Interaction between blood lead concentration and δ‐amino‐levulinic acid dehydratase gene polymorphisms increases the odds of essential tremor
Identifieur interne : 000272 ( Istex/Corpus ); précédent : 000271; suivant : 000273Interaction between blood lead concentration and δ‐amino‐levulinic acid dehydratase gene polymorphisms increases the odds of essential tremor
Auteurs : Elan D. Louis ; Lakeisha Applegate ; Joseph H. Graziano ; Michael Parides ; Vesna Slavkovich ; Hari K. BhatSource :
- Movement Disorders [ 0885-3185 ] ; 2005-09.
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Abstract
Blood lead (BPb) concentrations are elevated in essential tremor (ET) cases. The δ‐amino‐levulinic acid dehydratase (ALAD) gene codes for ALAD, the principal enzyme involved in lead kinetics. Carriers of the ALAD‐2 allele may be more susceptible to lead toxicity. The objective of this study was to test, using a case‐control design, whether an interaction between BPb concentration and ALAD allele status increases the odds of ET. Mean log BPb concentration was significantly higher in 63 cases than 101 controls (0.47 ± 0.26 vs. 0.35 ± 0.25 μg/dl). Eighteen (28.6%) cases vs. 17 (16.8%) controls had an ALAD‐2 allele (OR = 1.98; 95% CI = 0.93–4.21). In an adjusted logistic regression analysis, the interaction term (ALAD allele status × log BPb concentration) was associated with increased odds for ET. In stratified analyses, log BPb concentration was not associated with odds of ET in individuals with two ALAD‐1 alleles (OR = 2.69; 95% CI = 0.61–11.82), but in individuals with an ALAD‐2 allele, BPb concentration was significantly associated with odds of ET (OR = 80.29; 95% CI = 3.08–2,096.36). There was an interaction between BPb concentration and ALAD allele status; the odds of ET were greatly elevated in individuals with both an ALAD‐2 allele and an elevated BPb concentration. The presence of increased circulating BPb concentrations along with a greater potential for lead toxicity (ALAD‐2 allele) could result in greater cerebellar damage, thereby increasing the risk of developing tremor. © 2005 Movement Disorder Society
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DOI: 10.1002/mds.20565
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2005-09">2005-09</date><biblScope unit="vol">20</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1170">1170</biblScope><biblScope unit="page" to="1177">1177</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">873406DB6DB23184AD1270C893ED3D77E9C51C3D</idno><idno type="DOI">10.1002/mds.20565</idno><idno type="ArticleID">MDS20565</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>epidemiology</term><term>essential tremor</term><term>etiology</term><term>genetics</term><term>lead</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="fr">Blood lead (BPb) concentrations are elevated in essential tremor (ET) cases. The δ‐amino‐levulinic acid dehydratase (ALAD) gene codes for ALAD, the principal enzyme involved in lead kinetics. Carriers of the ALAD‐2 allele may be more susceptible to lead toxicity. The objective of this study was to test, using a case‐control design, whether an interaction between BPb concentration and ALAD allele status increases the odds of ET. Mean log BPb concentration was significantly higher in 63 cases than 101 controls (0.47 ± 0.26 vs. 0.35 ± 0.25 μg/dl). Eighteen (28.6%) cases vs. 17 (16.8%) controls had an ALAD‐2 allele (OR = 1.98; 95% CI = 0.93–4.21). In an adjusted logistic regression analysis, the interaction term (ALAD allele status × log BPb concentration) was associated with increased odds for ET. In stratified analyses, log BPb concentration was not associated with odds of ET in individuals with two ALAD‐1 alleles (OR = 2.69; 95% CI = 0.61–11.82), but in individuals with an ALAD‐2 allele, BPb concentration was significantly associated with odds of ET (OR = 80.29; 95% CI = 3.08–2,096.36). There was an interaction between BPb concentration and ALAD allele status; the odds of ET were greatly elevated in individuals with both an ALAD‐2 allele and an elevated BPb concentration. The presence of increased circulating BPb concentrations along with a greater potential for lead toxicity (ALAD‐2 allele) could result in greater cerebellar damage, thereby increasing the risk of developing tremor. © 2005 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Elan D. Louis MS, MD</name><affiliations><json:string>Gertrude H. Sergievsky Center, Columbia University, New York, New York, USA</json:string><json:string>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, USA</json:string><json:string>Department of Neurology, Columbia University, New York, New York, USA</json:string></affiliations></json:item><json:item><name>LaKeisha Applegate BA</name><affiliations><json:string>Gertrude