Movement Disorders (revue)

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Chemotherapy‐induced parkinsonism responsive to levodopa: An underrecognized entity

Identifieur interne : 003138 ( Istex/Corpus ); précédent : 003137; suivant : 003139

Chemotherapy‐induced parkinsonism responsive to levodopa: An underrecognized entity

Auteurs : Cathy Chuang ; Anne Constantino ; Casilda Balmaceda ; David Eidelberg ; Steven J. Frucht

Source :

RBID : ISTEX:8A274E6F221962934BC1966811DBBDDEAB2FE63E

English descriptors

Abstract

Parkinsonism is a rare neurological complication of cancer treatment. Although individual case reports of this syndrome have been reported, the clinical features and prevalence of this syndrome are unknown. We present 3 patients, encountered over 6 months at one institution, who developed parkinsonism after treatment with various chemotherapeutic agents. Parkinsonism was severe in 2 patients, affecting postural reflexes, speech, and swallowing. All 3 patients responded dramatically to treatment with levodopa, and parkinsonism spontaneously improved or remitted over months. This unusual complication of cancer therapy is treatable and may be underappreciated. © 2002 Movement Disorder Society

Url:
DOI: 10.1002/mds.10344

Links to Exploration step

ISTEX:8A274E6F221962934BC1966811DBBDDEAB2FE63E

Le document en format XML

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<affiliation>The Neurological Institute, Columbia‐Presbyterian Medical Center, New York, New York, USA</affiliation>
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<dateIssued encoding="w3cdtf">2003-03</dateIssued>
<dateCaptured encoding="w3cdtf">2001-12-07</dateCaptured>
<dateValid encoding="w3cdtf">2002-08-26</dateValid>
<copyrightDate encoding="w3cdtf">2003</copyrightDate>
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<abstract lang="en">Parkinsonism is a rare neurological complication of cancer treatment. Although individual case reports of this syndrome have been reported, the clinical features and prevalence of this syndrome are unknown. We present 3 patients, encountered over 6 months at one institution, who developed parkinsonism after treatment with various chemotherapeutic agents. Parkinsonism was severe in 2 patients, affecting postural reflexes, speech, and swallowing. All 3 patients responded dramatically to treatment with levodopa, and parkinsonism spontaneously improved or remitted over months. This unusual complication of cancer therapy is treatable and may be underappreciated. © 2002 Movement Disorder Society</abstract>
<subject lang="en">
<genre>Keywords</genre>
<topic>parkinsonism</topic>
<topic>chemotherapy</topic>
<topic>levodopa</topic>
</subject>
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<title>Movement Disorders</title>
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<titleInfo type="abbreviated">
<title>Mov. Disord.</title>
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<subject>
<genre>article category</genre>
<topic>Brief Report</topic>
</subject>
<identifier type="ISSN">0885-3185</identifier>
<identifier type="eISSN">1531-8257</identifier>
<identifier type="DOI">10.1002/(ISSN)1531-8257</identifier>
<identifier type="PublisherID">MDS</identifier>
<part>
<date>2003</date>
<detail type="volume">
<caption>vol.</caption>
<number>18</number>
</detail>
<detail type="issue">
<caption>no.</caption>
<number>3</number>
</detail>
<extent unit="pages">
<start>328</start>
<end>331</end>
<total>4</total>
</extent>
</part>
</relatedItem>
<identifier type="istex">8A274E6F221962934BC1966811DBBDDEAB2FE63E</identifier>
<identifier type="DOI">10.1002/mds.10344</identifier>
<identifier type="ArticleID">MDS10344</identifier>
<accessCondition type="use and reproduction" contentType="copyright">Copyright © 2003 Movement Disorders Society</accessCondition>
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