[18F]FDOPA PET and clinical features in parkinsonism due to manganism
Identifieur interne : 002B38 ( Istex/Corpus ); précédent : 002B37; suivant : 002B39[18F]FDOPA PET and clinical features in parkinsonism due to manganism
Auteurs : Brad A. Racette ; Jo Ann Antenor ; Lori Mcgee-Minnich ; Stephen M. Moerlein ; Tom O. Videen ; Vikas Kotagal ; Joel S. PerlmutterSource :
- Movement Disorders [ 0885-3185 ] ; 2005-04.
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- KwdEn :
Abstract
Manganese exposure reportedly causes a clinically and pathophysiologically distinct syndrome from idiopathic Parkinson's disease (PD). We describe the clinical features and results of positron emission tomography with 6‐[18F]fluorodopa ([18F]FDOPA PET) of a patient with parkinsonism occurring in the setting of elevated blood manganese. The patient developed parkinsonism associated with elevated serum manganese from hepatic dysfunction. [18F]FDOPA PET demonstrated relatively symmetric and severely reduced [18F]FDOPA levels in the posterior putamen compared to controls. The globus pallidum interna had increased signal on T1‐weighted magnetic resonance imaging (MRI) images. We conclude that elevated manganese exposure may be associated with reduced striatal [18F]FDOPA uptake, and MRI may reveal selective abnormality within the internal segment of the pallidum. This case suggests that the clinical and pathophysiological features of manganese‐associated parkinsonism may overlap with that of PD. © 2005 Movement Disorder Society
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DOI: 10.1002/mds.20381
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<front><div type="abstract" xml:lang="en">Manganese exposure reportedly causes a clinically and pathophysiologically distinct syndrome from idiopathic Parkinson's disease (PD). We describe the clinical features and results of positron emission tomography with 6‐[18F]fluorodopa ([18F]FDOPA PET) of a patient with parkinsonism occurring in the setting of elevated blood manganese. The patient developed parkinsonism associated with elevated serum manganese from hepatic dysfunction. [18F]FDOPA PET demonstrated relatively symmetric and severely reduced [18F]FDOPA levels in the posterior putamen compared to controls. The globus pallidum interna had increased signal on T1‐weighted magnetic resonance imaging (MRI) images. We conclude that elevated manganese exposure may be associated with reduced striatal [18F]FDOPA uptake, and MRI may reveal selective abnormality within the internal segment of the pallidum. This case suggests that the clinical and pathophysiological features of manganese‐associated parkinsonism may overlap with that of PD. © 2005 Movement Disorder Society</div>
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<titleGroup><title type="main" xml:lang="en">[<sup>18</sup>
F]FDOPA PET and clinical features in parkinsonism due to manganism</title>
<title type="short" xml:lang="en">[<sup>18</sup>
F]FDOPA PET in Manganism</title>
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<creator xml:id="au3" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Lori</givenNames>
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<fundingNumber>K23NS43351</fundingNumber>
<fundingNumber>NS41509</fundingNumber>
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<fundingInfo><fundingAgency>Greater St. Louis Chapter of the American Parkinson Disease Association</fundingAgency>
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<fundingInfo><fundingAgency>Sam and Barbara Murphy Fund</fundingAgency>
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<fundingInfo><fundingAgency>Elliot H. Stein Family Fund</fundingAgency>
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<fundingInfo><fundingAgency>Ruth Kopolow</fundingAgency>
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<p>Manganese exposure reportedly causes a clinically and pathophysiologically distinct syndrome from idiopathic Parkinson's disease (PD). We describe the clinical features and results of positron emission tomography with 6‐[<sup>18</sup>
F]fluorodopa ([<sup>18</sup>
F]FDOPA PET) of a patient with parkinsonism occurring in the setting of elevated blood manganese. The patient developed parkinsonism associated with elevated serum manganese from hepatic dysfunction. [<sup>18</sup>
F]FDOPA PET demonstrated relatively symmetric and severely reduced [<sup>18</sup>
F]FDOPA levels in the posterior putamen compared to controls. The globus pallidum interna had increased signal on T1‐weighted magnetic resonance imaging (MRI) images. We conclude that elevated manganese exposure may be associated with reduced striatal [<sup>18</sup>
F]FDOPA uptake, and MRI may reveal selective abnormality within the internal segment of the pallidum. This case suggests that the clinical and pathophysiological features of manganese‐associated parkinsonism may overlap with that of PD. © 2005 Movement Disorder Society</p>
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<!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>[18F]FDOPA PET and clinical features in parkinsonism due to manganism</title>
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<name type="personal"><namePart type="given">Brad A.</namePart>
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<affiliation>Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA</affiliation>
<affiliation>American Parkinson Disease Association Advanced Center for Parkinson Research, Washington University School of Medicine, St. Louis, Missouri, USA</affiliation>
<description>Correspondence: Washington University School of Medicine, 660 South Euclid Ave., Box 8111, St. Louis, MO 63110</description>
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<name type="personal"><namePart type="given">Jo Ann</namePart>
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<affiliation>Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA</affiliation>
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<name type="personal"><namePart type="given">Lori</namePart>
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<affiliation>Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA</affiliation>
<affiliation>American Parkinson Disease Association Advanced Center for Parkinson Research, Washington University School of Medicine, St. Louis, Missouri, USA</affiliation>
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<name type="personal"><namePart type="given">Stephen M.</namePart>
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<name type="personal"><namePart type="given">Tom O.</namePart>
<namePart type="family">Videen</namePart>
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<affiliation>Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA</affiliation>
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<name type="personal"><namePart type="given">Vikas</namePart>
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<name type="personal"><namePart type="given">Joel S.</namePart>
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<affiliation>American Parkinson Disease Association Advanced Center for Parkinson Research, Washington University School of Medicine, St. Louis, Missouri, USA</affiliation>
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<abstract lang="en">Manganese exposure reportedly causes a clinically and pathophysiologically distinct syndrome from idiopathic Parkinson's disease (PD). We describe the clinical features and results of positron emission tomography with 6‐[18F]fluorodopa ([18F]FDOPA PET) of a patient with parkinsonism occurring in the setting of elevated blood manganese. The patient developed parkinsonism associated with elevated serum manganese from hepatic dysfunction. [18F]FDOPA PET demonstrated relatively symmetric and severely reduced [18F]FDOPA levels in the posterior putamen compared to controls. The globus pallidum interna had increased signal on T1‐weighted magnetic resonance imaging (MRI) images. We conclude that elevated manganese exposure may be associated with reduced striatal [18F]FDOPA uptake, and MRI may reveal selective abnormality within the internal segment of the pallidum. This case suggests that the clinical and pathophysiological features of manganese‐associated parkinsonism may overlap with that of PD. © 2005 Movement Disorder Society</abstract>
<note type="funding">National Institutes of Health - No. K23NS43351; No. NS41509; </note>
<note type="funding">Greater St. Louis Chapter of the American Parkinson Disease Association</note>
<note type="funding">Barnes–Jewish Hospital Fund</note>
<note type="funding">Sam and Barbara Murphy Fund</note>
<note type="funding">Elliot H. Stein Family Fund</note>
<note type="funding">Ruth Kopolow</note>
<subject lang="en"><genre>Keywords</genre>
<topic>Parkinson's disease</topic>
<topic>manganese</topic>
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