H. Sergievsky Center, Columbia University, New York, New York, USA</json:string></affiliations></json:item><json:item><name>Joseph H. Graziano PhD</name><affiliations><json:string>Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York, USA</json:string><json:string>Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA</json:string></affiliations></json:item><json:item><name>Michael Parides PhD</name><affiliations><json:string>Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York, USA</json:string></affiliations></json:item><json:item><name>Vesna Slavkovich MS</name><affiliations><json:string>Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA</json:string></affiliations></json:item><json:item><name>Hari K. Bhat PhD</name><affiliations><json:string>Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>essential tremor</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>epidemiology</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>etiology</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>genetics</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>lead</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Blood lead (BPb) concentrations are elevated in essential tremor (ET) cases. The δ‐amino‐levulinic acid dehydratase (ALAD) gene codes for ALAD, the principal enzyme involved in lead kinetics. Carriers of the ALAD‐2 allele may be more susceptible to lead toxicity. The objective of this study was to test, using a case‐control design, whether an interaction between BPb concentration and ALAD allele status increases the odds of ET. Mean log BPb concentration was significantly higher in 63 cases than 101 controls (0.47 ± 0.26 vs. 0.35 ± 0.25 μg/dl). Eighteen (28.6%) cases vs. 17 (16.8%) controls had an ALAD‐2 allele (OR = 1.98; 95% CI = 0.93–4.21). In an adjusted logistic regression analysis, the interaction term (ALAD allele status × log BPb concentration) was associated with increased odds for ET. In stratified analyses, log BPb concentration was not associated with odds of ET in individuals with two ALAD‐1 alleles (OR = 2.69; 95% CI = 0.61–11.82), but in individuals with an ALAD‐2 allele, BPb concentration was significantly associated with odds of ET (OR = 80.29; 95% CI = 3.08–2,096.36). There was an interaction between BPb concentration and ALAD allele status; the odds of ET were greatly elevated in individuals with both an ALAD‐2 allele and an elevated BPb concentration. The presence of increased circulating BPb concentrations along with a greater potential for lead toxicity (ALAD‐2 allele) could result in greater cerebellar damage, thereby increasing the risk of developing tremor. © 2005 Movement Disorder Society</abstract><qualityIndicators><score>7.904</score><pdfVersion>1.3</pdfVersion><pdfPageSize>594 x 792 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>1539</abstractCharCount><pdfWordCount>5268</pdfWordCount><pdfCharCount>31365</pdfCharCount><pdfPageCount>8</pdfPageCount><abstractWordCount>242</abstractWordCount></qualityIndicators><title>Interaction between blood lead concentration and δ‐amino‐levulinic acid dehydratase gene polymorphisms increases the odds of essential tremor</title><genre><json:string>Serial article</json:string></genre><host><volume>20</volume><pages><total>8</total><last>1177</last><first>1170</first></pages><issn><json:string>0885-3185</json:string></issn><issue>9</issue><subject><json:item><value>Research Article</value></json:item></subject><genre></genre><language><json:string>unknown</json:string></language><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2005</publicationDate><copyrightDate>2005</copyrightDate><doi><json:string>10.1002/mds.20565</json:string></doi><id>873406DB6DB23184AD1270C893ED3D77E9C51C3D</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/873406DB6DB23184AD1270C893ED3D77E9C51C3D/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/873406DB6DB23184AD1270C893ED3D77E9C51C3D/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/873406DB6DB23184AD1270C893ED3D77E9C51C3D/fulltext/tei"><teiHeader type="text"><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Interaction between blood lead concentration and δ‐amino‐levulinic acid dehydratase gene polymorphisms increases the odds of essential tremor</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>Wiley Subscription Services, Inc., A Wiley Company</p></availability><date>2005</date></publicationStmt><notesStmt><note>National Institutes of Health - No. R01 NS39422; No. R01 NS42859;</note><note>General Clinical Research Center - No. RR00645;</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Interaction between blood lead concentration and δ‐amino‐levulinic acid dehydratase gene polymorphisms increases the odds of essential tremor</title><author><persName><forename type="first">Elan D.