[18F]FDOPA PET and clinical features in parkinsonism due to manganism
Identifieur interne : 002B38 ( Istex/Corpus ); précédent : 002B37; suivant : 002B39[18F]FDOPA PET and clinical features in parkinsonism due to manganism
Auteurs : Brad A. Racette ; Jo Ann Antenor ; Lori Mcgee-Minnich ; Stephen M. Moerlein ; Tom O. Videen ; Vikas Kotagal ; Joel S. PerlmutterSource :
- Movement Disorders [ 0885-3185 ] ; 2005-04.
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Abstract
Manganese exposure reportedly causes a clinically and pathophysiologically distinct syndrome from idiopathic Parkinson's disease (PD). We describe the clinical features and results of positron emission tomography with 6‐[18F]fluorodopa ([18F]FDOPA PET) of a patient with parkinsonism occurring in the setting of elevated blood manganese. The patient developed parkinsonism associated with elevated serum manganese from hepatic dysfunction. [18F]FDOPA PET demonstrated relatively symmetric and severely reduced [18F]FDOPA levels in the posterior putamen compared to controls. The globus pallidum interna had increased signal on T1‐weighted magnetic resonance imaging (MRI) images. We conclude that elevated manganese exposure may be associated with reduced striatal [18F]FDOPA uptake, and MRI may reveal selective abnormality within the internal segment of the pallidum. This case suggests that the clinical and pathophysiological features of manganese‐associated parkinsonism may overlap with that of PD. © 2005 Movement Disorder Society
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DOI: 10.1002/mds.20381
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Racette MD</name><affiliations><json:string>Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA</json:string><json:string>American Parkinson Disease Association Advanced Center for Parkinson Research, Washington University School of Medicine, St. Louis, Missouri, USA</json:string></affiliations></json:item><json:item><name>Jo Ann Antenor MPH</name><affiliations><json:string>Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA</json:string></affiliations></json:item><json:item><name>Lori McGee‐Minnich BSN</name><affiliations><json:string>Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA</json:string><json:string>American Parkinson Disease Association Advanced Center for Parkinson Research, Washington University School of Medicine, St. Louis, Missouri, USA</json:string></affiliations></json:item><json:item><name>Stephen M. 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Perlmutter MD</name><affiliations><json:string>Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA</json:string><json:string>American Parkinson Disease Association Advanced Center for Parkinson Research, Washington University School of Medicine, St. Louis, Missouri, USA</json:string><json:string>Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA</json:string><json:string>Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri, USA</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>manganese</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>PET</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Manganese exposure reportedly causes a clinically and pathophysiologically distinct syndrome from idiopathic Parkinson's disease (PD). We describe the clinical features and results of positron emission tomography with 6‐[18F]fluorodopa ([18F]FDOPA PET) of a patient with parkinsonism occurring in the setting of elevated blood manganese. The patient developed parkinsonism associated with elevated serum manganese from hepatic dysfunction. [18F]FDOPA PET demonstrated relatively symmetric and severely reduced [18F]FDOPA levels in the posterior putamen compared to controls. The globus pallidum interna had increased signal on T1‐weighted magnetic resonance imaging (MRI) images. We conclude that elevated manganese exposure may be associated with reduced striatal [18F]FDOPA uptake, and MRI may reveal selective abnormality within the internal segment of the pallidum. 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Stein Family Fund</note><note>Ruth Kopolow</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">[18F]FDOPA PET and clinical features in parkinsonism due to manganism</title><author><persName><forename type="first">Brad A.</forename><surname>Racette</surname><roleName type="degree">MD</roleName></persName><note type="correspondence"><p>Correspondence: Washington University School of Medicine, 660 South Euclid Ave., Box 8111, St. Louis, MO 63110</p></note><affiliation>Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA</affiliation><affiliation>American Parkinson Disease Association Advanced Center for Parkinson Research, Washington University School of Medicine, St. Louis, Missouri, USA</affiliation></author><author><persName><forename type="first">Jo Ann</forename><surname>Antenor</surname><roleName type="degree">MPH</roleName></persName><affiliation>Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA</affiliation></author><author><persName><forename type="first">Lori</forename><surname>McGee‐Minnich</surname><roleName type="degree">BSN</roleName></persName><affiliation>Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA</affiliation><affiliation>American Parkinson Disease Association Advanced Center for Parkinson Research, Washington University School of Medicine, St. Louis, Missouri, USA</affiliation></author><author><persName><forename type="first">Stephen M.</forename><surname>Moerlein</surname><roleName type="degree">PhD</roleName></persName><affiliation>Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA</affiliation></author><author><persName><forename type="first">Tom O.</forename><surname>Videen</surname><roleName type="degree">PhD</roleName></persName><affiliation>Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA</affiliation><affiliation>Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA</affiliation></author><author><persName><forename type="first">Vikas</forename><surname>Kotagal</surname><roleName type="degree">BSN</roleName></persName><affiliation>Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA</affiliation></author><author><persName><forename type="first">Joel S.</forename><surname>Perlmutter</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA</affiliation><affiliation>American Parkinson Disease Association Advanced Center for Parkinson Research, Washington University School of Medicine, St. Louis, Missouri, USA</affiliation><affiliation>Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA</affiliation><affiliation>Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri, USA</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. 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xml:id="au3" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Lori</givenNames><familyName>McGee‐Minnich</familyName><degrees>BSN</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Stephen M.</givenNames><familyName>Moerlein</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1 #af3"><personName><givenNames>Tom O.</givenNames><familyName>Videen</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Vikas</givenNames><familyName>Kotagal</familyName><degrees>BSN</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af1 #af2 #af3 #af4"><personName><givenNames>Joel S.