SCA did not differ from a sample of patients with major depressive disorder except for the movement‐related item. Neither depression prevalence nor use of antidepressants differed between genetic subtypes, with only sleep disturbance more common in SCA3. In a multivariate analysis, ataxia severity and female sex independently predicted depressive status in SCA. The PHQ algorithmic classification is appropriate for use in SCA but should stimulate further psychiatric evaluation if depression is indicated. Despite a higher risk for depression with more severe disease, the relation of depressive symptoms to SCA neurodegeneration remains to be shown. © 2011 Movement Disorder Society
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DOI: 10.1002/mds.23698
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Research, University of Tübingen, Tübingen, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology and Hertie‐Institute for Clinical Brain Research, University of Tübingen, Tübingen</wicri:regionArea></affiliation></author><author><name sortKey="Schols, Ludger" sort="Schols, Ludger" uniqKey="Schols L" first="Ludger" last="Schöls">Ludger Schöls</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Hertie‐Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology and Hertie‐Institute for Clinical Brain Research, University of Tübingen, Tübingen</wicri:regionArea></affiliation></author><author><name sortKey="Rakowicz, Maryla" sort="Rakowicz, Maryla" uniqKey="Rakowicz M" first="Maryla" last="Rakowicz">Maryla Rakowicz</name><affiliation wicri:level="1"><mods:affiliation>Department of Clinical Neurophysiology, Institute of Psychiatry and Neurology, Warsaw, Poland</mods:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Clinical Neurophysiology, Institute of Psychiatry and Neurology, Warsaw</wicri:regionArea></affiliation></author><author><name sortKey="Rola, Rafal" sort="Rola, Rafal" uniqKey="Rola R" first="Rafal" last="Rola">Rafal Rola</name><affiliation wicri:level="1"><mods:affiliation>First Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland</mods:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>First Department of Neurology, Institute of Psychiatry and Neurology, Warsaw</wicri:regionArea></affiliation></author><author><name sortKey="Zdzienicka, Elszbieta" sort="Zdzienicka, Elszbieta" uniqKey="Zdzienicka E" first="Elszbieta" last="Zdzienicka">Elszbieta Zdzienicka</name><affiliation wicri:level="1"><mods:affiliation>Department of Genetics, Institute of Psychiatry and Neurology, Warsaw, Poland</mods:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Genetics, Institute of Psychiatry and Neurology, Warsaw</wicri:regionArea></affiliation></author><author><name sortKey="Fancellu, Roberto" sort="Fancellu, Roberto" uniqKey="Fancellu R" first="Roberto" last="Fancellu">Roberto Fancellu</name><affiliation wicri:level="1"><mods:affiliation>Department of Biochemistry and Genetics, Fondazione‐IRCCS, Istituto Neurologico Carlo Besta, Milan, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biochemistry and Genetics, Fondazione‐IRCCS, Istituto Neurologico Carlo Besta, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Mariotti, Caterina" sort="Mariotti, Caterina" uniqKey="Mariotti C" first="Caterina" last="Mariotti">Caterina Mariotti</name><affiliation wicri:level="1"><mods:affiliation>Department of Biochemistry and Genetics, Fondazione‐IRCCS, Istituto Neurologico Carlo Besta, Milan, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biochemistry and Genetics, Fondazione‐IRCCS, Istituto Neurologico Carlo Besta, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Baliko, Lazlo" sort="Baliko, Lazlo" uniqKey="Baliko L" first="Lazlo" last="Baliko">Lazlo Baliko</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Stroke, County Hospital, Veszprém, Hungary</mods:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Neurology and Stroke, County Hospital, Veszprém</wicri:regionArea></affiliation></author><author><name sortKey="Melegh, Bela" sort="Melegh, Bela" uniqKey="Melegh B" first="Bela" last="Melegh">Bela Melegh</name><affiliation wicri:level="1"><mods:affiliation>Department of Medical Genetics and Child Development, University of Pécs, Hungary</mods:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Medical Genetics and Child Development, University of Pécs</wicri:regionArea></affiliation></author><author><name sortKey="Filla, Alessandro" sort="Filla, Alessandro" uniqKey="Filla A" first="Alessandro" last="Filla">Alessandro Filla</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University of Naples, Naples, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, University of Naples, Naples</wicri:regionArea></affiliation></author><author><name sortKey="Salvatore, Elena" sort="Salvatore, Elena" uniqKey="Salvatore E" first="Elena" last="Salvatore">Elena