Examination of the SGCE gene in Tourette syndrome patients with obsessive–compulsive disorder
Identifieur interne : 003729 ( Istex/Corpus ); précédent : 003728; suivant : 003730Examination of the SGCE gene in Tourette syndrome patients with obsessive–compulsive disorder
Auteurs : Patricia De Carvalho Aguiar ; Melissa Fazzari ; Joseph Jankovic ; Laurie J. OzeliusSource :
- Movement Disorders [ 0885-3185 ] ; 2004-10.
English descriptors
Abstract
Mutations in the ϵ‐sarcoglycan gene (SGCE) have been reported in families with myoclonus–dystonia (M‐D). In addition to abnormal movements, obsessive–compulsive disorder (OCD) has also been described in families with M‐D. OCD is a common feature in another movement disorder, namely Tourette syndrome (TS). The comorbidity of these disorders suggests that common genetic factors might be involved in their susceptibility. To evaluate this, we performed two sets of experiments. An association study using a polymorphism within an intron of the SGCE gene was assessed in patients with TS and OCD versus controls, and the SGCE gene itself was screened for mutations in all TS/OCD patients, followed by direct sequencing of the gene in a limited number of these patients. No correlation was found by either method. © 2004 Movement Disorder Society
Url:
DOI: 10.1002/mds.20156
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ISTEX:FEEBF8116908799DA3D7A5F8D40195ACFC395A8ELe document en format XML
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In addition to abnormal movements, obsessive–compulsive disorder (OCD) has also been described in families with M‐D. OCD is a common feature in another movement disorder, namely Tourette syndrome (TS). The comorbidity of these disorders suggests that common genetic factors might be involved in their susceptibility. To evaluate this, we performed two sets of experiments. An association study using a polymorphism within an intron of the SGCE gene was assessed in patients with TS and OCD versus controls, and the SGCE gene itself was screened for mutations in all TS/OCD patients, followed by direct sequencing of the gene in a limited number of these patients. No correlation was found by either method. © 2004 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Patricia De Carvalho Aguiar MD</name><affiliations><json:string>Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York, USA</json:string><json:string>Department of Neurology and Neurosurgery, Federal University of São Paulo, São Paulo, Brazil</json:string></affiliations></json:item><json:item><name>Melissa Fazzari MS</name><affiliations><json:string>Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA</json:string></affiliations></json:item><json:item><name>Joseph Jankovic MD</name><affiliations><json:string>Department of Neurology, Baylor College of Medicine, Houston, Texas, USA</json:string></affiliations></json:item><json:item><name>Laurie J. 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The comorbidity of these disorders suggests that common genetic factors might be involved in their susceptibility. To evaluate this, we performed two sets of experiments. An association study using a polymorphism within an intron of the SGCE gene was assessed in patients with TS and OCD versus controls, and the SGCE gene itself was screened for mutations in all TS/OCD patients, followed by direct sequencing of the gene in a limited number of these patients. 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In addition to abnormal movements, obsessive–compulsive disorder (OCD) has also been described in families with M‐D. OCD is a common feature in another movement disorder, namely Tourette syndrome (TS). The comorbidity of these disorders suggests that common genetic factors might be involved in their susceptibility. To evaluate this, we performed two sets of experiments. An association study using a polymorphism within an intron of the SGCE gene was assessed in patients with TS and OCD versus controls, and the SGCE gene itself was screened for mutations in all TS/OCD patients, followed by direct sequencing of the gene in a limited number of these patients. 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In addition to abnormal movements, obsessive–compulsive disorder (OCD) has also been described in families with M‐D. OCD is a common feature in another movement disorder, namely Tourette syndrome (TS). The comorbidity of these disorders suggests that common genetic factors might be involved in their susceptibility. To evaluate this, we performed two sets of experiments. An association study using a polymorphism within an intron of the SGCE gene was assessed in patients with TS and OCD versus controls, and the SGCE gene itself was screened for mutations in all TS/OCD patients, followed by direct sequencing of the gene in a limited number of these patients. No correlation was found by either method. © 2004 Movement Disorder Society</abstract><note type="funding">Myoclonus Research Foundation</note><note type="funding">CAPES foundation</note><note type="funding">National Institute of Neurological Diseases and Stroke - No. NS26656; </note><subject lang="en"><genre>Keywords</genre><topic>myoclonus–dystonia</topic><topic>ϵ‐sarcoglycan</topic><topic>Tourette syndrome</topic><topic>obsessive–compulsive disorder</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. 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|texte= Examination of the SGCE gene in Tourette syndrome patients with obsessive–compulsive disorder
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