Effect of LY 171555 and CY 208‐243 on tremor suppression in the MPTP monkey model of parkinsonism
Identifieur interne : 003345 ( Istex/Corpus ); précédent : 003344; suivant : 003346Effect of LY 171555 and CY 208‐243 on tremor suppression in the MPTP monkey model of parkinsonism
Auteurs : Baltazar Gomez-Mancilla ; René Boucher ; BédardSource :
- Movement Disorders [ 0885-3185 ] ; 1992.
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Abstract
The antitremor effect of the D2 agonist LY 171555 and of the D1 agonist CY 208‐243 alone and in combination was tested in a monkey previously rendered parkinsonian by MPTP and displaying exceptionally a rest termor in the limbs. The D2 agonist suppressed rest tremor in a dose‐dependent fashion. The D1 agonist by itself had no effect but it potentiated the effect of a small dose of LY 171555.
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DOI: 10.1002/mds.870070108
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ISTEX:F661EFAC21CA0B712BC4178F12C2BE5F499D6610Le document en format XML
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The D<sub>2</sub> agonist suppressed rest tremor in a dose‐dependent fashion. The D<sub>1</sub> agonist by itself had no effect but it potentiated the effect of a small dose of LY 171555.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Effect of LY 171555 and CY 208‐243 on tremor suppression in the MPTP monkey model of parkinsonism</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>TREMOR SUPPRESSION IN MONKEY MODEL OF PARKINSONISM</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Effect of LY 171555 and CY 208‐243 on tremor suppression in the MPTP monkey model of parkinsonism</title></titleInfo><name type="personal"><namePart type="given">Baltazar</namePart><namePart type="family">Gomez‐Mancilla</namePart><affiliation>Centre de Recherche en Neurobiologie, Hôpital de l'Enfant‐Jésus, Québec, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">René</namePart><namePart type="family">Boucher</namePart><affiliation>Centre de Recherche en Neurobiologie, Hôpital de l'Enfant‐Jésus, Québec, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="termsOfAddress">Dr.</namePart><namePart type="family">Bédard</namePart><affiliation>Centre de Recherche en Neurobiologie, Hôpital de l'Enfant‐Jésus, Québec, Canada</affiliation><description>Correspondence: Centre de Recherche en Neurobiologie, Hôpital de l'Enfant‐Jésus, 1401, 18 Rue, Québec, Canada G1J 1Z4</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">1992</dateIssued><copyrightDate encoding="w3cdtf">1992</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">3</extent><extent unit="references">23</extent></physicalDescription><abstract lang="en">The antitremor effect of the D2 agonist LY 171555 and of the D1 agonist CY 208‐243 alone and in combination was tested in a monkey previously rendered parkinsonian by MPTP and displaying exceptionally a rest termor in the limbs. 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