Salvatore</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University of Naples, Naples, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, University of Naples, Naples</wicri:regionArea></affiliation></author><author><name sortKey="Van De Warrenburg, Bart P C" sort="Van De Warrenburg, Bart P C" uniqKey="Van De Warrenburg B" first="Bart P. C." last="Van De Warrenburg">Bart P. C. Van De Warrenburg</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Donders Centre for Neuroscience, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands</mods:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Donders Centre for Neuroscience, Radboud University Nijmegen Medical Center, Nijmegen</wicri:regionArea></affiliation></author><author><name sortKey="Szymanski, Sandra" sort="Szymanski, Sandra" uniqKey="Szymanski S" first="Sandra" last="Szymanski">Sandra Szymanski</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, St. Josef Hospital, University Hospital of Bochum, Bochum, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, St. Josef Hospital, University Hospital of Bochum, Bochum</wicri:regionArea></affiliation></author><author><name sortKey="Infante, Jon" sort="Infante, Jon" uniqKey="Infante J" first="Jon" last="Infante">Jon Infante</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Hospital “Marqués de Valdecilla,” CIBERNED, Santander, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, University Hospital “Marqués de Valdecilla,” CIBERNED, Santander</wicri:regionArea></affiliation></author><author><name sortKey="Timmann, Dagmar" sort="Timmann, Dagmar" uniqKey="Timmann D" first="Dagmar" last="Timmann">Dagmar Timmann</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Hospital of Essen, Essen, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Hospital of Essen, Essen</wicri:regionArea></affiliation></author><author><name sortKey="Boesch, Sylvia" sort="Boesch, Sylvia" uniqKey="Boesch S" first="Sylvia" last="Boesch">Sylvia Boesch</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University of Innsbruck, Innsbruck, Austria</mods:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, University of Innsbruck, Innsbruck</wicri:regionArea></affiliation></author><author><name sortKey="Depondt, Chantal" sort="Depondt, Chantal" uniqKey="Depondt C" first="Chantal" last="Depondt">Chantal Depondt</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium</mods:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Neurology, Hôpital Erasme, Université Libre de Bruxelles, Brussels</wicri:regionArea></affiliation></author><author><name sortKey="Kang, Jun Uk" sort="Kang, Jun Uk" uniqKey="Kang J" first="Jun-Suk" last="Kang">Jun-Suk Kang</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University of Frankfurt, Frankfurt/M, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Frankfurt, Frankfurt/M</wicri:regionArea></affiliation></author><author><name sortKey="Schulz, Jorg B" sort="Schulz, Jorg B" uniqKey="Schulz J" first="Jörg B." last="Schulz">Jörg B. Schulz</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Clinic, RTHW Aachen, Aachen, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Clinic, RTHW Aachen, Aachen</wicri:regionArea></affiliation></author><author><name sortKey="Klopstock, Thomas" sort="Klopstock, Thomas" uniqKey="Klopstock T" first="Thomas" last="Klopstock">Thomas Klopstock</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Friedrich‐Baur‐Institute, University Hospital of Ludwig‐Maximilians‐University, München, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Friedrich‐Baur‐Institute, University Hospital of Ludwig‐Maximilians‐University, München</wicri:regionArea></affiliation></author><author><name sortKey="Lossnitzer, Nicole" sort="Lossnitzer, Nicole" uniqKey="Lossnitzer N" first="Nicole" last="Lossnitzer">Nicole Lossnitzer</name><affiliation wicri:level="1"><mods:affiliation>Department of Psychosomatic and General Internal Medicine, Medical University Hospital Heidelberg, Heidelberg, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychosomatic and General Internal Medicine, Medical University Hospital Heidelberg, Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Lowe, Bernd" sort="Lowe, Bernd" uniqKey="Lowe B" first="Bernd" last="Löwe">Bernd Löwe</name><affiliation wicri:level="1"><mods:affiliation>Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Hamburg‐Eppendorf and Hamburg‐Eilbek (Schön Clinics), Hamburg, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Hamburg‐Eppendorf and Hamburg‐Eilbek (Schön Clinics), Hamburg</wicri:regionArea></affiliation></author><author><name sortKey="Frick, Caroline" sort="Frick, Caroline" uniqKey="Frick C" first="Caroline" last="Frick">Caroline Frick</name><affiliation wicri:level="1"><mods:affiliation>Department of Psychiatry and Psychotherapy, University