Elevated concentration of cerebrospinal fluid tissue transglutaminase in Parkinson's disease indicating apoptosis
Identifieur interne : 003530 ( Istex/Corpus ); précédent : 003529; suivant : 003531Elevated concentration of cerebrospinal fluid tissue transglutaminase in Parkinson's disease indicating apoptosis
Auteurs : Istvan Vermes ; Ernst N. H. Jansen Steur ; Gustav F. Jirikowski ; Clemens HaanenSource :
- Movement Disorders [ 0885-3185 ] ; 2004-10.
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- KwdEn :
Abstract
Tissue transglutaminase (tTG) is activated during the apoptotic cell death cascade and plays a key role in the formation of apoptotic bodies. We found significant elevation of tTG concentration in the cerebrospinal fluid (CSF) of 54 patients with Parkinson's disease (PD) compared with that measured in 34 control subjects, thus showing increased neural cell apoptosis in patients with PD. © 2004 Movement Disorder Society
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DOI: 10.1002/mds.20197
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ISTEX:CD88BBAC7216F24186D742ADC45EFB70645E55D9Le document en format XML
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