</forename><surname>Louis</surname><roleName type="degree">MS, MD</roleName></persName><note type="correspondence"><p>Correspondence: Unit 198, Neurological Institute, 710 West 168th Street, New York, NY 10032</p></note><affiliation>Gertrude H. 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Carriers of the ALAD‐2 allele may be more susceptible to lead toxicity. The objective of this study was to test, using a case‐control design, whether an interaction between BPb concentration and ALAD allele status increases the odds of ET. Mean log BPb concentration was significantly higher in 63 cases than 101 controls (0.47 ± 0.26 vs. 0.35 ± 0.25 μg/dl). Eighteen (28.6%) cases vs. 17 (16.8%) controls had an ALAD‐2 allele (OR = 1.98; 95% CI = 0.93–4.21). In an adjusted logistic regression analysis, the interaction term (ALAD allele status × log BPb concentration) was associated with increased odds for ET. In stratified analyses, log BPb concentration was not associated with odds of ET in individuals with two ALAD‐1 alleles (OR = 2.69; 95% CI = 0.61–11.82), but in individuals with an ALAD‐2 allele, BPb concentration was significantly associated with odds of ET (OR = 80.29; 95% CI = 3.08–2,096.36). There was an interaction between BPb concentration and ALAD allele status; the odds of ET were greatly elevated in individuals with both an ALAD‐2 allele and an elevated BPb concentration. The presence of increased circulating BPb concentrations along with a greater potential for lead toxicity (ALAD‐2 allele) could result in greater cerebellar damage, thereby increasing the risk of developing tremor. © 2005 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>essential tremor</term></item><item><term>epidemiology</term></item><item><term>etiology</term></item><item><term>genetics</term></item><item><term>lead</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2004-11-16">Received</change><change when="2005-01-21">Registration</change><change when="2005-09">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/873406DB6DB23184AD1270C893ED3D77E9C51C3D/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="subtitle">Official Journal of the Movement Disorder Society</title><title type="short">Mov. 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Sergievsky Center, Columbia University, New York, New York, USA</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="US" type="organization"><unparsedAffiliation>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, USA</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="US" type="organization"><unparsedAffiliation>Department of Neurology, Columbia University, New York, New York, USA</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="US" type="organization"><unparsedAffiliation>Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York, USA</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="US" type="organization"><unparsedAffiliation>Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA</unparsedAffiliation></affiliation><affiliation xml:id="af6" countryCode="US" type="organization"><unparsedAffiliation>Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York, USA</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">essential tremor</keyword><keyword xml:id="kwd2">epidemiology</keyword><keyword xml:id="kwd3">etiology</keyword><keyword xml:id="kwd4">genetics</keyword><keyword xml:id="kwd5">lead</keyword></keywordGroup><fundingInfo><fundingAgency>National Institutes of Health</fundingAgency><fundingNumber>R01 NS39422</fundingNumber><fundingNumber>R01 NS42859</fundingNumber></fundingInfo><fundingInfo><fundingAgency>General Clinical Research Center</fundingAgency><fundingNumber>RR00645</fundingNumber></fundingInfo><abstractGroup><abstract type="main" xml:lang="fr"><title type="main">Abstract</title><p>Blood lead (BPb) concentrations are elevated in essential tremor (ET) cases. The δ‐amino‐levulinic acid dehydratase (ALAD) gene codes for ALAD, the principal enzyme involved in lead kinetics. Carriers of the ALAD‐2 allele may be more susceptible to lead toxicity. The objective of this study was to test, using a case‐control design, whether an interaction between BPb concentration and ALAD allele status increases the odds of ET. Mean log BPb concentration was significantly higher in 63 cases than 101 controls (0.47 ± 0.26 vs. 0.35 ± 0.25 μg/dl). Eighteen (28.6%) cases vs. 17 (16.8%) controls had an ALAD‐2 allele (OR = 1.98; 95% CI = 0.93–4.21). In an adjusted logistic regression analysis, the interaction term (ALAD allele status × log BPb concentration) was associated with increased odds for ET. In stratified analyses, log BPb concentration was not associated with odds of ET in individuals with two ALAD‐1 alleles (OR = 2.69; 95% CI = 0.61–11.82), but in individuals with an