Clinic Bonn, Bonn, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, University Clinic Bonn, Bonn</wicri:regionArea></affiliation></author><author><name sortKey="Rottl Nder, Daniela" sort="Rottl Nder, Daniela" uniqKey="Rottl Nder D" first="Daniela" last="Rottl Nder">Daniela Rottl Nder</name><affiliation wicri:level="1"><mods:affiliation>Department of Psychiatry and Psychotherapy, University Clinic Bonn, Bonn, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, University Clinic Bonn, Bonn</wicri:regionArea></affiliation></author><author><name sortKey="Schlaepfer, Thomas E" sort="Schlaepfer, Thomas E" uniqKey="Schlaepfer T" first="Thomas E." last="Schlaepfer">Thomas E. Schlaepfer</name><affiliation wicri:level="1"><mods:affiliation>Department of Psychiatry and Psychotherapy, University Clinic Bonn, Bonn, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, University Clinic Bonn, Bonn</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Psychiatry and Behavioral Science, Johns Hopkins University, Baltimore, Maryland, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry and Behavioral Science, Johns Hopkins University, Baltimore, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Klockgether, Thomas" sort="Klockgether, Thomas" uniqKey="Klockgether T" first="Thomas" last="Klockgether">Thomas Klockgether</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Hospital of Bonn, Bonn, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Hospital of Bonn, Bonn</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:50B77A4B4C970763DCD1BFCBA3F272B70C8B5985</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/mds.23698</idno><idno type="url">https://api.istex.fr/document/50B77A4B4C970763DCD1BFCBA3F272B70C8B5985/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000522</idno><idno type="wicri:Area/Istex/Curation">000522</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Depression comorbidity in spinocerebellar ataxia</title><author><name sortKey="Schmitz Bsch, Tanja" sort="Schmitz Bsch, Tanja" uniqKey="Schmitz Bsch T" first="Tanja" last="Schmitz-Hübsch">Tanja Schmitz-Hübsch</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Hospital of Bonn, Bonn, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Hospital of Bonn, Bonn</wicri:regionArea></affiliation></author><author><name sortKey="Coudert, Mathieu" sort="Coudert, Mathieu" uniqKey="Coudert M" first="Mathieu" last="Coudert">Mathieu Coudert</name><affiliation wicri:level="1"><mods:affiliation>Department of Biostatistics and Medical Informatics, Hôpital de la Pitié‐Salpêtrière, Assistance Publique‐Hôpitaux, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Biostatistics and Medical Informatics, Hôpital de la Pitié‐Salpêtrière, Assistance Publique‐Hôpitaux, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Modeling in Clinical Research, EA 3974, University Pierre et Marie Curie, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Modeling in Clinical Research, EA 3974, University Pierre et Marie Curie, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Tezenas Du Montcel, Sophie" sort="Tezenas Du Montcel, Sophie" uniqKey="Tezenas Du Montcel S" first="Sophie" last="Tezenas Du Montcel">Sophie Tezenas Du Montcel</name><affiliation wicri:level="1"><mods:affiliation>Department of Biostatistics and Medical Informatics, Hôpital de la Pitié‐Salpêtrière, Assistance Publique‐Hôpitaux, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Biostatistics and Medical Informatics, Hôpital de la Pitié‐Salpêtrière, Assistance Publique‐Hôpitaux, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Modeling in Clinical Research, EA 3974, University Pierre et Marie Curie, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Modeling in Clinical Research, EA 3974, University Pierre et Marie Curie, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Giunti, Paola" sort="Giunti, Paola" uniqKey="Giunti P" first="Paola" last="Giunti">Paola Giunti</name><affiliation wicri:level="1"><mods:affiliation>Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London</wicri:regionArea></affiliation></author><author><name sortKey="Labrum, Robyn" sort="Labrum, Robyn" uniqKey="Labrum R" first="Robyn" last="Labrum">Robyn Labrum</name><affiliation wicri:level="1"><mods:affiliation>Division of Neurogenetics, National Hospital of Neurology and Neurosurgery, Queen Square, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Neurogenetics, National Hospital of Neurology and Neurosurgery, Queen Square, London</wicri:regionArea></affiliation></author><author><name sortKey="Durr, Alexandra" sort="Durr, Alexandra" uniqKey="Durr A" first="Alexandra" last="Dürr">Alexandra Dürr</name><affiliation wicri:level="1"><mods:affiliation>INSERM, UMR_S679 Neurologie & Thérapeutique Expérimentale, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, UMR_S679 