Interaction between blood lead concentration and δ‐amino‐levulinic acid dehydratase gene polymorphisms increases the odds of essential tremor
Identifieur interne : 000272 ( Istex/Curation ); précédent : 000271; suivant : 000273Interaction between blood lead concentration and δ‐amino‐levulinic acid dehydratase gene polymorphisms increases the odds of essential tremor
Auteurs : Elan D. Louis [États-Unis] ; Lakeisha Applegate [États-Unis] ; Joseph H. Graziano [États-Unis] ; Michael Parides [États-Unis] ; Vesna Slavkovich [États-Unis] ; Hari K. Bhat [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2005-09.
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Abstract
Blood lead (BPb) concentrations are elevated in essential tremor (ET) cases. The δ‐amino‐levulinic acid dehydratase (ALAD) gene codes for ALAD, the principal enzyme involved in lead kinetics. Carriers of the ALAD‐2 allele may be more susceptible to lead toxicity. The objective of this study was to test, using a case‐control design, whether an interaction between BPb concentration and ALAD allele status increases the odds of ET. Mean log BPb concentration was significantly higher in 63 cases than 101 controls (0.47 ± 0.26 vs. 0.35 ± 0.25 μg/dl). Eighteen (28.6%) cases vs. 17 (16.8%) controls had an ALAD‐2 allele (OR = 1.98; 95% CI = 0.93–4.21). In an adjusted logistic regression analysis, the interaction term (ALAD allele status × log BPb concentration) was associated with increased odds for ET. In stratified analyses, log BPb concentration was not associated with odds of ET in individuals with two ALAD‐1 alleles (OR = 2.69; 95% CI = 0.61–11.82), but in individuals with an ALAD‐2 allele, BPb concentration was significantly associated with odds of ET (OR = 80.29; 95% CI = 3.08–2,096.36). There was an interaction between BPb concentration and ALAD allele status; the odds of ET were greatly elevated in individuals with both an ALAD‐2 allele and an elevated BPb concentration. The presence of increased circulating BPb concentrations along with a greater potential for lead toxicity (ALAD‐2 allele) could result in greater cerebellar damage, thereby increasing the risk of developing tremor. © 2005 Movement Disorder Society
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DOI: 10.1002/mds.20565
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Sergievsky Center, Columbia University, New York, New York</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Columbia University, New York, New York, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Columbia University, New York, New York</wicri:regionArea></affiliation></author><author><name sortKey="Applegate, Lakeisha" sort="Applegate, Lakeisha" uniqKey="Applegate L" first="Lakeisha" last="Applegate">Lakeisha Applegate</name><affiliation wicri:level="1"><mods:affiliation>Gertrude H. Sergievsky Center, Columbia University, New York, New York, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gertrude H. Sergievsky Center, Columbia University, New York, New York</wicri:regionArea></affiliation></author><author><name sortKey="Graziano, Joseph H" sort="Graziano, Joseph H" uniqKey="Graziano J" first="Joseph H." last="Graziano">Joseph H. 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Bhat</name><affiliation wicri:level="1"><mods:affiliation>Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2005-09">2005-09</date><biblScope unit="vol">20</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1170">1170</biblScope><biblScope unit="page" to="1177">1177</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">873406DB6DB23184AD1270C893ED3D77E9C51C3D</idno><idno type="DOI">10.1002/mds.20565</idno><idno type="ArticleID">MDS20565</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>epidemiology</term><term>essential tremor</term><term>etiology</term><term>genetics</term><term>lead</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="fr">Blood lead (BPb) concentrations are elevated in essential tremor (ET) cases. The δ‐amino‐levulinic acid dehydratase (ALAD) gene codes for ALAD, the principal enzyme involved in lead kinetics. Carriers of the ALAD‐2 allele may be more susceptible to lead toxicity. The objective of this study was to test, using a case‐control design, whether an interaction between BPb concentration and ALAD allele status increases the odds of ET. Mean log BPb concentration was significantly higher in 63 cases than 101 controls (0.47 ± 0.26 vs. 0.35 ± 0.25 μg/dl). Eighteen (28.6%) cases vs. 17 (16.8%) controls had an ALAD‐2 allele (OR = 1.98; 95% CI = 0.93–4.21). In an adjusted logistic regression analysis, the interaction term (ALAD allele status × log BPb concentration) was associated with increased odds for ET. In stratified analyses, log BPb concentration was not associated with odds of ET in individuals with two ALAD‐1 alleles (OR = 2.69; 95% CI = 0.61–11.82), but in individuals with an ALAD‐2 allele, BPb concentration was significantly associated with odds of ET (OR = 80.29; 95% CI = 3.08–2,096.36). There was an interaction between BPb concentration and ALAD allele status; the odds of ET were greatly elevated in individuals with both an ALAD‐2 allele and an elevated BPb concentration. The presence of increased circulating BPb concentrations along with a greater potential for lead toxicity (ALAD‐2 allele) could result in greater cerebellar damage, thereby increasing the risk of developing tremor. © 2005 Movement Disorder Society</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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