</givenNames><familyName>Perlmutter</familyName><degrees>MD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="US" type="organization"><unparsedAffiliation>Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="US" type="organization"><unparsedAffiliation>American Parkinson Disease Association Advanced Center for Parkinson Research, Washington University School of Medicine, St. Louis, Missouri, USA</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="US" type="organization"><unparsedAffiliation>Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="US" type="organization"><unparsedAffiliation>Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri, USA</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">manganese</keyword><keyword xml:id="kwd3">PET</keyword></keywordGroup><fundingInfo><fundingAgency>National Institutes of Health</fundingAgency><fundingNumber>K23NS43351</fundingNumber><fundingNumber>NS41509</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Greater St. Louis Chapter of the American Parkinson Disease Association</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Barnes–Jewish Hospital Fund</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Sam and Barbara Murphy Fund</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Elliot H. Stein Family Fund</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Ruth Kopolow</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Manganese exposure reportedly causes a clinically and pathophysiologically distinct syndrome from idiopathic Parkinson's disease (PD). We describe the clinical features and results of positron emission tomography with 6‐[<sup>18</sup>F]fluorodopa ([<sup>18</sup>F]FDOPA PET) of a patient with parkinsonism occurring in the setting of elevated blood manganese. The patient developed parkinsonism associated with elevated serum manganese from hepatic dysfunction. [<sup>18</sup>F]FDOPA PET demonstrated relatively symmetric and severely reduced [<sup>18</sup>F]FDOPA levels in the posterior putamen compared to controls. The globus pallidum interna had increased signal on T1‐weighted magnetic resonance imaging (MRI) images. We conclude that elevated manganese exposure may be associated with reduced striatal [<sup>18</sup>F]FDOPA uptake, and MRI may reveal selective abnormality within the internal segment of the pallidum. This case suggests that the clinical and pathophysiological features of manganese‐associated parkinsonism may overlap with that of PD. © 2005 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>[18F]FDOPA PET and clinical features in parkinsonism due to manganism</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>[18F]FDOPA PET in Manganism</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>[</title></titleInfo><name type="personal"><namePart type="given">Brad A.</namePart><namePart type="family">Racette</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA</affiliation><affiliation>American Parkinson Disease Association Advanced Center for Parkinson Research, Washington University School of Medicine, St. Louis, Missouri, USA</affiliation><description>Correspondence: Washington University School of Medicine, 660 South Euclid Ave., Box 8111, St. Louis, MO 63110</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jo Ann</namePart><namePart type="family">Antenor</namePart><namePart type="termsOfAddress">MPH</namePart><affiliation>Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Lori</namePart><namePart type="family">McGee‐Minnich</namePart><namePart type="termsOfAddress">BSN</namePart><affiliation>Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA</affiliation><affiliation>American Parkinson Disease Association Advanced Center for Parkinson Research, Washington University School of Medicine, St. Louis, Missouri, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Stephen M.</namePart><namePart type="family">Moerlein</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Tom O.</namePart><namePart type="family">Videen</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA</affiliation><affiliation>Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Vikas</namePart><namePart type="family">Kotagal</namePart><namePart type="termsOfAddress">BSN</namePart><affiliation>Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Joel S.</namePart><namePart type="family">Perlmutter</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA</affiliation><affiliation>American Parkinson Disease Association Advanced Center for Parkinson Research, Washington University School of Medicine, St. Louis, Missouri, USA</affiliation><affiliation>Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA</affiliation><affiliation>Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2005-04</dateIssued><dateCaptured encoding="w3cdtf">2004-01-11</dateCaptured><dateValid encoding="w3cdtf">2004-09-29</dateValid><copyrightDate encoding="w3cdtf">2005</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">1</extent><extent unit="references">40</extent><extent unit="words">3317</extent></physicalDescription><abstract lang="en">Manganese exposure reportedly causes a clinically and pathophysiologically distinct syndrome from idiopathic Parkinson's disease (PD). We describe the clinical features and results of positron emission tomography with 6‐[18F]fluorodopa ([18F]FDOPA PET) of a patient with parkinsonism occurring in the setting of elevated blood manganese. The patient developed parkinsonism associated with elevated serum manganese from hepatic dysfunction. [18F]FDOPA PET demonstrated relatively symmetric and severely reduced [18F]FDOPA levels in the posterior putamen compared to controls. The globus pallidum interna had increased signal on T1‐weighted magnetic resonance imaging (MRI) images. We conclude that elevated manganese exposure may be associated with reduced striatal [18F]FDOPA uptake, and MRI may reveal selective abnormality within the internal segment of the pallidum. This case suggests that the clinical and pathophysiological features of manganese‐associated parkinsonism may overlap with that of PD. © 2005 Movement Disorder Society</abstract><note type="funding">National Institutes of Health - No. K23NS43351; No. NS41509; </note><note type="funding">Greater St. Louis Chapter of the American Parkinson Disease Association</note><note type="funding">Barnes–Jewish Hospital Fund</note><note type="funding">Sam and Barbara Murphy Fund</note><note type="funding">Elliot H. Stein Family Fund</note><note type="funding">Ruth Kopolow</note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>manganese</topic><topic>PET</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Brief Report</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>20</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>492</start><end>496</end><total>5</total></extent></part></relatedItem><identifier type="istex">DD78D59D10E6EA0C5079C1062B84D49F4D7D55F2</identifier><identifier type="DOI">10.1002/mds.20381</identifier><identifier type="ArticleID">MDS20381</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2005 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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