Neurologie & Thérapeutique Expérimentale, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>AP‐HP, Hôpital de la Salpêtrière, Department of Genetics and Cytogenetics, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP‐HP, Hôpital de la Salpêtrière, Department of Genetics and Cytogenetics, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Ribai, Pascale" sort="Ribai, Pascale" uniqKey="Ribai P" first="Pascale" last="Ribai">Pascale Ribai</name><affiliation wicri:level="1"><mods:affiliation>INSERM, UMR_S679 Neurologie & Thérapeutique Expérimentale, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, UMR_S679 Neurologie & Thérapeutique Expérimentale, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>AP‐HP, Hôpital de la Salpêtrière, Department of Genetics and Cytogenetics, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP‐HP, Hôpital de la Salpêtrière, Department of Genetics and Cytogenetics, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Charles, Perrine" sort="Charles, Perrine" uniqKey="Charles P" first="Perrine" last="Charles">Perrine Charles</name><affiliation wicri:level="1"><mods:affiliation>INSERM, UMR_S679 Neurologie & Thérapeutique Expérimentale, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, UMR_S679 Neurologie & Thérapeutique Expérimentale, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>AP‐HP, Hôpital de la Salpêtrière, Department of Genetics and Cytogenetics, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP‐HP, Hôpital de la Salpêtrière, Department of Genetics and Cytogenetics, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Linnemann, Christoph" sort="Linnemann, Christoph" uniqKey="Linnemann C" first="Christoph" last="Linnemann">Christoph Linnemann</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Hertie‐Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology and Hertie‐Institute for Clinical Brain Research, University of Tübingen, Tübingen</wicri:regionArea></affiliation></author><author><name sortKey="Schols, Ludger" sort="Schols, Ludger" uniqKey="Schols L" first="Ludger" last="Schöls">Ludger Schöls</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Hertie‐Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology and Hertie‐Institute for Clinical Brain Research, University of Tübingen, Tübingen</wicri:regionArea></affiliation></author><author><name sortKey="Rakowicz, Maryla" sort="Rakowicz, Maryla" uniqKey="Rakowicz M" first="Maryla" last="Rakowicz">Maryla Rakowicz</name><affiliation wicri:level="1"><mods:affiliation>Department of Clinical Neurophysiology, Institute of Psychiatry and Neurology, Warsaw, Poland</mods:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Clinical Neurophysiology, Institute of Psychiatry and Neurology, Warsaw</wicri:regionArea></affiliation></author><author><name sortKey="Rola, Rafal" sort="Rola, Rafal" uniqKey="Rola R" first="Rafal" last="Rola">Rafal Rola</name><affiliation wicri:level="1"><mods:affiliation>First Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland</mods:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>First Department of Neurology, Institute of Psychiatry and Neurology, Warsaw</wicri:regionArea></affiliation></author><author><name sortKey="Zdzienicka, Elszbieta" sort="Zdzienicka, Elszbieta" uniqKey="Zdzienicka E" first="Elszbieta" last="Zdzienicka">Elszbieta Zdzienicka</name><affiliation wicri:level="1"><mods:affiliation>Department of Genetics, Institute of Psychiatry and Neurology, Warsaw, Poland</mods:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Genetics, Institute of Psychiatry and Neurology, Warsaw</wicri:regionArea></affiliation></author><author><name sortKey="Fancellu, Roberto" sort="Fancellu, Roberto" uniqKey="Fancellu R" first="Roberto" last="Fancellu">Roberto Fancellu</name><affiliation wicri:level="1"><mods:affiliation>Department of Biochemistry and Genetics, Fondazione‐IRCCS, Istituto Neurologico Carlo Besta, Milan, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biochemistry and Genetics, Fondazione‐IRCCS, Istituto Neurologico Carlo Besta, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Mariotti, Caterina" sort="Mariotti, Caterina" uniqKey="Mariotti C" first="Caterina" last="Mariotti">Caterina Mariotti</name><affiliation wicri:level="1"><mods:affiliation>Department of Biochemistry and Genetics, Fondazione‐IRCCS, Istituto Neurologico Carlo Besta, Milan, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biochemistry and Genetics, Fondazione‐IRCCS, Istituto Neurologico Carlo Besta, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Baliko, Lazlo" sort="Baliko, Lazlo" uniqKey="Baliko L" first="Lazlo" last="Baliko">Lazlo Baliko</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Stroke, County Hospital, Veszprém, Hungary</mods:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Neurology