ALAD‐2 allele, BPb concentration was significantly associated with odds of ET (OR = 80.29; 95% CI = 3.08–2,096.36). There was an interaction between BPb concentration and ALAD allele status; the odds of ET were greatly elevated in individuals with both an ALAD‐2 allele and an elevated BPb concentration. The presence of increased circulating BPb concentrations along with a greater potential for lead toxicity (ALAD‐2 allele) could result in greater cerebellar damage, thereby increasing the risk of developing tremor. © 2005 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 4-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Interaction between blood lead concentration and δ‐amino‐levulinic acid dehydratase gene polymorphisms increases the odds of essential tremor</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Essential Tremor</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Interaction between blood lead concentration and δ‐amino‐levulinic acid dehydratase gene polymorphisms increases the odds of essential tremor</title></titleInfo><name type="personal"><namePart type="given">Elan D.</namePart><namePart type="family">Louis</namePart><namePart type="termsOfAddress">MS, MD</namePart><affiliation>Gertrude H. Sergievsky Center, Columbia University, New York, New York, USA</affiliation><affiliation>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, USA</affiliation><affiliation>Department of Neurology, Columbia University, New York, New York, USA</affiliation><description>Correspondence: Unit 198, Neurological Institute, 710 West 168th Street, New York, NY 10032</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LaKeisha</namePart><namePart type="family">Applegate</namePart><namePart type="termsOfAddress">BA</namePart><affiliation>Gertrude H. Sergievsky Center, Columbia University, New York, New York, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Joseph H.</namePart><namePart type="family">Graziano</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York, USA</affiliation><affiliation>Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michael</namePart><namePart type="family">Parides</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Vesna</namePart><namePart type="family">Slavkovich</namePart><namePart type="termsOfAddress">MS</namePart><affiliation>Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hari K.</namePart><namePart type="family">Bhat</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2005-09</dateIssued><dateCaptured encoding="w3cdtf">2004-11-16</dateCaptured><dateValid encoding="w3cdtf">2005-01-21</dateValid><copyrightDate encoding="w3cdtf">2005</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="tables">2</extent><extent unit="references">49</extent><extent unit="words">5792</extent></physicalDescription><abstract lang="fr">Blood lead (BPb) concentrations are elevated in essential tremor (ET) cases. The δ‐amino‐levulinic acid dehydratase (ALAD) gene codes for ALAD, the principal enzyme involved in lead kinetics. Carriers of the ALAD‐2 allele may be more susceptible to lead toxicity. The objective of this study was to test, using a case‐control design, whether an interaction between BPb concentration and ALAD allele status increases the odds of ET. Mean log BPb concentration was significantly higher in 63 cases than 101 controls (0.47 ± 0.26 vs. 0.35 ± 0.25 μg/dl). Eighteen (28.6%) cases vs. 17 (16.8%) controls had an ALAD‐2 allele (OR = 1.98; 95% CI = 0.93–4.21). In an adjusted logistic regression analysis, the interaction term (ALAD allele status × log BPb concentration) was associated with increased odds for ET. In stratified analyses, log BPb concentration was not associated with odds of ET in individuals with two ALAD‐1 alleles (OR = 2.69; 95% CI = 0.61–11.82), but in individuals with an ALAD‐2 allele, BPb concentration was significantly associated with odds of ET (OR = 80.29; 95% CI = 3.08–2,096.36). There was an interaction between BPb concentration and ALAD allele status; the odds of ET were greatly elevated in individuals with both an ALAD‐2 allele and an elevated BPb concentration. The presence of increased circulating BPb concentrations along with a greater potential for lead toxicity (ALAD‐2 allele) could result in greater cerebellar damage, thereby increasing the risk of developing tremor. © 2005 Movement Disorder Society</abstract><note type="funding">National Institutes of Health - No. R01 NS39422; No. R01 NS42859; </note><note type="funding">General Clinical Research Center - No. RR00645; </note><subject lang="en"><genre>Keywords</genre><topic>essential tremor</topic><topic>epidemiology</topic><topic>etiology</topic><topic>genetics</topic><topic>lead</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. 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