and Stroke, County Hospital, Veszprém</wicri:regionArea></affiliation></author><author><name sortKey="Melegh, Bela" sort="Melegh, Bela" uniqKey="Melegh B" first="Bela" last="Melegh">Bela Melegh</name><affiliation wicri:level="1"><mods:affiliation>Department of Medical Genetics and Child Development, University of Pécs, Hungary</mods:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Medical Genetics and Child Development, University of Pécs</wicri:regionArea></affiliation></author><author><name sortKey="Filla, Alessandro" sort="Filla, Alessandro" uniqKey="Filla A" first="Alessandro" last="Filla">Alessandro Filla</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University of Naples, Naples, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, University of Naples, Naples</wicri:regionArea></affiliation></author><author><name sortKey="Salvatore, Elena" sort="Salvatore, Elena" uniqKey="Salvatore E" first="Elena" last="Salvatore">Elena Salvatore</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University of Naples, Naples, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, University of Naples, Naples</wicri:regionArea></affiliation></author><author><name sortKey="Van De Warrenburg, Bart P C" sort="Van De Warrenburg, Bart P C" uniqKey="Van De Warrenburg B" first="Bart P. C." last="Van De Warrenburg">Bart P. C. Van De Warrenburg</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Donders Centre for Neuroscience, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands</mods:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Donders Centre for Neuroscience, Radboud University Nijmegen Medical Center, Nijmegen</wicri:regionArea></affiliation></author><author><name sortKey="Szymanski, Sandra" sort="Szymanski, Sandra" uniqKey="Szymanski S" first="Sandra" last="Szymanski">Sandra Szymanski</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, St. Josef Hospital, University Hospital of Bochum, Bochum, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, St. Josef Hospital, University Hospital of Bochum, Bochum</wicri:regionArea></affiliation></author><author><name sortKey="Infante, Jon" sort="Infante, Jon" uniqKey="Infante J" first="Jon" last="Infante">Jon Infante</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Hospital “Marqués de Valdecilla,” CIBERNED, Santander, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, University Hospital “Marqués de Valdecilla,” CIBERNED, Santander</wicri:regionArea></affiliation></author><author><name sortKey="Timmann, Dagmar" sort="Timmann, Dagmar" uniqKey="Timmann D" first="Dagmar" last="Timmann">Dagmar Timmann</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Hospital of Essen, Essen, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Hospital of Essen, Essen</wicri:regionArea></affiliation></author><author><name sortKey="Boesch, Sylvia" sort="Boesch, Sylvia" uniqKey="Boesch S" first="Sylvia" last="Boesch">Sylvia Boesch</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University of Innsbruck, Innsbruck, Austria</mods:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, University of Innsbruck, Innsbruck</wicri:regionArea></affiliation></author><author><name sortKey="Depondt, Chantal" sort="Depondt, Chantal" uniqKey="Depondt C" first="Chantal" last="Depondt">Chantal Depondt</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium</mods:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Neurology, Hôpital Erasme, Université Libre de Bruxelles, Brussels</wicri:regionArea></affiliation></author><author><name sortKey="Kang, Jun Uk" sort="Kang, Jun Uk" uniqKey="Kang J" first="Jun-Suk" last="Kang">Jun-Suk Kang</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University of Frankfurt, Frankfurt/M, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Frankfurt, Frankfurt/M</wicri:regionArea></affiliation></author><author><name sortKey="Schulz, Jorg B" sort="Schulz, Jorg B" uniqKey="Schulz J" first="Jörg B." last="Schulz">Jörg B. Schulz</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Clinic, RTHW Aachen, Aachen, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Clinic, RTHW Aachen, Aachen</wicri:regionArea></affiliation></author><author><name sortKey="Klopstock, Thomas" sort="Klopstock, Thomas" uniqKey="Klopstock T" first="Thomas" last="Klopstock">Thomas Klopstock</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Friedrich‐Baur‐Institute, University Hospital of Ludwig‐Maximilians‐University, München, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Friedrich‐Baur‐Institute, University Hospital of Ludwig‐Maximilians‐University, München</wicri:regionArea></affiliation></author><author><name sortKey="Lossnitzer, Nicole" sort="Lossnitzer, Nicole" uniqKey="Lossnitzer N" first="Nicole" last="Lossnitzer">Nicole Lossnitzer</name><affiliation wicri:level="1"><mods:affiliation>Department of Psychosomatic and General Internal Medicine, Medical University Hospital Heidelberg, Heidelberg, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychosomatic and General Internal Medicine, Medical University Hospital Heidelberg, Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Lowe, Bernd" sort="Lowe, Bernd" uniqKey="Lowe B" first="Bernd" last="Löwe">Bernd Löwe</name><affiliation wicri:level="1"><mods:affiliation>Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Hamburg‐Eppendorf and Hamburg‐Eilbek (Schön Clinics), Hamburg, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Hamburg‐Eppendorf and Hamburg‐Eilbek (Schön Clinics), Hamburg</wicri:regionArea></affiliation></author><author><name sortKey="Frick, Caroline" sort="Frick, Caroline" uniqKey="Frick C" first="Caroline" last="Frick">Caroline Frick</name><affiliation wicri:level="1"><mods:affiliation>Department of Psychiatry and Psychotherapy, University Clinic Bonn, Bonn, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, University Clinic Bonn, Bonn</wicri:regionArea></affiliation></author><author><name sortKey="Rottl Nder, Daniela" sort="Rottl Nder, Daniela" uniqKey="Rottl Nder D" first="Daniela" last="Rottl Nder">Daniela Rottl Nder</name><affiliation wicri:level="1"><mods:affiliation>Department of Psychiatry and Psychotherapy, University Clinic Bonn, Bonn, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, University Clinic Bonn, Bonn</wicri:regionArea></affiliation></author><author><name sortKey="Schlaepfer, Thomas E" sort="Schlaepfer, Thomas E" uniqKey="Schlaepfer T" first="Thomas E." last="Schlaepfer">Thomas E. Schlaepfer</name><affiliation wicri:level="1"><mods:affiliation>Department of Psychiatry and Psychotherapy, University Clinic Bonn, Bonn, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, University Clinic Bonn, Bonn</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Psychiatry and Behavioral Science, Johns Hopkins University, Baltimore, Maryland, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry and Behavioral Science, Johns Hopkins University, Baltimore, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Klockgether, Thomas" sort="Klockgether, Thomas" uniqKey="Klockgether T" first="Thomas" last="Klockgether">Thomas Klockgether</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Hospital of Bonn, Bonn, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Hospital of Bonn, Bonn</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-04">2011-04</date><biblScope unit="vol">26</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="870">870</biblScope><biblScope unit="page" to="876">876</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">50B77A4B4C970763DCD1BFCBA3F272B70C8B5985</idno><idno type="DOI">10.1002/mds.23698</idno><idno type="ArticleID">MDS23698</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>cerebellum</term><term>depression</term><term>prevalence studies</term><term>spinocerebellar ataxia</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This is a description of the prevalence and profile of depressive symptoms in dominant spinocerebellar ataxia (SCA). Depressive symptoms were assessed in a convenience sample of 526 genetically confirmed and clinically affected patients (117 SCA1, 163 SCA2, 139 SCA3, and 107 SCA6) using the Patient Health Questionnaire (PHQ). In addition, depressive status according to the examiner and the use of antidepressants was recorded. Depression self‐assessment was compared with an interview‐based psychiatric assessment in a subset of 26 patients. Depression prevalence estimates were 17.1% according to the PHQ algorithm and 15.4% when assessed clinically. The sensitivity of clinical impression compared with PHQ classification was low (0.35), whereas diagnostic accuracy of PHQ compared with psychiatric interview in the subset was high. Antidepressants were used by 17.7% of patients and in >10% of patients without current clinically relevant depressive symptoms. Depression profile in SCA did not differ from a sample of patients with major depressive disorder except for the movement‐related item. Neither depression prevalence nor use of antidepressants differed between genetic subtypes, with only sleep disturbance more common in SCA3. In a multivariate analysis, ataxia severity and female sex independently predicted depressive status in SCA. The PHQ algorithmic classification is appropriate for use in SCA but should stimulate further psychiatric evaluation if depression is indicated. Despite a higher risk for depression with more severe disease, the relation of depressive symptoms to SCA neurodegeneration remains to be shown. © 2011 Movement Disorder Society</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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